Verfügbarkeit: Oxford handbook of oncology

Oxford handbook of oncology: [your essential guide to diagnosis and management]

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	Oxford [u.a.] Oxford Univ. Press 2010
Ausgabe:	3. ed., extensively rev. and updated
Schriftenreihe:	Oxford medical publications
Schlagworte:	Cancer > Handbooks, manuals, etc Oncology > Handbooks, manuals, etc Neoplasms > Handbooks Onkologie Einführung
Online-Zugang:	Klappentext Inhaltsverzeichnis
Beschreibung:	Includes bibliographical references and index
Beschreibung:	XXXVII, 845 S. Ill., graph. Darst.
ISBN:	9780199563135 0199563136

Internformat

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Datensatz im Suchindex

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adam_text	XI Detailed contents Symbols and abbreviations xxm List of plates xxxvii Part 1 Background 1 Multidisciplinary approach to cancer ____________________3 2 Aetiology and epidemiology 5 Genetic factors 6 Gender 8 External factors 10 Infections 14 Exposures 16 Further reading 18 3 Genetics of cancer 19 The cancer phenotype 20 MultiStep carcinogenesis 24 What is the relevance of genetic changes in sporadic cancers? 25 Genetic predisposition to cancer 26 Predictive genetic testing 27 Implications of genetic testing for the affected individual 28 Common cancer predispositions 30__________________________ Part 2 Principles of treatment 4 Surgical oncology 35 General principles 36 Diagnosis and staging 40 Curative surgery 42 Palliative surgery 44 Surgery for metastatic disease 48____________________________ 5 Principles of radiation oncology 53 Introduction 54 Radiobiologv of normal tissues 56 x¡¡ DETAILED CONTENTS Radiotherapy fractionation 60 External beam radiotherapy 64 Progress in external beam radiotherapy 68 Recent advances in external beam radiotherapy 70 Electron beam therapy 72 Brachytherapy 76 Intra-operative radiotherapy 80 The role of unsealed radionuclides 82 Total body irradiation (TBI) 86_____________________________. 6 Principles of chemotherapy ° Rationale for combination therapy 90 Alkylating agents 91 Anti-tumour antibiotics 92 Anti-metabolites 94 Cisplatin and derivatives 100 Topoisomerase inhibitors 104 Anti-microtubule agents 106 Drug resistance 110 Dose intensification 1 11 Chemo-irradiation 114_________________________ 7 Principles of symptom control in palliative care 11 7 Introduction / ÍS Symptom control 122 Pain management 124 Nausea and vomiting 134 Hiccup 142 Constipation 144 Diarrhoea Í46 Cachexia and anorexia 148 Respiratory symptoms 150 Pruritus 154 Lymphoedema Í56 Mouthcare 158 Control of psychological distress 162 Symptom control at the end of life 164 DETAILED CONTENTS : x¡¡¡ Integrated care pathway 166 Further reading Í66 8 Late effects of chemotherapy and radiotherapy 167 Introduction 168 Endocrine and metabolic dysfunction 169 Fertility issues 170 Organ-specific problems 172 Secondary malignancies 1 74 Neuropsychological consequences 175 Further reading 176_____________________________________ 9 Hormone therapy 177 Introduction 178 Types of endocrine therapy 180 Predictors of response 184 Resistance to hormone therapy 185 Controversies 186 10 Biological and targeted therapies 187 Introduction 188 Active immunotherapy 190 Adoptive immunotherapy 194 Small-molecule inhibitors 196 Monoclonal antibodies 202 Tumour vaccines 206 Conclusion 207 Further reading 208 Part 3 Clinical trials, cancer prevention, and screening 11 Clinical trials 211 Methodology in cancer 212 Quality of life 214_______________________________________ 12 Cancer prevention 21 S Prevention strategies: introduction 2 to Cancer genetic and environmental, risks 217 xiv DETAILED CONTENTS Smoking-related cancers 218 Cancer prevention: diet 220 Clinical trials of cancer prevention 222 Cancer chemoprevention 224 The role of surgery in cancer prevention 22b Further reading 227 ________ 13 Population screening for cancer 229 Screening for cancer 230 Further reading 234____________________________________ Part 4 Specific types of cancer 14 Thoracic cancer 237 Lungcancer 238 Non-small-cell lung cancer (NSCLC) 244 Surgery for NSCLC 248 Chemotherapy of NSCLC 252 Radiation therapy for NSCLC 256 Small-cell lung cancer (SCLC) 260 Chemotherapy for SCLC 262 Radiotherapy for SCLC 266 Mesothelioma 268 Thymic tumours 272_____________________________________ 15 