Collateral circulation of the heart:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIV, 418 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9781848823419 |
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| 100 | 1 | |a Seiler, Christian |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Collateral circulation of the heart |c Christian Seiler |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2009 | |
| 300 | |a XIV, 418 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Collateral Circulation |x physiology | |
| 650 | 4 | |a Coronary Circulation |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804139305520594944 |
|---|---|
| adam_text | Contents
1
Relevance of the Human Coronary Collateral Circulation
......... 1
1.1
Historical Aspects
................................... 1
1.1.1
Introduction
.................................. 1
1.1.2
First Observations of Collateral Vessels
............ 3
1.1.3
Post-mortem Assessment
........................ 8
1.1.4
In Vivo Assessment
............................ 20
1.2
Interspecies
Differences
.............................. 27
1.2.1
Introduction
.................................. 27
1.2.2
Pig Versus Dog as a Model for the Human Coronary
Collateral Circulation
.......................... 28
1.2.3
Extensive
Interspecies
Comparison of the Coronary
Collateral Circulation
.......................... 33
1.3
Individual Relevance
................................ 35
1.3.1
Introduction
.................................. 35
1.3.2
Collaterals and Transcoronary Ablation of
Šeptal
Hypertrophy
................................. 36
1.3.3
Coronary Collateral Steal
....................... 39
1.3.4
Risk of Coronary Restenosis and Collateral
Flow
........................................ 40
1.3.5
Beneficial Effect of Collaterals on Myocardial
Salvage
...................................... 41
1.4
Collective Prognostic Relevance
........................ 46
1.4.1
Introduction
.................................. 47
1.4.2 Endpoints
for Defining Prognosis and Assessment
of Collateral Flow
............................. 47
1.4.3
Acute Coronary Artery Disease and Clinical Events
in Relation to Collaterals
....................... 52
1.4.4
Chronic Coronary Artery Disease and Clinical Events
in Relation to Collaterals
....................... 56
Abbreviations
........................................... 63
References
.............................................. 64
Contents
Assessment of the Human Coronary Collateral Circulation
........ 71
2.1
Theoretical Aspects in the Assessment of the Coronary
Collateral Circulation
................................ 71
2.1.1
Introduction
.................................. 72
2.1.2
Coronary Blood Flow Measurements in the Animal
Model
....................................... 72
2.1.3
Structural Design and Function of the Coronary
Circulation
................................... 73
2.1.4
Signs of Developing Tolerance to Myocardial
Ischaemia
.................................... 82
2.2
Non-invasive Characterization of Collaterals
............. 89
2.2.1
Indicators for the Coronary Collateral
Circulation
................................... 89
2.2.2
The Surface Lead
ECG
for Estimation of the
Collateral Circulation
.......................... 90
2.3
The Coronary Occlusion Model
........................ 97
2.3.1
Introduction
.................................. 98
2.3.2
Natural Occlusion Model
....................... 100
2.3.3
Artificial Occlusion Model
...................... 104
2.3.4
Angina Pectoris and
ECG
During Coronary
Occlusion
.................................... 106
2.3.5 LV
Function During Coronary Occlusion
..........
