Retroviruses: molecular biology, genomics and pathogenesis
"Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include importa...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Wymondham
Caister
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses. However interest in these viruses extends beyond their disease causing capabilities. For example, research in this area led to the discovery of oncogenes, a major advance in the field of cancer genetics. Studies of retroviruses have contributed greatly to our understanding of mechanisms that regulate eukaryotic gene expression. In addition retroviruses are proving to be valuable research tools in molecular biology and have been used successfully in gene therapy (e.g. to treat X-linked severe combined immunodeficiency). Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV"--Publisher's description. |
| Beschreibung: | XVIII, 454 S. Ill., graph. Darst. |
| ISBN: | 9781904455554 |
Internformat
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| 245 | 1 | 0 | |a Retroviruses |b molecular biology, genomics and pathogenesis |c ed. by Reinhard Kurth ... |
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| 520 | 3 | |a "Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses. However interest in these viruses extends beyond their disease causing capabilities. For example, research in this area led to the discovery of oncogenes, a major advance in the field of cancer genetics. Studies of retroviruses have contributed greatly to our understanding of mechanisms that regulate eukaryotic gene expression. In addition retroviruses are proving to be valuable research tools in molecular biology and have been used successfully in gene therapy (e.g. to treat X-linked severe combined immunodeficiency). Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV"--Publisher's description. | |
| 650 | 4 | |a Genomics | |
| 650 | 4 | |a Retroviridae |x genetics | |
| 650 | 4 | |a Retroviridae |x pathogenicity | |
| 650 | 4 | |a Retroviruses | |
| 650 | 4 | |a Retroviruses |x Genetics | |
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Datensatz im Suchindex
| _version_ | 1804141092324507648 |
|---|---|
| adam_text | Contents
List of Contributors
v
Preface
¡x
List of Abbreviations
x¡¡¡
1
An Everlasting War Dance Between Retrotransposons and their Metazoan Hosts
1
David E. Symer and Jef D. Boeke
2
Endogenous Retroviruses
35
Joachim Denner
3
Retroviral Particles, Proteins and Genomes
71
Norbert
Banned,
Uwe
Fiebíg
and Oliver
Hohn
4
Retroviral Entry and Uncoating
107
Walther Mothes and Pradeep D. Uchil
5
Reverse Transcription and Integration
129
Alan
Engelman
6
Transcription, Splicing and Transport of Retroviral
RNA
161
Tina Lenasi, Xavier
Contreras
and
В.
Matija
Peterlin
7
Assembly and Release
187
Heinrich G. Göttlinger
and
Winfried Weissenhom
8
Transmission and Epidemiology
217
Hans
Lutz,
Gerhard Hunsmann and
Jörg Schüpbach
9
Pathogenesis of Oncoviral Infections
237
Finn Skou Pedersen and Annette
Balle Sorensen
10
Pathogenesis of Immunodeficiency Virus Infections
269
Guido Poli
and
Volker Erfle
11
Retroviral Restriction Factors
285
Jeremy Luban
¡v I
Contents
12
Molecular Vaccines and Correlates of Protection
309
Stephen Norley and
Reinhard
Kurth
13
Gammaretroviral and Lentiviral Vectors for Gene Delivery
347
Michael D.
Mühlebach, Silke Schule, Nina Gerlach, Matthias Schweizer,
Christian J. Buchholz, Christine Hohenadl and Klaus Cichutek
14
Non-primate Mammalian and Fish Retroviruses
371
Maribeth V.
Eiden,
Kathryn Radke, Joel Rovnak and Sandra L. Quackenbush
15
Simian Exogenous Retroviruses
395
Jonathan Luke Heeney and Ernst J.
Verschoor
16
HTLVandHIV
417
Marvin S. Reitz, Jr and Robert
С
Gallo
Index
445
|
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| spelling | Retroviruses molecular biology, genomics and pathogenesis ed. by Reinhard Kurth ... Wymondham Caister 2010 XVIII, 454 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier "Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses. However interest in these viruses extends beyond their disease causing capabilities. For example, research in this area led to the discovery of oncogenes, a major advance in the field of cancer genetics. Studies of retroviruses have contributed greatly to our understanding of mechanisms that regulate eukaryotic gene expression. In addition retroviruses are proving to be valuable research tools in molecular biology and have been used successfully in gene therapy (e.g. to treat X-linked severe combined immunodeficiency). Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV"--Publisher's description. Genomics Retroviridae genetics Retroviridae pathogenicity Retroviruses Retroviruses Genetics Retroviren (DE-588)4121587-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Retroviren (DE-588)4121587-4 s DE-604 Kurth, Reinhard 1942-2014 Sonstige (DE-588)106316648 oth Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018944985&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Retroviruses molecular biology, genomics and pathogenesis Genomics Retroviridae genetics Retroviridae pathogenicity Retroviruses Retroviruses Genetics Retroviren (DE-588)4121587-4 gnd |
| subject_GND | (DE-588)4121587-4 (DE-588)4143413-4 |
| title | Retroviruses molecular biology, genomics and pathogenesis |
| title_auth | Retroviruses molecular biology, genomics and pathogenesis |
| title_exact_search | Retroviruses molecular biology, genomics and pathogenesis |
| title_full | Retroviruses molecular biology, genomics and pathogenesis ed. by Reinhard Kurth ... |
| title_fullStr | Retroviruses molecular biology, genomics and pathogenesis ed. by Reinhard Kurth ... |
| title_full_unstemmed | Retroviruses molecular biology, genomics and pathogenesis ed. by Reinhard Kurth ... |
| title_short | Retroviruses |
| title_sort | retroviruses molecular biology genomics and pathogenesis |
| title_sub | molecular biology, genomics and pathogenesis |
| topic | Genomics Retroviridae genetics Retroviridae pathogenicity Retroviruses Retroviruses Genetics Retroviren (DE-588)4121587-4 gnd |
| topic_facet | Genomics Retroviridae genetics Retroviridae pathogenicity Retroviruses Retroviruses Genetics Retroviren Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018944985&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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