Clinical trials in psychiatry:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2008
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | VII, 236 S. Ill., graph. Darst. |
| ISBN: | 9780470513026 |
Internformat
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| 250 | |a 2. ed. | ||
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 2008 | |
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| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Clinical trials | |
| 650 | 4 | |a Mental illness | |
| 650 | 4 | |a Psychiatry |x Research |x Methodology | |
| 650 | 4 | |a Psychiatry |x methods | |
| 650 | 4 | |a Randomized Controlled Trials as Topic |x methods | |
| 650 | 4 | |a Research Design | |
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Datensatz im Suchindex
| _version_ | 1804139370523918336 |
|---|---|
| adam_text | Contents
Preface to the first edition ix
Preface to the second edition xi
1 Treatments, good, bad or worthless - and how do we tell? 1
1.1 Treatments worthless - and worse 1
1.2 A brief history of treating the mentally ill 5
1.3 Summary 11
2 The randomized clinical trial 13
2.1 Introduction 13
2.2 The clinical trial 17
2.3 Ethical issues in clinical trials 29
2.4 Informed consent 33
2.5 Compliance 36
2.6 Summary 40
3 Design issues in clinical trials 43
3.1 Introduction 43
3.2 Clinical trial designs 44
3.3 Methods of randomization 56
3.4 Methods of masking treatments 62
3.5 The size of a clinical trial 63
3.6 Interim analysis 66
3.7 Summary 70
4 Special problems of trials in psychiatry 71
4.1 Introduction 71
4.2 Explanatory versus pragmatic trials 72
4.3 Complex interventions 79
4.4 Outcome measures in psychiatry 81
4.5 Summary 87
vi CONTENTS
5 Some statistical issues in the analysis of psychiatric
trials 89
5.1 Introduction 89
5.2 P-vatues and confidence intervals 90
5.3 Using baseline data 91
5.4 Longitudinal data 97
5.5 Missing values and dropouts in longitudinal data 103
5.6 Multiple outcome measures 108
5.7 Intention-to-treat 109
5.8 Economic evaluation of trials 112
5.9 Number needed to treat 116
5.10 Summary 116
6 Analysing data from a psychiatric trial: an example 119
6.1 Introduction 119
6.2 Beating the Blues 119
6.3 Analysis of the post-treatment BDI scores 123
6.4 Graphical displays and summary measure analysis of longitudinal
data 128
6.5 Random effects models for the BtB data 135
6.6 The dropout problem in the BtB data 142
6.7 Summary 144
7 Systematic reviews and meta-analysis 145
7.1 Introduction 145
7.2 Study selection 148
7.3 Publication bias 151
7.4 The statistics of meta-analysis 153
7.5 Some examples of meta-analysis of psychiatric trials 155
7.6 Summary 160
8 RCTs in psychiatry: threats, challenges and the future 163
8.1 Introduction 163
8.2 Can randomized clinical trials in psychiatry be justified? 164
8.3 Are randomized clinical trials really necessary? 169
8.4 Conflicts of interest 170
8.5 Scandals, trials and tribulations 171
8.6 The future of psychiatric trials 173
8.7 Defending the clinical trial 178
8.8 Summary 179
Appendix A Issues in the management of clinical trials - how
to do if 181
A.I Introduction 181
A.2 Clinical trial protocols 182
A.3 Getting the costs right 185
A.4 Collecting and managing the data 186
A.5 Writing the patient information sheet 188
A.6 Getting informed consent 189
CONTENTS vii
A.7 Maintaining recruitment 190
A.8 Doing the follow-up 191
A.9 Useful web sites 191
Appendix B Writing a trial report 195
B.I Introduction 195
Appendix C Useful software for clinical trials 201
C.I Introduction 201
C.2 Data management 201
C.3 Design 202
C.4 Analysis 202
Bibliography 205
Index 223
|
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| discipline | Medizin |
| edition | 2. ed. |
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| indexdate | 2024-07-09T21:43:00Z |
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| isbn | 9780470513026 |
| language | English |
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| physical | VII, 236 S. Ill., graph. Darst. |
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| spelling | Everitt, Brian 1944- Verfasser (DE-588)121459411 aut Clinical trials in psychiatry Brian S. Everitt ; Simon Wessely 2. ed. Chichester [u.a.] Wiley 2008 VII, 236 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Clinical trials Mental illness Psychiatry Research Methodology Psychiatry methods Randomized Controlled Trials as Topic methods Research Design Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Psychiatrie (DE-588)4047667-4 gnd rswk-swf Methodologie (DE-588)4139716-2 gnd rswk-swf Psychiatrie (DE-588)4047667-4 s Klinisches Experiment (DE-588)4164223-5 s Methodologie (DE-588)4139716-2 s DE-604 Wessely, Simon Verfasser (DE-588)173203043 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017727908&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Everitt, Brian 1944- Wessely, Simon Clinical trials in psychiatry Clinical trials Mental illness Psychiatry Research Methodology Psychiatry methods Randomized Controlled Trials as Topic methods Research Design Klinisches Experiment (DE-588)4164223-5 gnd Psychiatrie (DE-588)4047667-4 gnd Methodologie (DE-588)4139716-2 gnd |
| subject_GND | (DE-588)4164223-5 (DE-588)4047667-4 (DE-588)4139716-2 |
| title | Clinical trials in psychiatry |
| title_auth | Clinical trials in psychiatry |
| title_exact_search | Clinical trials in psychiatry |
| title_full | Clinical trials in psychiatry Brian S. Everitt ; Simon Wessely |
| title_fullStr | Clinical trials in psychiatry Brian S. Everitt ; Simon Wessely |
| title_full_unstemmed | Clinical trials in psychiatry Brian S. Everitt ; Simon Wessely |
| title_short | Clinical trials in psychiatry |
| title_sort | clinical trials in psychiatry |
| topic | Clinical trials Mental illness Psychiatry Research Methodology Psychiatry methods Randomized Controlled Trials as Topic methods Research Design Klinisches Experiment (DE-588)4164223-5 gnd Psychiatrie (DE-588)4047667-4 gnd Methodologie (DE-588)4139716-2 gnd |
| topic_facet | Clinical trials Mental illness Psychiatry Research Methodology Psychiatry methods Randomized Controlled Trials as Topic methods Research Design Klinisches Experiment Psychiatrie Methodologie |
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