Verfügbarkeit: Structure and dynamics using NMR spectroscopy

Structure and dynamics using NMR spectroscopy:

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Bibliographische Detailangaben
1. Verfasser:	Klages, Jochen Jan 1978- (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	München Verl. Dr. Hut 2009
Ausgabe:	1. Aufl.
Schriftenreihe:	Organische Chemie
Schlagworte:	Biomolekül NMR-Spektroskopie Knochen-Morphogenese-Proteine Strukturaufklärung Kopplungskonstante Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	Zugl.: München, Techn. Univ., Diss., 2008
Beschreibung:	XX, 256 S. graph. Darst. 210 mm x 148 mm, 423 gr.
ISBN:	9783868531831

Internformat

MARC


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Datensatz im Suchindex

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adam_text	CONTENTS 1 INTRODUCTION 1 2 THEORETICAL ASPECTS 5 2.1 HARTMANN-HAHN TRANSFER 5 2.1.1 HARTMANN-HAHN TRANSFER IN THE PRODUCT OPERATOR FORMALISM 7 2.1.2 MULTIPLE PULSE SEQUENCES 10 2.1.3 LIOUVILLE- VON NEUMANN EQUATION 11 2.1.4 EFFECTIVE HAMILTONIAN 13 2.1.5 AVERAGE HAMILTONIAN THEORY 15 2.1.6 THE TOGGLING FRAME 16 2.1.7 INVARIANT TRAJECTORY 17 2.1.8 ZERO-QUANTUM SUPPRESSION 19 2.2 RESIDUAL DIPOLAR COUPLINGS 21 2.2.1 GENERAL CONSIDERATIONS 21 2.2.2 ALIGNMENT MEDIA 26 2.3 RELAXATION AND DYNAMICS 29 2.3.1 GENERAL CONSIDERATIONS 29 2.3.2 NMR TIMESCALES 30 2.3.3 MOLECULAR SOURCES OF RELAXATION 32 2.3.4 CORRELATION FUNCTION AND SPECTRAL DENSITY 35 2.3.5 SELECTED RELAXTION MECHANISMS 39 2.3.6 MODEL-FREE ANALYSIS 49 2.3.7 BACK-CALCULATION OF NOESY SPECTRA 56 3 TOWARDS THE MEASUREMENT OF WH-RDCS 59 3.1 INTRODUCTION 59 3.2 MODIFYING THE DIPOLAR COUPLING TENSOR 63 3.2.1 THEORY 63 3.2.2 EXPERIMENTAL 72 3.3 MEASURING 1 H- 1 H RESIDUAL DIPOLAR COUPLINGS 75 BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/997723416 DIGITALISIERT DURCH I CONTENTS 3.3.1 ZERO-QUANTUM SUPPRESSION 79 3.3.2 EXTRACTING TRANSFER AMPLITUDES 80 3.3.3 FITTING TOCSY SPECTRA 82 3.4 DISCUSSION 93 3.4.1 MODIFYING THE AVERAGE DIPOLAR COUPLING TENSOR . . 93 3.4.2 MEASURING 1 H- 1 H RESIDUAL DIPOLAR COUPLINGS .... 97 3.5 CONCLUSION 99 THE BONE MORPHOGENETIC PROTEIN RECEPTOR IA 101 4.1 INTRODUCTION 101 4.1.1 BMPS AND RELATED PROTEINS 101 4.1.2 RECEPTORS OF THE TGF-/3 SUPERFAMILY 103 4.1.3 SIGNAL TRANSDUCTION 104 4.1.4 LIGAND/RECEPTOR INTERACTIONS - SPECIFITY AND AFFINITY 106 4.1.5 STRUCTURAL BASIS FOR THE LIGAND/RECEPTOR INTERACTION 110 4.2 RESONANCE ASSIGNMENT 116 4.2.1 BACKBONE ASSIGNMENT 116 4.2.2 SIDECHAIN ASSIGNMENT 117 4.3 SECONDARY STRUCTURE, DIHEDRAL ANGLES, AND HYDROGEN BONDS 119 4.3.1 TALOS 120 4.3.2 VTF/V^-COUPLINGS 122 4.3.3 X 1 - AND X 2 -ANGLE RESTRAINTS 123 4.3.4 HYDROGEN BONDS 124 4.4 TERTIARY STRUCTURE 127 4.5 RESIDUAL DIPOLAR COUPLINGS 133 4.6 TITRATION STUDIES 135 4.6.1 TITRATION WITH TFE 135 4.6.2 TITRATION WITH ACTR-IIB AND CYCJO-(FPRFPA) . . . . 135 4.7 DYNAMICAL INVESTIGATIONS 136 4.7.1 DIFFUSION AND HYDRODYNAMIC CALCULATIONS 137 4.7.2 PS-NS DYNAMICS 139 4.8 DISCUSSION 140 4.8. CONTENTS X 5.1.1 CYCLOSPORIN A - GENERAL REMARKS 155 5.1.2 PHARMACOLOGICAL EFFECT OF CYCLOSPORIN A 159 5.2 RDC MEASUREMENTS 161 5.3 STRUCTURE CALCULATION 165 5.4 DISCUSSION 173 5.4.1 STRUCTURAL INFLUENCE OF PDMS AND GENERAL REMARKS 173 5.4.2 SIDECHAIN CONFORMATIONS 176 5.5 CONCLUSION 178 6 SUMMARY 179 A J-ONLY-TOCSY 183 A.I SAMPLE PREPARATION 183 A.2 TOCSY SPECTRA 184 A.2.1 EXPERIMENTAL 184 A.2.2 PULSE PROGRAMS 185 A.3 SIMULATIONS 189 A.3.1 CALCULATING THE DIPOLAR COUPLING TENSOR 189 A.3.2 TOCSY AND ROESY OFFSET PROFILES 190 A.3.3 FITTING OF EXPERIMENTAL TRANSFER AMPLITUDES . . . . 190 B STRUCTURE AND DYNAMICS OF BMPR-IAEC/RF 191 B.I SAMPLE PREPARATION 191 B.2 EXPERIMENTS AND ASSIGNMENT OF BMPR-IAEC/ 8 F 194 B.3 DIHEDRAL ANGLE RESTRAINTS FOR BMPR-IAE C/SF 198 B.4 STRUCTURAL INDICATORS 200 B.5 DYNAMICAL PARAMETERS OF BRIA 201 C STRUCTURE REFINEMENT OF PEPTIDES WITH RDCS 203 C.I SAMPLE PREPARARTION 203 C.2 NMR MEASUREMENTS FOR CSA 203 C.3 STRUCTURE CALCULATION OF CSA 207 BIBLIOGRAPHY 211
