Essays on peripheral nerve repair and regeneration:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2009
|
| Schriftenreihe: | International review of neurobiology
87 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. - Literaturangaben |
| Beschreibung: | XXII, 572 S. Ill., graph. Darst. |
| ISBN: | 9780123750846 |
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| 650 | 4 | |a Nerve Regeneration | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Essays on peripheral nerve repair and regeneration
Autor: Geuna, Stefano
Jahr: 2009
CONTENTS
Contributors xv
Preface xxi
Peripheral Nerve Repair and Regeneration Research: A Historical Note
Bruno Battiston, Igor Papalia, Pierluigi Tos, and Stefano Geuna
I. Introduction 1
II. The 19th Century 2
III. The 20th Century 3
IV. Conclusions 4
References 6
Development of the Peripheral Nerve
Suleyman Kaplan, Ersan Odaci, Bunyami Unal, Bunyamin Sahin,
and mlchele fornaro
I. Introduction 10
II. Development of the Neural Components of the Peripheral Nerve 12
III. Development of the Nonneural Components of the Peripheral Nerve... 19
IV. Conclusion 22
References 23
Histology of the Peripheral Nerve and Changes Occurring
During Nerve Regeneration
Stefano Geuna, Stefania Raimondo, Giulia Ronchi, Federica Di Scipio,
Pierluigi Tos, Krzysztof Czaja, and Michele Fornaro
I. Introduction 28
II. Structure and Ultrastructure of the Peripheral Nerve 29
HI. Morphological Changes after Nerve Damage and Regeneration 35
IV. Conclusions 40
References 41
v
vi CONTENTS
Methods and Protocols in Peripheral Nerve Regeneration Experimental
Research: Part I—Experimental Models
Pierluigi Tos, Giulia Ronchi, Igor Papalia, Vera Sallen, JosetTE Legagneux,
Stefano Geuna, and Maria G. Giacobini-Robecchi
I. Introduction 48
II. In Vitro Models of Axonal Elongation 48
III. In Vivo Animal Models for the Study of Nerve Repair
and Regeneration 51
IV. Experimental Lesion Paradigms for Nerve Regeneration Research 52
V. Selection of the Nerve Model 62
VI. Interfering Conditions and Disease Models 70
VII. Conclusions 71
References 73
Methods and Protocols in Peripheral Nerve Regeneration Experimental
Research: Part II—Morphological Techniques
Stefania Raimondo, Michele Fornaro, Federica Di Scipio, Giulia Ronchi,
Maria G. Giacobini-Robecchi, and Stefano Geuna
I. Introduction 82
II. Light Microscopy 82
III. Immunohistochemistry and Confocal Microscopy 86
IV. Electron Microscopy 90
V. Histomorphometry (Stereology) 93
VI. Conclusions 99
References 101
Methods and Protocols in Peripheral Nerve Regeneration Experimental
Research: Part III—Electrophysiological Evaluation
Xavier Navarro and Esther Udina
I. Introduction 106
II. Nerve Conduction Tests: Technical Bases 107
III. Electrophysiological Evaluation of Axonal Regeneration 109
IV. Electrophysiological Evaluation of Regeneration and
Reinnervation Ill
V. Electrophysiological Evaluation of Spinal Reflexes
and Central Connectivity 118
VI. EMG: Evaluation of Muscle Reinnervation 120
VII. Electrophysiological Characterization of Electrical Properties of
Regenerated Nerves 122
References 123