Ill
2.4
Angiographie
Collateral Assessment
.................... 114
2.4.1
Introduction
.................................. 115
2.4.2
Angiographie
Collateral Pathways
................ 116
2.4.3
Qualitative
Angiographie
Methods
................ 119
2.4.4 Semiquantitative
Angiographie
Methods
........... 123
2.4.5
Washout Collaterometry
........................ 124
2.5
Quantitative Coronary Pressure and
Doppler
Sensor
Measurements
...................................... 126
2.5.1
Introduction
.................................. 127
2.5.2
Determinants of Distal Coronary
Occlusive
Pressure
..................................... 130
2.5.3
Validation of Pressure-Derived Collateral
Flow Index
................................... 131
2.5.4
Technical Considerations, Limitations, Pitfalls and
Risks of Collateral Flow Index Measurements
....... 142
2.6
Quantitative Collateral
Perfusion
Measurements
.......... 149
2.6.1
Myocardial Contrast Echocardiography for Collateral
Perfusion
Measurement
......................... 149
2.6.2
Relevance of Direct Coronary Pressure-Flow
Measurements
................................ 153
Abbreviations
........................................... 155
References
.............................................. 156
Contents
Pathogenesis
of the
Human
Coronary Collateral Circulation
....... 165
3.1
Introduction
....................................... 165
3.2
Frequency Distribution of Collateral Flow in Humans
...... 168
3.2.1
Introduction
.................................. 168
3.2.2
Prevalence of Collaterals in the Absence of CAD
..... 169
3.2.3
Prevalence of Collaterals in
Non-occlusive CAD
..... 180
3.2.4
Prevalence of Collaterals in
Occlusive CAD
......... 184
3.3
Clinical Determinants of Collateral Flow
................ 188
3.3.1
Introduction
.................................. 189
3.3.2
Determinants of Preformed Coronary
Collaterals
................................... 191
3.3.3
Determinants of Collateral Function in CAD
....... 196
3.4
Cellular Determinants of Collateral Flow
................ 205
3.4.1
Introduction
.................................. 206
3.4.2
Trigger of Arteriogenesis
........................ 206
3.4.3
Endothelial Activation
......................... 209
3.4.4
The Role of Monocytes
......................... 213
3.4.5
The Role of Lymphocytes
....................... 219
3.4.6
The Role of Stem and Progenitor Cells
............. 219
3.5
Genetic Determinants of Collateral Flow
................ 221
3.5.1
Introduction
.................................. 221
3.5.2
Evidence from Experimental Studies
............... 222
3.5.3
Genetic Markers of Human Coronary Collaterals
.... 224
Abbreviations
........................................... 226
References
.............................................. 228
Pathophysiology of the Human Coronary Collateral Circulation
.... 235
4.1
Introduction
....................................... 235
4.2
Fluid Shear Stress and
Vasomotor
Function
.............. 235
4.2.1
Introduction
.................................. 236
4.2.2
Limited and Adaptive Arterial Wall Shear Stress
..... 237
4.2.3
Flow-Mediated Vascular Function in Native and
Collateral Arteries
............................. 242
4.3
Vascular Resistance Distribution and the Collateral
Network
.......................................... 255
4.3.1
Introduction
.................................. 255
4.3.2
Redistribution of Blood due to Altering Microvascular
Resistances
................................... 256
4.3.3
Redistribution of Blood due to Altering
Macrovascular Resistances
...................... 265
4.4
Stimuli for Lowering Coronary Collateral Resistance
....... 271
4.4.1
Introduction
.................................. 271
4.4.2
Neurohumoral
and Pharmacological Stimuli
........ 271
4.4.3
Single and Repetitive Bouts of Myocardial
Ischaemia
.................................... 281
xiv Contents
4.5 Extracoronary
Physical Determinants of Collateral
Flow
............................................. 286
4.5.1
Introduction
.................................. 287
4.5.2 LV
Preload, Diastolic Coronary
Perfusion
Pressure
and Heart Rate
............................... 288
4.5.3 LV
Contraction
............................... 294
4.5.4 LV
Afterload
................................. 296
Abbreviations
........................................... 297
References
.............................................. 297
5
Therapeutic Promotion of the Human Coronary Collateral
Circulation
............................................. 305
5.1
Introduction
....................................... 305
5.2
Angiogenic Therapy
................................. 307
5.2.1
Angiogenesis
................................. 308
5.2.2
Angiogenic Protein and Gene Delivery
............. 310
5.2.3
Other Pharmacological Substances with Potential
Angiogenic Activity
............................ 327
5.3
Arteriogenic Therapy
................................ 332
5.3.1
Arteriogenesis
................................ 333
5.3.2
Arteriogenic Substances
........................ 340
5.4
Cell-Based Promotion of the Collateral Circulation
........ 356
5.4.1
Introduction
.................................. 357
5.4.2
Vasculogenesis
................................ 357
5.4.3
Cell-Based Therapy of Myocardial Ischaemia
in Humans
................................... 360
5.5
Physical Promotion of the Collateral Circulation
.......... 364
5.5.1
Introduction
.................................. 365
5.5.2
Recurrent Increase in Cardiac Output
............. 367
5.5.3
Prolongation of Diastole
........................ 381
5.5.4
Diastolic
Perfusion
Pressure Augmentation
......... 384
5.5.5
Coronary Back Pressure Augmentation
............ 386
5.6
Issues of Neovascularization to be Resolved
.............. 388
5.6.1
Introduction
.................................. 389
5.6.2
Arteriogenesis Versus Atherogenesis
............... 389
5.6.3
Neovascularization and Tumour Growth
........... 390
5.6.4
Growth Factor Delivery Mode
................... 391
Abbreviations
........................................... 393
References
.............................................. 394
Index
..................................................... 409
Established options for revasculari/ation
include
angioplasty ant) .surgical bypass, both
ot which are unsuitable in 2O-3O°(> ol patients
in whom the extent ol coronary atherosclerosis
is especially
sexére.
