Glucokinase and glycemic disease: from basics to novel therapeutics
The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addr...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Karger
2004
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| Schriftenreihe: | Frontiers in diabetes
Vol. 16 |
| Schlagworte: | |
| Online-Zugang: | BFB01 BSB01 BTW01 EUV01 FAN01 FAW01 FFW01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FWS01 FWS02 GEM01 LCO01 SAB01 SAM01 SBG01 SBR01 SND01 TUM01 UBA01 UBG01 UBM01 UBR01 UBT01 UBW01 UER01 UPA01 Volltext |
| Zusammenfassung: | The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus.The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs).This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists |
| Beschreibung: | 1 Online-Ressource (X, 406 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783318010800 |
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| 520 | |a The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus.The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. Finally, the book contains the latest information on the recently discovered class of weight drugs that activate glucokinase (i.e. glucokinase activators or GKAs).This volume is of great interest to basic and clinical diabetes researchers, geneticists, biochemists, physiologists and pharmacologists | ||
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV036069160 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T11:41:30Z |
| institution | BVB |
| isbn | 9783318010800 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018960465 |
| oclc_num | 837704960 |
| open_access_boolean | |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-11 DE-83 DE-M382 DE-70 DE-578 DE-1046 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-355 DE-BY-UBR DE-20 DE-1102 DE-1028 DE-573 DE-859 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-521 DE-522 DE-526 DE-12 DE-11 DE-83 DE-M382 DE-70 DE-578 DE-1046 |
| physical | 1 Online-Ressource (X, 406 Seiten) Illustrationen, Diagramme |
| psigel | ZDB-1-KEB |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Karger |
| record_format | marc |
| series | Frontiers in diabetes |
| series2 | Frontiers in diabetes |
| spellingShingle | Glucokinase and glycemic disease from basics to novel therapeutics Frontiers in diabetes Endocrinology Genetics Metabolism Biochemistry Diabetes Enzymology Pharmacology Physiology Glucokinase (DE-588)4157667-6 gnd |
| subject_GND | (DE-588)4157667-6 (DE-588)4143413-4 |
| title | Glucokinase and glycemic disease from basics to novel therapeutics |
| title_auth | Glucokinase and glycemic disease from basics to novel therapeutics |
| title_exact_search | Glucokinase and glycemic disease from basics to novel therapeutics |
| title_full | Glucokinase and glycemic disease from basics to novel therapeutics volume editors: F. M. Matschinsky, M. A. Magnuson |
| title_fullStr | Glucokinase and glycemic disease from basics to novel therapeutics volume editors: F. M. Matschinsky, M. A. Magnuson |
| title_full_unstemmed | Glucokinase and glycemic disease from basics to novel therapeutics volume editors: F. M. Matschinsky, M. A. Magnuson |
| title_short | Glucokinase and glycemic disease |
| title_sort | glucokinase and glycemic disease from basics to novel therapeutics |
| title_sub | from basics to novel therapeutics |
| topic | Endocrinology Genetics Metabolism Biochemistry Diabetes Enzymology Pharmacology Physiology Glucokinase (DE-588)4157667-6 gnd |
| topic_facet | Endocrinology Genetics Metabolism Biochemistry Diabetes Enzymology Pharmacology Physiology Glucokinase Aufsatzsammlung |
| url | https://karger.com/books/book/2479 |
| volume_link | (DE-604)BV039142753 |
| work_keys_str_mv | AT matschinskyfranzm glucokinaseandglycemicdiseasefrombasicstonoveltherapeutics AT magnusonma glucokinaseandglycemicdiseasefrombasicstonoveltherapeutics |