Yeast: Molecular and cell biology
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XIV, 334 S. Ill., graph. Darst. 240 mm x 170 mm |
| ISBN: | 9783527326099 |
Internformat
MARC
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| 245 | 1 | 0 | |a Yeast |b Molecular and cell biology |c Horst Feldmann |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2010 | |
| 300 | |a XIV, 334 S. |b Ill., graph. Darst. |c 240 mm x 170 mm | ||
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Datensatz im Suchindex
| _version_ | 1805093267538182144 |
|---|---|
| adam_text |
Contents
Preface
XI
Foreword
XIII
1
Introduction
1
1.1
Historical Aspects
1
1.2
Yeast as a Eukaryotic Model System
2
2
The "Early Days" of Nucleic Acids
5
2.1
Molecular Biology of tRNA
5
2.2
Ribosomes, Ribosomal RNAs, and Ribosomal Proteins
2.3
Messenger RNAs
10
2.3.1
Structure of Yeast mRNAs
10
2.3.2
Introns
and Processing of pre-mRNA
11
3
Genetic Engineering and Reverse Genetics
15
3.1
The Molecular Revolution
15
3.2
Transformation of Yeast Cells
16
3.3
More Genetic Tools from Yeast Cells
16
3.4
The Two-Hybrid System
17
4
Cell Structures and Functions
19
4.1
The Yeast Cell
19
4.2
Yeast Envelope and Cell Skeleton
19
4.3
Yeast Chromosome Structure and Function
21
A
3.1
Centromeres
21
4.3.2
Replication Origins and Replication
21
4.3.3
Telomeres
23
4.3.4
Retrotransposons in Yeast
25
4.3.4.1
Types and Structure
25
4.3.4.2
Ту
Replication
27
VI
I Contents
4.3.4.3
Interactions between
Ту
Elements and their Host
28
4.3.5
Extrachromosomal Elements: Yeast
Prions
29
5
Cellular Dynamics
33
5.1
Cell Propagation
33
5.1.1
Budding
33
5.1.2
Septins
34
5.1.3
Spindle Dynamics
34
5.2
Regulatory ATPases
-
AAA+Proteins
36
5.2.1
ATP-Dependent Proteases
36
5.2.2
Membrane Fusion Proteins
37
5.2.3
Cdc48
37
5.2.4
Peroxisomal AAA Proteins
38
5.2.5
Katanin and Vps4p
38
5.2.6
Dynein
39
5.2.7 DNA
Replication Proteins
39
5.2.8
RuvB-Like Proteins
39
5.3
Protein Modification by Proteins and Programmed
Protein Degradation
40
5.3.1
The Ubiquitin-Proteasome System
40
5.3.1.1
Ubiquitin and Factors in the Ubiquitin-Mediated Pathway
40
5.3.1.2
Yeast Proteasomes
43
5.3.1.3
Regulation of Yeast Proteasome Activity
46
5.3.2
More Functions for Ubiquitin
46
5.3.3
Ubiquitin-Like Proteins (ULPs) and Cognate Factors
47
5.3.3.1
SUMO
47
5.3.3.2
RUBI
49
5.3.3.3
Ubiquitin Domain Proteins
49
5.4
The Yeast Cell Cycle, Cell Division, and Chromosome Segregation
51
5.4.1
The Cell Cycle
51
5.4.2
Sister Chromatids: Cohesion and Separation
53
5.4.3
The Spindle Checkpoint
56
5.4.4
Chromosome Segregation During Meiosis
58
5.5
Intracellular Protein Sorting and Transport
58
5.5.1
The "Signal Hypothesis"
59
5.5.2
Central Role of the Endoplasmic Reticulum
60
5.5.3
Intracellular Protein Trafficking and Sorting
60
5.5.4
ER-Associated Protein Degradation
65
5.5.5
The Vacuolar Network
66
5.5.6
Endocytosis and the Multivesicular Body Sorting Pathway
67
5.5.7
Exocytosis
70
5.5.8
Nuclear Traffic
71
5.6
Membrane Transporters in Yeast
75
5.6.1
Channels and ATPases
76
5.6.1.1
ЬГ
-ATPases
76
Contents
VII
5.6.1.2 Ca2+-Signaling and Transport
Pathways in Yeast
76
5.6.2
Transition Metal Transport
79
5.6.2.1
Iron
79
