Peptide and protein design for biopharmaceutical applications:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2009
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Publisher description Table of contents only Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XII, 294 S. Ill., graph. Darst. |
| ISBN: | 9780470319611 |
Internformat
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| 245 | 1 | 0 | |a Peptide and protein design for biopharmaceutical applications |c ed. Knud J. Jensen |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Chichester |b Wiley |c 2009 | |
| 300 | |a XII, 294 S. |b Ill., graph. Darst. | ||
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| 650 | 0 | |a Protein drugs / Design | |
| 650 | 0 | |a Peptides / Design | |
| 650 | 0 | |a Protein engineering | |
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Datensatz im Suchindex
| _version_ | 1804140711844511744 |
|---|---|
| adam_text | Titel: Peptide and protein design for biopharmaceutical applications
Autor: Jensen, Knud J.
Jahr: 2009
Contents
List of Contributors ix
Preface xi
1 Introduction 1
KnudJ. Jensen
2 Computational Approaches in Peptide and Protein Design:
An Overview 5
Gregory V. Nikiforovich and Garland R. Marshall
2.1 Introduction 5
2.2 Basics and Tools 6
2.2.1 The Importance of Computational Approaches 6
2.2.2 Tools and Procedures: Force Fields and
Sampling 9
2.3 Computational Study of Cyclopentapeptide Inhibitors
of CXCR4 31
2.3.1 The 3D Pharmacophore Model for FC131 32
2.3.2 A 3D Model of the TM Region of CXCR4 36
2.3.3 Docking of FC131 to CXCR4 39
Acknowledgements 42
References 42
3 Aspects of Peptidomimetics 49
Veronique Maes and Dirk Tourwe
3.1 Introduction 49
3.2 Modified Peptides 51
3.3 Pseudopeptides 65
vi CONTENTS
3.4 Secondary Structure Mimics (Excluding
Turn Mimics) 75
3.4.1 (3-strand Mimetics 75
3.4.2 Helix Mimetics 87
3.5 Examples of Peptidomimetics 92
3.6 Conclusion 104
References 105
4 Design of Cyclic Peptides 133
Oliver Demmer, Andreas O. Frank and Horst Kessler
4.1 Introduction 133
4.1.1 Pharmaceutical Research Today 133
4.1.2 General Advantages of Cyclic Peptide
Structures 134
4.1.3 Examples of Cyclic Peptides of Medicinal
Interest 135
4.1.4 General Considerations 137
4.2 Peptide Cyclization 138
4.2.1 Possibilities of Peptide Cyclization 138
4.2.2 Synthesis of Cyclic Peptides 139
4.2.3 Chemical Modifications of Cyclic Peptides 141
4.2.4 Concluding Remarks 146
4.3 Conformation and Dynamics of Cyclic Peptides 146
4.3.1 Reductions in Conformational Space 146
4.3.2 Conformational Arrangements in Cyclic
Structures 148
4.3.3 Flexibility of Cyclized Scaffolds 151
4.3.4 Experimental Structure Characterization 152
4.4 Concepts in the Rational Design of Cyclic Peptides 154
4.4.1 The Influence of Amino Acid Composition 154
4.4.2 The Dunitz-Waser Concept 155
4.4.3 The Spatial Screening Technique 156
4.4.4 General Strategy for Finding Active Hits 157
4.5 Examples of Cyclic Peptides as Drug Candidates 159
4.5.1 Cilengitide as Integrin Inhibitor 159
4.5.2 CXCR4 Antagonists 163
4.5.3 Sandostatin and the Veber-Hirschmann
Peptide as Examples of Rational Design 164
4.6 Conclusion 166
References 166
CONTENTS vii
5 Carbohydrates in Peptide and Protein Design 177
Knud J. Jensen and Jesper Brask
5.1 Introduction 177
5.2 Configurational and Conformational Properties of
Carbohydrates 178
5.3 Carbohydrates in Peptidomimetics 181
5.4 Glycopeptides 183
5.5 Carbohydrates as Scaffolds in the Design of
Nonpeptide Peptidomimetics 185
5.6 Sugar Amino Acids 187
5.7 Cyclodextrin-Peptide Conjugates 193
5.8 Carboproteins: Protein Models on Carbohydrate
Templates 198
5.9 Conclusion 199
References 200
6 De Novo Design of Proteins 207
Knud J. Jensen
6.1 Introduction 207
6.2 Secondary Structure Elements 208
