Genes, environment, and psychopathology: understanding the causes of psychiatric and substance use disorders
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Guilford
2006
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Formerly CIP |
| Beschreibung: | XX, 412 S. Ill., graph. Darst. |
| ISBN: | 9781593853167 1593853165 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
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| 005 | 20090826 | ||
| 007 | t | ||
| 008 | 090629s2006 ad|| |||| 00||| eng d | ||
| 015 | |a GBA656126 |2 dnb | ||
| 020 | |a 9781593853167 |9 978-1-59385-316-7 | ||
| 020 | |a 1593853165 |9 1-59385-316-5 | ||
| 035 | |a (OCoLC)69671890 | ||
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| 100 | 1 | |a Kendler, Kenneth S. |d 1950- |e Verfasser |0 (DE-588)13725718X |4 aut | |
| 245 | 1 | 0 | |a Genes, environment, and psychopathology |b understanding the causes of psychiatric and substance use disorders |c Kenneth S. Kendler ; Carol A. Prescott |
| 264 | 1 | |a New York [u.a.] |b Guilford |c 2006 | |
| 300 | |a XX, 412 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Formerly CIP | ||
| 650 | 2 | |a Mental Disorders |a genetics | |
| 650 | 2 | |a Mental Disorders |a epidemiology | |
| 650 | 2 | |a Risk Factors | |
| 650 | 2 | |a Twin Studies | |
| 650 | 7 | |a Drugsgebruik |2 gtt | |
| 650 | 7 | |a Erfelijkheid |2 gtt | |
| 650 | 4 | |a Maladies mentales - Aspect de l'environnement | |
| 650 | 4 | |a Maladies mentales - Aspect génétique | |
| 650 | 7 | |a Psychische stoornissen |2 gtt | |
| 650 | 4 | |a Épidémiologie psychiatrique | |
| 650 | 4 | |a Statistik | |
| 650 | 4 | |a Mental illness |x Etiology | |
| 650 | 4 | |a Mental illness |x Genetic aspects | |
| 650 | 4 | |a Substance abuse |x Etiology | |
| 650 | 4 | |a Substance abuse |x Genetic aspects | |
| 650 | 0 | 7 | |a Psychische Störung |0 (DE-588)4047686-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Humangenetik |0 (DE-588)4072653-8 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Prescott, Carol A. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017643535&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017643535 | ||
Datensatz im Suchindex
| _version_ | 1804139249433313280 |
|---|---|
| adam_text | List of Sidebars
I.I. Collaborators in the Development of the Virginia Adult Twin Study 3
of Psychiatric and Substance Use Disorders
2.1. Content of the Twin Interviews 29
3.1. Tetrachoric Correlations 38
3.2. Calculating Twin-Model Estimates 42
3.3. Interpretation of Heritability Coefficients 44
4.1. Assessment of Major Depression (MD) 54
4.2. Confidence Intervals 56
4.3. Assessment of Panic 60
4.4. Assessment of Generalized Anxiety Disorder (GAD) 64
4.5. Assessment of Phobias 68
5.1. Assessment of Antisocial Behavior 83
5.2. Substance Abuse and Dependence in the DSM 89
5.3. Assessment of Alcohol Use, Abuse, and Dependence 90
5.4. Assessment of Tobacco Use and Nicotine Dependence 93
5.5. Assessment of Caffeine Use and Use-Related Problems 95
5.6. Assessment of Illicit Drug Use, Abuse, and Dependence 98
5.7. Assessment of Bulimia 104
6.1. Assessment of Twin Environmental Similarity 117
7.1. Assessment of Parenting in the VATSPSUD 131
7.2. Defining Parental Loss 138
7.3. Assessment of Childhood Sexual Abuse 144
xi
xii List of Sidebars
8.1. Types of Stressful Life Events 151
8.2. Diagnostic Definitions Used in SLE Studies 153
8.3. Life Event Ratings 155
8.4. Psychological Dimensions of Life Events 157
8.5. Measuring Social Support 163
11.1. Understanding Models for Comorbidity 201
11.2. Personality 218
11.3. Assessment of Drinking Motives 221
16.1. Measures Used for Study of Parenting and Problem Drinking 305
16.2. Model for Moderated Genetic and Environmental Effects 309
16.3. Assessment of Family Dysfunction 312
17.1. Predictor Variables 322
Contents
List of Sidebars xi
List of Abbreviations xiii
Introduction 1
Overture 2
Structure 4
The Development of the VATSPSUD 5
