Primer to the immune response:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg
Elsevier
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes index. |
| Beschreibung: | XVII, 436 S. zahlr. Ill. u. graph. Darst. 28 cm |
| ISBN: | 9780123741639 0123741637 |
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| 100 | 1 | |a Mak, Tak W. |d 1945- |e Verfasser |0 (DE-588)131833316 |4 aut | |
| 245 | 1 | 0 | |a Primer to the immune response |c Tak W. Mak and Mary E. Saunders ; contrib. Maya R. Chaddah ... |
| 264 | 1 | |a Heidelberg |b Elsevier |c 2008 | |
| 300 | |a XVII, 436 S. |b zahlr. Ill. u. graph. Darst. |c 28 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 650 | 4 | |a Immune response | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Immune System | |
| 650 | 4 | |a Immune System Diseases | |
| 650 | 4 | |a Immunity | |
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| 700 | 1 | |a Saunders, Mary E. |e Verfasser |4 aut | |
| 700 | 1 | |a Chaddah, Maya R. |e Sonstige |4 oth | |
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| adam_text | IMAGE 1
CONTENTS
PREFACE TO THE TEXT PREFACE TO THE IMMUNOMOVIE BIOGRAPHIES
ACKNOWLEDGMENTS PART I: BASIC IMMUNOLOGY
CHAPTER 1: INTRODUCTION TO THE IMMUNE RESPONSE
A. NON-INDUCED INNATE MECHANISMS
B. INDUCED INNATE MECHANISMS
I. PATTERN RECOGNITION MOLECULES
II. THE COMPLEMENT SYSTEM
III. THE CONCEPT OF DANGER
IV. THE INFLAMMATORY RESPONSE
V. CELLULAR INTERNALIZATION MECHANISMS
VI. NK, 76 T AND NKT CELL ACTIVITIES
V
VII
IX
XI
A. HISTORICAL ORIENTATION
B. THE NATURE OF THE IMMUNE RESPONSE
C. TYPES OF IMMUNE RESPONSES: INNATE AND ADAPTIVE
1. GENERAL FEATURES OF INNATE IMMUNITY
II. GENERAL FEATURES OF ADAPTIVE IMMUNITY
D. INTERPLAY BETWEEN THE INNATE AND ADAPTIVE RESPONSES
E. CLINICAL IMMUNOLOGY
CHAPTER 2: COMPONENTS OF THE IMMUNE SYSTEM
A. CELLS OF THE IMMUNE SYSTEM 1. TYPES OF HEMATOPOIETIC CELLS
II. CELLS OF THE MYELOID LINEAGE
III. CELLS OF THE LYMPHOID LINEAGE
IV. DENDRITIC CELLS
V. MAST CELLS
VI. HEMATOPOIESIS
VII. APOPTOSIS
B. HOW LEUKOCYTES COMMUNICATE
1. INTRACELLULAR COMMUNICATION: SIGNAL TRANSDUCTION
II. INTERCELLULAR COMMUNICATION: CYTOKINES
C. LYMPHOID TISSUES
1. OVERVIEW
II. PRIMARY LYMPHOID TISSUES
III. SECONDARY LYMPHOID TISSUES
D. CELLULAR MOVEMENT IN THE IMMUNE SYSTEM
1. LEUKOCYTE EXTRAVASATION
II. LYMPHOCYTE RECIRCULATION
III. LYMPHOCYTE HOMING
CHAPTER 3: INNATE IMMUNITY
4
4
6
7
7
11
12
15
16 16
16
20
22
22
22
24
24
24
25
28
28
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32
34
34
36
37
41
43 44
44
45
50
51
52
56
CHAPTER 4: THE B CELL RECEPTOR: PROTEINS AND GENES 59
A. IMMUNOGLOBULIN PROTEINS 60