CONTENTS vii
Methods and Protocols in Peripheral Nerve Regeneration Experimental
Research: Part IV—Kinematic Gait Analysis to Quantify Peripheral
Nerve Regeneration in the Rat
Luis M. Costa, Maria J. Simoes, Ana C. Mauricio,
and Artur S. P. Varejao
I. Introduction 128
II. Walking Track Analysis 129
III. Computerized Gait Analysis 131
IV. Gait Analysis in the Forelimb Nerve Injury Models 135
V. Conclusions and Future Perspectives 136
References 136
Current Techniques and Concepts in Peripheral Nerve Repair
Maria Siemionow and Grzegorz Brzezicki
I. Introduction 142
II. Timing of Nerve Repair 144
III. Direct Repair 145
IV. Nerve Grafting 150
V. Conduit Repair 158
VI. Conclusions 163
References 164
Artificial Scaffolds for Peripheral Nerve Reconstruction
Valeria Chiono, Chiara Tonda-Turo, and Gianluca Ciardelli
I. Introduction 174
II. Materials for Peripheral Nerve Repair 176
HI. Techniques for the Production of Scaffolds for Peripheral
Nerve Repair from Synthetic Polymers 183
IV. Functionalized Bioactive Materials for Axon Regeneration 186
V. Conclusion 190
References 191
Conduit Luminal Additives for peripheral Nerve Repair
Hede Yan, Feng Zhang, Michael B. Chen, and William C. Lineaweaver
I. Introduction 200
II. Cellular Components 200
III. Structural Components 204
IV. Neurotrophic Components 208
viii CONTENTS
V. VEGF 210
VI. GDNF 210
VII. Combined Additives 211
VIII. Recommendations 212
IX. Conclusion 218
References 219
Tissue Engineering of Peripheral Nerves
Bruno Battiston, Stefania Raimondo, Pierluigi Tos,
Valentina Gaidano, Chiara Audisio, Anna Scevola,
ISABELLE PERROTEAU, AND STEFANO GeUNA
I. Introduction 228
II. Microsurgery 229
III. Cell and Tissue Transplantation 230
IV. Material Science—Biomaterials for Nerve Reconstruction 235
V. Gene Transfer 237
VI. Clinical Experience 238
VII. Conclusions 241
References 242
Mechanisms Underlying the End-to-Side Nerve Regeneration
Eleana Bontioti and Lars B. Dahlin
I. Introduction 252
II. Proposed Mechanisms and Experimental Techniques 252
III. Proximal Stump Contamination 254
IV. Collateral Sprouting 254
V. Terminal/Regenerating Sprouting 258
VI. Stimuli Needed for Triggering Nerve Sprouting 261
VII. Pruning 262
VIII. Brain Plasticity 263
References 264
Experimental Results in End-To-Side Neurorrhaphy
Alexandros E. Beris and Marios G. LyRissas
I. Introduction 269
II. Source of Regenerating Axons 270
III. Molecular Mechanism of Collateral Sprouting 271
IV. Degree of Motor Versus Sensory Regeneration 273
V. Results in Various End-to-Side Surgical Models 274
VI. Conclusions 276
References 277
CONTENTS IX
End-to-Side Nerve Regeneration: From the Laboratory Bench
to Clinical Applications
Pierluigi Tos, Stefano Artiaco, Igor Papalia, Ignazio Marcocgio,
Stefano Geuna, and Bruno Battiston
I. Introduction 282
II. Basic Science Studies 283
III. Clinical Studies 285
IV. Future Perspectives 288
References 289
Novel Pharmacological Approaches to Schwann Cells as
Neuroprotective Agents for Peripheral Nerve Regeneration
Valerio Magnaghi, Patrizia Procacci, and Ada Maria Tata
I. Introduction 296
II. GABAergic System 297
