Verfügbarkeit: Human CD38 and related molecules

Human CD38 and related molecules:

In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pat...

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Weitere Verfasser:	Mehta, Kapil (HerausgeberIn), Malavasi, Fabio (HerausgeberIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Basel Karger 2000
Schriftenreihe:	Chemical immunology Vol. 75
Schlagworte:	Immunology Biochemistry Oncology Hematology Leukemia Pharmacology Pathophysiologie Antigen CD38 Aufsatzsammlung
Online-Zugang:	BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext
Zusammenfassung:	In recent years, CD38 has emerged from a simple differentiation marker to a multifunctional cell surface protein. It can serve as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca2+mobilizing agent, cyclic ADP-ribose. Since intracellular calcium plays a key role in cell signaling pathways leading to cell growth, apoptosis, and differentiation, the enzymatic functions of CD38 may contribute to an array of immunoregulatory functions. Ligation of CD38 with agonistic antibodies induces diverse effects in hematopoietic cells which range from growth stimulation to induction and prevention of apoptosis, induction of cytokines, and activation of certain kinases. Based on these observations a ligand for CD38 was recently identified and characterized. The natural ligand is capable of transducing signals similar to the agonistic antibody, following its interaction with cell surface CD38. Recent reports have suggested an association of CD38 in diverse human pathologies such as HIV, chronic B lymphocytic leukemia, myeloma, lymphoma, diabetes, and retinoic acid syndrome. This book offers the first single source on CD38 antigen and related molecules for new and experienced investigators. It will allow them to pose new and right questions in an attempt to elucidate the biological relevance and significance of these molecules in cancer, immunology, pharmacology and biochemistry
Beschreibung:	1 Online-Ressource (XII, 281 Seiten)
ISBN:	9783318004694

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Datensatz im Suchindex

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genre	(DE-588)4143413-4 Aufsatzsammlung gnd-content
genre_facet	Aufsatzsammlung
id	DE-604.BV036069182
illustrated	Not Illustrated
indexdate	2024-08-01T11:41:42Z
institution	BVB
isbn	9783318004694
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-018960485
oclc_num	728410634
open_access_boolean
owner	DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-11 DE-578 DE-1046
owner_facet	DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-83 DE-M382 DE-70 DE-11 DE-578 DE-1046
physical	1 Online-Ressource (XII, 281 Seiten)
psigel	ZDB-1-KEB
publishDate	2000
publishDateSearch	2000
publishDateSort	2000
publisher	Karger
record_format	marc
series	Chemical immunology
series2	Chemical immunology
spellingShingle	Human CD38 and related molecules Chemical immunology Immunology Biochemistry Oncology Hematology Leukemia Pharmacology Pathophysiologie (DE-588)4044898-8 gnd Antigen CD38 (DE-588)4586420-2 gnd
subject_GND	(DE-588)4044898-8 (DE-588)4586420-2 (DE-588)4143413-4
title	Human CD38 and related molecules
title_auth	Human CD38 and related molecules
title_exact_search	Human CD38 and related molecules
title_full	Human CD38 and related molecules volume editors: Kapil Mehta, Fabio Malavasi
title_fullStr	Human CD38 and related molecules volume editors: Kapil Mehta, Fabio Malavasi
title_full_unstemmed	Human CD38 and related molecules volume editors: Kapil Mehta, Fabio Malavasi
title_short	Human CD38 and related molecules
title_sort	human cd38 and related molecules
topic	Immunology Biochemistry Oncology Hematology Leukemia Pharmacology Pathophysiologie (DE-588)4044898-8 gnd Antigen CD38 (DE-588)4586420-2 gnd
topic_facet	Immunology Biochemistry Oncology Hematology Leukemia Pharmacology Pathophysiologie Antigen CD38 Aufsatzsammlung
url	https://karger.com/books/book/2337
volume_link	(DE-604)BV022500180
work_keys_str_mv	AT mehtakapil humancd38andrelatedmolecules AT malavasifabio humancd38andrelatedmolecules

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