I. THE NATURE OF IMMUNOGLOBULIN PROTEINS 60
II. STRUCTURE OF IMMUNOGLOBULIN PROTEINS 60
III. STRUCTURAL VARIATION IN THE V REGION 62
IV. STRUCTURAL VARIATION IN THE C REGION 62
B. IMMUNOGLOBULIN GENES 67
I. OVERVIEW 67
II. STRUCTURE OF THE IG LOCI 68
III. FROM EXONS TO IG PROTEINS 69
IV. V(D)J RECOMBINATION 70
V. ORDER OF IG LOCUS REARRANGEMENT 71
VI. ANTIBODY DIVERSITY GENERATED BY SOMATIC RECOMBINATION 71
C. ANTIGEN-ANTIBODY INTERACTION 73
I. STRUCTURAL REQUIREMENTS 73
II. INTERMOLECULAR FORCES 74
III. THE STRENGTH OF ANTIGEN-ANTIBODY BINDING 74
IV. CROSS-REACTIVITY 74
CHAPTER 5: B CELL DEVELOPMENT, ACTIVATION AND EFFECTOR FUNCTIONS 79
A. B CELL DEVELOPMENT: MATURATION PHASE I. PRO-B CELLS
II. PRE-B CELLS
III. IMMATURE B CELLS IN THE BONE MARROW: RECEPTOR EDITING
IV. THE TRANSITION TO MATURITY: IGM AND IGD COEXPRESSION
V. MATURE NAIVE B CELLS IN THE PERIPHERY
B. B CELL DEVELOPMENT: DIFFERENTIATION PHASE
I. THE NATURE OF B CELL IMMUNOGENS
II. B CELL ACTIVATION BY TD IMMUNOGENS
III. CELLULAR INTERACTIONS DURING B CELL ACTIVATION
IV. GERMINAL CENTER PROCESSES THAT DIVERSIFY ANTIBODIES
V. PLASMA CELL DIFFERENTIATION
VI. MEMORY B CELL DIFFERENTIATION
C. EFFECTOR FUNCTIONS OF ANTIBODIES
I. NEUTRALIZATION
II. CLASSICAL COMPLEMENT ACTIVATION
III. OPSONIZATION
IV. ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC)
D. IMMUNOGLOBULIN ISOTYPES IN BIOLOGICAL CONTEXT
I. NATURAL DISTRIBUTION OF ANTIBODIES IN THE BODY
II. MORE ABOUT IGM
III. MORE ABOUT IGD
IV. MORE ABOUT IGG
V. MORE ABOUT IGA
VI. MORE ABOUT IGE
80
80 80
82
82
83
83
83
86
88
89
92
93
94
94 94
95
95
96
96 96
97
97
97
98
XTFI
IMAGE 2
CONTENTS
CHAPTER 6: THE MAJOR HISTOCOMPATIBILITY COMPLEX 101
A. OVERVIEW OF THE MAJOR HISTOCOMPATIBILITY COMPLEX 102 I. HLA COMPLEX
102
II. H-2 COMPLEX 104
B. MHC CLASS I AND CLASS II PROTEINS 104
I. MHC CLASS I PROTEINS 105
II. MHC CLASS II PROTEINS 106
III. X-RAY CRYSTALLOGRAPHY OF MHC CLASS I AND II MOLECULES 107
C. MHC CLASS I AND CLASS II GENES 107
I. POLYCENICITY OF MHC CLASS I AND II GENES 107
II. POLYMORPHISM OF MHC CLASS I AND II GENES 109
III. CODOMINANCE OF MHC EXPRESSION 109
IV. MHC HAPLOTYPES 110
V. EXPRESSION OF MHC GENES 110
D. PHYSIOLOGY OF THE MHC 110
I. POLYMORPHISM AND THE BIOLOGICAL ROLE OF THE MHC 110
II. MHC AND IMMUNE RESPONSIVENESS 110
III. MHC AND DISEASE PREDISPOSITION 111
CHAPTER 7: ANTIGEN PROCESSING AND PRESENTATION 115
A. OVERVIEW OF ANTIGEN PROCESSING AND PRESENTATION 116
B. EXOGENOUS ANTIGEN PROCESSING 117
I. PROFESSIONAL APCS 117
II. GENERATION OF PEPTIDES VIA THE EXOGENOUS PATHWAY 120
III. MHC CLASS II MOLECULES IN THE RER AND ENDOSOMES 121
IV. PEPTIDE LOADING ONTO MHC CLASS II 122