III. Neuroactive Steroids 299
IV. Glutamate 302
V. Cholinergic System 303
VI. Purinergic System 305
VII. Mitogen-Activated Protein Kinases (MAPKs) 307
VIII. Other Approaches 308
IX. Conclusions 309
References 310
Melatonin and Nerve Regeneration
Ersan Odaci and Suleyman Kaplan
I. Introduction 318
II. The Effects of Melatonin on Peripheral Nerves 321
HI. Melatonin Toxicity on Peripheral Nerves 328
IV. Conclusion 329
References 330
Transthyretin: An Enhancer of Nerve Regeneration
Carolina E. Fleming, Fernando Milhazes Mar,
Filipa Franquinho, and Monica M. Sousa
I. Introduction 337
II. Transthyretin 338
X CONTENTS
III. TTRKOMice 339
IV. TTRMutations as the Cause of FAP 339
V. TTREnhances Nerve Regeneration 340
VI. Conclusion 344
References 344
Enhancement of Nerve Regeneration and Recovery
by Immunosuppressive Agents
Damien P. Kuffler
I. Introduction 348
II. Promoting Axon Regeneration 350
III. Neuroprotection 352
IV. Timing of Administration of FK506 353
V. Concentration of Neurotrophic Activity 354
VI. Mechanisms of Action of FK506 354
VII. Side Effects of FK506 355
VIII. Clinical Applications 356
IX. Conclusion 356
References 357
The Role of Collagen in Peripheral Nerve Repair
GUIDO KOOPMANS, BlRGIT HASSE, AND NEKTARIOS SlNIS
I. Introduction 364
II. Peripheral Nerve Collagens: Structure, Synthesis and Function 365
III. Excessive Collagen Formation can Act as Mechanical
Barrier After PNI 372
IV. Inhibition of Collagen Synthesis Affects Peripheral
Nerve Regeneration 373
References 375
Gene Therapy Perspectives for Nerve Repair
Serena Zacchigna and Mauro Giacca
I. Introduction 381
II. Gene Transfer Technologies to Target the Peripheral
Nervous System 382
III. Emerging Concepts in Gene Therapy for Nerve Repair 386
IV. Conclusions 389
References 389
CONTENTS xi
Use of Stem Cells for Improving Nerve Regeneration
Giorgio Tekenghi, Mikael Wiberg, and Paul J. Kingham
I. Nerve Repair and Regeneration 393
II. Schwann Cells for Nerve Regeneration 394
III. Stem Cells for Regenerative Medicine 396
IV. Stem Cells for Nerve Regeneration-. 397
V. Conclusions 398
References 399
Transplantation of Olfactory Ensheathing Cells for
Peripheral Nerve Regeneration
Christine RADtke, Jeffe^ D. Kocsis, and Peter M. Vogt
I. Consequences of Nerve Injury 406
II. Unique Properties of Olfactory Efsheathing Cells., 407
III. OECs in Spinal Cord Injury 408
IV. OECs in Peripheral Nerve Repair and Contribution of OEC
Transplantation to Peripheral Net^e Repair 408
V. Challenges in Cell-Therapy Approaches for Peripheral Nerve Repair .... 410
VI. Prospects of Cell-Based Clinical Approaches 411
References 413
Manual Stimulation of Target Muscles has Different Impact
on Functional Recovery after Injury of Pure Motor
or Mixed Nerves
Nektarios Sinis, Thodora. IVIanou, Frank Werdin, Armin Kraus,
Hans E. SchallER, Orlando Guntinas-Lichius, Maria Grosheva,
Andrey IrintcHev, Emanouil Skouras, Sarah Dunlop,
AND DoYCHlN N. ANGELOV
I. Introduction 418
II. Manual Stimulation 420
III. Discussion 425
References 429
Electrical Stimulation for Improving Nerve Regeneration:
Where do we Stand?
