Forkhead transcription factors: vital elements in biology and medicine
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
[Dordrecht u.a.]
Springer [u.a.]
2009
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| Schriftenreihe: | Advances in experimental medicine and biology
665 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 269 S. Ill., graph. Darst. |
| ISBN: | 9781441915986 |
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Datensatz im Suchindex
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| adam_text | FORKHEAD TRANSCRIPTION FACTORS VITAL ELEMENTS IN BIOLOGY AND MEDICINE
EDITED BY KENNETH MAIESE, MD DIVISION OF CELLULAR AND MOLECULAR CEREBRAL
ISCHEMIA, DEPARTMENTS OF NEUROLOGY AND ANATOMY AND CELL BIOLOGY, BARBARA
ANN KARMANOS CANCER INSTITUTE, CENTER FOR MOLECULAR MEDICINE AND
GENETICS, INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES, WAYNE STATE
UNIVERSITY SCHOOL OF MEDICINE, DETROIT, MICHIGAN, USA SPRINGER
SCIENCE+BUSINESS MEDIA, LLC LANDES BIOSCIENCE CONTENTS SECTION I.
INSIGHTS INTO IMMUNITY, INFECTION AND CANCER 1. FOXOL, T-CELL
TRAFFICKING AND IMMUNE RESPONSES 3 FLORENT CARRETTE, STEPHANIE FABRE AND
GEORGES BISMUTH ABSTRACT 3 INTRODUCTION 3 MECHANISMS OF T-CELL HOMING
INTO LYMPH NODES 3 FOXOL, L-SELECTIN AND T-CELL HOMING 5 FOXOL AND
T-CELL PROLIFERATION 7 NEW POTENTIAL TARGETS OF FOXOL TO IMPOSE T-CELL
FATE 9 FOXOL, T-CELL EGRESS AND PERIPHERAL HOMING 10 CONCLUSION 11 2.
FOXP3 AND ITS ROLE IN THE IMMUNE SYSTEM 17 CHANG H. KIM ABSTRACT 17
INTRODUCTION 17 STRUCTURE AND FUNCTION OF FOXP3 18 EXPRESSION OF FOXP3
19 ONTOGENY AND MIGRATION OF FOXP3+ CELLS 20 MECHANISMS OF SUPPRESSION
MEDIATED BY FOXP3+ T-CELLS 21 ROLE OF FOXP3+ T-CELLS IN SUPPRESSION OF
DISEASES 23 FUNCTIONS OF FOXP3 IN NONHEMATOPOIETIC CELLS 24 CONCLUDING
REMARKS 24 XVI CONTENTS 3. MOLECULAR REGULATION OF CELLULAR IMMUNITY
BYFOXP3 30 ALICIA N. MCMURCHY, SARA DI NUNZIO, MARIA GRAZIA RONCAROLO,
ROSA BACCHETTA AND MEGAN K. LEVINGS ABSTRACT 30 INTRODUCTION 30
DISCOVERY OF FOXP3 AND KEY STRUCTURAL FEATURES 31 PHENOTYPE AND FUNCTION
OF FOXP3+ TREG CELLS 32 ROLE OF FOXP3 IN THE DEVELOPMENT OF TREG CELLS
32 ROLE OF FOXP3 IN CONVENTIONAL T-CELLS 34 MOLECULAR AND CELLULAR
BIOLOGY OF IPEX 34 ISOFORMS OF FOXP3 IN HUMANS 35 FOXP3 PROTEIN
INTERACTIONS 36 POST-TRANSLATIONAL MODIFICATIONS OF FOXP3 38 EPIGENETIC
