Adenocarcinoma of the esophagogastric junction:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2010
|
| Schriftenreihe: | Recent results in cancer research
182 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 191 S. Ill., graph. Darst. |
| ISBN: | 9783540705789 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804140846648393728 |
|---|---|
| adam_text | IMAGE 1
1 EPIDEMIOLOGY OF ADENOCARCINOMA OF THE ESOPHAGUS,
GASTRIC CARDIA, AND UPPER GASTRIC THIRD 1
MANUEL VIAL, LUIS GRANDE, AND MANUEL PERA
1.1 INTRODUCTION 1
1.2 DEMOGRAPHICS, TRENDS, AND GEOGRAPHIC VARIATIONS OF ADENOCARCINOMA OF
THE ESOPHAGUS AND EGJ 2
1.3 AGE, GENDER, AND RACE 4
1.4 GASTROESOPHAGEAL REFLUX DISEASE AND ACE AND EGJ 4
1.5 BARRETT S ESOPHAGUS AND ACE AND EGJ 5
1.6 OBESITY 7
1.7 ADDITIONAL RISK FACTORS FOR ACE AND EGJ 9
1.7.1 TOBACCO 9
1.7.2 ALCOHOL 9
1.7.3 DIET AND NUTRITION 9
1.7.4 MEDICATIONS 10
1.7.5 HELICOBACTER PYLORI INFECTION 11
1.8 SUMMARY 11
REFERENCES 12
2 CLINICAL CLASSIFICATION SYSTEMS OF ADENOCARCINOMA OF THE
ESOPHAGOGASTRIC JUNCTION 19
STEFAN PAUL MOENIG AND ARNULF H. HOELSCHER
2.1 ESOPHAGOGASTRIC JUNCTION 19
2.1.1 INTRODUCTION 19
2.1.2 DEFINITION 19
2.1.3 DIFFERENT CLASSIFICATION SYSTEMS 20
2.2 CLASSIFICATION OF ADENOCARCINOMA OF THE EGJ TYPE I-III 21
2.2.1 DEFINITION AND TOPOGRAPHICAL CLASSIFICATION 21
2.2.2 DIAGNOSIS 21
2.2.3 BIOLOGICAL AND CLINICAL VARIATIONS 23
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/989738779
DIGITALISIERT DURCH
IMAGE 2
CONTENTS
2.2.4 SURGICAL CONSEQUENCES 25
2.3 CONCLUSIONS 26
REFERENCES 26
3 HISTOPATHOLOGIC CLASSIFICATION OF ADENOCARCINOMA OF THE
ESOPHAGOGASTRIC JUNCTION 29
STEPHAN E. BALDUS
3.1 INTRODUCTION 29
3.2 DEFINITION OF THE ESOPHAGOGASTRIC JUNCTION 30
3.3 WHO CLASSIFICATION OF TUMORS OF THE DIGESTIVE SYSTEM 31
3.3.1 GENERAL PRINCIPLES 31
3.4 HISTOPATHOLOGIC SUBTYPES 31
3.5 PRECANCEROUS LESIONS AND HISTOGENETIC ASPECTS 31
3.6 PROGNOSTIC ASPECTS OF HISTOPATHOLOGIC CLASSIFICATION 33
3.7 UICC CLASSIFICATION AND GRADING 34
3.8 HISTOPATHOLOGIC REGRESSION GRADING AFTER NEOADJUVANT THERAPY , 34
REFERENCES 36
4 THE PATHOGENESIS OF BARRETT S METAPLASIA AND THE PROGRESSION TO
ESOPHAGEAL ADENOCARCINOMA 39
BRECHTJE A. GROTENHUIS, J. JAN B. VAN LANSCHOT, WINAND N.M. DINJENS, AND
BAS P.L. WIJNHOVEN
4.1 INTRODUCTION 39
4.2 NORMAL ESOPHAGEAL EPITHELIUM 40
4.3 PATHOGENESIS OF BARRETT S METAPLASIA 41
4.3.1 DEVELOPMENT OF BARRETT S ESOPHAGUS: CONGENITAL VS. ACQUIRED 41
4.3.2 DEFINITION OF BARRETT S METAPLASIA 41
4.3.3 GASTROESOPHAGEAL REFLUX DISEASE 41
4.3.4 CELL OF ORIGIN OF BARRETT S METAPLASIA 47
4.3.5 TRANSFORMATION INTO A COLUMNAR EPITHELIUM 49
4.3.6 CLONAL EXPANSION 49
4.4 PROGRESSION TO ESOPHAGEAL ADENOCARCINOMA 50
4.4.1 HALLMARKS OF CANCER PROGRESSION 51
4.4.2 GENETIC INSTABILITY 53
4.5 SUMMARY 54
REFERENCES 54
5 DIFFERENCES IN THE MOLECULAR BIOLOGY OF ADENOCARCINOMA OF THE