any_adam_object	1
author	Klages, Jochen Jan 1978-
author_GND	(DE-588)139598243
author_facet	Klages, Jochen Jan 1978-
author_role	aut
author_sort	Klages, Jochen Jan 1978-
author_variant	j j k jj jjk
building	Verbundindex
bvnumber	BV035845021
classification_tum	CHE 220d CHE 295d CHE 244d
ctrlnum	(OCoLC)643447030 (DE-599)DNB997723416
dewey-full	543.66 572.36
dewey-hundreds	500 - Natural sciences and mathematics
dewey-ones	543 - Analytical chemistry 572 - Biochemistry
dewey-raw	543.66 572.36
dewey-search	543.66 572.36
dewey-sort	3543.66
dewey-tens	540 - Chemistry and allied sciences 570 - Biology
discipline	Chemie / Pharmazie Biologie Chemie
edition	1. Aufl.
format	Book
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spelling	Klages, Jochen Jan 1978- Verfasser (DE-588)139598243 aut Structure and dynamics using NMR spectroscopy Jochen Jan Klages 1. Aufl. München Verl. Dr. Hut 2009 XX, 256 S. graph. Darst. 210 mm x 148 mm, 423 gr. txt rdacontent n rdamedia nc rdacarrier Organische Chemie Zugl.: München, Techn. Univ., Diss., 2008 Biomolekül (DE-588)4135124-1 gnd rswk-swf NMR-Spektroskopie (DE-588)4075421-2 gnd rswk-swf Knochen-Morphogenese-Proteine (DE-588)4305932-6 gnd rswk-swf Strukturaufklärung (DE-588)4183788-5 gnd rswk-swf Kopplungskonstante (DE-588)4260284-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Biomolekül (DE-588)4135124-1 s Strukturaufklärung (DE-588)4183788-5 s NMR-Spektroskopie (DE-588)4075421-2 s Kopplungskonstante (DE-588)4260284-1 s DE-604 Knochen-Morphogenese-Proteine (DE-588)4305932-6 s 1\p DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018703236&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Klages, Jochen Jan 1978- Structure and dynamics using NMR spectroscopy Biomolekül (DE-588)4135124-1 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd Knochen-Morphogenese-Proteine (DE-588)4305932-6 gnd Strukturaufklärung (DE-588)4183788-5 gnd Kopplungskonstante (DE-588)4260284-1 gnd
subject_GND	(DE-588)4135124-1 (DE-588)4075421-2 (DE-588)4305932-6 (DE-588)4183788-5 (DE-588)4260284-1 (DE-588)4113937-9
title	Structure and dynamics using NMR spectroscopy
title_auth	Structure and dynamics using NMR spectroscopy
title_exact_search	Structure and dynamics using NMR spectroscopy
title_full	Structure and dynamics using NMR spectroscopy Jochen Jan Klages
title_fullStr	Structure and dynamics using NMR spectroscopy Jochen Jan Klages
title_full_unstemmed	Structure and dynamics using NMR spectroscopy Jochen Jan Klages
title_short	Structure and dynamics using NMR spectroscopy
title_sort	structure and dynamics using nmr spectroscopy
topic	Biomolekül (DE-588)4135124-1 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd Knochen-Morphogenese-Proteine (DE-588)4305932-6 gnd Strukturaufklärung (DE-588)4183788-5 gnd Kopplungskonstante (DE-588)4260284-1 gnd
topic_facet	Biomolekül NMR-Spektroskopie Knochen-Morphogenese-Proteine Strukturaufklärung Kopplungskonstante Hochschulschrift
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018703236&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT klagesjochenjan structureanddynamicsusingnmrspectroscopy

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