Experimental design for the life sciences:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2011
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 178 S. Ill., graph. Darst. |
| ISBN: | 9780199569120 |
Internformat
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Datensatz im Suchindex
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| adam_text | EXPERIMENTAL DESIGN FOR THE LIFE SCIENCES THIRD EDITION GRAEME D. RUXTON
UNIVERSITY OF GLASGOW NICK COLEGRAVE UNIVERSITY OF EDINBURGH OXFORD
UNIVERSITY PRESS CONTENTS 1 WHY YOU SHOULD CARE ABOUT DESIGN 1 1.1 WHY
EXPERIMENTS NEED TO BE DESIGNED 1 1.2 THE COSTS OF POOR DESIGN 2 1.2.1
TIME AND MONEY 2 1.2.2 ETHICAL ISSUES 3 1.3 THE RELATIONSHIP BETWEEN
EXPERIMENTAL DESIGN AND STATISTICS 4 1.4 WHY GOOD EXPERIMENTAL DESIGN IS
PARTICULARLY IMPORTANT TO LIFE SCIENTISTS 5 1.4.1 RANDOM VARIATION 5
1.4.2 CONFOUNDING FACTORS 6 SUMMARY 7 2 STARTING WITH A WELL-DEFINED
HYPOTHESIS 8 2.1 WHY YOUR EXPERIMENT SHOULD BE FOCUSED: QUESTIONS,
HYPOTHESES, AND PREDICTIONS 8 2.1.1 AN EXAMPLE OF MOVING FROM A QUESTION
TO HYPOTHESES, AND THEN TO AN EXPERIMENTAL DESIGN 10 2.1.2 AN EXAMPLE OF
MULTIPLE HYPOTHESES 11 2.1.3 WHERE DO (GOOD) IDEAS COME FROM IN THE
FIRST PLACE? 13 2.2 PRODUCING THE STRONGEST EVIDENCE WITH WHICH TO
CHALLENGE A HYPOTHESIS 14 2.2.1 INDIRECT MEASURES 15 2.2.2 CONSIDERING
ALL POSSIBLE OUTCOMES OF AN EXPERIMENT 15 2.3 SATISFYING SCEPTICS 17 2.4
THE IMPORTANCE OF A PILOT STUDY AND PRELIMINARY DATA 17 2.4.1 MAKING
SURE THAT YOU ARE ASKING A SENSIBLE QUESTION 18 2.4.2 MAKING SURE THAT
YOUR TECHNIQUES WORK 19 2.5 EXPERIMENTAL MANIPULATION VERSUS NATURAL
VARIATION 21 2.5.1 AN EXAMPLE HYPOTHESIS THAT COULD BE TACKLED BY EITHER
MANIPULATION OR CORRELATION 21 2.5.2 ARGUMENTS FOR DOING A CORRELATIONAL
STUDY 23 2.5.3 ARGUMENTS FOR DOING A MANIPULATIVE STUDY 24 2.5.4
SITUATIONS WHERE MANIPULATION IS IMPOSSIBLE 26 2.6 DECIDING WHETHER TO
WORK IN THE FIELD OR THE LABORATORY 29 2.7 IN VIVO VERSUS IN VITRO
STUDIES 31 2.8 THERE IS NO PERFECT STUDY 31 SUMMARY 32 3
BETWEEN-INDIVIDUAL VARIATION, REPLICATION, AND SAMPLING 34 3.1
BETWEEN-INDIVIDUAL VARIATION 34 3.2 REPLICATION 35 3.3 PSEUDOREPLICATION
45 3.3.1 EXPLAINING WHAT PSEUDOREPLICATION IS 45 3.3.2 COMMON SOURCES OF
PSEUDOREPLICATION 48 3.3.3 DEALING WITH PSEUDOREPLICATION 51 3.3.4
ACCEPTING THAT SOMETIMES PSEUDOREPLICATION IS UNAVOIDABLE 53 3.3.5
PSEUDOREPLICATION, THIRD VARIABLES, AND CONFOUNDING VARIABLES 54 3.3.6
COHORT EFFECTS, CONFOUNDING VARIABLES, AND CROSS-SECTIONAL STUDIES 54
3.4 RANDOMIZATION 55 3.4.1 WHY YOU OFTEN WANT A RANDOM SAMPLE 56 3.4.2
HAPHAZARD SAMPLING 56 3.4.3 SELF-SELECTION 57 3.4.4 SOME PITFALLS
ASSOCIATED WITH RANDOMIZATION PROCEDURES 58 3.4.5 RANDOMIZING THE ORDER