C. ENDOGENOUS ANTIGEN PROCESSING 122
I. GENERATION OF PEPTIDES VIA THE ENDOGENOUS PATHWAY 122
II. TRANSPORT OF PEPTIDES INTO THE ENDOPLASMIC RETICULUM 122
III. MHC CLASS I MOLECULES IN THE RER 123
IV. PEPTIDE LOADING ONTO MHC CLASS I 124
D. CROSS-PRESENTATION ON MHC CLASS I 124
E. OTHER METHODS OF ANTIGEN PRESENTATION 125
I. ANTIGEN PRESENTATION BY MHC CLASS IB MOLECULES 125
II. NON-PEPTIDE ANTIGEN PRESENTATION BY CD1 MOLECULES 125
CHAPTER 8: THE T CELL RECEPTOR: PROTEINS AND GENES 129
A. TCR PROTEINS AND ASSOCIATED MOLECULES I. BASIC TCR STRUCTURE
II. THE CD3 COMPLEX
III. THE CD4 AND CD8 CORECEPTORS
B. TCR GENES
I. STRUCTURE OF THE TCR LOCI
II. ORDER OF REARRANGEMENT
III. V(D)J RECOMBINATION
IV. TCR GENE TRANSCRIPTION AND PROTEIN ASSEMBLY
V. TCR DIVERSITY
C. TCR-ANTIGEN INTERACTION
130
130 131
132
133
133
135
135
136
136
137
CHAPTER 9: T CELL DEVELOPMENT, ACTIVATION AND EFFECTOR FUNCTIONS 141
A. T CELL DEVELOPMENT I. COMPARISON OF B AND T CELL DEVELOPMENT
II. COLONIZATION OF THE THYMUS
III. THYMOCYTE MATURATION IN THE THYMUS
B. T CELL ACTIVATION
I. MEETING OF NAIVE T CELLS AND DCS
II. SIGNAL 1
III. SIGNAL 2
IV. SIGNAL 3
C. TH CELL DIFFERENTIATION AND EFFECTOR FUNCTION
I. OVERVIEW
II. DIFFERENTIATION OF TH CELLS INTO THL AND TH2 EFFECTORS
III. ACTIVATION OF THL AND TH2 CELLS
IV. EFFECTOR FUNCTIONS OF THL AND TH2 CELLS
V. NATURE OF TH RESPONSES
D. TC CELL DIFFERENTIATION AND EFFECTOR FUNCTION
I. OVERVIEW
II. GENERATION AND ACTIVATION OF CTLS
III. MECHANISMS OF TARGET CELL DESTRUCTION
IV. DISSOCIATION
E. CONTROL OF EFFECTOR T CELLS
F. MEMORY T CELLS
I. MEMORY T CELL LOCALIZATION
II. MEMORY T CELL ACTIVATION
III. MEMORY T CELL EFFECTOR FUNCTIONS
IV. MEMORY T CELL LIFE SPAN
CHAPTER 10: REGULATION OF IMMUNE RESPONSES IN
THE PERIPHERY
A. SELF TOLERANCE OF LYMPHOCYTES IN THE PERIPHERY I. T CELL SELF
TOLERANCE
II. B CELL SELF TOLERANCE
B. CONTROL OF LYMPHOCYTE RESPONSES IN THE PERIPHERY
I. REGULATORY T CELLS
II. IMMUNOSUPPRESSIVE CYTOKINES
III. IMMUNE DEVIATION
IV. IMMUNE PRIVILEGE
C. SPECIAL TOLERANCE SITUATIONS
I. MATERNAL-FETAL TOLERANCE
II. NEONATAL TOLERANCE
D. EXPERIMENTAL TOLERANCE
I. CHARACTERISTICS OF EXPERIMENTAL TOLERANCE
II. CHARACTERISTICS OF TOLEROGENS
CHAPTER 11: INK, Y8 T AND NKT CELLS
142 142
142
144
149
149
149
149
151
151
151
151
152
153
155
155
155
155
156
156
156
157
157
158
158
158
161
162 162
164
164
164
167
167
167
167
167
168
169
169
169
173
A. NATURAL KILLER (NK) CELLS I. OVERVIEW
II. EFFECTOR FUNCTIONS
III. DEVELOPMENT
174
174
175
177
XIV
IMAGE 3
CONTENTS
B. Y 5T CELLS I. OVERVIEW
II. ANATOMICAL DISTRIBUTION
III. ANTIGEN RECOGNITION AND ACTIVATION
IV. EFFECTOR FUNCTIONS
V. DEVELOPMENT
