Cell and tissue reaction engineering: with a contribution by Martin Fussenegger and Wilfried Weber
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2009
|
| Series: | Principles and practice
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| Subjects: | |
| Online Access: | Kapitel 1 Cover Inhaltsverzeichnis |
| Physical Description: | XI, 363 S. Ill., graph Darst. |
| ISBN: | 9783540681755 9783642018749 |
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Record in the Search Index
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| adam_text |
Titel: Cell and tissue reaction engineering
Autor: Eibl, Regine
Jahr: 2009
Contents
Part I Mammalian Cells
1 Mammalian Cell Culture Technology: An Emerging Field 3
D. Eibl, R. Eibl, and R. Portner
1.1 Definition and History 3
1.2 Fields of Application and Products from Mammalian Cells 6
1.3 Future Prospects 8
1.4 Exercises 9
References 9
Complementary Reading 11
2 Characteristics of Mammalian Cells
and Requirements for Cultivation 13
R. Portner
2.1 Differences Between Mammalian Cells, Plant Cells
and Microbes: Consequences of These Differences 13
2.2 Types of Mammalian Cells 14
2.2.1 From Primary Cells to Permanent
(Established) Cell Lines 15
2.2.2 Hybridom Cells for Production of Monoclonal
Antibodies 17
2.2.3 Culture Collections and Cell Banking 20
2.3 Culture Media 21
2.4 Characteristics of Cell Growth and Metabolism 24
2.4.1. Short Introduction to Cell Metabolism 24
2.4.2 2 Glucose, Glutamine and Amino Acids as Carbon
and Energy Source 26
2.4.3 : TBe Effects of Lactate and Ammonia 29
2.4.4 s Oxygen Uptake and Carbon Dioxide Production 31
2.5 Kinetic Modelling of Cell Growth and Metabolism 32
2.5.1 Introduction to Kinetic Modelling for Mammalian Cells 32
2.5.2 Set-Up of an Unstructured Model 33
vii
viii Contents
2.5.3 Structured Models 44
2.5.4 Conclusions for Set-Up of a Kinetic Model 45
2.6 Questions and Problems 46
List of Symbols , 47
References 47
Complementary Reading 53
3 Bioreactors for Mammalian Cells: General Overview 55 •
D.ELblandR.Eibl :
3.1 Technical Terminology: Bioreactor/Fermentor,
Bioreactor Facility 56 \
3.2 Suitable Bioreactor Types for Mammalian Cell Cultures 57 \
3.2.1 Categorization, Functional Principle, Possible j
Fields of Application 57 I
3.2.2 Bioreactor Trends and the Increasing Acceptance
of Disposables 66
3.3 Special Case: Bioreactors for Patient-Specific
Therapies Based on Functional Tissue and Stem Cells 69
3.3.1 Bioreactors for Growing 3D Tissues 70
3.3.2 Bioreactors for Large-Scale Expansion
and Differentiation of Stem Cells 72
3.4 Conclusions 73
3.5 Questions and Problems 74
List of Abbreviations and Symbols 74
References 75
Complementary Reading 82
4 Special Engineering Aspects 83
P. Czermak, R. Partner, and A. Brix
4.1 Cell Damage by Shear and Aeration 83
4.1.1 General Aspects 83
4.1.2 Model Analysis 85
4.1.3 Cell Damage in Bioreactors 92
4.2 Oxygen Supply 102
4.2.1 Introduction 102
4.2.2 Limitations for Oxygen Transfer 105
4.2.3 Oxygen Supply Systems (Aeration Systems) 108
4.2.4 Consequences for Reactor Design and Operation 120
4.3 Immobilization of Cells 122
4.3.1 Carriers for Cell Immobilization 123
4.3.2 Encapsulation 134
Contents ix
4.4 Culture Modes 136
4.4.1 Principles of Culture Modes 136
4.4.2 Examples of Different Culture Modes 141
4.4.3 Process Strategies for Fed-Batch 147
4.4.4 Process Strategies Applied in Industrial Processes 149
4.5 Monitoring and Controlling in Animal Cell Culture 152
4.5.1 Temperature 152
4.5.2 pH 153
4.5.3 Oxygen Partial Pressure 154
4.5.4 Carbon Dioxide Partial Pressure 156
4.5.5 Metabolites and Products 156
4.5.6 Cell Density and Viability 159
4.5.7 Agitation 160
4.6 Questions and Problems 160
4.6.1 Problem 160
4.6.2 Problem 160
List of Symbols 162
References 164
Complementary Reading 171
5 Bioreactor Design and Scale-Up 173
G. Catapano, P. Czermak, R. Eibl, D. Eibl, and R. Portner
5.1 Bioreactor Design 173
5.1.1 Bioreactors for Suspended Cells 176
5.1.2 Fixed Bed and Fluidized Bed Bioreactors: Design,
Performance and Scale-Up 199
5.1.3 Membrane Bioreactors 217
