New concepts of psychostimulants induced neurotoxicity:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2009
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| Schriftenreihe: | International review of neurobiology
88 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XVI, 473 S. Ill., graph. Darst. |
| ISBN: | 9780123745040 |
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| 245 | 1 | 0 | |a New concepts of psychostimulants induced neurotoxicity |c ed. by Hari Shanker Sharma |
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Datensatz im Suchindex
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Titel: New concepts of psychostimulants induced neurotoxicity
Autor: Sharma, Hari Shanker
Jahr: 2009
CONTENTS
Contributors xi
Preface xv
Effects of Psychostimulants on Neurotrophins: Implications for
Psychostimulant-lnduced Neurotoxicity
Francesco Angelucci, Valerio Ricci, Gianfranco Spalletta,
Carlo Caltagirone, Aleksander A. Mathe, and Pietro Bria
I. Introduction 2
II. Psychostimulants 2
III. Neurotrophins 6
IV. Neurotrophins and Psychostimulants 8
V. Psychostimulants, Neurotoxicity, and Neurotrophins 12
VI. Psychostimulants, Neurotrophins, and Psychosis 14
VII. Conclusions 15
References 16
Dosing Time-Dependent Actions of Psychostimulants
H. Manev and T. Uz
I. Introduction: The Concept of the Dosing Time-Dependent
Actions of Drugs 26
II. Diurnal Variations in the Behavioral Actions of Psychostimulants 27
III. Diurnal Variations in the CNS Systems 29
IV. Diurnal Variations and Melatonin 32
V. Possible Clinical Implications 36
VI. Conclusions 37
References 38
Dopamine-lnduced Behavioral Changes and Oxidative Stress in
Methamphetamine-lnduced Neurotoxicity
Taizo Kita, Ikuko Miyazaki, Masato Asanuma, Mika Takeshima, and
George C. Wagner
I. Background: Neuronal Damage Caused by Amphetamines 44
II. Dopamine Quinone Formation as a Dopaminergic Neuron-Specific
Neurotoxic Factor in Methamphetamine-lnduced Neurotoxicity 50
v
vi CONTENTS
III. Methamphetamine-Induced Behavioral Changes: Relation to
Neuronal Damage 53
IV. Conclusion 56
References 57
Acute Methamphetamine Intoxication: Brain Hyperthermia, Blood-brain
Barrier, Brain Edema, and Morphological Cell Abnormalities
Eugene A. Kiyatkin and Hari S. Sharma
I. Introduction 66
II. Basic Terminology and Major Topics of This Study 67
III. Brain Temperature Responses to METH are Dose-Dependent and
Modulated by Activity State and Environmental Conditions 70
IV. Acute METH Intoxication Results in BBB Leakage, Acute Glial Activation,
and Morphological Alterations of Brain Cells: Role of
Brain Temperature 76
V. Conclusions 93
References 97
Molecular Bases of Methamphetamine-Induced Neurodegeneration
Jean Lud Cadet and Irina N. Krasnova
I. Epidemiology of Methamphetamine Abuse 102
II. Clinical Toxicology of METH Abuse 102
III. Role of Oxidative Stress in METH Toxicity 103
IV. Involvement of AP-1-Related Transcription Factors in METH-Induced
Neurotoxicity 104
V. Role of DNA Damage in METH-Induced Toxicity 105
VI. METH Toxicity and Excitotoxicity 105
VII. Role of Blood-Brain Barrier Dysfunction in METH Toxicity 106
VIII. Involvement of Mitochondrial Death Pathway in
METH-Induced Apoptosis 107
IX. Involvement of the Endoplasmic Reticulum-Dependent Death
Pathway in METH-Induced Apoptosis 107
X. Microglial Reactions and METH Toxicity 108
XI. Neuroprotective Mechanisms and METH Toxicity 109
References 112
Involvement of Nicotinic Receptors in Methamphetamine- and
Mdma-lnduced Neurotoxicity: Pharmacological Implications
E. Escubedo, J. Camarasa, C. Chipana, S. Garcia-Rates, and D. Pubill
I. Long-Term Effects of Amphetamine Derivatives on CNS 123
II. The Role of Reactive Species in Amphetamine Derivatives-Induced
Neurotoxicity 124
III. Model of Semipurified Synaptosomes 125
CONTENTS vii
IV. Methamphetamine-Induced ROS Production in Semipurified
Synaptosomes 126
V. Different Oxidative Profile and Nitric Oxide Dependence of