C. NKT CELLS
I. OVERVIEW
II. ANTIGEN RECOGNITION AND ACTIVATION
III. EFFECTOR FUNCTIONS
IV. DEVELOPMENT
CHAPTER 12: MUCOSAL AND CUTANEOUS IMMUNITY
A. THE NATURE OF PATHOGENS AND DISEASE
B. INNATE DEFENSE AGAINST PATHOGENS
C. IMMUNITY TO EXTRACELLULAR BACTERIA
I. DISEASE MECHANISMS
II. IMMUNE EFFECTOR MECHANISMS
III. EVASION STRATEGIES
D. IMMUNITY TO INTRACELLULAR BACTERIA
I. DISEASE MECHANISMS
II. IMMUNE EFFECTOR MECHANISMS
III. EVASION STRATEGIES
E. IMMUNITY TO VIRUSES
I. DISEASE MECHANISMS
II. IMMUNE EFFECTOR MECHANISMS
III. EVASION STRATEGIES
F. IMMUNITY TO PARASITES
I. DISEASE MECHANISMS
II. IMMUNE EFFECTOR MECHANISMS
III. EVASION STRATEGIES
G. IMMUNITY TO FUNGI
I. DISEASE MECHANISMS
II. IMMUNE EFFECTOR MECHANISMS
III. EVASION STRATEGIES
H. PRIONS
178
178
178
179
180
181
182
182
182
182
183
187
A. MUCOSAL IMMUNITY 188
I. OVERVIEW 188
II. THE GUT-ASSOCIATED LYMPHOID TISSUE (GALT) 189
III. THE NASOPHARYNX- AND BRONCHI-ASSOCIATED LYMPHOID TISSUES
(NALT AND BALT) 191
IV. IMMUNE RESPONSES IN THE GALT, NALT AND BALT 192
V. IMMUNE RESPONSES IN OTHER MALT 195
B. CUTANEOUS IMMUNITY 196
I. COMPONENTS OF THE SALT 196
II. IMMUNE RESPONSES IN THE SALT 198
PART II: CLINICAL IMMUNOLOGY 203
CHAPTER 13: IMMUNITY TO INFECTION 205
206
206
207
207
208
210
210
210
211
213
214
214
215
217
220
220
220
221
223
223
223
223
224
CHAPTER 14: VACCINATION 227
A. VACCINE DESIGN I. EFFICACY AND SAFETY
II. PATHOGEN CHARACTERISTICS
B. TYPES OF VACCINES
I. LIVE, ATTENUATED VACCINES
II. KILLED VACCINES
III. TOXOIDS
IV. SUBUNIT VACCINES
V. PEPTIDE VACCINES
VI. DNA VACCINES
C. ADJUVANTS AND DELIVERY VEHICLES
I. ADJUVANTS
II. DELIVERY VEHICLES
D. PROPHYLACTIC VACCINES
I. STANDARD IMMUNIZATIONS
II. VACCINES FOR SPECIAL SITUATIONS
E. THE DARK SIDE OF VACCINES
F. PASSIVE IMMUNIZATION
G. FUTURE DIRECTIONS
I. PROPHYLACTIC VACCINES
II. THERAPEUTIC VACCINES
CHAPTER 15: HIV AND ACQUIRED
IMMUNODEFICIENCY SYNDROME
A. WHAT IS HIV?
I. OVERVIEW OF THE HIV-1 LIFE CYCLE
II. HIV-1 STRUCTURE
B. HIV INFECTION AND AIDS
I. MOLECULAR EVENTS
II. CLINICAL EVENTS
III. HIV CLASSIFICATION
C. IMMUNE RESPONSES DURING HIV INFECTION
I. TH RESPONSES
II. CTL RESPONSES
III. ANTIBODY RESPONSES
IV. CYTOKINES
V. NK CELLS
VI. COMPLEMENT
D. HOST FACTORS INFLUENCING THE COURSE OF HIV
INFECTION
I. TRANSMISSION OF HIV
II. RESISTANCE TO HIV INFECTION
III. CLINICAL COURSE VARIABILITY
E. ANIMAL MODELS OF AIDS
I. PRIMATE MODELS OF AIDS
II. MOUSE MODELS OF AIDS
F. HIV VACCINES
I. OVERVIEW
II. BARRIERS TO HIV VACCINE DEVELOPMENT
229
229
230
231
231
232
232
232
233
233
234
234
234
234
234
239
241
242
242
242
244
247
249 249
250
252
252
252
254
255
255
255
256
256
256
256
256
