Disorders of hemoglobin: genetics, pathophysiology, and clinical management
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge Univ. Press
2009
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Table of contents only Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XX, 826 S. Ill., graph. Darst. |
| ISBN: | 9780521875196 |
Internformat
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| 245 | 1 | 0 | |a Disorders of hemoglobin |b genetics, pathophysiology, and clinical management |c ed. by Martin H. Steinberg ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Cambridge [u.a.] |b Cambridge Univ. Press |c 2009 | |
| 300 | |a XX, 826 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Hemoglobinopathy | |
| 650 | 4 | |a Hemoglobinopathies |x genetics | |
| 650 | 4 | |a Hemoglobinopathies |x physiopathology | |
| 650 | 4 | |a Hemoglobinopathies |x therapy | |
| 650 | 0 | 7 | |a Hämoglobinopathie |0 (DE-588)4022815-0 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804140767061475328 |
|---|---|
| adam_text | Titel: Disorders of hemoglobin
Autor: Steinberg, Martin H.
Jahr: 2009
Contents
List of Contributors page ix
Foreword, by H. Franklin Bunn xv
Preface xvii
Introduction, by David J. Weatherall xix
SECTION ONE. THE MOLECULAR, CELLULAR, AND GENETIC BASIS OF HEMOGLOBIN
DISORDERS
Douglas R. Higgs and Bernard G. Forget
1 A Developmental Approach to Hematopoiesis 3
Elaine Dzierzak
2 Erythropoiesis 24
Sjaak Philipsen and William G. Wood
3 The Normal Structure and Regulation of Human Globin Gene Clusters 46
Bernard G. Forget and Ross C. Hardison
4 Nuclear Factors That Regulate Erythropoiesis 62
Gerd A. Blobel and Mitchell J. Weiss
5 Molecular and Cellular Basis of Hemoglobin Switching 86
George Stamatoyannopoulos, Patrick A. Navas, and Qiliang Li
6 Structure and Function of Hemoglobin and Its Dysfunction in Sickle Cell
Disease 101
Daniel B. Kim-Shapiro
7 Hemoglobins of the Embryo, Fetus, and Adult 119
Martin H. Steinberg and Ronald L. Nagel
SECTION TWO. PATHOPHYSIOLOGY OF HEMOGLOBIN AND ITS DISORDERS
Martin H. Steinberg
8 Rheology and Vascular Pathobiology in Sickle Cell Disease and Thalassemia 139
Dhananjay K. Kaul
9 The Erythrocyte Membrane 158
Patrick G. Gallagher and Clinton H. Joiner
v
vj Contents
10 The Biology of Vascular Nitric Oxide 185
Jane A. Leopold and Joseph Loscalzo
11 Mechanisms and Clinical Complications of Hemolysis in Sickle Cell Disease and
Thalassemia 201
Gregory J. Kato and Mark I Gladwin
12 Animal Models of Hemoglobinopathies and Thalassemia 225
Mary Fabry
SECTION THREE, a THALASSEMIA
Douglas R. Higgs
13 The Molecular Basis of a Thalassemia 241
Douglas R. Higgs
14 The Pathophysiology and Clinical Features of a Thalassaemia 266
Douglas R. Higgs
15 Unusual Types of a Thalassemia 296
Douglas R. Higgs, Veronica J. Buckle, Richard Gibbons, and David Steensma
SECTION FOUR. THE (5 THALASSEMIAS
Bernard G. Forget
16 The Molecular Basis of p Thalassemia, 5p Thalassemia, and Hereditary
Persistence of Fetal Hemoglobin 323
Swee Lay Thein and William G. Wood
17 Clinical Aspects of p Thalassemia and Related Disorders 357
Nancy F. Olivieri and David J. Weatherall
18 Hemoglobin E Disorders 417
Suthat Fucharoen and David J. Weatherall
SECTION FIVE. SICKLE CELL DISEASE
Martin H. Steinberg
19 Clinical and Pathophysiological Aspects of Sickle Cell Anemia 437
Martin H. Steinberg, Kwaku Ohene-Frempong, and Matthew M. Heeney
20 Sickle Cell Pain: Biology, Etiology, and Treatment 497
Samir K. Ballas and James R. Eckman
21 Hemoglobin SC Disease and Hemoglobin C Disorders 525
Martin H. Steinberg and Ronald L. Nagel
22 Sickle Cell Trait 549
Martin H. Steinberg