IN WHICH YOU TREAT REPLICATES 59 3.4.6 RANDOM SAMPLES AND REPRESENTATIVE
SAMPLES 59 3.5 SELECTING THE APPROPRIATE NUMBER OF REPLICATES 60 3.5.1
EDUCATED GUESSWORK 61 3.5.2 FORMAL POWER ANALYSIS 61 CONTENTS XV 3.5.3
FACTORS AFFECTING THE POWER OF AN EXPERIMENT 61 3.5.4 RELATION BETWEEN
POWER AND TYPE I AND TYPE II ERRORS 63 SUMMARY . 74 4 DIFFERENT
EXPERIMENTAL DESIGNS 75 4.1 CONTROLS 75 4.1.1 DIFFERENT TYPES OF CONTROL
76 4.1.2 BLIND PROCEDURES 77 4.1.3 MAKING SURE THE CONTROL IS AS
EFFECTIVE AS POSSIBLE 79 4.1.4 THE ETHICS OF CONTROLLING 80 4.1.5
SITUATIONS WHERE A CONTROL IS NOT REQUIRED 80 4.2 COMPLETELY RANDOMIZED
AND FACTORIAL EXPERIMENTS 81 4.2.1 EXPERIMENTS WITH SEVERAL FACTORS 82
4.2.2 CONFUSING LEVELS AND FACTORS 85 4.2.3 ADVANTAGES AND DISADVANTAGES
OF COMPLETE RANDOMIZATION 85 4.3 BLOCKING 88 4.3.1 BLOCKING ON
INDIVIDUAL CHARACTERS, SPACE, AND TIME 89 4.3.2 THE ADVANTAGES AND
DISADVANTAGES OF BLOCKING 90 4.3.3 PAIRED DESIGNS 91 4.3.4 HOW TO SELECT
BLOCKS 91 4.3.5 COVARIATES 92 4.4 WITHIN-SUBJECT DESIGNS 93 4.4.1 THE
ADVANTAGES OF A WITHIN-SUBJECT DESIGN 93 4.4.2 THE DISADVANTAGES OF A
WITHIN-SUBJECT DESIGN 94 4.4.3 ISN T REPEATEDLY MEASURING THE SAME
INDIVIDUAL PSEUDOREPLICATION? 95 4.4.4 WITH MULTIPLE TREATMENTS,
WITHIN-SUBJECT EXPERIMENTS CAN TAKE A LONGTIME 96 4.4.5 WHICH SEQUENCES
SHOULD YOU USE? 97 4.5 SPLIT-PLOT DESIGNS (SOMETIMES CALLED SPLIT-UNIT
DESIGNS) 98 4.6 THINKING ABOUT THE STATISTICS 100 SUMMARY 102 XVI
CONTENTS 5 TAKING MEASUREMENTS 5.1 CALIBRATION 5.2 INACCURACY AND
IMPRECISION 5.3 INTRA-OBSERVER VARIABILITY 5.3.1 DESCRIBING THE PROBLEM
5.3.2 TACKLING THE PROBLEM 5.3.3 REPEATABILITY 5.3.4 REMEMBER, YOU CAN
BE CONSISTENT BUT STILL CONSISTENTLY WRONG 5.4 INTER-OBSERVER
VARIABILITY 5.4.1 DESCRIBING THE PROBLEM 5.4.2 TACKLING THE PROBLEM 5.5
DECIDING HOW TO MEASURE 5.5.1 DEFINING CATEGORIES 5.5.2 HOW FINE-SCALE
TO MAKE INTERVAL/RATIO MEASUREMENTS 5.6 OBSERVER EFFECTS 5.7 RECORDING
DATA 5.7.1 DON T TRY TO RECORD TOO MUCH INFORMATION AT ONCE 5.7.2 BEWARE
OF SHORTHAND CODES 5.7.3 KEEP MORE THAN ONE COPY OF YOUR DATA 5.7.4
WRITE OUT YOUR EXPERIMENTAL PROTOCOL FORMALLY AND IN DETAIL, AND KEEP A
DETAILED FIELD JOURNAL OR LAB BOOK 5.7.5 DON T OVER-WORK 5.8 COMPUTERS
AND AUTOMATED DATA COLLECTION 5.9 FLOOR AND CEILING EFFECTS 5.10
OBSERVER BIAS 104 105 106 108 108 109 109 110 112 112 112 113 113 113
114 115 115 116 116 116 117 117 118 119 5.11 TAKING MEASUREMENTS OF
HUMANS AND ANIMALS IN THE LABORATORY 119 5.12 SENSITIVITY AND
SPECIFICITY 120 SUMMARY 123 CONTENTS XVII 6 FINAL THOUGHTS 124 6.1 HOW
TO SELECT THE LEVELS FOR A TREATMENT 125 6.2 SUBSAMPLING: MORE WOODS OR
MORE TREES? 127 6.3 USING UNBALANCED GROUPS FOR ETHICAL REASONS 129 6.4
OTHER SAMPLING SCHEMES 132 6.4.1 SEQUENTIAL SAMPLING 132 6.4.2.