An alternative treatment
strategy for rcvasculari/ation is therefore
warranted both to control symptoms as well as
to alter the course ol advanced coronary artery
disease. An ideal candidate to till in this gap is
therapeutic promotion of coronary collateral
growth, that is, the induction oi natural
anastomoses
ol ischemic
areas. In order to
reach this goal, a comprehensive
understanding ot the human coronary
collateral circulation with regard to its
rele
ance,
accurate assessment, the
pathogenetic and pathopliysiological aspects,
лги
(he
luttèrent
therapeutic options is
mandatory.
(
olliiWrtil
(
.¡rmliitioii
ol tlw
Heart focuses on
the practical
aspectsol
human coronarv
collateral vessels.
Professor Seiler, an
international expert on the
subiect,
has written
this authoritative reference to pro
ide
a
comprehends
с
re iew ot the topi«., its impact
and clinical rele
ance.
Suitable tor all
cardiologists, (.ardioN as», iil.ir radiologists,
internal medicine and critical care phvsicians,
students ol cardioxascular medicine and
human ph siologists, the book contains mam
stunning illustrations that give a flavor of the
huge ariabi!it in collateral essel
tonnation
and the possibilities lor alle
iating ischemic
s mptoms in manv patients.
Collateral
Circulation
of the
Heart
|
| any_adam_object | 1 |
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| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.17 |
| dewey-search | 612.17 |
| dewey-sort | 3612.17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV035630035 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:41:58Z |
| institution | BVB |
| isbn | 9781848823419 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017685010 |
| oclc_num | 455153772 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-20 |
| physical | XIV, 418 S. zahlr. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| spelling | Seiler, Christian Verfasser aut Collateral circulation of the heart Christian Seiler Dordrecht [u.a.] Springer 2009 XIV, 418 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Collateral Circulation physiology Coronary Circulation physiology Kollateralkreislauf (DE-588)4325772-0 gnd rswk-swf Herz (DE-588)4024632-2 gnd rswk-swf Herz (DE-588)4024632-2 s Kollateralkreislauf (DE-588)4325772-0 s DE-604 Erscheint auch als Online-Ausgabe 978-1-84882-342-6 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017685010&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017685010&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Seiler, Christian Collateral circulation of the heart Collateral Circulation physiology Coronary Circulation physiology Kollateralkreislauf (DE-588)4325772-0 gnd Herz (DE-588)4024632-2 gnd |
| subject_GND | (DE-588)4325772-0 (DE-588)4024632-2 |
| title | Collateral circulation of the heart |
| title_auth | Collateral circulation of the heart |
| title_exact_search | Collateral circulation of the heart |
| title_full | Collateral circulation of the heart Christian Seiler |
| title_fullStr | Collateral circulation of the heart Christian Seiler |
| title_full_unstemmed | Collateral circulation of the heart Christian Seiler |
| title_short | Collateral circulation of the heart |
| title_sort | collateral circulation of the heart |
| topic | Collateral Circulation physiology Coronary Circulation physiology Kollateralkreislauf (DE-588)4325772-0 gnd Herz (DE-588)4024632-2 gnd |
| topic_facet | Collateral Circulation physiology Coronary Circulation physiology Kollateralkreislauf Herz |
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