256
257
257
257
258
258
258
258
258
XV
IMAGE 4
CONTENTS
C. TREATMENT OF HIV INFECTION WITH ANTI-RETROVIRAL DRUGS 259 I. CLASSES
OF ANTI-RETROVIRAL DRUGS 259
II. LIMITATIONS OF ANTI-RETROVIRAL DRUGS 260
CHAPTER 16: TUMOR IMMUNOLOGY 263
A. TUMOR BIOLOGY 1. TUMORS AND CANCERS
II. CARCINOGENESIS
III. TUMORIGENIC GENETIC ALTERATIONS
B. TUMOR ANTIGENS
1. TUMOR-ASSOCIATED ANTIGENS (TAAS)
II. TUMOR-SPECIFIC ANTIGENS (TSAS)
C. IMMUNE RESPONSES TO TUMOR CELLS
1. ACUTE INFLAMMATION
II. 78 T CELLS
III. NKT CELLS
IV. NK CELLS
V. (X* T CELLS
VI. B CELLS
D. HURDLES TO EFFECTIVE ANTI-TUMOR IMMUNITY
1. SECRETION OF IMMUNOSUPPRESSIVE CYTOKINES
II. PROMOTION OF REGULATORY O* T CELL RESPONSES
III. INHIBITION OF T CELL SIGNALING
IV. AVOIDANCE OF RECOGNITION
E. CANCER THERAPY
1. CONVENTIONAL THERAPIES
II. IMMUNOTHERAPY
CHAPTER 17: TRANSPLANTATION
A. THE MOLECULAR BASIS OF GRAFT REJECTION 1. IMMUNE RECOGNITION OF
ALLOGENEIC MHC MOLECULES
II. IMMUNE RECOGNITION OF MINOR HISTOCOMPATIBILITY ANTIGENS
B. SOLID ORGAN TRANSPLANTATION
1. IMMUNOLOGY OF SOLID ORGAN TRANSPLANT REJECTION
II. CLINICAL GRAFT REJECTION
III. GRAFT-VERSUS-HOST DISEASE (GVHD) IN SOLID ORGAN TRANSPLANTS
C. MINIMIZING GRAFT REJECTION
1. HLA MATCHING
II. ALLOANTIBODY ANALYSIS
III. IMMUNOSUPPRESSION
IV. INDUCTION OF GRAFT TOLERANCE
D. HEMATOPOIETIC CELL TRANSPLANTATION
1. GRAFT REJECTION IN HCT
II. GRAFT-VERSUS-HOST DISEASE (GVHD) IN HCT
III. GRAFT-VERSUS-LEUKEMIA (GVL) EFFECT
E. BLOOD TRANSFUSIONS
CHAPTER 18: IMMUNE HYPERSENSITIVITY
264 264
265
267
269
270
270
271
271
272
272
273
273
273
273
274
274
274
274
274
274
275
283
284 284
286
287
287
288
290
290
290
293
293
293
295
295
296
296
296
301
A. TYPE I HYPERSENSITIVITY: IGE-MEDIATED OR IMMEDIATE
I. WHAT IS TYPE I HS?
II. MECHANISMS UNDERLYING TYPE I HS
302
302
302
III. EXAMPLES OF TYPE I HS 306
IV. DETERMINANTS ASSOCIATED WITH TYPE I HS 308
V. THERAPY OF TYPE I HS 310
B. TYPE II HYPERSENSITIVITY: DIRECT ANTIBODY-MEDIATED
CYTOTOXIC HYPERSENSITIVITY 311
I. WHAT IS TYPE II HS? 311
II. MECHANISMS UNDERLYING TYPE II HS 311
III. EXAMPLES OF TYPE II HS 312
C. TYPE III HYPERSENSITIVITY: I M M U NE COMPLEX-MEDIATED
HYPERSENSITIVITY 314
I. WHAT IS TYPE III HS? 314
II. MECHANISM UNDERLYING TYPE III HS 314
III. EXAMPLES OF TYPE III HS 315
D. TYPE IV HYPERSENSITIVITY: DELAYED-TYPE OR CELL-MEDIATED
HYPERSENSITIVITY 316
I. WHAT IS TYPE IV HS? 316
II. EXAMPLES OF TYPE IV HS AND THEIR MECHANISMS 316
CHAPTER 19: AUTOIMMUNE DISEASES 321
A. WHAT IS AN AUTOIMMUNE DISEASE? 322
B. MECHANISMS UNDERLYING AUTOIMMUNE DISEASES 323
I. INFLAMMATION 323
II. MOLECULAR MIMICRY BY PATHOGEN ANTIGENS 324
III. INHERENT DEFECTS IN IMMUNE SYSTEM COMPONENTS 325