ESOPHAGUS, GASTRIC CARDIA, AND UPPER GASTRIC THIRD 65 KUNO LEHMANN AND
PAUL M. SCHNEIDER
5.1 INTRODUCTION 65
5.2 MICROSATELITE INSTABILITY (MSI) AND LOSS OF HETEROZYGOSITY (LOH) 66
IMAGE 3
CONTENTS
5.3 DIFFERENCE IN PHENOTYPE ON HISTOLOGY AND IMMUNOHISTOCHEMISTRY 66
5.4 DIFFERENCES IN THE HALLMARKS OF CANCER 67
5.5 SELF-SUFFICIENCY IN GROWTH SIGNALS 67
5.6 INSENSITIVITY TO ANTIGROWTH SIGNALS 67
5.7 EVASION OF APOPTOSIS 68
5.8 LIMITLESS REPLICATIVE POTENTIAL 68
5.9 SUSTAINED ANGIOGENESIS 68
5.10 TISSUE INVASION 68
5.11 CONCLUSION 69
REFERENCES 69
6 CLINICAL STAGING OF ADENOCARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION 73
JULIA CORDIN, KUNO LEHMANN, AND PAUL M. SCHNEIDER
6.1 INTRODUCTION 73
6.2 ESTABLISHING THE DIAGNOSIS 73
6.3 THE TUMOR CENTER LOCALIZATION DETERMINES THE CLASSIFICATION 74
6.4 PREOPERATIVE TNM STAGING DEFINES FURTHER TREATMENT STRATEGIES 75
6.5 IMAGING TECHNIQUES FOR AEG 75
6.6 ENDOSCOPIE ULTRASOUND (EUS) 75
6.7 COMPUTED TOMOGRAPHY (CT) 77
6.8 18 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY ( 18 FDG-PET) 78
6.9 MRI 78
6.10 STAGING LAPAROSCOPY EXCLUDES PERITONEAL DISEASE 78
6.11 CONCLUSION 79
REFERENCES 80
7 ENDOSCOPIE MUCOSAL RESECTION FOR STAGING AND THERAPY OF ADENOCARCINOMA
OF THE ESOPHAGUS, GASTRIC CARDIA, AND UPPER GASTRIC THIRD 85
HENRIETTE HEINRICH AND PETER BAUERFEIND
7.1 INTRODUCTION 85
7.2 STAGING AND MARKING BEFORE ER 86
7.3 ENDOSCOPIE RESECTION TECHNIQUES 86
7.4 RESULTS OF ER 87
7.5 RESULTS IN EARLY BARRETT S ADENOCARCINOMA OR HGD 87
7.6 COMPLICATIONS OF ER IN BARRETT ESOPHAGUS 88
7.7 ER FOR HGC OR EARLY CANCER AT THE ESOPHAGOGASTRIC JUNCTION 88
7.8 ER FOR GASTRIC NEOPLASIA 89
7.9 CONCLUSION 89
REFERENCES 89
IMAGE 4
CONTENTS
8 SURGICAL STRATEGIES FOR ADENOCARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION
93
MARC SCHIESSER AND PAUL M. SCHNEIDER
8.1 INTRODUCTION 93
8.2 SURGICAL STRATEGIES FOR AEG SIEWERT TYPE 1 95
8.2.1 RECONSTRUCTION 99
8.2.2 LIMITED RESECTION 99
8.2.3 MINIMAL INVASIVE OPERATION TECHNIQUES 100
8.3 SURGICAL STRATEGIES FOR AEG SIEWERT TYPE II AND III 101
8.3.1 LIMITED RESECTION 103
8.3.2 MINIMAL INVASIVE TECHNIQUES 103
8.3.3 SENTINEL NODE TECHNIQUE 103
8.4 SUMMARY 104
REFERENCES 104
9 CURRENT STATUS OF SENTINEL LYMPH NODE BIOPSY IN ADENOCARCINOMA OF THE
DISTAL ESOPHAGUS, GASTRIC CARDIA, AND PROXIMAL STOMACH 107
STEPHAN GRETSCHEL AND PETER M. SCHLAG
9.1 INTRODUCTION 107
9.2 PATTERN OF LYMPH NODE METASTASES 107
9.3 EXTENSION OF RESECTION 108
9.4 THE TECHNIQUES OF SENTINEL NODE BIOPSY 108
9.5 UPSTAGING 110
9.6 USING THE SLN AS FROZEN SECTION DURING SURGERY 110
9.7 CURRENT STATUS OF SENTINEL LYMPH NODE BIOPSY IN GASTRIC CANCER 110
9.8 SENTINEL LYMPH NODE CONCEPT IN AEG I LL
REFERENCES 112
10 CURRENT DIAGNOSIS AND FUTURE IMPACT OF MICROMETASTASCS FOR
THERAPEUTIC STRATEGIES IN ADENOCARCINOMA OF THE ESOPHAGUS, GASTRIC
CARDIA, AND UPPER GASTRIC THIRD 115
ASAD KUTUP, EMRE F. YEKEBAS, AND JAKOB R. IZBICKI
