Mechanisms of epithelial defense
Mechanisms of epithelial defense:

Epithelial defense against infectious agents relies on the recognition of microbial products by pattern recognition receptors and the local production of antimicrobial peptides. This book provides a state-of-the-art overview of the basic characteristics and clinical relevance of antimicrobial peptid...

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Bibliographische Detailangaben
Weitere Verfasser: Kabelitz, Dietrich (HerausgeberIn), Schröder, Jens-Michael (HerausgeberIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Basel Karger 2005
Schriftenreihe:Chemical immunology and allergy Vol. 86
Schlagworte:
Immunology
Dermatology
Infectious Diseases
Bacteriology
Cell Biology
Defensine
Epithel
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Zusammenfassung:Epithelial defense against infectious agents relies on the recognition of microbial products by pattern recognition receptors and the local production of antimicrobial peptides. This book provides a state-of-the-art overview of the basic characteristics and clinical relevance of antimicrobial peptides, with special emphasis on their role in skin, intestinal and lung inflammation. The evolutionary significance of antimicrobial peptides is highlighted by an in-depth analysis of their structure, activity and gene regulation in <i>Drosophila melanogaster</i>. Toll-like receptors are an important class of pattern recognition receptors, whose roles in recognizing bacterial molecular patterns and in the intracellular signalling pathways involved in the differentiation and function of dendritic cells are discussed. Finally, this book also addresses the role of intraepithelial lympho cytes in epithelial defense, notably of gammadelta T cells which form a link between innate and adaptive immune responses. The combined analysis of epithelial and lymphoid cells and effector mechanisms sheds new light on the epithelial defense system in physiological and pathophysiological conditions. Immunologists, dermatologists, microbiologists, and infectious disease specialists will greatly benefit from the wealth of new findings presented by leading investigators
Beschreibung:cellular and molecular mechanisms highlighted by experts in the field
Beschreibung:1 Online-Ressource (XII, 189 Seiten) Illustrationen, Diagramme
ISBN:9783318011746
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