Amphetamine and MDMA 130
VI. Nicotinic Antagonists Block METH and MDMA-Induced
ROS Production 134
VII. MLA as a Neuroprotective Substance for METH- and MDMA-Induced
Dopaminergic Neurotoxicity 135
VIII. Memantine: A New Tool to Prevent Amphetaminic Neurotoxicity 137
IX. Effects on Serotonin and Dopamine Uptake: Nicounic
Receptor Modulation 143
X. Nicotinic Receptors and the Cognitive Impairment Induced by
Amphetamine Derivatives 146
XI. Amphetamine Derivative Interaction with Nicotinic Receptors 150
References 156
Ethanol Alters the Physiology of Neuron-Glia Communication
Antonio Gonzalez and Gines M. Salido
I. Introduction 168
II. Cytoarchitecture in the CNS 169
III. Focus onto Macroglia: The "Special" Role of Astrocytes in
the CNS 171
IV. Receptors in Glial Cells Cellular Signalization 176
V. Release of Intercellular Messengers 179
VI. Effects of Ethanol on Developing CNS 179
VII. Ethanol and Glial Oxidative Stress 181
VIII. Ethanol, Inflammation, and Glial Cell Death 185
IX. Astroglia and Neuroprotection 186
X. Conclusion 188
References 189
Therapeutic Targeting of "DARPP-32": A Key Signaling Molecule in
the Dopiminergic Pathway for the Treatment of Opiate Addiction
Supriya D. Mahajan, Ravikumar Aalinkeel, Jessica L. Reynolds,
Bindukumar B. Nair, Donald E. Sykes, Zihua Hu, Adela Bonoiu,
Hong Ding, Paras N. Prasad, and Stanley A. Schwartz
I. Introduction 200
II. Study Design 202
III. Material and Methods 203
IV. Results 208
V. Discussion 214
References 220
viii CONTENTS
Pharmacological and Neurotoxicological Actions Mediated
By Bupropion and Diethylpropion
Hugo R. Arias, Abel Santamaiua, and Syed F. Ali
I. Introduction 224
II. Neurotransmitter Release Modulation by Bupropion and
Diethylpropion 226
III. NeurotoxicityofDEPandBP 238
IV. Molecular Interaction of BP with DAT and NET 241
V. Role of AChRs in Depression and in the Pharmacological Action
of Antidepressants 241
VI. Conclusions 249
References 250
Neural and Cardiac Toxicities Associated With
3, 4-Methylenedioxymethamphetamine (MDMA)
Michael H. Baumann and Richard B. Rothman
I. Introduction 258
II. Effects of MDMA on Monoamine Neurons 259
III. Long-Term Effects of MDMA on 5-HT Systems 265
IV. Scaling Methods and MDMA Dosing 267
V. Functional Consequences of MDMA-Induced 5-HT Depletion 274
VI. Reversal of MDMA-Induced 5-HT Depletion by
L-5-Hydroxytryptophan 283
VII. MDMA and Valvular Heart Disease 284
VIII. Summary 286
References 287
Cocaine-Induced Breakdown of the Blood-Brain
Barrier and Neurotoxicity
Hari S. Sharma, Dafin Muresanu, Aruna Sharma, and
Ranjana Patnaik
I. Introduction 298
II. Cocaine Facilitates Blood-Brain Barrier Transport to HIV-1
in the Brain 299
III. Cocaine and Cytotoxicity 300
IV. Cocaine Affects Astrocytic Functions 301
V. Cocaine Induces Stress Response and Upregulates Heat
Shock Protein Expression 301
VI. Cocaine Influences Serotonin Metabolism 302
VII. Cocaine Affects Cerebral Circulation 303
VIII. Cocaine-Induced Hyperthermia 303
IX. Our Investigations on Cocaine-Induced Neurotoxicity 304
X. Novel Observations on Cocaine-Induced Brain Pathology 309
CONTENTS ix
XI. Modulation of Serotonin 5-HT2 and 5-HT3 Receptors Influences
Cocaine-Induced Neurotoxicity 324
XII. Cocaine-Induced BBB Dysfunction and Neurotoxicity Is Age Related 325
XIII. General Conclusion and Future Perspectives 326
References 327
Cannabinoid Receptors in Brain: Pharmacogenetics, Neuropharmacology,
Neurotoxicology, and Potential Therapeutic Applications
Emmanuel S. Onaivi
I. Introduction 336
II. Cannabinoid Genomics 337
III. Cannabinoid Neuropharmacology, Neurogenesis, Neurotoxicology,
and Neuroprotective Properties 342
IV. Chromosomal Mapping of the OVS Genes 342
V. Polymorphic Structure of CVK Genes 344
VI. Genes Encoding Endocannabinoid Transporter (s) as
Pharmacotherapeutic Targets 350
VII. Variations in Cannabinoid Receptor Genes: Functional and
Pharmacotherapeutic Implications 351