PART I. BACKGROUND
1. The Scientific and Social Context of the Virginia Adult Twin 11
Study of Psychiatric and Substance Use Disorders
Biometrical Genetics 11
Psychiatric Twin Studies 12
Psychiatric Epidemiology 13
A New Paradigm for Twin Studies 15
Genes 16
The Social and Political Context of the VATSPSUD 17
Our Philosophy of Science 18
2. Methodology Used in the VATSPSUD 20
Organization and Terminology 20
Samples 21
Selection and Recruitment 22
The Female-Female Twin Study 22
The Female-Female-Parent Study 25
The Male-Male/Male-Female Twin Study 25
Representativeness of Our Samples 27
xv
xvi Contents
Assessment 28
Overview 28
Assessment of Zygosity 30
Assessment Procedures 31
3. Twinning and Twin Models 34
Representativeness of Twins 36
Analysis Basics 37
Twin-Pair Similarity 37
Basics of Twin Models 40
Structural Models and Model Fitting 41
Statistical Significance and Precision 43
Path Diagrams 45
PART II. GENETIC RISK
4. Internalizing Disorders 51
Major Depression 51
Genetic and Environmental Influences 53
Discussion and Implications 57
Panic Disorder 58
Genetic and Environmental Influences 59
Discussion and Implications 62
Generalized Anxiety Disorder 63
Discussion and Implications 65
Phobias 66
Theories of Etiology 67
Genetic and Environmental Influences 70
Discussion and Implications 73
Summary 74
5. Externalizing and Substance Use Disorders 81
Antisocial Behavior 82
Results from Twin-Pair Models 84
Genetic Influences: Evidence and Implications 86
Shared Environmental Influences 87
Substance Abuse and Dependence 87
Alcohol 88
Nicotine 93
Caffeine 95
Illicit Substances 97
Genetic Mechanisms 100
The Role of Environmental Factors in Liability
to Substance Use Disorders 102
Bulimia 103
Contents xvii
6. Twin Model Assumptions 114
Random Mating 114
Equal Environment Assumption 115
Similarity of Environmental Exposures 116
Parental Treatment 121
Physical Resemblance 122
Perceived versus True Zygosity 122
Summary 124
PART III. ENVIRONMENTAL RISK
7. Childhood Experiences and Risk for Psychopathology 129
Is Parenting Received in Childhood Associated with Adult
Psychopathology? 130
Interactions among Parent Dimensions 135
Interpretations 136
Is Parental Loss a Risk Factor for Psychiatric Disorders? 137
Is Childhood Sexual Abuse Associated with Psychiatric
Disorders? 142
Summary 144
8. Adult Experiences and Risk for Psychopathology 148
Stressful Life Events 148
Severity and Number of Events 153
Independence versus Dependence of Events 154
Psychological Dimensions of Events and Episode Type 156
Causality 160
Social Support 162
Summary 165
PART IV. A CLOSER LOOK AT GENETIC
AND ENVIRONMENTAL INFLUENCES
9. Sex Differences 169
Types of Sex Differences 169
Major Depression 172
Anxiety Disorders 174
Antisocial Behavior 175
Alcoholism 176
Nicotine Dependence 177
Illicit Substance Abuse and Dependence 178
Summary 179
xviii Contents
10. Genetic and Environmental Influences on Stability 181
and Change
Stability and Change in Major Depression in Women 182
Implications 185
Influences on the Development of Antisocial Behavior 188
Stability and Change in Alcohol Consumption in Women 192
Effects of Age and Cohort 194
Summary 196
11. The Genetics of What?: Comorbidity, General versus Specific 199
Effects, and Risk Indicators
Studying the Sources of Comorbidity 200
Comorbidity of Major Depression and Generalized
Anxiety 201
Comorbidity of Major Depression and Social Phobia 202
Mechanisms for Comorbidity:
Alcoholism and Major Depression 203
Common and Specific Risk Factors for Multiple Disorders 207
Common and Specific Influences on Phobia Subtypes 208
Common and Specific Influences
on Substance Use Disorders 211
Multivariate Analyses of Psychiatric
and Substance Use Disorders 213
Risk Indicators 216
Novelty Seeking as an Indicator of Risk
for Cannabis Use and Abuse 217
Mediators of Risk 219
Drinking Motivations as Mediators
versus Indicators of Risk for Alcoholism 220
Neuroticism as an Indicator or Mediator of Risk