10.1 INTRODUCTION 115
10.2 INCIDENCE OF NODAL MICROMETASTASES 116
10.3 MODE OF SPREAD 117
10.4 EFFECT OF NODAL MICROINVOLVEMENT ON SURVIVAL 119
10.5 CURRENT AND FUTURE PERSPECTIVES 121
REFERENCES 122
IMAGE 5
CONTENTS
11 QUALITY INDICATORS OF SURGERY FOR ADENOCARCINOMA OF THE ESOPHAGUS AND
GASTROESOPHAGEAL JUNCTION 127
TONI LERNT, GEORGES DECKER, WILLY COOSEMANS, PAUL DE LEYN, HERBERT
DECALUWE, PHILIPPE NAFTEUX, AND DIRK VAN RAEMDONCK
11.1 INTRODUCTION 127
11.2 QUALITY ISSUES IN THE DEFINITION OF CANCER OF THE GASTROESOPHAGEAL
JUNCTION (GEJ) 128
11.3 QUALITY CONTROL AND QUALITY ISSUES IN THE STAGING OF ESOPHAGEAL
CANCER 130
11.4 QUALITY ISSUES IN THE USE AND INDICATIONS FOR INDUCTION CHEMO- AND
CHEMORADIOTHERAPY 132
11.4.1 CHEMOTHERAPY 132
11.4.2 CHEMORADIOTHERAPY 133
11.5 TYPE OF SURGICAL APPROACH, EXTENT OF ESOPHAGEAL/GASTRIC RESECTION,
AND EXTENT OF LYMPH NODE DISSECTION 135
11.6 USE (AND MISUSE?) OF MINIMALLY INVASIVE ESOPHAGECTOMY TECHNIQUES
137
11.7 QUALITY OF PERIOPERATIVE MANAGEMENT 138
11.8 CONCLUSION 139
REFERENCES 139
12 PERI-OPERATIVE AND COMPLICATION MANAGEMENT FOR ADENOCARCINOMA OF THE
OESOPHAGUS AND OESOPHAGIGASTRIC JUNCTION 143
K. TOBIAS E. BECKURTS
12.1 PATIENT SELECTION AND EVALUATION 143
12.2 PRE-OPERATIVE PREPARATION 144
12.3 ANAESTHESIA 144
12.4 OPERATIVE PROPHYLAXIS OF COMPLICATIONS 145
12.5 IMMEDIATE POST-OPERATIVE CARE 146
12.6 SURGICAL COMPLICATIONS 147
12.7 MANAGEMENT OF PULMONARY COMPLICATIONS 148
12.8 POSTOPERATIVE NUTRITION 149
12.9 SUMMARY 149
REFERENCES 150
13 MULTIMODALITY THERAPY FOR ADENOCARCINOMA OF THE ESOPHAGUS, GASTRIC
CARDIA, AND UPPER GASTRIC THIRD 155 JOHN V. REYNOLDS, THOMAS J. MURPHY,
AND NARAYAMASAMY RAVI
13.1 INTRODUCTION 155
13.2 MULTIMODAL THERAPY 156
13.3 THE EVIDENCE-BASE FOR NEOADJUVANT AND ADJUVANT APPROACHES 156
IMAGE 6
XIV CONTENTS
13.3.1 NEOADJUVANT CHEMOTHERAPY 156
13.3.2 NEOADJUVANT CHEMORADIOTHERAPY 158
13.3.3 POSTOPERATIVE COMBINATION THERAPY 160
13.4 NEW COMBINATIONS AND NOVEL AGENTS 160
13.5 CONCLUSIONS 161
REFERENCES 164
14 METABOLIC RESPONSE EVALUATION BY PET DURING NEOADJUVANT TREATMENT FOR
ADENOCARCINOMA OF THE ESOPHAGUS AND ESOPHAGOGASTRIC JUNCTION 167
A. SENDLER
14.1 RESPONSE EVALUATION 169
14.2 RESPONSE EVALUATION BY CT SCAN STUDIES AND EUS 170
14.3 RESPONSE EVALUATION BY PET AFTER NEOADJUVANT TREATMENT 171 14.4 PET
DURING TREATMENT 173
14.5 CONCLUSION 174
REFERENCES 175
15 MOLECULAR RESPONSE PREDICTION IN MULTIMODALITY TREATMENT FOR
ADENOCARCINOMA OF THE ESOPHAGUS AND ESOPHAGOGASTRIC JUNCTION 179
GEORG LURJE AND HEINZ-JOSEF LENZ
15.1 INTRODUCTION 179
15.2 MOLECULAR MARKERS; DEFINING THEIR ROLE 180
15.2.1 EPIDERMAL GROWTH FACTOR RECEPTORS (EGFR, HER2/NEU) 182 15.2.2
TUMOR SUPPRESSOR GENSP53 182
15.2.3 SURVIVIN 183
15.2.4 CYCLOOXYGENASE-2 (COX-2) 183
15.2.5 EXCISION REPAIR CROSS-COMPLEMENTING 1 (ERCC1) 184
15.2.6 GENE EXPRESSION MICROARRAY PROFILING 184
