Fluorine in medicinal chemistry and chemical biology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley-Blackwell
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 624, [16] S. Ill., graph. Darst. |
| ISBN: | 9781405167208 |
Internformat
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| 245 | 1 | 0 | |a Fluorine in medicinal chemistry and chemical biology |c ed. by Iwao Ojima |
| 264 | 1 | |a Chichester |b Wiley-Blackwell |c 2009 | |
| 300 | |a XVI, 624, [16] S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 500 | |a Literaturangaben | ||
| 650 | 0 | |a Organofluorine compounds | |
| 650 | 0 | |a Fluorination / Physiological effect | |
| 650 | 0 | |a Bioorganic chemistry | |
| 650 | 0 | |a Pharmaceutical chemistry | |
| 650 | 4 | |a Bioorganic chemistry | |
| 650 | 4 | |a Chemistry, Pharmaceutical |x methods | |
| 650 | 4 | |a Drug Discovery | |
| 650 | 4 | |a Fluorination |x Physiological effect | |
| 650 | 4 | |a Fluorine Compounds | |
| 650 | 4 | |a Fluorine |x chemistry | |
| 650 | 4 | |a Organofluorine compounds | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 4 | |a Structure-Activity Relationship | |
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Datensatz im Suchindex
| _version_ | 1804140780879609856 |
|---|---|
| adam_text | Titel: Fluorine in medicinal chemistry and chemical biology
Autor: Ojima, Iwao
Jahr: 2009
Contents
Preface page ix
List of Contributors xi
Abbreviations xv
Introduction: Basic Aspects of Fluorine in Chemistry and Biology 1
1 Unique Properties of Fluorine and Their Relevance to
Medicinal Chemistry and Chemical Biology 3
Takashi Yamazaki, Takeo Taguchi, and Iwao Ojima
Medicinal Chemistry 47
2 Fluorinated Prostanoids: Development of Tafluprost,
a New Anti-glaucoma Agent 49
Yasushi Matsumura
3 Fluorinated Conformationally Restricted Glutamate Analogues for
CNS Drug Discovery and Development 67
Atsuro Nakazato
4 Fluorinated Inhibitors of Matrix Metalloproteinases 99
Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani,
Florent Huguenot, Monica Sani, Alessandro Volonterio,
Rajfaella Majfezzoni, and Matteo Zanda
5 Fluoro-Taxoid Anticancer Agents 117
Antonella Pepe, Larisa Kuznetsova, Liang Sun, and Iwao Ojima
6 Antimalarial Fluoroartemisinins: Increased Metabolic and
Chemical Stability 141
Jean-Pierre Begue and Daniele Bonnet-Delpon
7 Synthesis and Biological Activity of Fluorinated Nucleosides 165
Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa, and
Tomoyuki Onishi
vi Contents
Synthetic Methods for Medicinal Chemistry and Chemical Biology 199
8 Synthesis of gem-Difluoromethylenated Nucleosides via
gem-Difluoromethylene-containing Building Blocks 201
Wei-Dong Meng and Feng-Ling Qing
9 Recent Advances in the Syntheses of Fluorinated Amino Acids 213
Kenji Uneyama
10 Fluorinated Moieties for Replacement of Amide and Peptide Bonds 257
Takeo Taguchi and Hikaru Yanai
11 Perfluorinated Heteroaromatic Systems as Scaffolds for
Drug Discovery 291
David Armstrong, Matthew W. Cartwright, Emma L. Parks,
Graham Pattison, Graham Sandford, Rachel Slater, Ian Wilson John A.