REGULATION OF FOXP3 AND ITS TARGET GENES 39 ROLE OF FOXP3 IN TREG VERSUS
THL7 CELL DEVELOPMENT 40 CONCLUSION 41 4. THE BIOLOGY OF FOXP3: A KEY
PLAYER IN IMMUNE SUPPRESSION DURING INFECTIONS, AUTOIMMUNE DISEASES AND
CANCER 47 FRANCES MERCER AND DERYA UNUTMAZ ABSTRACT 47 INTRODUCTION 47
THE DISCOVERY OF FOXP3 47 FUNCTIONAL AND STRUCTURAL FEATURES OF FOXP3 48
FOXP3 REGULATION AND FUNCTION 50 ROLE OF FOXP3 IN CANCER 52 FOXP3 IN
INFECTIOUS DISEASES 52 FOXP3 IN TRANSPLANTATION TOLERANCE 53 FOXP3 IN
AUTOIMMUNE DISEASES 54 EMERGING AND POTENTIAL THERAPEUTIC INTERVENTION
54 SECTION II. ELUCIDATING THE COMPONENTS RESPONSIBLE FOR VASCULAR
DEVELOPMENT AND DISEASE IN THE CARDIOVASCULAR SYSTEM 5. THE COOPERATIVE
ROLES OF FOXC1 AND FOXC2 IN CARDIOVASCULAR DEVELOPMENT 63 TSUTOMU KUME
ABSTRACT 63 INTRODUCTION 63 FOXCL AND FOXC2 PROTEINS 63 CONTENTS XVII
OVERLAPPING EXPRESSION OIFOXCL AND FOXC2 DURING DEVELOPMENT 64
DEVELOPMENTAL DEFECTS IN FOXC MUTANT MOUSE EMBRYOS 64 MUTATIONS IN FOXC1
AND F0XC2 GENES ASSOCIATED WITH DEVELOPMENTAL DISORDERS IN HUMANS 65
COOPERATIVE ROLES OF FOXCL AND FOXC2 IN CARDIOVASCULAR DEVELOPMENT 66
FOXC FUNCTION IN ARTERIAL SPECIFICATION 66 FOXC FUNCTION IN LYMPHATIC
VESSEL DEVELOPMENT 68 FOXC FUNCTION IN ANGIOGENESIS 68 FOXC FUNCTION IN
THE SECOND HEART FIELD 70 FOXC FUNCTION IN CARDIAC NEURAL CREST CELLS 72
FOXC FUNCTION IN EPICARDIAL-DERIVED CELLS 72 FUTURE DIRECTIONS 73 6.
FOXO PROTEINS AND CARDIAC PATHOLOGY 78 ALBERT WONG AND ELIZABETH A.
WOODCOCK ABSTRACT 78 THE FOXO FAMILY 78 THE SPECTRUM OF TRANSCRIPTIONAL
RESPONSES MEDIATED BY FOXO FAMILY MEMBERS.... 78 REGULATION OF FOXO
PROTEINS 79 TRANSCRIPTIONAL PARTNERS OF FOXO 81 FOXO TRANSCRIPTION
FACTORS IN CARDIAC PATHOLOGY 82 CONCLUSION 85 7. THE FORKHEAD
TRANSCRIPTION FACTORS PLAY IMPORTANT ROLES IN VASCULAR PATHOLOGY AND
IMMUNOLOGY 90 XIAO-FENG YANG, PU FANG, SHU MENG, MICHAEL JAN, XINYU
XIONG, YING YIN AND HONG WANG ABSTRACT 90 INTRODUCTION 90 INTRODUCTION
OF THE FOX TRANSCRIPTION FACTOR SUPERFAMILY 91 FOX TRANSCRIPTION FACTORS
AND ENDOTHELIAL CELL PATHOLOGY 93 FOX TRANSCRIPTION FACTORS AND VASCULAR
SMOOTH MUSCLE CELLS (VSMCS) 96 FOX TRANSCRIPTION FACTORS, INFLAMMATION
AND IMMUNE SYSTEM 98 CONCLUSION 100 8. REGULATORY T-CELLS, FOXP3 AND
ATHEROSCLEROSIS 106 MICHAL ENTIN-MEER, ARNON AFEK AND JACOB GEORGE