Breast cancer 275 Introduction 276 Epidemiology 278 Genetics of breast cancer 280 Pathology 282 Prognostic factors 284 Breast cancer screening 286 Presentation and staging 290 Management of non-invasive (in situ) breast cancer 294 Management of early invasive breast cancer 296 Loco-regional radiotherapy 300 Adjuvant systemic therapy 302 Management of locally advanced breast cancer 306 DETAILED CONTENTS Prognosis 307 Management of metastatic breast cancer 308 16 Colorectal cancer 313 Introduction 314 Colorectal caneen surgery 316 Adjuvant chemotherapy of colorectal cancer 378 Chemotherapy for advanced colorectal cancer 320 Radiotherapy in colorectal cancer 324________________________ 17 Anal cancer 325 Introduction 326 Anal squamous cell carcinoma 328 Rarer tumours 332 Practical points 332______________________________________ 18 Upper gastrointestinal cancer 333 Oesophageal cancer 334 Gastric cancer 338 Cancers of the small intestine 342 Cancer of the pancreas 344 Cancer of the biliary tract and gall bladder 348 Hepatocellular carcinoma 350 Gastrointestinal stronfiai tumours 352________________________ 19 Endocrine cancers 355 Thyroid cancer 356 Surgery for thyroid cancer 362 Radioiodine treatment for thyroid cancer 366 External beam radiotherapy for thyroid cancer 368 Chemotherapy for thyroid cancer 369 Novel therapies for thyroid cancer 370 Surveillance, follow-up, and prognosis for thyroid cancer 371 DETAILED CONTENTS Adrenal cancer 372 Neurobiastoma 376 Further reading 378 20 Genitourinary cancers 379 Renal cancer 380 Wilms tumour 388 Cancer of the bladder and ureter 394 Prostate cancer 400 Management of prostate cancer 404 Testicutar cancer 410 Management of testicular cancer 414 Penile cancer 418 Further reading 420______________________________________ 21 Gynaecological cancer 4^1 Ovarian cancer 422 Cancer of the uterine corpus 426 Cancer of the cervix 430 Vaginal and vulval cancer 434 Trophoblastic tumours 436 Further reading 442________________________—— 22 Head and neck cancers ^43 Introduction 444 Aetiology 446 Epidemiology 448 Screening and prevention 449 Pathology 450 Presentation 452 Investigations 454 TNM staging 456 Management 460 Prognosis and follow-up 4é<5 Rehabilitation 468 DETAILED CONTENTS Intra-ocular tumours 470 Further reading 472 23 Tumours of the central nervous system 473 Primary CNS tumours 474 Investigations and staging 480 Treatment of primary CNS tumours 482 Radiotherapy for primary CNS tumours 488 Chemotherapy for primary CNS tumours 492 Prognosis for primary CNS tumours 494 Recent advances and future treatments for primary CNS tumours 496 Brain métastases 498 Further reading 502______________________________________ 24 Skin cancers 503 Introduction 504 Malignant melanoma 506 Management of malignant melanoma 512 Management of metastatic disease 516 Intra-ocular melanoma 518 Non-melanoma skin cancer 520 Merkel cell carcinoma 524 Further reading 525______________________________________ 25 Haematological malignancies 527 Acute leukaemia 52S Chronic myeloid leukaemia (CML) 536 Myelodysptastic syndromes (MDS) 540 Chronic lymphoid leukaemias 544 Hodgkin lymphoma (HL) 552 Non-Hodgkin lymphomas (NHL) 558 Myeloma 568 Further reading 576_____________________________________ 26 Bone and soft-tissue malignancies 577 Osteosarcoma 578 DETAILED CONTENTS Ewing s sarcoma 584 Other primary bone tumours 588 Soft-tissue sarcomas 590 Rhabdomyosarcoma 596 ___ 27 Cancer of unknown primary (CUP) 5 Confirming the diagnosis 600 Investigation of métastases to lymph nodes and peritoneum 602 Investigation of métastases to other sites 604 Investigation of a pleural effusion 606 Aetiology and pathology of CUP 608 Management of CUP 610 Further reading 612_____________________________________ 28 Paraneoplastic syndromes *13 Introduction 614 Endocrine paraneoplastic syndromes 6Í6 Neurological paraneoplastic syndromes 618 Haematologicai paraneoplastic syndromes 620 Dermatological paraneoplastic syndromes 62 f Other syndromes 622 Constitutional symptoms 623 Further reading 624____________________. 