Aptamers in bioanalysis:
This title details bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications.
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J. [u.a.]
Wiley
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | This title details bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications. |
| Beschreibung: | XVII, 313 S. Ill., graph. Darst. |
| ISBN: | 0470148306 9780470148303 |
Internformat
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| 245 | 1 | 0 | |a Aptamers in bioanalysis |c ed. by M. Mascini |
| 264 | 1 | |a Hoboken, N.J. [u.a.] |b Wiley |c 2009 | |
| 300 | |a XVII, 313 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 520 | 3 | |a This title details bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications. | |
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| 689 | 0 | 1 | |a Biochemische Analyse |0 (DE-588)4255721-5 |D s |
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| 700 | 1 | |a Mascini, Marco |4 edt | |
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Datensatz im Suchindex
| _version_ | 1804140718585806848 |
|---|---|
| adam_text | Titel: Aptamers in bioanalysis
Autor: Mascini, Marco
Jahr: 2009
CONTENTS
PREFACE xi
CONTRIBUTORS xv
I INTRODUCTION
1 APTAMERS: LIGANDS FOR ALL REASONS 3
Jean-Jacques Toulme, Jean-Pierre Daguer, and Eric Dausse
I. I Introduction / 3
1.2 The Power of Selection and Aptamer Refinement / 5
1.3 The Chemistry Drives the Shape / 7
1.4 Aptaregulators / 11
1.5 Aptasensors / 15
1.6 Prospects / 18
References / 20
2 SELEX AND ITS RECENT OPTIMIZATIONS 31
Beate Strehlitz and Regina Stoltenburg
2.1 Introduction / 31
2.2 Aptamers and Their Selection by SELEX / 32
v
Vi CONTENTS
2.3 Modifications of SELEX Technology / 35
2.4 Advantages and Limitations of Aptamers and Their Selection
Technology / 41
2.5 Applications of Aptamers Being Developed for the Market / 43
2.6 Future Perspectives / 45
References / 50
II BIOSENSORS
3 ELECTROCHEMICAL APTASENSORS 63
Itamar Willner and Maya Zayats
3.1 Introduction / 63
3.2 Electrochemical Aptasensor Based on Redox-Active
Aptamer Monolayers Linked to Electrodes / 66
3.3 Enzyme-Based Amplified Electrochemical Aptasensors / 69
3.4 Amplified Electrochemical Aptasensors Based on
Nanoparticles / 72
3.5 Label-Free Electrochemical Aptasensors / 75
3.6 Field-Effect Transistor-Based Aptasensors / 78
3.7 Conclusions and Perspectives / 81
References / 81
4 APTAMERS: HYBRIDS BETWEEN NATURE
AND TECHNOLOGY 87
Moritz K. Beissenhirtz, Eik Leupold, Walter Stocklein, Ulla
Wollenberger, Oliver Panke, Fred Lisdat, and Frieder W. Scheller
4.1 Introduction / 87
4.2 Specific Features of Aptamers / 88
4.3 Electrochemical Detection of Nucleic Acids / 88
4.4 Cytochrome c Binding by Aptamers / 90
4.5 DNA Machines and Aptamers / 92
References / 98
5 DETECTION OF PROTEIN-APTAMER INTERACTIONS
BY MEANS OF ELECTROCHEMICAL INDICATORS
AND TRANSVERSE SHEAR MODE METHOD 101
Tibor Hianik
5.1 Introduction / 101
5.2 Immobilization of Aptamers on a Solid Support / 102
CONTENTS VH
5.3 Detection of Aptamer-Ligand Interactions / 104
5.3.1 Electrochemical Methods / 105
5.3.2 Acoustic Methods / 117
5.4 Conclusions / 124
References / 125
6 BIOSENSORS USING THE APTAMERIC ENZYME
SUBUNIT: THE USE OF APTAMERS IN THE ALLOSTERIC
CONTROL OF ENZYMES 129
Kazunori Ikebukuro, Wataru Yoshida, and Koji Sode
6.1 Aptamers as Molecular Recognition Elements of
Biosensors / 129
6.1.1 Comparing Aptamers to Antibodies / 129
6.1.2 Signaling Aptamers / 131
6.2 Homogeneous Sensing / 133
6.2.1 Biosensor Systems That Do Not Require
Bound-Free Separation / 133
6.2.2 Aptameric Enzyme Subunit / 133
6.3 Evolution-mimicking Algorithm for the Improvement of
Aptamers / 136
References / 137
7 NANOMATERIAL-BASED LABEL-FREE APTASENSORS 139
Kagan Kerman and Eiichi Tamiya
7.1 Introduction / 139
7.2 Label-Free Electrochemical Aptasensors / 139
7.3 Field-Effect Transistor-Based Aptasensors / 143
7.4 Label-Free Aptasensors Based on Localized Surface
Plasmon Resonance / 147
7.5 Forthcoming Challenges and Concluding Remarks / 151
References / 151
8 APTAMER-BASED BIOANALYTICAL ASSAYS:
AMPLIFICATION STRATEGIES 159
Sara Tombelli, Maria Minunni, and Marco Mascini
8.1 Introduction / 159
8.2 Bioanalytical Assays Based on Aptamer-Functionalized
Nanoparticles / 160
8.3 Aptamers and Quantum Dot-Based Assays / 164
viii contents
8.4 Aptazymes and Aptamer-Based Machines / 168
8.5 Polymerase Chain Reaction as an Amplification Method in
Aptamer-Based Assays / 173
8.6 Conclusions / 176
References / 177
III APPLICATIONS