ABSTRACT 106 ATHEROSCLEROSIS, INFLAMMATION AND AUTOIMMUNITY 106
REGULATORY T-CELLS, DEVELOPMENTAL AND FUNCTIONAL ASPECTS 106 FOXP3 IN
EXPERIMENTAL MODELS OF AUTOIMMUNITY AND ATHEROSCLEROSIS 109 FOXP3,
REGULATORY T-CELLS AND ATHEROSCLEROSIS IN HUMANS 110 TREG AND
ATHEROSCLEROSIS: PROSPECTS ILL XVIII CONTENTS SECTION III. DISSECTING
THE PATHWAYS OF NEURONAL INTEGRATION AND PLASTICITY IN THE NERVOUS
SYSTEM 9. FOXP GENES, NEURAL DEVELOPMENT, SPEECH AND LANGUAGE DISORDERS
117 HIROSHI TAKAHASHI, KAORU TAKAHASHI AND FU-CHIN LIU ABSTRACT 117
INTRODUCTION 117 THE FOXP SUBFAMILY 118 DISCOVERY OF FOXP2 AS A
LANGUAGE GENE 118 FOXP2 AND SPECIFIC LANGUAGE IMPAIRMENT (SLI) AND
AUTISM 119 EXPRESSION OF FOXP SUBFAMILY MEMBERS IN THE BRAIN 119
LANGUAGE IMPAIRMENTS IN THE AFFECTED MEMBERS OF THE KE FAMILY 123
IMAGING STUDIES ON THE KE FAMILY 123 THE F0XP2 EXPRESSION PATTERN IN THE
BRAIN AND ITS RELATION TO THE COGNITIVE FUNCTIONS OF SPEECH AND LANGUAGE
123 PHENOTYPE IN FOXP2 MUTANT MICE 124 TRANSCRIPTIONAL ACTIVITY OF THE
FOXP2 PROTEIN 125 FOXP2 UPSTREAM AND DOWNSTREAM GENES 125 PERSPECTIVES
126 10. PATHOPHYSIOLOGICAL RELEVANCE OF FORKHEAD TRANSCRIPTION FACTORS
IN BRAIN ISCHEMIA 130 KOHJI FUKUNAGA AND NORIFIIMI SHIODA ABSTRACT 130
FOXO PHOSPHORYLATION REGULATING SHUTTLING BETWEEN NUCLEUS AND CYTOPLASM
130 FOXO PHOSPHORYLATION IN RESPONSE TO OXIDATIVE AND ISCHEMIC STRESSES
132 DECREASED AKT ACTIVITY FOLLOWING BRAIN ISCHEMIA TRIGGERS ACTIVATION
OF PROAPOPTOTIC PROTEINS 133 DEPHOSPHORYLATION AND ACTIVATION OF FOXOS
FOLLOWING BRAIN ISCHEMIA 133 CROSSTALK BETWEEN AKT AND CALCINEURIN
SIGNALING IN NEURONAL DEATH 134 SYNERGISTIC ACTIVATION OF FAS-LIGAND
PROMOTER BY NFATS AND FOXOS 134 DOWNSTREAM TARGETS FOR FOXOL IN DELAYED
NEURONAL DEATH 136 REGULATION OF FOXO PATHWAYS BY SIRT1 137 THERAPEUTIC
PERSPECTIVES 137 11. NEW INSIGHTS FOR FOXO AND CELL-FATE DECISION IN HIV
INFECTION AND HIV ASSOCIATED NEUROCOGNITIVE DISORDER 143 MIN CUI,
YUNLONG HUANG, YONG ZHAO AND JIALIN ZHENG ABSTRACT 143 INTRODUCTION 143
FOXO IN HIV-1 INFECTION AND HIV-1 ASSOCIATED NEUROCOGNITIVE DISORDERS
146 FOXO IN T-CELL DEPLETION 147 FOXO IN MACROPHAGE/MONOCYTE PATHOLOGY
OF HIV-1 INFECTION 148 CONTENTS XIX FOXO AND HIV-1 MEDIATED CENTRAL
NERVOUS SYSTEM DAMAGE 150 SUMMARY AND FUTURE DIRECTIONS 154 SECTION IV.
