Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch-und-Buch-Verl.
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Biomarker in Synovia und Serum von Pferden für den Nachweis von Gelenkerkrankungen |
| Beschreibung: | 170 S. graph. Darst. 21 cm |
| ISBN: | 9783866645110 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV035593466 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 090701s2008 gw d||| m||| 00||| eng d | ||
| 015 | |a 09,A25,0835 |2 dnb | ||
| 016 | 7 | |a 992999545 |2 DE-101 | |
| 020 | |a 9783866645110 |c kart. : EUR 38.00 |9 978-3-86664-511-0 | ||
| 024 | 3 | |a 9783866645110 | |
| 028 | 5 | 2 | |a 86664-511-0 |
| 035 | |a (OCoLC)391399481 | ||
| 035 | |a (DE-599)DNB992999545 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BE | ||
| 049 | |a DE-188 | ||
| 082 | 0 | |a 636.1089672 |2 22/ger | |
| 084 | |a 630 |2 sdnb | ||
| 100 | 1 | |a Fietz, Simone Angelika |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |c by Simone Angelika Fietz |
| 264 | 1 | |a Berlin |b Mensch-und-Buch-Verl. |c 2008 | |
| 300 | |a 170 S. |b graph. Darst. |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Nebentitel: Biomarker in Synovia und Serum von Pferden für den Nachweis von Gelenkerkrankungen | ||
| 502 | |a Zugl.: Berlin, Freie Univ., Diss., 2008 | ||
| 650 | 7 | |a horses |2 cabt | |
| 650 | 7 | |a horse diseases |2 cabt | |
| 650 | 7 | |a joint diseases |2 cabt | |
| 650 | 7 | |a synovial fluid |2 cabt | |
| 650 | 7 | |a blood serum |2 cabt | |
| 650 | 7 | |a biochemical markers |2 cabt | |
| 650 | 7 | |a diagnostic techniques |2 cabt | |
| 650 | 7 | |a peroxidase |2 cabt | |
| 650 | 7 | |a metalloproteinases |2 cabt | |
| 650 | 2 | |a matrix metalloproteinases | |
| 650 | 7 | |a cartilage |2 cabt | |
| 650 | 7 | |a metabolism |2 cabt | |
| 650 | 4 | |a Pferdekrankheit - Gelenkkrankheit - Biomarker | |
| 650 | 4 | |a Pferd | |
| 650 | 0 | 7 | |a Biomarker |0 (DE-588)4425928-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Gelenkkrankheit |0 (DE-588)4121336-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pferdekrankheit |0 (DE-588)4045515-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Pferdekrankheit |0 (DE-588)4045515-4 |D s |
| 689 | 0 | 1 | |a Gelenkkrankheit |0 (DE-588)4121336-1 |D s |
| 689 | 0 | 2 | |a Biomarker |0 (DE-588)4425928-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017648647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017648647 | ||
Datensatz im Suchindex
| _version_ | 1804139257091063808 |
|---|---|
| adam_text | TABLE OF CONTENTS PAGE 1 ABBREVIATIONS 6 2 INTRODUCTION 8 3 LITERATURE
REVIEW 9 3.1 BIOLOGY OF SYNOVIAL JOINT 9 3.1.1 DEFINITION OF SYNOVIAL
JOINT 9 3.1.2 JOINT CAPSULE 9 3.1.3 SYNOVIAL FLUID 11 3.1.4 ARTICULAR
CARTILAGE 12 3.1.4.1 CHONDROCYTES 12 3.1.4.2 EXTRACELLULAR MATRIX 13
3.1.4.3 INTERSTITIAL WATER 14 3.1.4.4 ARTICULAR CARTILAGE ORGANISATION
15 3.1.5 SUBCHONDRAL BONE 15 3.2 PATHOBIOLOGY OF SYNOVIAL JOINT 16 3.2.1
ROLEOF THE SYNOVIAL MEMBRANE 16 3.2.2 ROLE OF THE CHONDROCYTE 18 3.2.3
ROLE OF THE SUBCHONDRAL BONE 19 3.3 JOINT DISEASES 20 3.3.1
OSTEOARTHRITIS 20 3.3.2 OSTEOCHONDROSIS DISSECANS 22 3.3.3 SEPTIC
ARTHRITIS 23 3.4 SYNOVIAL FLUID ANALYSIS 24 3.5 BIOMARKERS OF JOINT
DISEASE 26 3.5.1 MYELOPEROXIDASE 28 3.5.2 MATRIX METALLPROTEINASES -2
AND -9 30 3.5.3 MARKERS OF CARTILAGE METABOLISM: C2C, CTXII, CPII, CS846
33 4 OBJECTTVES 37 5 MATERIALS 38 5.1 EQUINE SAMPLES 33 5.2 CHEMICALS 40
5.3 EQUIPMENT AND SOFTWARE 42 6 METHODS 43 6.1 CYTOLOGICAL EXAMINATION
43 BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/992999545
DIGITALISIERT DURCH 7.2.1 WBC COUNT AND PROTEIN CONCENTRATION 67 TABLE
OF CONTENTS 6.2 PROTEIN QUANTIFICATION 43 6.3 MPO ANALYSIS 44 6.3.1 MPO
PHOTOMETRIC ACTIVITY ASSAY 44 6.3.1.1 INHIBITION STUDY 45 6.3.1.2
INFLUENCE OF H 2 O 2 CONCENTRATION 45 6.3.1.3 INFLUENCE OF VISCOSITY 45
6.3.1.4 INFLUENCE OF SAMPLE DILUTION 46 6.3.1.5 REPRODUCIBILITY 46 6.3.2
MPO FLUOROMETRIC ACTIVITY ASSAY 46 6.3.3 MPO ELISA 47 6.4 MMP ANALYSIS
48 6.4.1 GELATIN ZYMOGRAPHY 48 6.4.2 MMP-2 AND -9 IMMUNOCAPTURE ACTIVITY
ASSAYS 49 6.5 MARKERS OF CARTILAGE METABOLISM 50 6.5.1 CARTILAGE
DEGRADATION ASSAYS 50 6.5.1.1 C2C ELISA 50 6.5.1.2 CTXII ELISA 50 6.5.2
CARTILAGE SYNTHESIS ASSAYS 51 6.5.2.1 CPII ELISA 51 6.5.2.2 CS846 ELISA
52 6.6 DATA PRESENTATION AND STATISTICAL ANALYSIS 52 7 RESULTS 54 7.1
METHODOLOGICA! STUDY 54 7.1.1 MPO PHOTOMETRIC ACTIVITY ASSAY 54 7.1.1.1
