Biomaterials for treating skin loss:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press [u.a.]
2009
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Woodhead publishing in materials
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 246 S. Ill., graph. Darst. |
| ISBN: | 1420099892 9781420099898 9781845693633 |
Internformat
MARC
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| 245 | 1 | 0 | |a Biomaterials for treating skin loss |c ed. by Dennis Orgill ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press [u.a.] |c 2009 | |
| 300 | |a XIV, 246 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Woodhead publishing in materials | |
| 650 | 4 | |a Skin |x Diseases |x Treatment | |
| 650 | 4 | |a Skin |x Wounds and injuries |x Treatment | |
| 650 | 4 | |a Biomedical materials | |
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Datensatz im Suchindex
| _version_ | 1804139393047330816 |
|---|---|
| adam_text | Contents
Contributor contact details
xi
Part I Introduction
1
Introduction: development of skin substitutes
3
D. P. Orgill, Brigham and Women s Hospital, USA
C. Blanco, Joseph M. Still Research Foundation, USA
1.1
Historical development
3
1.2
Skin regeneration
5
1.3
Intellectual property and financial issues
6
1.4
Changing medical practice
7
1.5
References
7
2
Skin replacement products and markets
9
E. Garfein, Montefiore Medical Center, USA
9
10
12
15
16
16
3
Biomechanics of skin
18
V. Saxena, Massachusetts Institute of Technology, USA
3.1
Skin biomechanics
18
3.2
Structure of skin
19
3.3
Definition of mechanical properties
20
3.4
Wounded skin contraction
21
3.5
Modeling skin using finite element methods
22
2.1
Introduction
2.2
Indications for skin replacement
2.3
The products
2.4
The marketplace
2.5
Conclusion
2.6
References
vi
Contents
3.6
Forces
on cells
3.7
Conclusion
3.8
References
23
23
23
4
The pathophysiologic basis for wound
25
healing and cutaneous regeneration
D. T. Nguyen, D. P. Orgill and G. F. Murphy,
Brigham and Women s Hospital, USA.
4.1
Introduction
25
4.2
Skin microanatomy and physiology
26
4.3
Wound repair and scar formation
32
4.4
Pathologic wound healing
38
4.5
Comparison between fetal and post-natal skin
39
4.6
Wound repair versus regeneration: fundamental differences
41
4.7
Issues of stem cells and cellular plasticity
45
4.8
Historic developments and future trends
49
4.9
References
51
5
Skin grafts
58
S. D. IMAHARA and M. B. KLEIN,
University of Washington, USA
5.1
Definitions
58
5.2
Skin anatomy and physiology
58
5.3
Autologous skin grafts
61
5.4
Principles of allogeneic skin grafts
67
5.5
Principles of skin xenografts
72
5.6
Future trends
73
5.7
Summary
74
5.8
References
74
6
Understanding the cellular basis of skin growth
80
L. Guo, Brigham and Women s Hospital, USA
6.1
Introduction
80
6.2
Structure of the skin
80
6.3
Skin development and growth
83
6.4
Experimental models for predicting cellular interactions
85
6.5
Conclusions
86
6.6
References
86
Contents
vii
7
The regulatory approval process for
biomaterials
87
for treating skin loss
J. E.
O Grady,
Integra LifeSciences Corporation, USA
7.1
Introduction
87
7.2
Regulatory requirements
88
7.3
Medical device approval in the European Union
91
7.4
Combination products
93
7.5
The Global Harmonization Task Force (GHTF)
101
7.6
Quality system
101
7.7
Clinical trials
102
7.8
Humanitarian device exemption
107
7.9
Human tissue and cellular based products
108
7.10
User fees
109
7.11
Future trends in the regulatory process
109
7.12
References
110
Part II Epidermal and dermal replacement technologies
8
Alternative delivery of keratinocytes for
115
epidermal replacement
F. M. Wood, McComb Research Foundation, Burns Service of
Western Australia, University of Western Australia, Australia
115
117
117
118
119
120
9
Enhancing skin epidermal stability
124
J. R.
Sharpe
and
N.
