Diagnostic methods in leukaemias and lymphomas:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English German |
| Veröffentlicht: |
Bremen [u.a.]
UNI-MED-Verl.
2009
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | UNI-MED science
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 158 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9781848151451 9783837411560 |
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| 650 | 2 | |a Laboratory Techniques and Procedures | |
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Titel: Diagnostic methods in leukaemias and lymphomas
Autor: Haferlach, Torsten
Jahr: 2009
Contents 7
1 Contents
i
j ^J General aspects of the laboratory diagnosis in leukaemias and lymphomas 14
i 1.1. Collection of material 14
1.1.1. Bone marrow biopsy and aspiration 14
' 1.1.2. Site of removal 14
1.1.2.1. Bone marrow biopsy 15
1.1.2.2. Bone marrow aspirates 15
1.2. Distribution of samples 16
1.3. Lymph node biopsy 16
1.4. Lumbar puncture 16
m[ Cytomorphological diagnosis 18
2.1. Examination of the peripheral blood 18
2.2. Examination of bone marrow aspirates 19
2.2.1. Processing and evaluation of bone marrow aspirates 19
2.3. Classification of leukaemias and MDS 21
2.4. Assessment of the remission status in leukaemias and lymphomas 24
m Haematology analysers 28
3.1. The blood count 28
3.2. Influencing and disturbance variables of the blood count 30
3.3. Differential blood count 32
3.4. Determination of reticulocytes 33
m Iliac crest biopsy diagnosis 36
4.1. Bone marrow diagnosis in a historical context 36
4.2. Histotechnical requirements 36
4.2.1. Plastic embedding of iliac crest biopsies 36
4.2.2. Paraffin embedding of iliac crest biopsies 37
4.2.2.1. Principal advantages of paraffin embedding 37
4.2.2.2. Typical artefacts 37
4.2.2.2.1. Artefacts from acid decalcification 37
4.2.2.2.2. Fixation artefacts 37
4.2.2.3. Recommended fixation 39
4.2.2.4. Neutral decalcification using chelators 39
4.2.2.5. Paraffin embedding, staining 39
4.2.2.5.1. Standard stains 39
4.2.2.5.2. Immunohistochemical processes 39
4.3. Algorithm for iliac crest biopsy diagnosis 42
4.3.1. Implications of the size of iliac crest biopsies 42
4.3.2. Osteological findings 43
4.3.3. Fat cells and general cell density of the bone marrow 44
4.3.4. Reticulin fibres - fibrosis 44
4.3.5. Iron content of the bone marrow 45
4.3.6. Cytological analysis of bone marrow sections 47
8 Contents
4.4. Histology versus cytology 48
4.4.1. Sampling error of marrow aspiration in focal marrow fibrosis 48
4.4.2. Detection of fragile cells in the iliac crest biopsy 48
4.4.3. Marrow-bone and bone-marrow interactions 49
4.4.3.1. Hypercalcaeiffia syndromes 49
4.4.3.2. Osteopetrosis 49
4.4.3.3. Paget's disease of bone 49
4.4.4. Detection of tumour metastases 50
4.4.5. Histotopography of neoplastic haematopoiesis 51
4.5. Lymphatic structural elements and lymphornas in the bone marrow 52
4.5.1. Non-neoplastic lymphatic cells in the bone marrow 52
4.5.1.1. Diffusely distributed lymphocytes 52
4.5.1.2. Peri-meta-arteriolar plasma cells 52
4.5.1.3. Bone marrow lymphoid nodules 54
4.5.2. Histotopographical typology of lymphomas in the bone marrow 58
4.5.2.1. Intrasinusoidal lymphomas 58
4.5.2.2. Perisinusoidal lymphomas 59
4.5.2.3. Peri-meta-arteriolar lymphomas 60
4.5.2.3.1. Peri-meta-arteriolar immunocytomas with pseudo-pseudo Gaucher cells 62
4.5.2.4. Paratrabecular lymphomas 65
4.5.2.5. Paratrabecular lymphomas with osteoclastic reaction 65
4.5.2.6. Peritrabecular lyrnphomas 66
4.5.2.7. Disordered interstitial lymphomas 68
4.5.2.8. Disordered tumorigenic lymphomas 68
4.5.3. Discordant lymphomas 70
4.5.4. Composite lymphomas 70
m Immunophenotyping 80
5.1. Method of immunophenotyping using multiparameter flow cytometry (MFC) 80
5.1.1. Differentiation of different populations based on their light scatter characteristics 80
5.1.2. Use of fluorescence-labelled monoclonal antibodies .81