9 KINETIC CAPILLARY ELECTROPHORESIS FOR
SELECTION, CHARACTERIZATION, AND ANALYTICAL
UTILIZATION OF APTAMERS 183
Sergey N. Krylov
9.1 Introduction / 183
9.1.1 Kinetic Capillary Electrophoresis / 183
9.1.2 The Concept of NECEEM and ECEEM / 185
9.2 Selection of Aptamers Using KCE Methods for Partitioning
and Affinity Control / 188
9.2.1 NECEEM-Based Selection of Aptamers / 188
9.2.2 ECEEM-Based Selection of Aptamers / 197
9.2.3 Optimization of PCR / 198
9.2.4 Future of KCE Methods for Aptamer Selection / 200
9.3 Measurements of Binding Parameters of Target-Aptamer
Interaction by KCE Methods / 200
9.3.1 Foundation / 200
9.3.2 Temperature Control Inside the Capillary / 202
9.3.3 Examples / 203
9.4 Quantitative Affinity Analysis of a Target Using Aptamer
as an Affinity Probe / 205
9.4.1 Foundation / 205
9.4.2 Example / 208
9.5 Conclusions / 209
References / 210
10 APTAMERS FOR SEPARATION OF ENANTIOMERS 213
Corinne Ravelet and Eric Peyrin
10.1 Introduction / 213
10.2 Generation and Properties of Enantioselective
Aptamers / 214
CONTENTS ix
10.3 Immobilized Aptamers for Enantiomeric Separation by Liquid
Chromatography / 215
10.3.1 Stationary-Phase Preparation and Column
Packing / 216
10.3.2 DNA Aptamer-Based CSPs / 216
10.3.3 RNA Aptamer-Based CSPs and the Mirror-Image
Strategy / 217
10.3.4 Class-Specific Aptamer-Based CSPs / 219
10.4 Aptamers for Analysis of Enantiomers by Capillary
Electrophoresis / 221
10.4.1 Aptamers as Chiral Additives in the Background
Electrolyte for CE Enantiomeric Separation / 221
10.4.2 Aptamers for the Design of an Affinity CE-Based
Enantioselective Competitive Assay / 223
10.5 Conclusions / 226
References / 226
11 APTAMER-MODIFIED SURFACES FOR AFFINITY
CAPTURE AND DETECTION OF PROTEINS IN
CAPILLARY ELECTROPHORESIS AND MALDI-MASS
SPECTROMETRY 229
Linda B. McGown
11.1 Introduction / 229
11.2 Aptamer-Modified Capillaries in Affinity Capillary
Electrophoresis / 230
11.3 Aptamer-Modified Surfaces for Affinity MALDI-MS / 232
11.3.1 Overview / 232
11.3.2 Affinity MALDI-MS of Thrombin / 233
11.3.3 Affinity MALDI-MS of IgE / 235
11.3.4 Summary / 242
11.4 Beyond Aptamers: Genome-Inspired DNA Binding
Ligands / 242
References / 248
12 STRATEGY FOR USE OF SMART ROUTES TO PREPARE
LABEL-FREE APTASENSORS FOR BIOASSAY USING
DIFFERENT TECHNIQUES 251
Singling Li, Hui Wei, and Shaojun Dong
12.1 Introduction / 251
12.2 Electrochemical Aptasensors / 254
X CONTENTS
12.2.1 POSOALF Mode / 254
12.2.2 PFSOALF Mode / 257
12.2.3 Electrochemical Impedimetric Aptasensors / 257
12.2.4 Electrochemical Aptasensors with Nonlabeled Redox
Probes / 263
12.3 Fluorescent Molecular Switches / 265
12.3.1 POSFALF Mode / 266
12.3.2 PFSFALF Mode / 268
12.4 Colorimetry / 272
12.4.1 POSFALF Mode / 273
12.4.2 PFSFALF Mode / 274
12.5 Hemin-Aptamer DNAzyme-Based Aptasensor / 281
12.6 Liquid Chromatography, Electrochromatography, and Capillary
Electrophoresis Applications / 284
12.7 Other Aptasensors / 290
12.8 Conclusions / 290
References / 290
INDEX 299
|
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| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
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| spelling | Aptamers in bioanalysis ed. by M. Mascini Hoboken, N.J. [u.a.] Wiley 2009 XVII, 313 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier This title details bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications. Oligonucleotides Biochemische Analyse (DE-588)4255721-5 gnd rswk-swf Aptamer (DE-588)4441960-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Aptamer (DE-588)4441960-0 s Biochemische Analyse (DE-588)4255721-5 s DE-604 Mascini, Marco edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018641983&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Aptamers in bioanalysis Oligonucleotides Biochemische Analyse (DE-588)4255721-5 gnd Aptamer (DE-588)4441960-0 gnd |
| subject_GND | (DE-588)4255721-5 (DE-588)4441960-0 (DE-588)4143413-4 |
| title | Aptamers in bioanalysis |
| title_auth | Aptamers in bioanalysis |
| title_exact_search | Aptamers in bioanalysis |
| title_full | Aptamers in bioanalysis ed. by M. Mascini |
| title_fullStr | Aptamers in bioanalysis ed. by M. Mascini |
| title_full_unstemmed | Aptamers in bioanalysis ed. by M. Mascini |
| title_short | Aptamers in bioanalysis |
| title_sort | aptamers in bioanalysis |
| topic | Oligonucleotides Biochemische Analyse (DE-588)4255721-5 gnd Aptamer (DE-588)4441960-0 gnd |
| topic_facet | Oligonucleotides Biochemische Analyse Aptamer Aufsatzsammlung |
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