Pharmacology: principles and practice
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 594 S. Ill., graph. Darst. |
| ISBN: | 9780123695215 |
Internformat
MARC
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| 245 | 1 | 0 | |a Pharmacology |b principles and practice |c ed. by Miles Hacker ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2009 | |
| 300 | |a XI, 594 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Pharmaceutical Preparations | |
| 650 | 4 | |a Pharmacology | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-018706259 | ||
Datensatz im Suchindex
| _version_ | 1804140819790168064 |
|---|---|
| adam_text | Contents
Contributors
ix
Preface
xi
Chapter
1
History of Pharmacology
—
From Antiquity
to the Twentieth Century
1
1.1
What Is Pharmacology?
1
1.2
What Is the Position of Pharmacology in the Field
of Therapeutics?
2
1.3
The Beginnings of Pharmacology
2
1.4
Pharmacology of the Greco-Roman Era
3
1.5
Pharmacology and the Middle Ages
3
1.6
Pharmacology and the Renaissance
4
1.7
Pharmacology and the Baroque Period
5
1.8
The Birth of Modern Pharmacology
5
Chapter
2
Dosage Forms and Their Routes
of Administration
9
2.1
Introduction
9
2.2
Therapeutic Ramifications in Selecting the
Appropriate Dosage Forms
10
2.3
Routes of Drug Administration
14
Chapter
3
Membranes and Drug Action
31
3.1
Introduction
31
3.2
What Is a Membrane?
32
3.3
Membrane Environment
45
3.4
The Role of Drug Polarity
47
3.5
Crossing the Membrane
49
3.6
The Membrane as a Drug Target
52
3.7
Drug Transporters
56
3.8
Key Points and Conclusion
57
Chapter
4
Ligand-Receptor Binding and Tissue
Response
63
4.1
Introduction
63
4.2
Dose-Response Curves
63
4.3
Receptors
64
4.4
Affinity
64
4.5
Efficacy
65
4.6
Antagonism
68
4.7
Constitutive Receptor Activity
72
4.8
Extended Ternary Complex Model
72
4.9
Conclusions
73
5.4
Adaptive Response, Preconditioning and
Autoprotection:
How These Concepts Relate to
Hormesis
95
5.5
Implementing Hormesis into Pharmacology and
Toxicology
95
5.6
Remaining Issues
98
5.7
Summary and Conclusion
99
Chapter
6
Signal Transduction and Second
Messengers
103
6.1
Receptor Communication
103
6.2
Receptor/Second Messenger Crosstalk
110
6.3
Signal Transduction Targets for Drug Discovery
111
Chapter
7
Drug Distribution
113
7.1
Introduction
113
7.2
Biological Membranes
114
7.3
Factors Influencing Drug Distribution
122
7.4
Pharmacokinetic/Pharmacodynamic Distribution
Properties
124
7.5
Specific Tissue Barriers
125
7.6
Summary
127
Chapter
8
Drug Metabolism
131
8.1
Introduction
131
8.2
Drug-Metabolizing Enzymes
137
8.3
Conclusions and Key Points
168
Chapter
9
Drug Excretion
175
Chapter
5
Hormesis and Pharmacology
5.1
Introduction
75
5.2
Hormesis
81
5.3
Selected Issues
93
75
9.1
Introduction
175
9.2
Overview of Membrane Transporters Involved in
Drug Excretion
176
9.3
Renal Drug Excretion
181
9.4
Hepatobiliary Excretion
188
9.5
Other Routes of Drug Excretion
194
9.6
Drug Excretion: Issues to Consider
196
9.7
Conclusions and Future Perspectives
197
Chapter
10
Pharmacokinetic Modeling
201
10.1
Introduction
202
10.2
Chemical Transport
206
10.3
Absorption
211
10.4
Distribution
213
10.5
Elimination (Metabolism and Excretion)
216
10.6
Organization of Single-Dose Pharmacokinetic
Model Information
220
10.7
One Compartment Bolus IV Injection
(Instantaneous Absorption) Model
221
10.8
One Compartment IV Infusion (Zero-Order
Absorption) Model
227
Contents
10.9
One Compartment First-Order Absorption
Model
233
10.10
Two Compartment Bolus IV Injection
(Instantaneous Absorption) Model
240
10.11
Two Compartment IV Infusion (Zero-Order
Absorption) Model
248
10.12
Two Compartment First-Order Absorption
Model
253
10.13
Generalized Multicompartment Models
260
10.14
Multiple Dosing Models
264
10.15
Advanced Pharmacokinetic Modeling
Topics
271
10.16
Summary of Key Points
276
Chapter
11
Bioanalytical Tools for Drug Analysis
279
11.1
Introduction
279
11.2
Small Molecule Chemical
Bioanalysis
280
11.3
Theoretical Fundamentals of
Chromatography