5.1.4 Disposable Bioreactors 242
5.2 Selection of Bioreactor and Operation Mode 245
5.3 How to Grow Mammalian Cells from Cryopreserved
Vial to Production Bioreactor 246
5.4 Questions and Problems 249
List of Symbols 250
References 253
Complementary Reading 259
Part II Special Applications
6 Insect Cell-Based Recombinant Protein Production 263
W. Weber and M. Fussenegger
6.1 Insect Cell Culture 263
6.2 Special Aspects: Engineering Baculoviruses as Vectors 264
6.3 Bioreactor Concepts 267
x Contents
6.4 Process Design 268
6.4.1 Optimization of Nutrient Supply 268
6.4.2 Optimization of Production Kinetics 268
6.5 Applications 270
6.6 Current Trends in Insect Cell-Based Protein Production 270
6.6.1 Elimination of Product Protein Proteolysis 273
6.7 Limitations 273
References 274
Complementary Reading 276
7 Bioreactors for Bioartificial Organs 279
G. Catapano
7.1 Introduction 279
7.2 Cells for Bioartificial Organs 280
7.2.1 Expression of the Adult Cell Phenotype 283
7.3 Bioreactor Design for Bioartificial Organs 285
7.3.1 Extravascular (EV) Bioreactors 289
7.3.2 Intravascular (IV) Bioreactors 295
7.3.3 Membrane Immunoprotection
in Bioartificial Organs 302
7.4 Commercial Bioreactors and Applications 304
List of Symbols 310
References 311
8 Plant Cell-Based Bioprocessing 315
R. Eibl and D. Eibl
8.1 Plant Cell Culture Basics 316
8.1.1 Characteristics of Plant Cells and Culture Conditions 316
8.1.2 Media 317
8.1.3 Plant Cell Culture Types and Their In Vitro Initiation 319
8.1.4 Routine Working Methods in Plant Cell Cultivation 326
8.2 Bioreactors for Plant Cell Cultures 330
8.2.1 General Considerations 330
8.2.2 Suitable Bioreactors for Plant Cell Suspension Cultures 332
8.2.3 Suitable Bioreactors for Hairy Roots 335
8.3 Approaches to Improving Productivity in Plant Cell-Based
Bioprocessing 340
8.4 Application Examples and Potential Active
Agent Candidates 342
8.5 Conclusions 343
8.6 Questions and Problems 344
Contents xi
List of Abbreviations and Symbols 345
References 347
Complementary Reading 356
Index 357
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| spelling | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber Regine Eibl ... Berlin [u.a.] Springer 2009 XI, 363 S. Ill., graph Darst. txt rdacontent n rdamedia nc rdacarrier Principles and practice Biotechnologie (DE-588)4069491-4 gnd rswk-swf Tissue Engineering (DE-588)4646061-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Tissue Engineering (DE-588)4646061-5 s Biotechnologie (DE-588)4069491-4 s DE-604 Eibl, Regine ctb Erscheint auch als Online-Ausgabe Cell and tissue reaction engineering DE-576;springer application/pdf http://swbplus.bsz-bw.de/bsz286932695kap.htm 20081111114359 Kapitel 1 DE-576;springer image/jpeg http://swbplus.bsz-bw.de/bsz286932695cov.htm 20090113095244 Cover HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018636876&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber Biotechnologie (DE-588)4069491-4 gnd Tissue Engineering (DE-588)4646061-5 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4646061-5 (DE-588)4143413-4 |
| title | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber |
| title_auth | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber |
| title_exact_search | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber |
| title_full | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber Regine Eibl ... |
| title_fullStr | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber Regine Eibl ... |
| title_full_unstemmed | Cell and tissue reaction engineering with a contribution by Martin Fussenegger and Wilfried Weber Regine Eibl ... |
| title_short | Cell and tissue reaction engineering |
| title_sort | cell and tissue reaction engineering with a contribution by martin fussenegger and wilfried weber |
| title_sub | with a contribution by Martin Fussenegger and Wilfried Weber |
| topic | Biotechnologie (DE-588)4069491-4 gnd Tissue Engineering (DE-588)4646061-5 gnd |
| topic_facet | Biotechnologie Tissue Engineering Aufsatzsammlung |
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