ABC transporters and multidrug resistance:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2009
|
| Schriftenreihe: | Wiley series in drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIII, 459 S. Ill., graph. Darst. |
| ISBN: | 9780470227343 |
Internformat
MARC
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| 300 | |a XIII, 459 S. |b Ill., graph. Darst. | ||
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| 650 | 0 | |a Drug resistance in cancer cells | |
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| 650 | 4 | |a Drug Resistance, Multiple | |
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| 650 | 4 | |a Multidrug Resistance-Associated Proteins | |
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Datensatz im Suchindex
| _version_ | 1805086997897805824 |
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| adam_text |
Titel: ABC transporters and multidrug resistance
Autor: Boumendjel, Ahcène
Jahr: 2009
CONTENTS
PREFACE ix
CONTRIBUTORS xi
INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE? 1
Jonathan A. Sheps and Victor Ling
PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION
OF THE STRUCTURE, GENOME, NORMAL TISSUE
EXPRESSION, PHYSIOLOGICAL ASPECT, AND
MECHANISM OF ACTION 15
1 The P-glycoprotein 170: Just a multidrug resistance protein or a
protean molecule? 17
Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert,
Mireille Verdier, and Marie-Helene Ratinaud
2 Multidrug resistance-associated protein (MRP/ABCC proteins) 47
Mylene Honorat, Charles Dumontet, and Lea Payen
3 ABCG2: A new challenge in cancer drug resistance 83
Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken,
Patricia A. Fetsch, and Susan E. Bates
v
vi CONTENTS
PART II ABC PROTEINS AND ONCOLOGY: EXPRESSION,
DETECTION, AND IMPLICATION OF ABC
PROTEINS IN HEMATOLOGICAL MALIGNANCIES
AND SOLID TUMORS 119
4 Expression, detection, and implication of ABC proteins in acute
myeloblastie leukemia 121
Ollivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie
5 ABC proteins and oncology: Expression, detection, and
implication of ABC proteins in solid tumors 143
Jean Francois Bernaudin, Anne Fajac, Jocelyne Fleury-Feith,
Khaldoun Kerrou, and Roger Lacave
PART HI ABC PROTEINS AND PATHOGENIC
MICROORGANISMS 177
6 ABC transporters and resistance to antibiotics 179
Serge Michalet and Marie-Genevieve Dijoux-Franca
7 ABC proteins involved in protozoan parasite resistance 195
Bruno Pradines
PART IV MULTIDRUG RESISTANCE (MDR) MODULATION
THROUGH INHIBITION OF ABC TRANSPORTERS:
DESIGN OF INHIBITORS AND MECHANISM
OF ACTION 239
8 Reversal agents for P-glycoprotein-mediated multidrug resistance 241
Hamid Morjani and Claudie Madoulet
9 Reversal agents of multidrug resistance mediated by multidrug
resistance-associated proteins (MRPs) 261
Ahcene Boumendjel, Anne Florin, and Jean Boutonnat
10 Reversal agents for breast cancer resistance protein
(BCRP)-mediated multidrug resistance 289
Jean Boutonnat, Anne Florin, and Ahcene Boumendjel
11 Strategies to overcome drug resistance in acute
and chronic leukemias 315
Eric Solary, Vincent Ribrag, and Stephane de Botton
12 Multidrug resistance reversal in solid tumors 349
Tatiana Bogush and Jacques Robert
CONTENTS vii
PART V BIOLOGICAL AND CLINICAL ASPECTS OF
MULTIDRUG RESISTANCE: THE ROLE OF
THE TRANSPORTERS AT THE MAIN PROTECTION
BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE
BIOAVAILABILITY OF MANY TYPES
OF DRUGS AND MEDICATIONS 363
13 ABC superfamily transporters at the human blood-brain barrier 365
Jean-Michel Scherrmann
14 The role of ABC transporters at the intestinal barrier 385
Roos L. Oostendorp, Jos H. Beijnen, and Jan H.M. Schellens
15 Genetic polymorphisms in ABC transporters 411
Leslie W. Chinn and Deanna L. Kroetz
PERSPECTIVES 437
INDEX 441 |
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| discipline | Chemie / Pharmazie Biologie |
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| indexdate | 2024-07-20T08:45:08Z |
| institution | BVB |
| isbn | 9780470227343 |
| language | English |
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| physical | XIII, 459 S. Ill., graph. Darst. |
| publishDate | 2009 |
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| spelling | ABC transporters and multidrug resistance ed. by Ahcène Boumendjel ... Hoboken, NJ Wiley 2009 XIII, 459 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley series in drug discovery and development Literaturangaben ATP-binding cassette transporters Drug resistance in cancer cells Drug Resistance, Multiple Multidrug Resistance-Associated Proteins Neoplasms drug therapy Multidrug-Resistenz (DE-588)4315848-1 gnd rswk-swf ABC-Transporter (DE-588)4472594-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content ABC-Transporter (DE-588)4472594-2 s Multidrug-Resistenz (DE-588)4315848-1 s DE-604 Boumendjel, Ahcène Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018940051&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | ABC transporters and multidrug resistance ATP-binding cassette transporters Drug resistance in cancer cells Drug Resistance, Multiple Multidrug Resistance-Associated Proteins Neoplasms drug therapy Multidrug-Resistenz (DE-588)4315848-1 gnd ABC-Transporter (DE-588)4472594-2 gnd |
| subject_GND | (DE-588)4315848-1 (DE-588)4472594-2 (DE-588)4143413-4 |
| title | ABC transporters and multidrug resistance |
| title_auth | ABC transporters and multidrug resistance |
| title_exact_search | ABC transporters and multidrug resistance |
| title_full | ABC transporters and multidrug resistance ed. by Ahcène Boumendjel ... |
| title_fullStr | ABC transporters and multidrug resistance ed. by Ahcène Boumendjel ... |
| title_full_unstemmed | ABC transporters and multidrug resistance ed. by Ahcène Boumendjel ... |
| title_short | ABC transporters and multidrug resistance |
| title_sort | abc transporters and multidrug resistance |
| topic | ATP-binding cassette transporters Drug resistance in cancer cells Drug Resistance, Multiple Multidrug Resistance-Associated Proteins Neoplasms drug therapy Multidrug-Resistenz (DE-588)4315848-1 gnd ABC-Transporter (DE-588)4472594-2 gnd |
| topic_facet | ATP-binding cassette transporters Drug resistance in cancer cells Drug Resistance, Multiple Multidrug Resistance-Associated Proteins Neoplasms drug therapy Multidrug-Resistenz ABC-Transporter Aufsatzsammlung |
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