23 Other Sickle Hemoglobinopathies 564
Martin H. Steinberg
SECTION SIX. OTHER CLINICALLY IMPORTANT DISORDERS OF HEMOGLOBIN
Martin H. Steinberg
24 Unstable Hemoglobins, Hemoglobins with Altered Oxygen Affinity,
Hemoglobin M, and Other Variants of Clinical and Biological Interest 589
Martin H. Steinberg and Ronald L. Nagel
Contents vii
25 Dyshemoglobinemias 607
Neeraj Agarwal, Ronald L. Nagel, and Josef T. Prchal
SECTION SEVEN. SPECIAL TOPICS IN HEMOGLOBINOPATHIES
Martin H. Steinberg
26 Population Genetics and Global Health Burden 625
David J. Weatherall and Thomas N. Williams
27 Genetic Modulation of Sickle Cell Disease and Thalassemia 638
Martin H. Steinberg and Ronald L. Nagel
28 Laboratory Methods for Diagnosis and Evaluation of Hemoglobin Disorders 658
Mary Fabry and John M. Old
SECTION EIGHT. NEW APPROACHES TO THE TREATMENT OF HEMOGLOBINOPATHIES AND
THALASSEMIA
Martin H. Steinberg
29 Transfusion and Iron Chelation Therapy in Thalassemia and Sickle Cell Disease 689
Janet L. Kwiatkowski and John B. Porter
30 Induction of Fetal Hemoglobin in the Treatment of Sickle Cell Disease
and p Thalassemia 745
Yogen Saunthararajah and George F. Atweh
31 Novel Approaches to Treatment 755
Kirkwood A. Pritchard Jr., Alicia Rivera, Cheryl Hillery, and Carlo Brugnara
32 Stem Cell Transplantation 774
Emanuele Angelucci and Mark Walters
33 Prospects for Gene Therapy of Sickle Cell Disease and Thalassemia 791
Derek A. Persons, Brian P. Sorrentino, and Arthur W. Nienhuis
Index 815
|
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| spelling | Disorders of hemoglobin genetics, pathophysiology, and clinical management ed. by Martin H. Steinberg ... 2. ed. Cambridge [u.a.] Cambridge Univ. Press 2009 XX, 826 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Hemoglobinopathy Hemoglobinopathies genetics Hemoglobinopathies physiopathology Hemoglobinopathies therapy Hämoglobinopathie (DE-588)4022815-0 gnd rswk-swf Hämoglobinopathie (DE-588)4022815-0 s DE-604 Steinberg, Martin H. Sonstige oth http://www.loc.gov/catdir/toc/ecip0824/2008032334.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018673044&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Disorders of hemoglobin genetics, pathophysiology, and clinical management Hemoglobinopathy Hemoglobinopathies genetics Hemoglobinopathies physiopathology Hemoglobinopathies therapy Hämoglobinopathie (DE-588)4022815-0 gnd |
| subject_GND | (DE-588)4022815-0 |
| title | Disorders of hemoglobin genetics, pathophysiology, and clinical management |
| title_auth | Disorders of hemoglobin genetics, pathophysiology, and clinical management |
| title_exact_search | Disorders of hemoglobin genetics, pathophysiology, and clinical management |
| title_full | Disorders of hemoglobin genetics, pathophysiology, and clinical management ed. by Martin H. Steinberg ... |
| title_fullStr | Disorders of hemoglobin genetics, pathophysiology, and clinical management ed. by Martin H. Steinberg ... |
| title_full_unstemmed | Disorders of hemoglobin genetics, pathophysiology, and clinical management ed. by Martin H. Steinberg ... |
| title_short | Disorders of hemoglobin |
| title_sort | disorders of hemoglobin genetics pathophysiology and clinical management |
| title_sub | genetics, pathophysiology, and clinical management |
| topic | Hemoglobinopathy Hemoglobinopathies genetics Hemoglobinopathies physiopathology Hemoglobinopathies therapy Hämoglobinopathie (DE-588)4022815-0 gnd |
| topic_facet | Hemoglobinopathy Hemoglobinopathies genetics Hemoglobinopathies physiopathology Hemoglobinopathies therapy Hämoglobinopathie |
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