Tessa Gordon, Olewau: A. R. Sulaiman, and Adil Ladak
I. Introduction.... 434
II. Basis for Poor Functional Recovery After Nerve Injury and Repair 434
I
xii CONTENTS
III. The Potential of Brief Electrical Stimulation for Accelerating
Axon Regeneration . • ¦ 435
IV. Conclusions ••. 441
References 442
Phototherapy in Peripheral Nerve Injury: Effects on Muscle
Preservation and Nerve Regeneration
Shimon RocHKind, Stepai-JO Geuna, and Asher Shainberg
I. Introduction ¦¦. 446
II. Phototherapy in Detiervated Muscle Preservation 448
III. Phototherapy in Peripheral Nerve Regeneration 452
IV. Phototherapy on Nerve Cell Grovrtfr In Vitro as a Potential
Procedure for Cell Therapy 457
V. 780-nm Laser Phototherapy in Clinical Trial 458
VI. Conclusions 461
References 462
Age-Related Differences in the Rein nervation after
Peripheral Nerve Injury
Uros Kovacic, Janez Sketelj, and Fajko F. Bajrovic
I. Introduction 466
II. Age-Related Changes in thePNS... 466
III. Ageing and Reinnervation After peripheral Nerve Injury 468
IV. Possible Reasons for Impaired Reinnervation with Aging 471
V. Conclusions 477
References 477
Neural Plasticity After Nerve Injury and Regeneration
XaviER Navarro
I. Introduction 484
II. Neuronal Survival and Reaction to Axotomy 485
III. Plastic Changes and Remodeling at the Spinal Cord 490
IV. Plastic Changes and Reorganization at Cortical and
Subcortical Levels 492
V. Remodeling CNS Plasticity 497
References 498
CONTENTS xiii
Future Perspective in Peripheral Nerve Reconstruction
Lars Dahlin, Fredrik Johansson, Charlotta Lindwall,
and Martin Kanje
I. Introduction 508
II. Intracellular Signaling 508
III. Development of Nerve Repair and Reconstruction 509
IV. Nerve Reconstruction: Technique and Alternatives 510
V. Signal Transduction in Peripheral Nerve Regeneration 511
VI. Nanotechnology and Nerve Regeneration 514
VII. Clinical Development: Future Perspectives 522
References 524
Index 531
Contents of Recent Volumes 543
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| spelling | Essays on peripheral nerve repair and regeneration ed. by Stefano Geuna ... Amsterdam [u.a.] Elsevier 2009 XXII, 572 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier International review of neurobiology 87 Einzelaufnahme eines Zeitschr.-Bd. - Literaturangaben Nerve Regeneration Nerves, Peripheral Nervous system Regeneration Peripheral Nerves Peripherer Nerv (DE-588)4173789-1 gnd rswk-swf Nervenregeneration (DE-588)4041641-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Peripherer Nerv (DE-588)4173789-1 s Nervenregeneration (DE-588)4041641-0 s b DE-604 Geuna, Stefano Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017756490&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Essays on peripheral nerve repair and regeneration Nerve Regeneration Nerves, Peripheral Nervous system Regeneration Peripheral Nerves Peripherer Nerv (DE-588)4173789-1 gnd Nervenregeneration (DE-588)4041641-0 gnd |
| subject_GND | (DE-588)4173789-1 (DE-588)4041641-0 (DE-588)4143413-4 |
| title | Essays on peripheral nerve repair and regeneration |
| title_auth | Essays on peripheral nerve repair and regeneration |
| title_exact_search | Essays on peripheral nerve repair and regeneration |
| title_full | Essays on peripheral nerve repair and regeneration ed. by Stefano Geuna ... |
| title_fullStr | Essays on peripheral nerve repair and regeneration ed. by Stefano Geuna ... |
| title_full_unstemmed | Essays on peripheral nerve repair and regeneration ed. by Stefano Geuna ... |
| title_short | Essays on peripheral nerve repair and regeneration |
| title_sort | essays on peripheral nerve repair and regeneration |
| topic | Nerve Regeneration Nerves, Peripheral Nervous system Regeneration Peripheral Nerves Peripherer Nerv (DE-588)4173789-1 gnd Nervenregeneration (DE-588)4041641-0 gnd |
| topic_facet | Nerve Regeneration Nerves, Peripheral Nervous system Regeneration Peripheral Nerves Peripherer Nerv Nervenregeneration Aufsatzsammlung |
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