29 AIDS-related malignancies s^5 Introduction 626 Effects of HAART 627 Kaposi s sarcoma 628 Systemic non-Hodgkin s lymphoma 632 Primary CNS lymphoma 634 Cervical cancer ¡n HIV-positive females 636 Non-AIDS-defining malignancies 638 Further reading 640______________________________________ 30 Childhood cancers presenting in adults ć41 Introduction 642 DETAILED CONTENTS Embryonal tumours 644 Soft-tissue sarcomas 646 Further reading 647 Part 5 Emergencies in oncology 31 Spinal cord compression and bone marrow suppression 651 Spinal cord compression 652 Bone marrow suppression 656 Red cell transfusion in cancer patients 660 32 Superior vena cava obstruction and raised intracranial pressure 661 Superior vena cava obstruction (SVCO) 662 Raised intracranial pressure (ICP) 666________________________ 33 Stridor 669 Aetiology 670 Presentation 67Í Management and investigation 672 Treatment of malignant airways obstruction in stable patients 673 Further reading 674______ ^ ____________________________ 34 Thromboembolic and cardiac emergencies 675 Thromboembolic disease and cancer 676 Disseminated intravascular coagulation and malignant disease 680 Cardiac disease and cancer 682 Further reading 684 _________________________________ 35 Obstruction 685 Intestinal obstruction 686 Urinary tract obstruction 690 Obstructive jaundice 692 Further reading 696__________ 36 Biochemical crises 697 Malignant hypercalcaemia 698 Hyponatraemia 700 DETAILED CONTENTS Hyperkalaemia 702 Hyperglycaemia and hypoglycaemia 703 Acute renal failure 704 Tumour lysis syndrome 70h __________ 37 Complications of long-term central venous lines and chemotherapy extravasation 70 Complications of long-term central venous lines 710 Chemotherapy extravasation 714_______________________ Part 6 The way forward 38 Novel therapeutic strategies 717 New drug discovery 718 Novel radiotherapeutic approaches 722 Targeted radiotherapy 724 Combined modalities 726________________________________ 39 Gene therapy and immunotherapy for cancer 727 Introduction 728 Somatic correction of gene defect 730 Genetic pro-drug activation (GPAT) 732 Genetic immunomodulation 734 Gene delivery 738_______________________ 40 Biomarkers and cancer 741 Biomarkers and cancer 742 Clinical applications of biomarkers 74S Further reading 752____________________—— Part 7 Appendices 1 NCIC common toxicity criteria (CTC) grading system (March 1998, revised) 755 Common toxicity criteria (CTC) 756 Adverse event module 810 Infection module 811 Performance status scales/scores 8 ! 2 RTOG/EORTC late radiation morbidity scoring scheme 814 DETAILED CONTENTS Bone marrow transplantation (BMT): specific adverse events 818 Bone marrow transplantation: complex/multicomponent events 822 2 Nomogram for determination of body surface area 825 3 Performance status 827 4 Support agencies addresses and websites 829 Index 831 This third edition of the successful Oxford Hondbook of Oncology, remains, like previous editions, a practical guide to clinical consultations in oncology. It provides coverage of the scientific basis and diagnosis of cancers, as well as updates on new drugs, biomarkers, the presentation of childhood cancers in adults and the psychosocial aspects of oncology. Now fully updated, this handbook has been extensively revised and features additional images and further reading. An essential tool for the management of everyday clinical situations, this new edition reflects recent advances in the field, in a user-friendly and easily accessible format It will be invaluable to ¡unior doctors in oncology, palliative care and general medicine, as well as specialist nurses, GP s, medical students, pharmacists and allied health professionals
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title	Oxford handbook of oncology [your essential guide to diagnosis and management]
title_alt	Handbook of oncology Oncology
title_auth	Oxford handbook of oncology [your essential guide to diagnosis and management]
title_exact_search	Oxford handbook of oncology [your essential guide to diagnosis and management]
title_full	Oxford handbook of oncology [your essential guide to diagnosis and management] ed. by Jim Cassidy ...
title_fullStr	Oxford handbook of oncology [your essential guide to diagnosis and management] ed. by Jim Cassidy ...
title_full_unstemmed	Oxford handbook of oncology [your essential guide to diagnosis and management] ed. by Jim Cassidy ...
title_short	Oxford handbook of oncology
title_sort	oxford handbook of oncology your essential guide to diagnosis and management
title_sub	[your essential guide to diagnosis and management]
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