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Current trends in monoclonal antibody development and manufacturing:

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Bibliographische Detailangaben
Weitere Verfasser:	Shire, Steven J. (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	New York [u.a.] Springer [u.a.] 2010
Schriftenreihe:	Biotechnology pharmaceutical aspects ; 11
Schlagworte:	Antibodies, Monoclonal > analysis Antibodies, Monoclonal > biosynthesis Antibodies, Monoclonal > pharmacokinetics Biotechnology > methods Monoclonal antibodies
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	XIV, 351 S. Ill., graph. Darst.
ISBN:	9780387766423

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MARC


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Datensatz im Suchindex

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adam_text	Titel: Current trends in monoclonal antibody development and manufacturing Autor: Shire, Steven J. Jahr: 2010 Contents 1 Introduction........................................................................................ 1 Wayne R. Gombotz and Steven J. Shire Part I Design Of Therapeutic MABS 2 CDR Repair: A Novel Approach to Antibody Humanization........... 9 Mark S. Dennis 3 Nanobodies, Single-Domain Antigen-Binding Fragments of Camelid Heavy-Chain Antibodies................................................. 29 Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens Part II Expression and Production of MABS 4 GPEx® A Flexible Method for the Rapid Generation of Stable, High Expressing, Antibody Producing Mammalian Cell Lines........ 51 Gregory T. Bleck 5 Advancing Our Cell Culture Platform: Incorporating Lessons Learned and New Technologies........................................... 63 Carole Heath Part III Recovery and Purification 6. Addressing Changes Associated with Technology Transfer: A Case Study...................................................................................... 75 Michele M. Myers, Camille Keating, Joann Bannon, Donald S. Neblock, and Peter W. Wojciechowski 7 Concepts for Disposables in Biopharmaceutical Manufacture.......... 87 Joachim K. Walter and Uwe Gottschalk Part IV Formulation and Delivery 8 Formulation and Delivery Issues for Monoclonal Antibody Therapeutics....................................................................... 103 Ann L. Dougherty and Randall J. Mrsny x Contents 9 Challenges in the Development of High Protein Concentration Formulations............................................................... 131 Steven J. Shire, Zahra Shahrokh, and Jun Liu 10 Protein Immobilization by Crystallization and Precipitation: An Alternative to Lyophilization....................................................... 149 Karoline Bechtold-Peters Part V Analytics and Specification Setting for MABS 11 Characterizing High Affinity Antigen/Antibody Complexes by Kinetic and Equilibrium Based Methods...................................... 179 Andrew W. Drake, David G. Myszka, and Scott L. Klakamp 12 Analytical Characterization of Monoclonal Antibodies: Linking Structure to Function............................................................ 193 Reed J. Harris, Edward T. Chin, Frank Macchi, Rodney G. Keck, Bao-Jen Shyong, Victor T. Ling, Armando J. Cordoba, Melinda Marian, Don Sinclair, John E. Battersby, and Andy J.S. Jones 13 Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation.................................... 207 James D. Andya, Jun Liu, and Steven J. Shire 14 Biophysical Signatures of Monoclonal Antibodies........................... 229 N. Harn, T. Spitznagel, M. Perkins, C. Allan, S. Shire, and C. R. Middaugh Part VI Pharmacokinetics and Immunogenicity 15 Impact of Fc Glycosylation on Monoclonal Antibody Effector Functions and Degradation by Proteases............................... 249 T. Shantha Raju 16 Immunogenicity Assessment of Antibody Therapeutics................... 271 R Stas, Y. Gansemans, and I. Lasters Part VII Armed Antibodies and New Classes of Antibodies 17 Production of Monoclonal Antibodies in E. coli............................... 295 Dorothea E. Reilly and Daniel G. Yansura 18 Recent Advancements in the Use of Antibody Drug Conjugates for Cancer Therapy......................................................... 309 Peter D. Senter 19 Antibody Radiolabeling..................................................................... 323 Corinne Bensimon and Russell Redshaw Index.......................................................................................................... 345
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spelling	Current trends in monoclonal antibody development and manufacturing ed. by Steven J. Shire... New York [u.a.] Springer [u.a.] 2010 XIV, 351 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnology : pharmaceutical aspects 11 Antibodies, Monoclonal analysis Antibodies, Monoclonal biosynthesis Antibodies, Monoclonal pharmacokinetics Biotechnology methods Monoclonal antibodies Shire, Steven J. edt Biotechnology pharmaceutical aspects ; 11 (DE-604)BV021640956 11 DE-601 pdf/application http://www.gbv.de/dms/bs/toc/54749386X.pdf kostenfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018929697&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Current trends in monoclonal antibody development and manufacturing Biotechnology Antibodies, Monoclonal analysis Antibodies, Monoclonal biosynthesis Antibodies, Monoclonal pharmacokinetics Biotechnology methods Monoclonal antibodies
title	Current trends in monoclonal antibody development and manufacturing
title_auth	Current trends in monoclonal antibody development and manufacturing
title_exact_search	Current trends in monoclonal antibody development and manufacturing
title_full	Current trends in monoclonal antibody development and manufacturing ed. by Steven J. Shire...
title_fullStr	Current trends in monoclonal antibody development and manufacturing ed. by Steven J. Shire...
title_full_unstemmed	Current trends in monoclonal antibody development and manufacturing ed. by Steven J. Shire...
title_short	Current trends in monoclonal antibody development and manufacturing
title_sort	current trends in monoclonal antibody development and manufacturing
topic	Antibodies, Monoclonal analysis Antibodies, Monoclonal biosynthesis Antibodies, Monoclonal pharmacokinetics Biotechnology methods Monoclonal antibodies
topic_facet	Antibodies, Monoclonal analysis Antibodies, Monoclonal biosynthesis Antibodies, Monoclonal pharmacokinetics Biotechnology methods Monoclonal antibodies
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