STRATIFIED SAMPLING 132 6.4.3 SYSTEMATIC SAMPLING 134 6.5 LATIN SQUARE
DESIGNS 134 6.6 MORE ON INTERACTIONS 136 6.6.1 COVARIATES CAN INTERACT
TOO 136 6.6.2 THE IMPORTANCE OF INTERACTIONS (AND THE INTERACTION
FALLACY) 138 6.6.3 SIMPSON S PARADOX 141 6.7 DEALING WITH HUMAN SUBJECTS
142 6.7.1 DECEPTION 144 6.7.2 COLLECTING DATA WITHOUT PERMISSION 144
6.7.3 CONFIDENTIALITY 145 6.7.4 DISCRETION 145 6.7.5 RANDOMIZED RESPONSE
146 6.7.6 ETHICAL GUIDELINES 147 6.7.7 VOLUNTEERS 147 6.7.8 HONESTY OF
SUBJECTS 147 6.7.9 THERE IS NO PERFECT STUDY: A REPRISE 148 6.8 SPECIAL
TERMINOLOGY OF EXPERIMENTAL DESIGN USED IN THE BIOMEDICAL LITERATURE 148
SUMMARY 152 SAMPLE ANSWERS TO SELF-TEST QUESTIONS 155 FLOW CHART ON
EXPERIMENTAL DESIGN 167 BIBLIOGRAPHY 172 INDEX 177
|
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| author | Ruxton, Graeme D. Colegrave, Nick |
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| dewey-full | 570.724 |
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| dewey-tens | 570 - Biology |
| discipline | Biologie Psychologie |
| edition | 3. ed. |
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| spelling | Ruxton, Graeme D. Verfasser (DE-588)1071366084 aut Experimental design for the life sciences Graeme D. Ruxton ; Nick Colegrave 3. ed. Oxford [u.a.] Oxford Univ. Press 2011 XVII, 178 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biowissenschaften (DE-588)4129772-6 gnd rswk-swf Biologie (DE-588)4006851-1 gnd rswk-swf Experiment (DE-588)4015999-1 gnd rswk-swf Versuchsplanung (DE-588)4078859-3 gnd rswk-swf Biologie (DE-588)4006851-1 s Biowissenschaften (DE-588)4129772-6 s Experiment (DE-588)4015999-1 s Versuchsplanung (DE-588)4078859-3 s DE-188 Colegrave, Nick Verfasser (DE-588)135605946 aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018955865&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ruxton, Graeme D. Colegrave, Nick Experimental design for the life sciences Biowissenschaften (DE-588)4129772-6 gnd Biologie (DE-588)4006851-1 gnd Experiment (DE-588)4015999-1 gnd Versuchsplanung (DE-588)4078859-3 gnd |
| subject_GND | (DE-588)4129772-6 (DE-588)4006851-1 (DE-588)4015999-1 (DE-588)4078859-3 |
| title | Experimental design for the life sciences |
| title_auth | Experimental design for the life sciences |
| title_exact_search | Experimental design for the life sciences |
| title_full | Experimental design for the life sciences Graeme D. Ruxton ; Nick Colegrave |
| title_fullStr | Experimental design for the life sciences Graeme D. Ruxton ; Nick Colegrave |
| title_full_unstemmed | Experimental design for the life sciences Graeme D. Ruxton ; Nick Colegrave |
| title_short | Experimental design for the life sciences |
| title_sort | experimental design for the life sciences |
| topic | Biowissenschaften (DE-588)4129772-6 gnd Biologie (DE-588)4006851-1 gnd Experiment (DE-588)4015999-1 gnd Versuchsplanung (DE-588)4078859-3 gnd |
| topic_facet | Biowissenschaften Biologie Experiment Versuchsplanung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018955865&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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