COX-2 a new target for cancer prevention and treatment
COX-2: a new target for cancer prevention and treatment

Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth.The present book reviews these findings...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Weitere Verfasser: Dannenberg, Andrew J. (HerausgeberIn), DuBois, Raymond N. (HerausgeberIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Basel Karger 2003
Schriftenreihe:Progress in experimental tumor research Vol. 37
Schlagworte:
Oncology
Pharmacology
Gastroenterology
Preventive Medicine
Prävention
Inhibitor
Prostaglandinsynthase
Therapie
Krebs > Medizin
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Zusammenfassung:Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth.The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists
Beschreibung:1 Online-Ressource (VIII, 291 Seiten) Illustrationen, Diagramme
ISBN:9783318009408
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