5.1.3. CD45 gating 82
5.1.4. Multipararneter flow cytometry 82
5.1.5. Sample processing .83
5.1.6. Use of different antibody panels 83
5.2. Use of imrnunophenotyping in diagnosis 83
5.2.1. Acute leukaernias 83
5.2.1.1. Acute lymphoblastic leukaemia (ALL) 83
5.2.1.1.1. Pro-B ALL .84
5.2.1.1.2. Common AU(c-ALL) .84
5.2.1.1.3. Pre-BALL .84
5.2.1.1.4. MatureBAlL.--. 84
5.2.1.1.5. Pro-TALL .85
5.2.1.1.6. Pre-TALL 85
5.2.1.1.7. Cortical TALL .85
5.2.1.1.8. MatureTAU. 85
5.2.1.2. Acute myeloid leukaemia (AMD 85
5.2.1.3. Biphenotypic acute leukaemia 85
5.2.2. Myelodysplastic syndromes (MDS) 86
5.2.3. Chronic myeloid leukaemia (CML) 86
Contents 9
5.2.4. Mature B-cell neoplasms 86
' 5.2.4.1. B-CLL and B-PLL 86
I 5.2.4.2. Marginal zone lymphoma and related B-cell neoplasms 87
5.2.4.3. Hairy cell leukaemia 88
5.2.4.4. Plasmacytoma 88
5.2.4.5. Follicular lymphoma 88
5.2.4.6. Mantle cell lymphoma 88
5.2.4.7. Diffuse large B-cell lymphoma 88
5.2.4.8. Burkitt's lymphoma 88
5.2.5. T-cell and NK-cell neoplasms 88
5.2.5.1. T-cell and NK-cell large granular lymphocytic (LGL) leukaemia 88
5.2.5.2. Mycosis fungoides, Sezary syndrome 88
5.2.5.3. T-prolymphocytic leukaemia (T-PLL) 89
5.2.6. PNH 89
5.3. Monitoring of minimal residual disease (MRD) 89
5.3.1. MRD in ALL 90
5.3.2. MRDinAML 90
5.3.3. MRDinCLL 92
|P[ Cytogenetics and fluorescence in situ hybridisation 94
6.1 • Chromosome analysis 94
6.1.1. Importance of chromosome analysis, indication 94
6.1 -2. Examination material 94
6.1.3. Conventional chromosome analysis using banding techniques 94
6.2. Fluoroescence in situ hybridisation (FISH) 94
6.2.1. Interphase FISH 95
6.2.2. Metaphase FISH 96
6.2.2.1. 24-colour FISH 96
6.2.3. Comparative genome hybridisation (CGH) 96
6.3. Nomenclature 98
6.3.1. Chromosome analysis 98
6.3.2. Fluorescence in situ hybridisation on interphase nuclei 99
6.4. Characteristic cytogenetic changes in AML 100
6.4.1. De novo AML 100
6.4.2. Secondary treatment-associated AML 102
6.5. Characteristic cytogenetic changes in ALL 102
6.6. Characteristic cytogenetic changes in CML 103
6.6.1. Primary diagnosis 103
6.6.2. Cytogenetic findings for treatment monitoring 104
6.7. Characteristic cytogenetic changes in CLL 104
6.8. Characteristic cytogenetic changes in NHL 105
I! Molecular genetics 110
7.1. Molecular methods in the diagnosis of leukaemias and lymphomas 110
7.1-1. Southern blot 110
7.1.2. Polymerase chain reaction (PCR) 111
7.1.2.1. Nested PCR 112
7.1.2.2. Fragment analysis (gene scan) 114
7.1.2.3. Chimerism analyses using microsatellite polymorphisms 114
7.1-2.4. Real time PCR 114
10 Contents
7.1.3. Sequence analysis 115
7.1.4. Method for mutation screening 116
7.2. Use of molecular methods in the diagnosis and during the course of the disease 117
7.2.1. Molecular methods in the diagnosis 117
7.2.2. Monitoring of remission using different PCR techniques 118
7.2.3. Sample material 119
7.3. Diagnosis of AML 119
7.3.1. Detection of fusion genes 119
7.3.2. Molecular mutations in acute myeloid leukaemia (AML) 120
7.3.3. Monitoring of remission in AML 121
7.4. Molecular diagnosis in myelodysplastic syndromes (MDS) 122
7.4.1. Detection of deletions in MDS 122
7.4.2. Detection of fusion genes in MDS 123
7.4.3. Molecular mutations in MDS 123
7.4.4. Marker in the course of MDS 123
7.5. Diagnosis of CML 124
7.5.1. Monitoring of disease course in CML 124
7.5.2. Imatinib resistance in BCR-ABL-positive leukaemia 124
7.6. Other myeloproliferative neoplasias (MPN) 125
7.6.1. Polycythaemia rubra vera 125
7.6.2. Essential thrombocythaemia 125
7.6.3. Osteomyelofibrosis 126
7.6.4. Chronic eosinophilic leukaemia 126
7.7. Lymphatic leukaemias and lymphomas 126
7.7.1. Molecular diagnosis of ALL 126
7.7.2. Molecular changes in ALL 127
7.7.3. Monitoring of the disease course in ALL 127
7.8. Molecular genetics in lymphomas 128
7.8.1. Chronic lymphatic leukaemia (CLL) 128
7.8.1.1. Deletions in CLL 128
7.8.1.2. Gene rearrangements in CLL 128
