Novel approaches to studying basal ganglia and related neuropsychiatric disorders:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2009
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| Schriftenreihe: | International review of neurobiology
89 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XI, 196 S. Ill. |
| ISBN: | 9780123748942 |
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Datensatz im Suchindex
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Titel: Novel approaches to studying basal ganglia and related neuropsychiatric disorders
Autor: Lu, Xiao-Hong
Jahr: 2009
CONTENTS
Contributors ix
Preface xi
Molecular Profiling of Striafonigral and Sfriatopallidal Medium
Spiny Neurons: Past, Present, and Future
Mary Kay Lobo
I. Introduction 2
II. Early Detection of Neuropeptides and GPCRs in
Striatonigral and Striatopallidal MSNs 8
III. Current Methods for Molecular Profiling in the Two MSN Subtypes 12
IV. The Next Stage for Genetic Profiling of the Two MSNs 17
V. Use of BAC Transgenic Fluorescent Reporter Mice to Evaluate
Molecular Pathways in the Two MSNs 19
VI. Cell Type-Specific Overexpression and Knockout Models 21
VII. Cell Type-Specific Mouse Models Evaluating Drug
and Natural Reward 23
VIII. Cell Type-Specific Mouse Models Evaluating Motor Behaviors 24
IX. Cell Type-Specific Models Evaluating Protein Modifications 25
X. Conclusions 25
References 26
BAC to Degeneration: Bacterial Artificial Chromosome (Bac)-Mediated
Transgenesis for Modeling Basal Ganglia Neurodegenerative Disorders
Xiao-Hong Lu
I. Introduction 38
II. Concept and Advantages of the BAC Transgenesis Approach 39
III. Generation of the BAC Transgenic Mice via Homologous
Recombination 40
IV. Technique Considerations and Possible Solutions 40
V. BAC Transgenic Models of Basal Ganglia
Neurodegenerative Disorders 42
VI. BAC Transgenesis to Model Huntington's Disorder (HD) 43
VII. BAC Transgenesis to Model Parkinson's Disease (PD) 45
v
vi CONTENTS
VIII. Modeling Neurodegenerative Diseases
via BAC Transgenesis, A Future Perspective 51
References 51
Behavioral Outcome Measures for the Assessment of
Sensorimotor Function in Animal Models of Movement Disorders
Sheila M. Fleming
I. Introduction 57
II. Sensorimotor Tests for Unilateral 6-OHDA Rat 58
III. Sensorimotor Tests for Genetic Mouse Models 60
References 62
The Role of DNA Methylation in the Central Nervous System
and Neuropsychiatric Disorders
Jian Feng and Guoping Fan
I. Introduction 68
II. DNA Methylation and DNA Methyltransferase 69
III. DNA Methylation Mediates Gene Silencing VI
TV. Role of DNA Methylation in the CNS and
Neuropsychiatric Disorders 73
V. Conclusion Remarks 79
References 79
Heritability of Structural Brain Traits: An Endophenotype Approach
to Deconstruct Schizophrenia
Nil Kaymaz and J. van Os
I. Introduction 86
II. Heritability of Brain Structure Phenotypes 91
III. Genes for Brain Structures in Healthy and Persons
with Schizophrenia 107
IV. Limitations and Clinical Relevance of the Studies 115
References 121
The Role of Striatal NMDA Receptors in Drug Addiction
Yao-Ying Ma, Carlos Cepeda, and Cai-Lian Cui
I. Introduction 132
II. NMDA Receptors in the Striatum 133
III. Role of Glutamate and NMDA Receptors in Drug Addiction 135
CONTENTS vii
IV. Neuropharmacological Studies and Clinical Implications 141
References 142
Deciphering Rett Syndrome With Mouse Genetics, Epigenomics,
and Human Neurons
Jifang Tao, Hao Wu, and Yi Eve Sun
I. Introduction 147
II. RTT Mouse Models 148
III. MeCP2 Expressions and Functions 149
IV. MeCP2 and Gene Expression 150
V. Posttranslational Modification of MeCP2 151
VI. Epigenomics 151
VII. Human Neuron-Based RTT Disease Model 153
VIII. Summary 155
References 155
Index 161
Contents of Recent Volumes 165 |
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| spelling | Lu, Xiao-Hong Verfasser aut Novel approaches to studying basal ganglia and related neuropsychiatric disorders ed. by Xiao-Hong Lu Amsterdam [u.a.] Elsevier 2009 XI, 196 S. Ill. txt rdacontent n rdamedia nc rdacarrier International review of neurobiology 89 Einzelaufnahme eines Zeitschr.-Bd. Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervendegeneration (DE-588)4300182-8 s Molekularbiologie (DE-588)4039983-7 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018705964&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lu, Xiao-Hong Novel approaches to studying basal ganglia and related neuropsychiatric disorders Nervendegeneration (DE-588)4300182-8 gnd Molekularbiologie (DE-588)4039983-7 gnd |
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| title | Novel approaches to studying basal ganglia and related neuropsychiatric disorders |
| title_auth | Novel approaches to studying basal ganglia and related neuropsychiatric disorders |
| title_exact_search | Novel approaches to studying basal ganglia and related neuropsychiatric disorders |
| title_full | Novel approaches to studying basal ganglia and related neuropsychiatric disorders ed. by Xiao-Hong Lu |
| title_fullStr | Novel approaches to studying basal ganglia and related neuropsychiatric disorders ed. by Xiao-Hong Lu |
| title_full_unstemmed | Novel approaches to studying basal ganglia and related neuropsychiatric disorders ed. by Xiao-Hong Lu |
| title_short | Novel approaches to studying basal ganglia and related neuropsychiatric disorders |
| title_sort | novel approaches to studying basal ganglia and related neuropsychiatric disorders |
| topic | Nervendegeneration (DE-588)4300182-8 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Nervendegeneration Molekularbiologie Aufsatzsammlung |
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