TRANSLATING VITAL CELLULAR MECHANISMS INTO SUCCESSFUL CLINICAL CARE 12.
FOXP3+ REGULATORY T-CELLS IN CHRONIC KIDNEY DISEASE: MOLECULAR PATHWAYS
AND CLINICAL IMPLICATIONS 163 PASCAL MEIER ABSTRACT 163 INTRODUCTION 163
PATHOBIOLOGY OF CD4/FOXP3+ REGULATORY T-CELLS 164 FORKHEAD BOX P3 AND
T-CELL RECEPTOR SIGNALING IN TREGS 165 COSTIMULATORY SIGNALING PATHWAYS
AND FOXP3 EXPRESSION 165 INTERLEUKIN-2 AND FOXP3 EXPRESSION 165 IMPAIRED
CD4+/FOXP3+ REGULATORY T-CELL FUNCTION IN PATIENTS WITH ESKD 166 PLACE
OF OXLDL IN TREGS APOPTOSIS IN PATIENTS WITH ESKD 166 PLACE OF 26S
PROTEASOME IN TREGS APOPTOSIS 166 FOXP3+ REGULATORY T-CELLS APOPTOSIS IN
UREMIA: ROLE OF THE 26S PROTEASOME 167 CONCLUSION 168 13.
TRANSCRIPTIONAL ROLE OF FOXOL IN DRUG RESISTANCE THROUGH ANTIOXIDANT
DEFENSE SYSTEMS 171 TOMOKO GOTO AND MASASHI TAKANO ABSTRACT 171
INTRODUCTION 171 DIFFERENTIAL EXPRESSION OF FOXOL IN CANCER CELLS 172
INDUCTION AND TRANSLOCATION OF FOXOL BY PACLITAXEL IN CANCER CELL LINES
172 FOXOL ATTENUATES SENSITIVITY TO PACLITAXEL-INDUCED CELL DEATH IN
PACLITAXEL RESISTANT CELL LINES 175 ATTENUATION OF OXIDATIVE STRESS BY
PACLITAXEL AND FOXOL IN OVARIAN CANCER CELL LINES 176 MNSOD EXPRESSION
IN PACLITAXEL SENSITIVE AND RESISTANT OVARIAN CANCER CELL LINES AND
OVARIAN CANCER SAMPLES 176 14. FOXP3 EXPRESSING REGULATORY T-CELLS IN
ALLERGIC DISEASE 180 KAYHAN T. NOURI-ARIA ABSTRACT 180 INTRODUCTION 180
BACKGROUND 181 REGULATORY T-CELLS IN HEALTH AND ALLERGIC CONDITIONS 182
MODULATION OF T REGS WITH TREATMENT 187 CONCLUSION 190 XX CONTENTS 15.