INHIBITION STUDY 54 7.1.1.2 INFLUENCE OF H 2 O 2 CONCENTRATION 56
7.1.1.3 INFLUENCE OF VISCOSITY 57 7.1.1.4 INFLUENCE OF SAMPLE DILUTION
58 7.1.1.5 REPRODUCIBILITY 60 7.1.2 MPO FLUOROMETRIC ACTIVITY ASSAY 61
7.1.3 GELATIN ZYMOGRAPHY 64 7.2 EVALUATION OF PARAMETERS IN SYNOVIAL
FLUID AND SERUM 67 TABLE OF CONTENTS 7.2.2 MPO ACTIVITY AND MPO
CONCENTRATION 69 7.2.3 MMP-2 AND -9 ACTIVITIES 72 7.2.4 C2C AND CTXII
CONCENTRATIONS 76 7.2.5 CPII AND CS846 CONCENTRATIONS 79 7.2.6 FOLLOW-UP
STUDY 82 7.3 DISCRIMINANT ANALYSIS 88 8 DISCUSSION 91 8.1 METHODOLOGICAL
STUDY 91 8.1.1 MPO PHOTOMTRIC ACTIVITY ASSAY 91 8.1.2 MPO FLUOROMETRIC
ACTIVITY ASSAY 93 8.1.3 GELATIN ZYMOGRAPHY 94 8.2 EVALUATION OF
PARAMETERS IN SYNOVIAL FLUID 95 8.2.1 WBC COUNT AND PROTEIN
CONCENTRATION 95 8.2.2 MPO ACTIVITY AND MPO CONCENTRATION 96 8.2.3 MMP-
2 AND -9 ACTIVITIES 98 8.2.4 CTXII AND C2C CONCENTRATIONS 102 8.2.5 CPII
AND CS846 CONCENTRATIONS 104 8.3 EVALUATION OF DISTINCT PARAMETERS IN
SERUM 106 8.4 DISCRIMINANT ANALYSIS 107 9 CONCLUSION 109 10 OUTLOOK 111
11 SUMMARY 112 12 ZUSAMMENFASSUNG 114 13 REFERENCES 117 14 LIST OF
FIGURES 145 15 LIST OF TABLES 148 16 DANKSAGUNG 150 17
SELBSTAENDIGKEITSERKLAERUNG 151 18 APPENDIX I 152 19 APPENDIX II 154 20
APPENDIX III 168
|
| any_adam_object | 1 |
| author | Fietz, Simone Angelika |
| author_facet | Fietz, Simone Angelika |
| author_role | aut |
| author_sort | Fietz, Simone Angelika |
| author_variant | s a f sa saf |
| building | Verbundindex |
| bvnumber | BV035593466 |
| ctrlnum | (OCoLC)391399481 (DE-599)DNB992999545 |
| dewey-full | 636.1089672 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 636 - Animal husbandry |
| dewey-raw | 636.1089672 |
| dewey-search | 636.1089672 |
| dewey-sort | 3636.1089672 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02392nam a2200637 c 4500</leader><controlfield tag="001">BV035593466</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">090701s2008 gw d||| m||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">09,A25,0835</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">992999545</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783866645110</subfield><subfield code="c">kart. : EUR 38.00</subfield><subfield code="9">978-3-86664-511-0</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783866645110</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">86664-511-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)391399481</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB992999545</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-188</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">636.1089672</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">630</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Fietz, Simone Angelika</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases</subfield><subfield code="c">by Simone Angelika Fietz</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin</subfield><subfield code="b">Mensch-und-Buch-Verl.</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">170 S.</subfield><subfield code="b">graph. Darst.</subfield><subfield code="c">21 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Nebentitel: Biomarker in Synovia und Serum von Pferden für den Nachweis von Gelenkerkrankungen</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Zugl.: Berlin, Freie Univ., Diss., 2008</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">horses</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">horse diseases</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">joint diseases</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">synovial fluid</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">blood serum</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">biochemical markers</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">diagnostic techniques</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">peroxidase</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">metalloproteinases</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">matrix metalloproteinases</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">cartilage</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">metabolism</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pferdekrankheit - Gelenkkrankheit - Biomarker</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pferd</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biomarker</subfield><subfield