15.2.7 CPG ISLAND METHYLATOR PHENOTYPE (CIMP) 185
15.3 CONCLUSION 186
REFERENCES 186
|
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| id | DE-604.BV035865099 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:06:28Z |
| institution | BVB |
| isbn | 9783540705789 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018722861 |
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| owner_facet | DE-29 DE-19 DE-BY-UBM DE-12 |
| physical | XIV, 191 S. Ill., graph. Darst. |
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| publisher | Springer |
| record_format | marc |
| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Adenocarcinoma of the esophagogastric junction Paul M. Schneider (ed.) Heidelberg [u.a.] Springer 2010 XIV, 191 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 182 Speiseröhrenkrebs (DE-588)4132808-5 gnd rswk-swf Adenocarcinom (DE-588)4141401-9 gnd rswk-swf Pylorus (DE-588)4115674-2 gnd rswk-swf Speiseröhre (DE-588)4056119-7 gnd rswk-swf Pyloruskrankheit (DE-588)4320552-5 gnd rswk-swf Speiseröhrenkrebs (DE-588)4132808-5 s Adenocarcinom (DE-588)4141401-9 s DE-604 Pyloruskrankheit (DE-588)4320552-5 s Pylorus (DE-588)4115674-2 s 1\p DE-604 Speiseröhre (DE-588)4056119-7 s 2\p DE-604 Schneider, Paul M. Sonstige oth Erscheint auch als Online-Ausgabe 978-3-540-70579-6 Recent results in cancer research 182 (DE-604)BV000000043 182 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018722861&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Adenocarcinoma of the esophagogastric junction Recent results in cancer research Speiseröhrenkrebs (DE-588)4132808-5 gnd Adenocarcinom (DE-588)4141401-9 gnd Pylorus (DE-588)4115674-2 gnd Speiseröhre (DE-588)4056119-7 gnd Pyloruskrankheit (DE-588)4320552-5 gnd |
| subject_GND | (DE-588)4132808-5 (DE-588)4141401-9 (DE-588)4115674-2 (DE-588)4056119-7 (DE-588)4320552-5 |
| title | Adenocarcinoma of the esophagogastric junction |
| title_auth | Adenocarcinoma of the esophagogastric junction |
| title_exact_search | Adenocarcinoma of the esophagogastric junction |
| title_full | Adenocarcinoma of the esophagogastric junction Paul M. Schneider (ed.) |
| title_fullStr | Adenocarcinoma of the esophagogastric junction Paul M. Schneider (ed.) |
| title_full_unstemmed | Adenocarcinoma of the esophagogastric junction Paul M. Schneider (ed.) |
| title_short | Adenocarcinoma of the esophagogastric junction |
| title_sort | adenocarcinoma of the esophagogastric junction |
| topic | Speiseröhrenkrebs (DE-588)4132808-5 gnd Adenocarcinom (DE-588)4141401-9 gnd Pylorus (DE-588)4115674-2 gnd Speiseröhre (DE-588)4056119-7 gnd Pyloruskrankheit (DE-588)4320552-5 gnd |
| topic_facet | Speiseröhrenkrebs Adenocarcinom Pylorus Speiseröhre Pyloruskrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018722861&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT schneiderpaulm adenocarcinomaoftheesophagogastricjunction |