R. Jordan, Blond Mclndoe Research
Foundation, UK; L. J. CURRIE, Derriford Hospital, UK
9.1
Introduction
124
9.2
Fibrin as a repair material
125
9.3
Hyaluronic acid and
Laserskin®
as a repair material
129
9.4
Summary
136
9.5
Future trends
137
9.6
References
138
8.1
Introduction
8.2
Methods of keratinocyte delivery
8.3
Direct application
8.4
Carrier systems
8.5
Summary
8.6
References
viii Contents
10
Human-derived acellular matrices for dermal
142
replacement
C. Т.
Wagner,
R. T. Owens, J. R.
Harper and
D. J.
Mcquillan,
LifeCell Corporation, USA
10.1
Introduction
142
10.2
Processing
native tissues
146
10.3
Material characterization
149
10.4
Functional evaluation
159
10.5
Universality of acellular regenerative tissue matrices
164
for soft tissue replacement
10.6
Future trends
167
10.7
Sources of further information and advice
168
10.8
References
168
10.9
Disclosure
173
11
Lyophilized xenogenic products for skin
174
replacement
N.
Melo
and R. Sheridan, Massachusetts General Hospital, USA
11.1
Introduction
174
11.2
Temporary skin substitutes
174
11.3
Permanent skin substitutes
175
11.4
Conclusions
178
11.5
References
178
Part III Combined dermal and epidermal replacement
12
Cultured skin substitutes
183
H. M. Powell, Shriners Hospitals for Children, USA
S. T.
Boyce, Shriners Hospitals for Children and
University of Cincinnati, USA
12.1
Introduction
183
12.2
Medical and surgical objectives for cultured skin
184
substitutes (CSS)
12.3
Design and composition of cultured skin substitutes
185
12.4
Clinical considerations
191
12.5
Clinical assessment
193
12.6
Regulatory issues
194
12.7
Future trends
195
12.8
Conclusions
200
12.9
References
200
Contents
¡χ
13
Use
of keratinocytes in combination with a
207
dermal replacement to treat skin loss
G. Pietramaggiori, Brigham and Women s Hospital, USA
13.1
Simultaneous substitution of
dermis
and epidermis:
207
from two-step to one-step skin replacement
13.2
Cell seeding
208
13.3
Methods of delivery of keratinocytes
208
13.4
References
210
14
Principles of skin regeneration
212
I. V. Yannas, Massachusetts Institute of Technology, USA
14.1
Introduction
212
14.2
The central problem of skin regeneration
213
14.3
Experimental variables in studies of skin regeneration
213
14.4
Applications of the wound closure rule
215
14.5
Scar formation may be secondary to wound contraction
216
14.6
Experimental studies of partial regeneration of skin
217
14.7
Regeneration of adult organs other than skin
219
14.8
Antagonistic relationship between contraction
219
and regeneration
14.9
Mechanism of regeneration by use of scaffolds
221
14.10
Future trends
225
14.11
Sources of further information and advice
226
14.12
References
226
15
Summary:
biomaterials
for treating skin loss
231
D. P. Orgill, Brigham and Women s Hospital, USA
C. Blanco, Joseph M. Still Research Foundation, USA
15.1
Technological advances
231
15.2
Changes in the market for skin substitutes
231
15.3
A more normal skin
-
regenerative response
233
15.4
References
234
Index
237
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| indexdate | 2024-07-09T21:43:22Z |
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| spelling | Biomaterials for treating skin loss ed. by Dennis Orgill ... 1. publ. Boca Raton [u.a.] CRC Press [u.a.] 2009 XIV, 246 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Woodhead publishing in materials Skin Diseases Treatment Skin Wounds and injuries Treatment Biomedical materials Biomaterial (DE-588)4267769-5 gnd rswk-swf Haut (DE-588)4023838-6 gnd rswk-swf Haut (DE-588)4023838-6 s Biomaterial (DE-588)4267769-5 s DE-604 Orgill, Dennis Sonstige oth Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017738722&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biomaterials for treating skin loss Skin Diseases Treatment Skin Wounds and injuries Treatment Biomedical materials Biomaterial (DE-588)4267769-5 gnd Haut (DE-588)4023838-6 gnd |
| subject_GND | (DE-588)4267769-5 (DE-588)4023838-6 |
| title | Biomaterials for treating skin loss |
| title_auth | Biomaterials for treating skin loss |
| title_exact_search | Biomaterials for treating skin loss |
| title_full | Biomaterials for treating skin loss ed. by Dennis Orgill ... |
| title_fullStr | Biomaterials for treating skin loss ed. by Dennis Orgill ... |
| title_full_unstemmed | Biomaterials for treating skin loss ed. by Dennis Orgill ... |
| title_short | Biomaterials for treating skin loss |
| title_sort | biomaterials for treating skin loss |
| topic | Skin Diseases Treatment Skin Wounds and injuries Treatment Biomedical materials Biomaterial (DE-588)4267769-5 gnd Haut (DE-588)4023838-6 gnd |
| topic_facet | Skin Diseases Treatment Skin Wounds and injuries Treatment Biomedical materials Biomaterial Haut |
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