code="0">(DE-588)4425928-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gelenkkrankheit</subfield><subfield code="0">(DE-588)4121336-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pferdekrankheit</subfield><subfield code="0">(DE-588)4045515-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Pferdekrankheit</subfield><subfield code="0">(DE-588)4045515-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Gelenkkrankheit</subfield><subfield code="0">(DE-588)4121336-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Biomarker</subfield><subfield code="0">(DE-588)4425928-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017648647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-017648647</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV035593466 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:41:12Z |
| institution | BVB |
| isbn | 9783866645110 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017648647 |
| oclc_num | 391399481 |
| open_access_boolean | |
| owner | DE-188 |
| owner_facet | DE-188 |
| physical | 170 S. graph. Darst. 21 cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Mensch-und-Buch-Verl. |
| record_format | marc |
| spelling | Fietz, Simone Angelika Verfasser aut Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases by Simone Angelika Fietz Berlin Mensch-und-Buch-Verl. 2008 170 S. graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Nebentitel: Biomarker in Synovia und Serum von Pferden für den Nachweis von Gelenkerkrankungen Zugl.: Berlin, Freie Univ., Diss., 2008 horses cabt horse diseases cabt joint diseases cabt synovial fluid cabt blood serum cabt biochemical markers cabt diagnostic techniques cabt peroxidase cabt metalloproteinases cabt matrix metalloproteinases cartilage cabt metabolism cabt Pferdekrankheit - Gelenkkrankheit - Biomarker Pferd Biomarker (DE-588)4425928-1 gnd rswk-swf Gelenkkrankheit (DE-588)4121336-1 gnd rswk-swf Pferdekrankheit (DE-588)4045515-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Pferdekrankheit (DE-588)4045515-4 s Gelenkkrankheit (DE-588)4121336-1 s Biomarker (DE-588)4425928-1 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017648647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fietz, Simone Angelika Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases horses cabt horse diseases cabt joint diseases cabt synovial fluid cabt blood serum cabt biochemical markers cabt diagnostic techniques cabt peroxidase cabt metalloproteinases cabt matrix metalloproteinases cartilage cabt metabolism cabt Pferdekrankheit - Gelenkkrankheit - Biomarker Pferd Biomarker (DE-588)4425928-1 gnd Gelenkkrankheit (DE-588)4121336-1 gnd Pferdekrankheit (DE-588)4045515-4 gnd |
| subject_GND | (DE-588)4425928-1 (DE-588)4121336-1 (DE-588)4045515-4 (DE-588)4113937-9 |
| title | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |
| title_auth | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |
| title_exact_search | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |
| title_full | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases by Simone Angelika Fietz |
| title_fullStr | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases by Simone Angelika Fietz |
| title_full_unstemmed | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases by Simone Angelika Fietz |
| title_short | Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |
| title_sort | biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases |
| topic | horses cabt horse diseases cabt joint diseases cabt synovial fluid cabt blood serum cabt biochemical markers cabt diagnostic techniques cabt peroxidase cabt metalloproteinases cabt matrix metalloproteinases cartilage cabt metabolism cabt Pferdekrankheit - Gelenkkrankheit - Biomarker Pferd Biomarker (DE-588)4425928-1 gnd Gelenkkrankheit (DE-588)4121336-1 gnd Pferdekrankheit (DE-588)4045515-4 gnd |
| topic_facet | horses horse diseases joint diseases synovial fluid blood serum biochemical markers diagnostic techniques peroxidase metalloproteinases matrix metalloproteinases cartilage metabolism Pferdekrankheit - Gelenkkrankheit - Biomarker Pferd Biomarker Gelenkkrankheit Pferdekrankheit Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017648647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fietzsimoneangelika biomarkersinequinesynovialfluidandserumforthediagnosisofjointdiseases |