Death receptors and cognate ligands in cancer:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2009
|
| Schriftenreihe: | Results and problems in cell differentiation
49 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIII, 280 S. Ill., graph. Darst. |
| ISBN: | 9783642030444 3642030440 9783642030451 |
Internformat
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| 490 | 1 | |a Results and problems in cell differentiation |v 49 | |
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| 650 | 4 | |a Neoplasms |x therapy | |
| 650 | 4 | |a Receptors, Death Domain |x physiology | |
| 650 | 4 | |a Receptors, Tumor Necrosis Factor |x physiology | |
| 650 | 4 | |a Tumor necrosis factor |x Physiological effect | |
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Datensatz im Suchindex
| _version_ | 1804141075545194496 |
|---|---|
| adam_text | Contents
The Role of TNF in Cancer
.................................................................... 1
Harald Wajant
Many Checkpoints on the Road to Cell Death:
Regulation of Fas-FasL Interactions and Fas Signaling
in Peripheral Immune Responses
........................................................... 17
Madhu Ramaswamy, Sophia Y. Cleland, Anthony
С
Cruz,
and Richard M.
Siegel
FasL Expression and Reverse Signalling
............................................... 49
M. Lettau, M. Paulsen, D. Kabelitz and O.
Janssen
Impact of TNF-R1 and CD95 Internalization
on Apoptotic and Antiapoptotic Signaling
............................................ 63
Stefan
Schütze
and
Wulf Schneider-Brachert
Ubiquitination and TNFRl Signaling
.................................................... 87
Ken-ichi Fujita and Srinivasa M. Srinivasula
From Biochemical Principles of Apoptosis
Induction by TRAIL to Application in Tumour Therapy
................... 115
Stefanie
M.
Cordier,
Kerstin Papenfuss,
and
Henning
Walczak
Therapeutic Targeting of
TWEAK/Fnl4
in Cancer:
Exploiting the Intrinsic Tumor Cell Killing Capacity
of the Pathway
.......................................................................................... 145
Jennifer S. Michaelson and Linda C. Burkly
APRIL in B-cell Malignancies and Autoimmunity
.............................. 161
Fiona C. Kimberley, Jan Paul Medema, and Michael
Hahne
Autophagy in Cancer and Chemotherapy
............................................. 183
Shida Yousefi and Hans-Uwe Simon
vi
Contents
Glucocorticoid-Mediated Apoptosis Resistance
of
Solid Tumors....... 191
Ingrid Herr, Markus W. Büchler, and Jürgen Mattern
Targeting Death-Receptors in Radiation
Therapy
............................... 219
Olivier
Niemöller and Claus
Belka
Death Ligands Designed to Kill: Development and
Application of Targeted Cancer Therapeutics Based on
Proapoptotic TNF Family Ligands
........................................................ 241
Jeannette Gerspach, Harald
Wajant, and Klaus Pfizenmaier
Index
.......................................................................................................... 275
Death receptors play a central role in directing apoptosis in mammalian cells.
This process of active cell death is important for a number of biological process¬
es, e.g. for the regulation of the immune system. Death receptors are cell surface
receptors that transmit apoptotic signals initiated by corresponding death lig-
ands. Many complex signaling pathways are activated and apoptosis is the final
result of a complex biochemical cascade of events.
Besides their
role
in the induction of cell death, evidence now exists that death
receptors are able to activate several non-apoptotic signaling pathways which,
depending on cellular context, may lead to apoptosis resistance, secretion of
pro-inflammatory proteins, proliferation and invasive growth of cancer cells.
This book looks at the molecular basis of death receptor signaling and the role
of death receptors in cancer development.
|
| any_adam_object | 1 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
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| dewey-search | 616.994 |
| dewey-sort | 3616.994 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV036042972 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:10:06Z |
| institution | BVB |
| isbn | 9783642030444 3642030440 9783642030451 |
| language | English |
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| physical | XIII, 280 S. Ill., graph. Darst. |
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| series | Results and problems in cell differentiation |
| series2 | Results and problems in cell differentiation |
| spelling | Death receptors and cognate ligands in cancer Holger Kalthoff (ed.) Berlin [u.a.] Springer 2009 XIII, 280 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Results and problems in cell differentiation 49 Cancer Treatment Carcinogenesis Molecular aspects Cell receptors Physiological effect Neoplasms etiology Neoplasms therapy Receptors, Death Domain physiology Receptors, Tumor Necrosis Factor physiology Tumor necrosis factor Physiological effect Tumor necrosis factor Receptors Physiological effect Ligand Biochemie (DE-588)4606532-5 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd rswk-swf Zelltod (DE-588)4207415-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Zelltod (DE-588)4207415-0 s Tumor-Nekrose-Faktor (DE-588)4202932-6 s Rezeptor (DE-588)4049722-7 s Ligand Biochemie (DE-588)4606532-5 s Signaltransduktion (DE-588)4318717-1 s DE-604 Kalthoff, Holger Sonstige (DE-588)110842561 oth Results and problems in cell differentiation 49 (DE-604)BV000022913 49 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018934789&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018934789&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Death receptors and cognate ligands in cancer Results and problems in cell differentiation Cancer Treatment Carcinogenesis Molecular aspects Cell receptors Physiological effect Neoplasms etiology Neoplasms therapy Receptors, Death Domain physiology Receptors, Tumor Necrosis Factor physiology Tumor necrosis factor Physiological effect Tumor necrosis factor Receptors Physiological effect Ligand Biochemie (DE-588)4606532-5 gnd Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Zelltod (DE-588)4207415-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4606532-5 (DE-588)4049722-7 (DE-588)4202932-6 (DE-588)4207415-0 (DE-588)4073781-0 (DE-588)4318717-1 (DE-588)4143413-4 |
| title | Death receptors and cognate ligands in cancer |
| title_auth | Death receptors and cognate ligands in cancer |
| title_exact_search | Death receptors and cognate ligands in cancer |
| title_full | Death receptors and cognate ligands in cancer Holger Kalthoff (ed.) |
| title_fullStr | Death receptors and cognate ligands in cancer Holger Kalthoff (ed.) |
| title_full_unstemmed | Death receptors and cognate ligands in cancer Holger Kalthoff (ed.) |
| title_short | Death receptors and cognate ligands in cancer |
| title_sort | death receptors and cognate ligands in cancer |
| topic | Cancer Treatment Carcinogenesis Molecular aspects Cell receptors Physiological effect Neoplasms etiology Neoplasms therapy Receptors, Death Domain physiology Receptors, Tumor Necrosis Factor physiology Tumor necrosis factor Physiological effect Tumor necrosis factor Receptors Physiological effect Ligand Biochemie (DE-588)4606532-5 gnd Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Zelltod (DE-588)4207415-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Cancer Treatment Carcinogenesis Molecular aspects Cell receptors Physiological effect Neoplasms etiology Neoplasms therapy Receptors, Death Domain physiology Receptors, Tumor Necrosis Factor physiology Tumor necrosis factor Physiological effect Tumor necrosis factor Receptors Physiological effect Ligand Biochemie Rezeptor Tumor-Nekrose-Faktor Zelltod Krebs Medizin Signaltransduktion Aufsatzsammlung |
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