Principles for modelling dose-response for the risk assessment of chemicals:
This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological stu...
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Geneva
World Health Organization
2009
|
| Series: | Environmental health criteria
239 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Summary: | This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description. |
| Physical Description: | XX, 137 S. |
| ISBN: | 9789241572392 |
Staff View
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| illustrated | Not Illustrated |
| indexdate | 2024-07-09T22:08:36Z |
| institution | BVB |
| isbn | 9789241572392 |
| language | English |
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| physical | XX, 137 S. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Principles for modelling dose-response for the risk assessment of chemicals first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals Geneva World Health Organization 2009 XX, 137 S. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 239 This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description. Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drugs Dose-response relationship Environmental Exposure prevention & control Models, Theoretical Risk Assessment methods Risk assessment Environmental health criteria 239 (DE-604)BV000011459 239 http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=3324694&custom_att_2=simple_viewer Principles for modelling dose response for the risk assessment of chemicals Inhaltsverzeichnis |
| spellingShingle | Principles for modelling dose-response for the risk assessment of chemicals Environmental health criteria Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drugs Dose-response relationship Environmental Exposure prevention & control Models, Theoretical Risk Assessment methods Risk assessment |
| title | Principles for modelling dose-response for the risk assessment of chemicals |
| title_auth | Principles for modelling dose-response for the risk assessment of chemicals |
| title_exact_search | Principles for modelling dose-response for the risk assessment of chemicals |
| title_full | Principles for modelling dose-response for the risk assessment of chemicals first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals |
| title_fullStr | Principles for modelling dose-response for the risk assessment of chemicals first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals |
| title_full_unstemmed | Principles for modelling dose-response for the risk assessment of chemicals first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals |
| title_short | Principles for modelling dose-response for the risk assessment of chemicals |
| title_sort | principles for modelling dose response for the risk assessment of chemicals |
| topic | Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drugs Dose-response relationship Environmental Exposure prevention & control Models, Theoretical Risk Assessment methods Risk assessment |
| topic_facet | Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drugs Dose-response relationship Environmental Exposure prevention & control Models, Theoretical Risk Assessment methods Risk assessment |
| url | http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=3324694&custom_att_2=simple_viewer |
| volume_link | (DE-604)BV000011459 |