IV. EPITOPE SPREADING 326
C. EXAMPLES OF AUTOIMMUNE DISEASES 327
I. SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 327
II. RHEUMATOID ARTHRITIS (RA) 327
III. ACUTE RHEUMATIC FEVER (ARF) 328
IV. TYPE 1 DIABETES MELLITUS (T1DM) 328
V. MULTIPLE SCLEROSIS (MS) 329
VI. ANKYLOSING SPONDYLITIS (AS) 330
VII. AUTOIMMUNE THYROIDITIS: GRAVES DISEASE (GD) AND
HASHIMOTO S THYROIDITIS (HT) 330
VIII. MYASTHENIA GRAVIS (MG) 331
IX. GUILLAIN-BARRE SYNDROME (GBS) 331
X. INFLAMMATORY BOWEL DISEASE (IBD): CROHN S DISEASE (CD) AND
ULCERATIVE COLITIS (UC) 331
D. DETERMINANTS OF AUTOIMMUNE DISEASES 332
I. GENETIC PREDISPOSITION 332
II. EXTERNAL TRIGGERS 334
III. HORMONAL INFLUENCES 336
E. THERAPY OF AUTOIMMUNE DISEASES 337
I. CONVENTIONAL THERAPIES 337
II. IMMUNOTHERAY 337
CHAPTER 20: HEMATOPOIETIC CANCERS 343
A. OVERVIEW OF THE BIOLOGY AND TREATMENT OF HEMATOPOIETIC CANCERS 344
I. WHAT ARE HEMATOPOIETIC CANCERS? 344
II. HEMATOPOIETIC CANCER CARCINOGENESIS 345
III. CLINICAL ASSESSMENT AND TREATMENT OF HCS 346
XVI
IMAGE 5
CONTENTS
B. LEUKEMIAS
I. ACUTE MYELOID LEUKEMIA (AML)
II. CHRONIC MYELOGENOUS LEUKEMIA (CML)
III. ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
IV. CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
C. MYELOMAS
I. CLINICAL FEATURES
II. GENETIC ABERRATIONS
III. TREATMENT
D. LYMPHOMAS
. HODGKIN S WMPHOMFT (HL)
II. NON-HODGKIN S LYMPHOMA (NHL)
APPENDIX A: SELECTED LANDMARK DISCOVERIES
IN IMMUNOLOGY
348
348
349
351
352
352
353
354
354
354
355
357
363
APPENDIX B: NOBEL PRIZES AWARDED FOR WORK IN
IMMUNOLOGY 365
APPENDIX C: COMPARATIVE IMMUNOLOGY 367
APPENDIX
APPENDIX
APPENDIX
D: SELECTED CD MARKERS
E: CYTOKINES, CHEMOKINES AND RECEPTORS
F: LABORATORY USES OF ANTIBODIES
371
381
387
A. SOURCES OF ANTIBODIES 387
I. ANTISERA 387
II. MONOCLONAL ANTIBODIES FROM HYBRIDOMAS 387
B. EXPERIMENTAL TECHNIQUES USING ANTIBODIES 388
I. TECHNIQUES BASED ON IMMUNE COMPLEX FORMATION 388
II. TECHNIQUES BASED ON TAGGING ANTIGEN-ANTIBODY PAIRS 388
III. TECHNIQUES FOR THE ISOLATION AND CHARACTERIZATION OF ANTIGENS 389
GLOSSARY
INDEX
399
423
XVII
|
| any_adam_object | 1 |
| author | Mak, Tak W. 1945- Saunders, Mary E. |
| author_GND | (DE-588)131833316 |
| author_facet | Mak, Tak W. 1945- Saunders, Mary E. |
| author_role | aut aut |
| author_sort | Mak, Tak W. 1945- |
| author_variant | t w m tw twm m e s me mes |
| building | Verbundindex |
| bvnumber | BV035697559 |
| callnumber-first | Q - Science |
| callnumber-label | QR186 |
| callnumber-raw | QR186 |
| callnumber-search | QR186 |
| callnumber-sort | QR 3186 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | WF 9820 |