284
11.4
Analytical Separations in Practice
290
11.5
Key Points and Conclusions
301
Chapter
12
Drug-Drug Interactions with an Emphasis
on Drug Metabolism and Transport
303
12.1
Introduction
303
12.2
DDIs Associated with Altered Drug
Metabolism
307
12.3
Drug Transporters and DDIs
317
12.4
DDIs Associated with Protein Binding
320
12.5
Conclusions and Key Points
324
Chapter
16
Ion Channels
387
16.1
Introduction
387
16.2
Ion Channel Structure and Function: Basic
Principles and Mechanisms
391
16.3
Ion Channel Pharmacology: Principles and
Mechanisms
396
16.4
Ion Channel Groups: Functional Implications and
Pharmacological Modulators
398
16.5
Methods for the study of ion channels
414
16.6
Ion Channels and Disease
420
16.7
Ion Channels as Drug Targets
421
16.8
Key Points and Conclusions
424
Chapter
17
Targeting the Cell Cycle to Kill Cancer
Cells
429
17.1
Introduction
429
17.2
The Cell Cycle
430
17.3
Cell Cycle Checkpoints
432
17.4
Mitotic Kinases as Targets of New
Chemotherapeutics
442
17.5
Conclusions
447
Chapter
18
Programmed Cell Death
455
Chapter
13
Adverse Drug Reactions
327
18.1
Introduction
455
18.2
Mechanism and
Reguládon
of PCD
456
18.3
Apoptosis in Health and Disease
465
18.4
Therapeutic Strategies for Targeting Apoptosis
18.5
Key Points and Conclusions
473
Chapter
19
Drug Discovery
475
467
13.1
Introduction
327
13.2
TypeAADRs
327
13.3
Examples of Type A ADRs
331
13.4
Avoiding Type A ADRs
332
13.5
Pharmacovigilance and ADR
333
13.6
Type
В
ADRs
334
13.7
Summary
349
19.1
Introduction
475
19.2
Underlying Principles
485
19.3
Drug Discovery Case Studies
19.4
Summary
554
532
Chapter
14
Risk Assessment
353
14.1
History-
353
14.2
Hazard Identification
354
14.3
Dose Response Assessment
14.4
Exposure Assessment
356
14.5
Risk Characterization
357
14.6
Radiological Risk Assessments
14.7
Risk Management
365
14.8
Risk Communication
367
355
364
Chapter
20
Genomics and Proteomics in Drug Design
and Discovery
561
20.1
Introduction
561
20.2
Genomics and Proteomics
561
20.3
Major Technological Platforms of Genomics and
Proteomics
563
20.4
Current Achievements and Potential Application of
Genomics and Proteomics in Drug Design and
Discovery
565
20.5
Conclusion and Future Prospects
569
Chapter
21
The Future of Pharmacology
575
Chapter
15
Drug Resistance
371
15.1
Introduction
371
15.2
Cancer Cell Drug Resistance
371
15.3
Drug Resistance in Infectious Diseases
15.4
Summary
385
379
21.1
Introduction
575
21.2
The Problem
575
21.3
Strategies for Searching for Future Drugs
576
21.4
Tools for Searching for Future Drugs
577
21.5
The Drugs of the Future
578
Index
581
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| spelling | Pharmacology principles and practice ed. by Miles Hacker ... Amsterdam [u.a.] Elsevier, Acad. Press 2009 XI, 594 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmaceutical Preparations Pharmacology Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Pharmakologie (DE-588)4045687-0 s DE-604 Hacker, Miles P. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018706259&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacology principles and practice Pharmaceutical Preparations Pharmacology Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4123623-3 |
| title | Pharmacology principles and practice |
| title_auth | Pharmacology principles and practice |
| title_exact_search | Pharmacology principles and practice |
| title_full | Pharmacology principles and practice ed. by Miles Hacker ... |
| title_fullStr | Pharmacology principles and practice ed. by Miles Hacker ... |
| title_full_unstemmed | Pharmacology principles and practice ed. by Miles Hacker ... |
| title_short | Pharmacology |
| title_sort | pharmacology principles and practice |
| title_sub | principles and practice |
| topic | Pharmaceutical Preparations Pharmacology Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Pharmaceutical Preparations Pharmacology Pharmakologie Lehrbuch |
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