Molecular pathogenesis of MODYs:

A timely collection of research papers by 18 leading scientists in the area of biochemical genetics of diabetes mellitus, these contributions focus on a well defined class of monogenic forms of the disease (i.e. MODYs 1–5) all caused by specific mutations or deletion of genes that control pancreatic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Weitere Verfasser: Matschinsky, Franz 1931- (HerausgeberIn), Magnuson, Mark A. (HerausgeberIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Basel Karger 2000
Schriftenreihe:Frontiers in diabetes Vol. 15
Schlagworte:
Online-Zugang:BFB01
BSB01
BTW01
EUV01
FAN01
FAW01
FFW01
FHI01
FHM01
FHN01
FHR01
FKE01
FNU01
FWS01
FWS02
GEM01
LCO01
SAB01
SAM01
SBG01
SBR01
SND01
TUM01
UBA01
UBG01
UBM01
UBR01
UBT01
UBW01
UER01
UPA01
Volltext
Zusammenfassung:A timely collection of research papers by 18 leading scientists in the area of biochemical genetics of diabetes mellitus, these contributions focus on a well defined class of monogenic forms of the disease (i.e. MODYs 1–5) all caused by specific mutations or deletion of genes that control pancreatic beta-cell functions: HNF-4alpha (1), glucokinase (2), HNF-1alpha (3), IDX-1 (4) and HNF-1beta (5).This volume offers a historical perspective of MODYs, and it also contains contributions which deal with the fundamental questions of pancreas and liver development, critical for the understanding of the syndrome complex discussed. Attempts have been made to highlight results and concepts that may be relevant for understanding type-II diabetes in general, exemplified by contributions that connect the field of pancreatic islet cell biology and pathology with the newest findings in the area of insulin action, e.g. the role of the insulin receptor and insulin receptor substrates (IRS 1–3). Covering a broad and novel approach on the subject of MODYs, this book looks into the future of molecular genetic and biochemical research in this area. It is recommended reading for basic research scientists in the area of diabetes mellitus, academically oriented endocrinologists and clinical researchers
Beschreibung:1 Online-Ressource (X, 271 Seiten) Illustrationen, Diagramme
ISBN:9783318004915