| ctrlnum | (OCoLC)191090303 (DE-599)BVBBV035697559 |
| dewey-full | 616.07/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/9 |
| dewey-search | 616.07/9 |
| dewey-sort | 3616.07 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV035697559 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:43:40Z |
| institution | BVB |
| isbn | 9780123741639 0123741637 |
| language | English |
| lccn | 2008001748 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017751537 |
| oclc_num | 191090303 |
| open_access_boolean | |
| owner | DE-29 DE-11 |
| owner_facet | DE-29 DE-11 |
| physical | XVII, 436 S. zahlr. Ill. u. graph. Darst. 28 cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Elsevier |
| record_format | marc |
| spelling | Mak, Tak W. 1945- Verfasser (DE-588)131833316 aut Primer to the immune response Tak W. Mak and Mary E. Saunders ; contrib. Maya R. Chaddah ... Heidelberg Elsevier 2008 XVII, 436 S. zahlr. Ill. u. graph. Darst. 28 cm txt rdacontent n rdamedia nc rdacarrier Includes index. Immune response Immunology Immune System Immune System Diseases Immunity Immunologie (DE-588)4026637-0 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Immunologie (DE-588)4026637-0 s DE-604 Saunders, Mary E. Verfasser aut Chaddah, Maya R. Sonstige oth SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017751537&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mak, Tak W. 1945- Saunders, Mary E. Primer to the immune response Immune response Immunology Immune System Immune System Diseases Immunity Immunologie (DE-588)4026637-0 gnd |
| subject_GND | (DE-588)4026637-0 (DE-588)4151278-9 |
| title | Primer to the immune response |
| title_auth | Primer to the immune response |
| title_exact_search | Primer to the immune response |
| title_full | Primer to the immune response Tak W. Mak and Mary E. Saunders ; contrib. Maya R. Chaddah ... |
| title_fullStr | Primer to the immune response Tak W. Mak and Mary E. Saunders ; contrib. Maya R. Chaddah ... |
| title_full_unstemmed | Primer to the immune response Tak W. Mak and Mary E. Saunders ; contrib. Maya R. Chaddah ... |
| title_short | Primer to the immune response |
| title_sort | primer to the immune response |
| topic | Immune response Immunology Immune System Immune System Diseases Immunity Immunologie (DE-588)4026637-0 gnd |
| topic_facet | Immune response Immunology Immune System Immune System Diseases Immunity Immunologie Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017751537&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT maktakw primertotheimmuneresponse AT saundersmarye primertotheimmuneresponse AT chaddahmayar primertotheimmuneresponse |