Christopher, David D. Miller, Paul W. Smith, and Antonio Vong
12 gem-Difluorocyclopropanes as Key Building Blocks for
Novel Biologically Active Molecules 313
Toshiyuki Itoh
13 Fluorous Mixture Synthesis (FMS) of Drug-like Molecules and
Enantiomers, Stereoisomers, and Analogues of Natural Products 335
Wei Zhang
14 Fluorine-18 Radiopharmaceuticals 361
Michael R. Kilbourn and Xia Shao
Applications of Fluorinated Amino Acids and
Peptides to Chemical Biology and Pharmacology 389
15 Application of Artificial Model Systems to Study the
Interactions of Fluorinated Amino Acids within the
Native Environment of Coiled Coil Proteins 391
Mario Salwiczek, Toni Vagt, and Beate Koksch
16 Fluorinated Amino Acids and Biomolecules in Protein Design and
Chemical Biology 411
He Meng, Ginevra A. Clark, and Krishna Kumar
17 Effects of Fluorination on the Bioorganic Properties of Methionine 447
John F. Honek
18 Structure Analysis of Membrane-Active Peptides
Using 19F-labeled Amino Acids and Solid-State NMR 463
Parvesh Wadhwani and Erik Strandberg
Contents vii
19 Study of Metabolism of Fluorine-containing Drugs Using In Vivo Magnetic
Resonance Spectroscopy 495
Erika Schneider and Roger Lin
Appendix 525
Approved Active Pharmaceutical Ingredients Containing Fluorine
Elizabeth Pollina Cormier, Manisha Das, and Iwao Ojima 525
Section 1. Fluorine-containing Drugs for Human Use Approved by
FDA in the United States 527
Section 2. Fluorine-containing Drugs for Veterinary Use Approved by
FDA in the United States 585
Index 605
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| indexdate | 2024-07-09T22:05:25Z |
| institution | BVB |
| isbn | 9781405167208 |
| language | English |
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| physical | XVI, 624, [16] S. Ill., graph. Darst. |
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| spelling | Fluorine in medicinal chemistry and chemical biology ed. by Iwao Ojima Chichester Wiley-Blackwell 2009 XVI, 624, [16] S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Organofluorine compounds Fluorination / Physiological effect Bioorganic chemistry Pharmaceutical chemistry Chemistry, Pharmaceutical methods Drug Discovery Fluorination Physiological effect Fluorine Compounds Fluorine chemistry Structure-Activity Relationship Fluororganische Verbindungen (DE-588)4154846-2 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf Naturstoffchemie (DE-588)4171332-1 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Fluororganische Verbindungen (DE-588)4154846-2 s Physiologie (DE-588)4045981-0 s Naturstoffchemie (DE-588)4171332-1 s Pharmazeutische Chemie (DE-588)4132158-3 s DE-604 Ojima, Iwao Sonstige oth DE-601 pdf/application http://www.gbv.de/dms/bs/toc/585706271.pdf kostenfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018681726&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fluorine in medicinal chemistry and chemical biology Organofluorine compounds Fluorination / Physiological effect Bioorganic chemistry Pharmaceutical chemistry Chemistry, Pharmaceutical methods Drug Discovery Fluorination Physiological effect Fluorine Compounds Fluorine chemistry Structure-Activity Relationship Fluororganische Verbindungen (DE-588)4154846-2 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Naturstoffchemie (DE-588)4171332-1 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4154846-2 (DE-588)4132158-3 (DE-588)4171332-1 (DE-588)4045981-0 |
| title | Fluorine in medicinal chemistry and chemical biology |
| title_auth | Fluorine in medicinal chemistry and chemical biology |
| title_exact_search | Fluorine in medicinal chemistry and chemical biology |
| title_full | Fluorine in medicinal chemistry and chemical biology ed. by Iwao Ojima |
| title_fullStr | Fluorine in medicinal chemistry and chemical biology ed. by Iwao Ojima |
| title_full_unstemmed | Fluorine in medicinal chemistry and chemical biology ed. by Iwao Ojima |
| title_short | Fluorine in medicinal chemistry and chemical biology |
| title_sort | fluorine in medicinal chemistry and chemical biology |
| topic | Organofluorine compounds Fluorination / Physiological effect Bioorganic chemistry Pharmaceutical chemistry Chemistry, Pharmaceutical methods Drug Discovery Fluorination Physiological effect Fluorine Compounds Fluorine chemistry Structure-Activity Relationship Fluororganische Verbindungen (DE-588)4154846-2 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Naturstoffchemie (DE-588)4171332-1 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Organofluorine compounds Fluorination / Physiological effect Bioorganic chemistry Pharmaceutical chemistry Chemistry, Pharmaceutical methods Drug Discovery Fluorination Physiological effect Fluorine Compounds Fluorine chemistry Structure-Activity Relationship Fluororganische Verbindungen Pharmazeutische Chemie Naturstoffchemie Physiologie |
| url | http://www.gbv.de/dms/bs/toc/585706271.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018681726&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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