Mast cells in allergic diseases:

The discovery of IgE and its association with mast cell histamine release provided the initial understanding of the role of mast cells in asthma and acute allergic reactions. However, mast cells are now recognized as tissue-dwelling effector cells that play multiple roles not only in immediate-type...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Weitere Verfasser: Saito, Hirohisa (HerausgeberIn), Okayama, Yoshimichi (HerausgeberIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Basel Karger 2005
Schriftenreihe:Chemical immunology and allergy Vol. 87
Schlagworte:
Online-Zugang:BFB01
BSB01
BTW01
EUV01
FAN01
FAW01
FFW01
FHI01
FHM01
FHN01
FHR01
FKE01
FNU01
FWS01
FWS02
GEM01
LCO01
SAB01
SAM01
SBG01
SBR01
SND01
TUM01
UBA01
UBG01
UBM01
UBR01
UBT01
UBW01
UER01
UPA01
Volltext
Zusammenfassung:The discovery of IgE and its association with mast cell histamine release provided the initial understanding of the role of mast cells in asthma and acute allergic reactions. However, mast cells are now recognized as tissue-dwelling effector cells that play multiple roles not only in immediate-type allergic reaction but also in innate immunity, inflammation, angiogenesis, and tissue remodeling. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with inflammatory tissues such as asthmatic lungs. This book focuses on the roles of mast cell products in allergic diseases and discusses strategies to regulate mast cell functions without perturbing their physiological roles. It also aims at understanding mast cells at the system level by creating a detailed model of cell regulation which is expected to lead to highly mast cell-specific, i.e. efficient and safe, drug targets. Allergologists, immunologists and pharmacologists interested in developing new drugs for allergies will benefit from these timely reviews
Beschreibung:1 Online-Ressource (XIV, 218 Seiten) Illustrationen, Diagramme
ISBN:9783318012323