VIII. Genetic Basis of Cannabis use and Dependence 353
IX. Functional Implication of Cannabinoid Pharmacotherapeutics 357
X. Conclusions and Future Directions 360
References 361
Intermittent Dopaminergic Stimulation causes Behavioral
Sensitization in the Addicted Brain and Parkinsonism
Francesco Fornai, Francesca Biagioni, Federica Fulceri, Luigi
Murri, Stefano Ruggieri, and Antonio Paparelli
I. General Overview 372
II. DA Release Produced by METH in the Normal Striatum 373
III. Increase of Extracellular DA Produced by Supplementing Exogenous
L-DOPA in a DA-Denervated Striatum 376
IV. The Postsynaptic Site: Occurrence of Sensitization Converge on
Common Phosphorylauon Processes 377
V. The Postsynaptic Site: Common Gene Expression 379
VI. The Common Trigger at the Postsynaptic Site: Inappropriate Activation
of Dj Receptors 381
VII. Convergence on Common Pathways: From Activation of Dl Receptors to
Gene-Dependent Plastic Changes 382
VIII. Convergence on Ultrastructural Changes and Site Specificity 385
IX. Behavioral Sensitization: METH-Induced Addiction and L-DOPA-Induced
Dyskinesia: Two Faces of a Coin 386
References 389
X CONTENTS
The Role of the Somatotrophic Axis in Neuroprotection
and Neuroregeneration of the Addictive Brain
Fred Nyberg
I. Introduction 400
II. The Somatotrophic Axis in Brain Function 400
III. Reversal of Drug-Induced Effects by GH 418
IV. Conclusion 419
References 420
Index 429
Contents of Recent Volumes 443 |
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| spelling | Sharma, H. S. Verfasser (DE-588)129264814 aut New concepts of psychostimulants induced neurotoxicity ed. by Hari Shanker Sharma Amsterdam [u.a.] Elsevier 2009 XVI, 473 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier International review of neurobiology 88 Einzelaufnahme eines Zeitschr.-Bd. Brain Effect of drugs on Neuropsychopharmacology Neurotoxicology Psychotropic drugs Physiological effect Stimulants Physiological effect Neurotoxizität (DE-588)4123836-9 gnd rswk-swf Psychotonikum (DE-588)4176283-6 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Psychotonikum (DE-588)4176283-6 s Nervendegeneration (DE-588)4300182-8 s DE-604 Neurotoxizität (DE-588)4123836-9 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018708866&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sharma, H. S. New concepts of psychostimulants induced neurotoxicity Brain Effect of drugs on Neuropsychopharmacology Neurotoxicology Psychotropic drugs Physiological effect Stimulants Physiological effect Neurotoxizität (DE-588)4123836-9 gnd Psychotonikum (DE-588)4176283-6 gnd Nervendegeneration (DE-588)4300182-8 gnd |
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| title | New concepts of psychostimulants induced neurotoxicity |
| title_auth | New concepts of psychostimulants induced neurotoxicity |
| title_exact_search | New concepts of psychostimulants induced neurotoxicity |
| title_full | New concepts of psychostimulants induced neurotoxicity ed. by Hari Shanker Sharma |
| title_fullStr | New concepts of psychostimulants induced neurotoxicity ed. by Hari Shanker Sharma |
| title_full_unstemmed | New concepts of psychostimulants induced neurotoxicity ed. by Hari Shanker Sharma |
| title_short | New concepts of psychostimulants induced neurotoxicity |
| title_sort | new concepts of psychostimulants induced neurotoxicity |
| topic | Brain Effect of drugs on Neuropsychopharmacology Neurotoxicology Psychotropic drugs Physiological effect Stimulants Physiological effect Neurotoxizität (DE-588)4123836-9 gnd Psychotonikum (DE-588)4176283-6 gnd Nervendegeneration (DE-588)4300182-8 gnd |
| topic_facet | Brain Effect of drugs on Neuropsychopharmacology Neurotoxicology Psychotropic drugs Physiological effect Stimulants Physiological effect Neurotoxizität Psychotonikum Nervendegeneration Aufsatzsammlung |
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