RNA interference and viruses: current innovations and future trends
"Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets such as hepatitis...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Norfolk
Caister Acad. Press
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories."--Publisher's description. |
| Beschreibung: | VII, 252 S. Ill., graph. Darst. |
| ISBN: | 9781904455561 |
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Datensatz im Suchindex
| _version_ | 1804140884461092864 |
|---|---|
| adam_text | RNA INTERFERENCE AND VIRUSES CURRENT INNOVATIONS AND FUTURE TRENDS
EDITED BY MIGUEL ANGEL MARTINEZ FUNDACIO IRSICAIXA HOSPITAL UNIVERSITARI
GERMANS TRIAS I PUJOL BADALONA SPAIN CAISTER ACADEMIC PRESS CONTENTS
LIST OF CONTRIBUTORS V PREFACE IX 1 RNAI: AN ANTIVIRAL DEFENCE SYSTEM IN
INSECTS 1 BERTSY GOIC AND MARIA-CARLA SALEH 2 RNA SILENCING IN PLANTS
AND THE ROLE OF VIRAL SUPPRESSORS 25 ANA GINER, JUAN JOSE LOPEZ-MOYA AND
LORANT LAKATOS 3 THE PROPERTIES AND ROLES OF VIRUS-ENCODED MICRORNAS 47
MELANIE TANGUY AND SEBASTIEN PFEFFER 4 VIRUS-ENCODED SUPPRESSORS OF RNA
SILENCING AND THE ROLE OF CELLULAR MIRNAS IN MAMMALIAN ANTIVIRAL IMMUNE
RESPONSES 67 JOOST HAASNOOT AND BEN BERKHOUT 5 HCV AND THE INTERACTION
WITH MIR-122 IN THE LIVER 89 GABRIELE FUCHS AND CARA T. PAGER 6 VIRAL
ESCAPE FROM RNAI IN MAMMALIAN CELLS 107 MARIA NEVOT AND MIGUEL ANGEL
MARTINEZ 7 RNAI GENE THERAPY TO CONTROL HIV-1 INFECTION 127 BEN BERKHOUT
AND OLIVIER TER BRAKE 8 ADVANCES IN THE USE OF RNAI TO TREAT CHRONIC
HEPATITIS B VIRUS INFECTION 143 ABDULLAH ELY AND PATRICK ARBUTHNOT 9
HEPATITIS C: NEW INSIGHTS AND THERAPEUTICS BY RNAI 161 QIUWEI PAN AND
LUC J.W. VAN DER LAAN 10 RNAI APPLICATIONS TO DEFEAT RESPIRATORY VIRAL
INFECTIONS 187 SAILEN BARIK 11 RNAI WITH VIRAL VECTORS THAT DELIVER
SMALL INTERFERENCE RNAS 197 JOVANNA GONZALEZ-ROJAS, XABIER ABAD AND PURI
FORTES INDEX 251
|
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| spelling | RNA interference and viruses current innovations and future trends ed. by Miguel Angel Martinez Norfolk Caister Acad. Press 2010 VII, 252 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier "Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories."--Publisher's description. Antiviral Agents Antiviral agents Host-virus relationships RNA Interference RNA editing RNA viruses Virology Research Virus inhibitors Viruses RNS-Interferenz (DE-588)4802706-6 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Virusinfektion (DE-588)4188401-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content RNS-Interferenz (DE-588)4802706-6 s Virusinfektion (DE-588)4188401-2 s Labortechnik (DE-588)4123602-6 s DE-604 Martínez, Miguel Angel Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018761483&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | RNA interference and viruses current innovations and future trends Antiviral Agents Antiviral agents Host-virus relationships RNA Interference RNA editing RNA viruses Virology Research Virus inhibitors Viruses RNS-Interferenz (DE-588)4802706-6 gnd Labortechnik (DE-588)4123602-6 gnd Virusinfektion (DE-588)4188401-2 gnd |
| subject_GND | (DE-588)4802706-6 (DE-588)4123602-6 (DE-588)4188401-2 (DE-588)4143413-4 |
| title | RNA interference and viruses current innovations and future trends |
| title_auth | RNA interference and viruses current innovations and future trends |
| title_exact_search | RNA interference and viruses current innovations and future trends |
| title_full | RNA interference and viruses current innovations and future trends ed. by Miguel Angel Martinez |
| title_fullStr | RNA interference and viruses current innovations and future trends ed. by Miguel Angel Martinez |
| title_full_unstemmed | RNA interference and viruses current innovations and future trends ed. by Miguel Angel Martinez |
| title_short | RNA interference and viruses |
| title_sort | rna interference and viruses current innovations and future trends |
| title_sub | current innovations and future trends |
| topic | Antiviral Agents Antiviral agents Host-virus relationships RNA Interference RNA editing RNA viruses Virology Research Virus inhibitors Viruses RNS-Interferenz (DE-588)4802706-6 gnd Labortechnik (DE-588)4123602-6 gnd Virusinfektion (DE-588)4188401-2 gnd |
| topic_facet | Antiviral Agents Antiviral agents Host-virus relationships RNA Interference RNA editing RNA viruses Virology Research Virus inhibitors Viruses RNS-Interferenz Labortechnik Virusinfektion Aufsatzsammlung |
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