6.2.1 The a-helix 208
6.2.2 Thep-sheet 214
6.2.3 Loops, Turns and Templates 214
6.3 Assembling a Specified Tertiary Structure from
Secondary Structural Elements 215
6.3.1 Computational Methods 215
6.3.2 Coiled Coils 216
6.3.3 a-helical Bundles 220
6.3.4 Fluorous Interactions 225
6.3.5 Additional Topics 228
6.4 Proteins on Templates 229
6.5 Foldamers 234
6.6 Biopharmaceutical Applications of De Novo
Design 236
6.6.1 a-helical Structures in Biopharmaceutical
Applications 236
6.6.2 Foldamers in Biopharmaceutical
Applications 238
References 238
viii CONTENTS
7 Design of Insulin Variants for Improved Treatment of
Diabetes 249
Thomas Hoeg-Jensen
7.1 Introduction 249
7.2 Diabetes Management and the Need for Insulin
Engineering 251
7.3 Insulin Structure 256
7.4 Prolonged-acting Insulin Solids 258
7.5 Prolonged-acting Insulin Solutions 259
7.6 Fast-acting Insulins 265
7.7 Glucose-sensitive Insulin Preparations 267
7.8 Alternative Insulin Delivery 271
7.9 Insulin Mimetics 272
7.10 Pushing the Limits of Insulin Engineering 273
7.11 Conclusion 274
References 275
Index 287
|
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| isbn | 9780470319611 |
| language | English |
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| physical | XII, 294 S. Ill., graph. Darst. |
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| spelling | Peptide and protein design for biopharmaceutical applications ed. Knud J. Jensen 1. publ. Chichester Wiley 2009 XII, 294 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Peptide drugs / Design Protein drugs / Design Peptides / Design Protein engineering Peptide drugs Design Peptides Design Protein drugs Design Peptide (DE-588)4045125-2 gnd rswk-swf Biopharmazie (DE-588)4006890-0 gnd rswk-swf Proteindesign (DE-588)4346801-9 gnd rswk-swf Peptide (DE-588)4045125-2 s Proteindesign (DE-588)4346801-9 s Biopharmazie (DE-588)4006890-0 s DE-604 Jensen, Knud J. Sonstige oth http://www.loc.gov/catdir/enhancements/fy0913/2009019177-d.html Publisher description http://www.loc.gov/catdir/enhancements/fy0913/2009019177-t.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018637831&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Peptide and protein design for biopharmaceutical applications Peptide drugs / Design Protein drugs / Design Peptides / Design Protein engineering Peptide drugs Design Peptides Design Protein drugs Design Peptide (DE-588)4045125-2 gnd Biopharmazie (DE-588)4006890-0 gnd Proteindesign (DE-588)4346801-9 gnd |
| subject_GND | (DE-588)4045125-2 (DE-588)4006890-0 (DE-588)4346801-9 |
| title | Peptide and protein design for biopharmaceutical applications |
| title_auth | Peptide and protein design for biopharmaceutical applications |
| title_exact_search | Peptide and protein design for biopharmaceutical applications |
| title_full | Peptide and protein design for biopharmaceutical applications ed. Knud J. Jensen |
| title_fullStr | Peptide and protein design for biopharmaceutical applications ed. Knud J. Jensen |
| title_full_unstemmed | Peptide and protein design for biopharmaceutical applications ed. Knud J. Jensen |
| title_short | Peptide and protein design for biopharmaceutical applications |
| title_sort | peptide and protein design for biopharmaceutical applications |
| topic | Peptide drugs / Design Protein drugs / Design Peptides / Design Protein engineering Peptide drugs Design Peptides Design Protein drugs Design Peptide (DE-588)4045125-2 gnd Biopharmazie (DE-588)4006890-0 gnd Proteindesign (DE-588)4346801-9 gnd |
| topic_facet | Peptide drugs / Design Protein drugs / Design Peptides / Design Protein engineering Peptide drugs Design Peptides Design Protein drugs Design Peptide Biopharmazie Proteindesign |
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