G protein-coupled receptors in drug discovery:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Humana Press
2009
|
| Schriftenreihe: | Methods in molecular biology
552 |
| Schlagworte: | |
| Beschreibung: | Includes bibliographical references and index New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G protein-coupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms ... [et al.] -- GPCR expression using baculovirus-infected Sf9 cells / A.L. Aloia ... [et al.] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert ... [et al.] -- [35S]GTPgammaS binding in G protein-coupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin -- Use of aequorin for G protein-coupled receptor hit identification and compound profiling / S.J. Brough and P. Shah -- BacMam: versatile gene delivery technology for GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. Ames -- Yeast assays for G protein-coupled receptors / S.J. Dowell and A.J. Brown -- GPCR microspot assays on solid substrates / Y. Fang and J. Lahiri -- Resonant waveguide grating biosensor for whole-cell GPCR assays / Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement of GPCR conformational changes / S. Granier ... [et al.] -- FLIPR assays of intracellular calcium in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Use of fluorescence indicators in receptor ligands / K.G. Harikumar and L.J. Miller -- Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation / K.G. Harikumar and L.J. Miller -- Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology / M. Kocan and K.D. Pfleger -- Using reporter gene technologies to detect changes in cAMP as a result of GPCR activation / D.J. Rodrigues and D. McLoughlin -- A quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- Xenopus oocyte electrophysiology in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation and phosphorylation of G protein-coupled receptors / W.G. Thomas |
| Beschreibung: | XI, 376 S. ill. |
Internformat
MARC
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Datensatz im Suchindex
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| spelling | G protein-coupled receptors in drug discovery ed. by Wayne R. Leifert New York Humana Press 2009 XI, 376 S. ill. txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 552 Includes bibliographical references and index New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G protein-coupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms ... [et al.] -- GPCR expression using baculovirus-infected Sf9 cells / A.L. Aloia ... [et al.] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert ... [et al.] -- [35S]GTPgammaS binding in G protein-coupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin -- Use of aequorin for G protein-coupled receptor hit identification and compound profiling / S.J. Brough and P. Shah -- BacMam: versatile gene delivery technology for GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. Ames -- Yeast assays for G protein-coupled receptors / S.J. Dowell and A.J. Brown -- GPCR microspot assays on solid substrates / Y. Fang and J. Lahiri -- Resonant waveguide grating biosensor for whole-cell GPCR assays / Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement of GPCR conformational changes / S. Granier ... [et al.] -- FLIPR assays of intracellular calcium in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Use of fluorescence indicators in receptor ligands / K.G. Harikumar and L.J. Miller -- Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation / K.G. Harikumar and L.J. Miller -- Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology / M. Kocan and K.D. Pfleger -- Using reporter gene technologies to detect changes in cAMP as a result of GPCR activation / D.J. Rodrigues and D. McLoughlin -- A quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- Xenopus oocyte electrophysiology in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation and phosphorylation of G protein-coupled receptors / W.G. Thomas G proteins / Receptors Drug development Receptors, G-Protein-Coupled / Laboratory Manuals Drug Discovery / Laboratory Manuals Pharmacie - Recherche ram Protéines G - Récepteurs ram Drug Discovery Laboratory Manuals G proteins Receptors Receptors, G-Protein-Coupled Laboratory Manuals Rezeptor (DE-588)4049722-7 gnd rswk-swf Screening (DE-588)4054045-5 gnd rswk-swf Untersuchungsmethode (DE-588)4324907-3 gnd rswk-swf Wirkstoff (DE-588)4066383-8 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf GTP-bindende Proteine (DE-588)4248354-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Arzneimittelforschung (DE-588)4003120-2 s Wirkstoff (DE-588)4066383-8 s Screening (DE-588)4054045-5 s GTP-bindende Proteine (DE-588)4248354-2 s Rezeptor (DE-588)4049722-7 s Untersuchungsmethode (DE-588)4324907-3 s DE-604 Leifert, Wayne R. Sonstige oth Methods in molecular biology 552 (DE-604)BV035362695 552 |
| spellingShingle | G protein-coupled receptors in drug discovery Methods in molecular biology G proteins / Receptors Drug development Receptors, G-Protein-Coupled / Laboratory Manuals Drug Discovery / Laboratory Manuals Pharmacie - Recherche ram Protéines G - Récepteurs ram Drug Discovery Laboratory Manuals G proteins Receptors Receptors, G-Protein-Coupled Laboratory Manuals Rezeptor (DE-588)4049722-7 gnd Screening (DE-588)4054045-5 gnd Untersuchungsmethode (DE-588)4324907-3 gnd Wirkstoff (DE-588)4066383-8 gnd Arzneimittelforschung (DE-588)4003120-2 gnd GTP-bindende Proteine (DE-588)4248354-2 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4054045-5 (DE-588)4324907-3 (DE-588)4066383-8 (DE-588)4003120-2 (DE-588)4248354-2 (DE-588)4143413-4 |
| title | G protein-coupled receptors in drug discovery |
| title_auth | G protein-coupled receptors in drug discovery |
| title_exact_search | G protein-coupled receptors in drug discovery |
| title_full | G protein-coupled receptors in drug discovery ed. by Wayne R. Leifert |
| title_fullStr | G protein-coupled receptors in drug discovery ed. by Wayne R. Leifert |
| title_full_unstemmed | G protein-coupled receptors in drug discovery ed. by Wayne R. Leifert |
| title_short | G protein-coupled receptors in drug discovery |
| title_sort | g protein coupled receptors in drug discovery |
| topic | G proteins / Receptors Drug development Receptors, G-Protein-Coupled / Laboratory Manuals Drug Discovery / Laboratory Manuals Pharmacie - Recherche ram Protéines G - Récepteurs ram Drug Discovery Laboratory Manuals G proteins Receptors Receptors, G-Protein-Coupled Laboratory Manuals Rezeptor (DE-588)4049722-7 gnd Screening (DE-588)4054045-5 gnd Untersuchungsmethode (DE-588)4324907-3 gnd Wirkstoff (DE-588)4066383-8 gnd Arzneimittelforschung (DE-588)4003120-2 gnd GTP-bindende Proteine (DE-588)4248354-2 gnd |
| topic_facet | G proteins / Receptors Drug development Receptors, G-Protein-Coupled / Laboratory Manuals Drug Discovery / Laboratory Manuals Pharmacie - Recherche Protéines G - Récepteurs Drug Discovery Laboratory Manuals G proteins Receptors Receptors, G-Protein-Coupled Laboratory Manuals Rezeptor Screening Untersuchungsmethode Wirkstoff Arzneimittelforschung GTP-bindende Proteine Aufsatzsammlung |
| volume_link | (DE-604)BV035362695 |
| work_keys_str_mv | AT leifertwayner gproteincoupledreceptorsindrugdiscovery |