5.6.2.2
Copper
80
5.6.2.3
Zinc
80
5.6.2.4
Manganese
81
5.6.3
Phosphate Transport
81
5.6.4
Nutrient and Ammonium Transport
82
6
Anatomy of the Transcription Machinery and Auxiliary
Complexes: Chromatin Remodeling
85
6.1
Transcriptional Regulation and Transcription Factors
85
6.2
RNA Polymerases
and Cofactors
86
6.2.1
RNA Polymerase
I
86
6.2.2
RNA
Polymerase III
86
6.2.3
RNA
Polymerase II
89
6.2.4
General Transcription Factors
92
6.2.4.1
TBP
92
6.2.4.2
TFIIA
92
6.2.4.3
TFIIB
92
6.2.4.4
TFIIE and TFIIF
93
6.2.4.5
TFIIH
93
6.2.4.6
Transcription Activators
93
6.2.4.7
TFIID
94
6.2.4.8
SRB/Mediator
95
6.2.4.9
SAGA
98
6.2.4.10
Transcriptional
Repressore
98
6.3
Coupling Transcription to Pre-mRNA Processing
99
6.4 DNA
Repair Connected to Transcription
101
6.5
Modification of Chromatin During Transcription
102
6.5.1
Chromatin-Modifying Activities
104
6.5.2
Chromatin Remodeling Complexes
106
7
Molecular Signaling Cascades and Gene Regulation
109
7.1
MAP Kinase Pathways
109
7.1.1
Mating-Type Pathway
110
7.1.2
Filamentation/Invasion Pathway
110
7.1.3
Control of Cell Integrity 111
7.1.4
High Osmolarity Growth Pathway
112
7.1.5
Spore Wall Assembly Pathway
114
7.2
General Control by Gene Repression
115
7.2.1
Ѕѕпб
-Tupl
Repression
115
7.2.2
Activation and Repression by
Rapi
227
7.3
Gene Regulation by Nutrients
117
7.3.1
The TOR System
227
VIII Contents
7.3.2 Regulation
of
Glucose
Metabolism
121
7.3.3
Regulation of
Galactose
Metabolism
124
7.3.4
General
Amino
Acid Control
126
7.3.5
Regulation of
Arginine
Metabolism
127
7.4
Stress Responses in Yeast
129
7
A.I Temperature Stress and Heat Shock Proteins
129
7
A.I Oxidative and Chemical Stresses
134
7.4.2.1
AP-1 Transcription Factors in Yeast
134
7.4.2.2
The STRE-Dependent System
336
7.4.2.3
Pleiotropic Drag Resistance: ABC Transporters
136
7A3
The Unfolded Protein Response
139
7.5
Posttranscriptional Control of Gene Expression in Yeast
139
7.5.1
Translation
139
7.5.2
Control and Pathways of mRNA Decay
140
7.5.3
Exosome-Mediated Pathways in Yeast
140
7.5.4
Nonsense-Mediated mRNA Decay
142
7.6
Protein Splicing
-
Yeast Interns
143
8
Yeast
Organeliar
Biogenesis and Function
147
8.1
Mitochondria
147
8.1.1
Genetic Biochemistry of Yeast Mitochondria
247
8.1.2
Mitochondrial Functions Critical to Cell Viability
150
8.1.2.1 Superoxide Dismutase 252
8.1.2.2
Iron Homeostasis
252
8.1.3
Biogenesis of Mitochondria: Protein Transport
252
8.1.3.1
The Presequence Pathway and the MIA Pathway
154
8.1.3.2
The Membrane Sorting Pathway: Switch Between TIM22
and TIM23
255
8.1.3.3
The
ß-Barrel
Pathway
256
8.1.3.4
The Endogenous Membrane Insertion Machinery
256
8.1.4
Mitochondrial Quality Control and Remodeling
156
8.2
Peroxisomes
258
9
Genome, Proteome, Transcriptome, Metabolome,
and Regulatory Networks
265
9.1
The Yeast Genome Sequencing Project
265
9.2
Characteristics of the Yeast Genome
266
9.2.1
Gene Organization
268
9.2.2
Genetic Redundancy: Gene Duplications
269
9.2.3
Gene Typification and Gene Families
270
9.2.4
Functional Analysis of Yeast Genes
272
9.3
Functional Genomics
272
9.3.1
Yeast Transcriptome
272
9.3.1.1
Genomic Profiling
272
9.3.1.2
Protein-DNA Interactions
272
Contents
IX
9.3.2