HUMAN CLINICAL PHENOTYPE ASSOCIATED WITH F0XN1 MUTATIONS 195 CLAUDIO
PIGNATA, ANNA FUSCO AND STEFANIA AMOROSI ABSTRACT 195 INTRODUCTION:
SEVERE COMBINED IMMUNODEFICIENCIES 195 THE NUDE/SCID PHENOTYPE 197 FOX
FAMILY MEMBERS AND IMMUNE SYSTEM 201 FOXN1 SKIN SPECIFIC EXPRESSION AND
T-CELL DEVELOPMENT 203 16. FOXL2: AT THE CROSSROADS OF FEMALE SEX
DETERMINATION AND OVARIAN FUNCTION 207 BERENICE A. BENAYOUN, AURELIE
DIPIETROMARIA, CLAUDE BAZIN AND REINER A. VEITIA ABSTRACT 207
INTRODUCTION 207 FOXL2 PROTEIN SEQUENCE IS HIGHLY CONSERVED 208
EXPRESSION OF FOXL2 208 DISEASE-CAUSING FOXL2 MUTATIONS IN HUMANS 209
REGULATION OF THE EXPRESSION AND ACTIVITY OF FOXL2 213 REGULATION OF
TARGET GENES AND OF CELLULAR FUNCTIONS BY FOXL2 217 THE FOXL2 RESPONSE
ELEMENT (FLRE) AND ITS SPECIFICITY 221 CONCLUSION 222 17. FOXO
TRANSCRIPTION FACTORS: FROM CELL FATE DECISIONS TO REGULATION OF HUMAN
FEMALE REPRODUCTION 227 JAN J. BROSENS, MIRANDA S. C. WILSON AND ERIC
W.-F. LAM ABSTRACT 227 INTRODUCTION 227 REGULATION OF FOXO ACTIVITY 228
FOXO AND CELL FATE 229 FOXO AND THE ENDOMETRIUM 233 FOXO AND THE OVARY
236 18. THE O CLASS: CRAFTING CLINICAL CARE WITH FOXO TRANSCRIPTION
FACTORS 242 KENNETH MAIESE, ZHAO ZHONG CHONG, JINLING HOU AND YAN CHEN
SHANG ABSTRACT 242 INTRODUCTION . . 243 FOXO PROTEIN EXPRESSION 243 FOXO
PROTEIN STRUCTURE AND FUNCTION AS TRANSCRIPTION FACTORS 243 FOXO
PROTEINS, POSTTRANSLATIONAL MODULATION, NOVEL SIGNAL TRANSDUCTION
PATHWAYS, AND CELL CYCLE REGULATION 244 CONTENTS XXI FOXO PROTEINS,
APOPTOSIS, AND OXIDATIVE STRESS 247 FOXO PROTEINS, METABOLISM AND CELL
LONGEVITY 248 FOXO PROTEINS, STEM CELLS AND CARDIOVASCULAR DEVELOPMENT
250 FOXO PROTEINS AND THE IMMUNE SYSTEM 251 FOXO PROTEINS AND CANCER 252
CONCLUSIONS AND FUTURE PERSPECTIVES FOR CLINICAL CARE 253 INDEX 261
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| spelling | Forkhead transcription factors vital elements in biology and medicine ed. by Kenneth Maiese. [Participants: Arnon Afek ...] [Dordrecht u.a.] Springer [u.a.] 2009 XXI, 269 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 665 Transcription factors Transcription factors - LCSH Maiese, Kenneth 1958- Sonstige (DE-588)140592946 oth Afek, Arnon Sonstige (DE-588)140631488 oth Advances in experimental medicine and biology 665 (DE-604)BV000003102 665 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018945551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Forkhead transcription factors vital elements in biology and medicine Advances in experimental medicine and biology Transcription factors Transcription factors - LCSH |
| title | Forkhead transcription factors vital elements in biology and medicine |
| title_auth | Forkhead transcription factors vital elements in biology and medicine |
| title_exact_search | Forkhead transcription factors vital elements in biology and medicine |
| title_full | Forkhead transcription factors vital elements in biology and medicine ed. by Kenneth Maiese. [Participants: Arnon Afek ...] |
| title_fullStr | Forkhead transcription factors vital elements in biology and medicine ed. by Kenneth Maiese. [Participants: Arnon Afek ...] |
| title_full_unstemmed | Forkhead transcription factors vital elements in biology and medicine ed. by Kenneth Maiese. [Participants: Arnon Afek ...] |
| title_short | Forkhead transcription factors |
| title_sort | forkhead transcription factors vital elements in biology and medicine |
| title_sub | vital elements in biology and medicine |
| topic | Transcription factors Transcription factors - LCSH |
| topic_facet | Transcription factors Transcription factors - LCSH |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018945551&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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