7.8.1.3. VH hypermutations in CLL 128
7.8.2. Mantle cell lymphoma (MCL) 129
7.8.3. Follicular lymphoma (FL) 129
7.8.4. MALT lymphomas 129
7.8.5. Lymphoplasmacytic lymphoma/immunocytoma (LPL) 129
7.8.6. Other marginal zone B-cell lymphomas 130
7.8.7. Hairy cell leukaemia 130
7.8.8. Plasmacytoma 130
7.8.9. Burkitt's lymphoma 130
H Gene expression analysis 136
8.1. Microarrays 136
8.2. Methodological basis 136
8.3. Examination material 137
8.4. Preparation 137
8.5. Signal detection and data recording 137
Contents 11
8.6. Data analysis and visualisation 138
8.7. Classification 140
8.8. Studies to date 141
8.9. Limitation 143
8.10. Outlook 144
^| Proteomics using the example of AML 148
9.1. Classics: two-dimensional gel electrophoresis, followed by MALDI-TOF mass
spectrometry 149
9.2. SELDI-TOF-MS and nHPLC-MS/MS 150
9.3. Chips: fishing not possible 150
^| List of abbreviations 154
B| Index 156 |
| any_adam_object | 1 |
| author_GND | (DE-588)111011159 |
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| bvnumber | BV035773048 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| dewey-search | 616.994190756 616.994460756 |
| dewey-sort | 3616.994190756 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. ed. |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-09-07T00:11:28Z |
| institution | BVB |
| isbn | 9781848151451 9783837411560 |
| language | English German |
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| record_format | marc |
| series2 | UNI-MED science |
| spelling | Labordiagnostik bei Leukämien und Lymphomen Diagnostic methods in leukaemias and lymphomas [Torsten Haferlach ...] 1. ed. Bremen [u.a.] UNI-MED-Verl. 2009 158 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier UNI-MED science Leukemia diagnosis Lymphoma diagnosis Laboratory Techniques and Procedures Labormedizin (DE-588)4073931-4 gnd rswk-swf Leukämie (DE-588)4035487-8 gnd rswk-swf Lymphom (DE-588)4036760-5 gnd rswk-swf Molekulare Diagnostik (DE-588)4589005-5 gnd rswk-swf Leukämie (DE-588)4035487-8 s Molekulare Diagnostik (DE-588)4589005-5 s Labormedizin (DE-588)4073931-4 s 1\p DE-604 Lymphom (DE-588)4036760-5 s 2\p DE-604 DE-604 Haferlach, Torsten Sonstige (DE-588)111011159 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018632699&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Diagnostic methods in leukaemias and lymphomas Leukemia diagnosis Lymphoma diagnosis Laboratory Techniques and Procedures Labormedizin (DE-588)4073931-4 gnd Leukämie (DE-588)4035487-8 gnd Lymphom (DE-588)4036760-5 gnd Molekulare Diagnostik (DE-588)4589005-5 gnd |
| subject_GND | (DE-588)4073931-4 (DE-588)4035487-8 (DE-588)4036760-5 (DE-588)4589005-5 |
| title | Diagnostic methods in leukaemias and lymphomas |
| title_alt | Labordiagnostik bei Leukämien und Lymphomen |
| title_auth | Diagnostic methods in leukaemias and lymphomas |
| title_exact_search | Diagnostic methods in leukaemias and lymphomas |
| title_full | Diagnostic methods in leukaemias and lymphomas [Torsten Haferlach ...] |
| title_fullStr | Diagnostic methods in leukaemias and lymphomas [Torsten Haferlach ...] |
| title_full_unstemmed | Diagnostic methods in leukaemias and lymphomas [Torsten Haferlach ...] |
| title_short | Diagnostic methods in leukaemias and lymphomas |
| title_sort | diagnostic methods in leukaemias and lymphomas |
| topic | Leukemia diagnosis Lymphoma diagnosis Laboratory Techniques and Procedures Labormedizin (DE-588)4073931-4 gnd Leukämie (DE-588)4035487-8 gnd Lymphom (DE-588)4036760-5 gnd Molekulare Diagnostik (DE-588)4589005-5 gnd |
| topic_facet | Leukemia diagnosis Lymphoma diagnosis Laboratory Techniques and Procedures Labormedizin Leukämie Lymphom Molekulare Diagnostik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018632699&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | UT labordiagnostikbeileukamienundlymphomen AT haferlachtorsten diagnosticmethodsinleukaemiasandlymphomas |