Yeast
Proteome 174
9.3.2.1 Protein
Analysis
174
9.3.2.2 Proteome Chips 175
9.3.2.3 Protein-Protein
Interactions and
Protein
Complexes
175
9.3.3
Yeast
Metabolome 177
9.3.4
Genetic Interaction
Networks:
Regulatory
Networks
and Oscillations
177
9.4
Hemiasconiycetous Yeasts and Evolutionary Aspects
178
9.4.1
Model Genomes
178
9.4.2
Evolutionary Aspects
181
10
Disease Genes in Yeast
185
10.1
General Aspects
385
10.2
Trinucleotide Repeats and
Neurodegenerative
Diseases
187
10.3
Aging and Age-Related Disorders
190
10.4
Mitochondrial Diseases
191
Π
Yeast in Biotechnology
197
11.1
Fermentation and Metabolic Engineering
197
11.1.1
"Typical" Fermentation Procedures
197
11.1.2
Food and Chemical Industries: Metabolic Engineering
198
11.2
Biopharmaceuticals from Health-Care Industries
201
11.3
Biomedical
Research
204
11.4
Environmental Technologies: Cell-Surface Display
204
12
Epilogue: The Future of Yeast Research
207
References
209
Appendix: Online Resources Useful in Yeast Research
327
Index
329 |
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| id | DE-604.BV035854853 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T10:24:46Z |
| institution | BVB |
| isbn | 9783527326099 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018712822 |
| oclc_num | 489629727 |
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| physical | XIV, 334 S. Ill., graph. Darst. 240 mm x 170 mm |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Feldmann, Horst 1932-2022 Verfasser (DE-588)139969454 aut Yeast Molecular and cell biology Horst Feldmann Weinheim Wiley-VCH 2010 XIV, 334 S. Ill., graph. Darst. 240 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Yeast Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Hefeartige Pilze (DE-588)4230509-3 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Hefeartige Pilze (DE-588)4230509-3 s Molekulargenetik (DE-588)4039987-4 s DE-604 Cytologie (DE-588)4070177-3 s b DE-604 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3320198&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018712822&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Feldmann, Horst 1932-2022 Yeast Molecular and cell biology Yeast Molekulargenetik (DE-588)4039987-4 gnd Hefeartige Pilze (DE-588)4230509-3 gnd Cytologie (DE-588)4070177-3 gnd |
| subject_GND | (DE-588)4039987-4 (DE-588)4230509-3 (DE-588)4070177-3 |
| title | Yeast Molecular and cell biology |
| title_auth | Yeast Molecular and cell biology |
| title_exact_search | Yeast Molecular and cell biology |
| title_full | Yeast Molecular and cell biology Horst Feldmann |
| title_fullStr | Yeast Molecular and cell biology Horst Feldmann |
| title_full_unstemmed | Yeast Molecular and cell biology Horst Feldmann |
| title_short | Yeast |
| title_sort | yeast molecular and cell biology |
| title_sub | Molecular and cell biology |
| topic | Yeast Molekulargenetik (DE-588)4039987-4 gnd Hefeartige Pilze (DE-588)4230509-3 gnd Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Yeast Molekulargenetik Hefeartige Pilze Cytologie |
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| work_keys_str_mv | AT feldmannhorst yeastmolecularandcellbiology |