for Depression 224
Summary 226
12. Three Extensions of the Twin Model 229
Genetic Influences on Conditional Processes 229
Cross-Generational Transmission of Risk 234
Dealing with Unreliability 237
Twin Measurement Model 238
Multiple-Rater Model 240
Conclusions about Unreliability 245
Summary 245
PART V. BRINGING IT ALL TOGETHER
13. The Genetics of the Environment 251
Stressful Life Events 252
Sources of Individual Differences in Reported Life Events:
A Cross-Sectional Study 252
Contents xix
Sources of Individual Differences in Reported Life Events:
A Longitudinal Study 255
Social Support 257
Parenting 260
Parenting Received 260
Parenting Given 262
Interpretation of Parenting Studies 262
Summary 263
14. Mechanisms for Genetic Control of Exposure 267
to the Environment
Mechanisms through Which Genetic Factors Influence Exposure
to Environmental Stress 267
Stressful Life Events 268
Social Support 270
Implications 270
Are the Genetic Risk Factors for Environmental Adversities Related
to Those for Psychiatric Disorders? 271
Summary 273
15. Is the Relation between Environmental Risk Factors 275
and Psychiatric Disorders Causal?
Cotwin-Control Design 276
Does Early Drinking Increase Risk for Alcoholism? 278
Are Stressful Life Events Causal for Depression? 281
Does Smoking Predispose to Depression? 282
Is Childhood Sexual Abuse Causal for Psychiatric
Disorders? 283
Childhood Parental Loss and Risk for Alcoholism 284
Summary 289
16. Genetic Control of Sensitivity to the Environment 291
Examples of Genetic Control of Sensitivity to the Environment 293
Evidence for Genetic Control of Sensitivity to the Environment
in the VATSPSUD 294
Genes, Stressful Live Events, and Major Depression 295
Are the Effects of Parental Alcoholism Moderated by Parental
Rearing Style? 304
Moderation of Genetic Effects by Environmental Risk Factors 307
Family Dysfunction and the Heritability of Neuroticism 308
Family Dysfunction and the Heritability
of Cigarette Smoking 313
Summary 315
17. Integrative Models 320
Integrative Model for Major Depression in Women 320
Childhood Risk Factors 323
Risk Factors of Early Adolescence 325
Risk Factors of Late Adolescence 327
xx Contents
Adult Risk Factors 327
Pastt-Year Risk Factors 327
Episode of Major Depression in the Past Year 327
Interpretation of Results 329
Integrative Model for Major Depression in Men 333
Methodological Limitations 336
18. Conclusions 339
The VATSPSUD and the New Molecular Genetics 348
Philosophical Implications 349
References 351
Publications from the VATSPSUD 377
Author Index 391
Subject Index 401
|
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| genre | Statistics |
| genre_facet | Statistics |
| id | DE-604.BV035588270 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:41:05Z |
| institution | BVB |
| isbn | 9781593853167 1593853165 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017643535 |
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| physical | XX, 412 S. Ill., graph. Darst. |
| publishDate | 2006 |
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| spelling | Kendler, Kenneth S. 1950- Verfasser (DE-588)13725718X aut Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders Kenneth S. Kendler ; Carol A. Prescott New York [u.a.] Guilford 2006 XX, 412 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Formerly CIP Mental Disorders genetics Mental Disorders epidemiology Risk Factors Twin Studies Drugsgebruik gtt Erfelijkheid gtt Maladies mentales - Aspect de l'environnement Maladies mentales - Aspect génétique Psychische stoornissen gtt Épidémiologie psychiatrique Statistik Mental illness Etiology Mental illness Genetic aspects Substance abuse Etiology Substance abuse Genetic aspects Psychische Störung (DE-588)4047686-8 gnd rswk-swf Humangenetik (DE-588)4072653-8 gnd rswk-swf Ätiologie (DE-588)4000646-3 gnd rswk-swf Erbe-Umwelt-Problem (DE-588)4136389-9 gnd rswk-swf Statistics Psychische Störung (DE-588)4047686-8 s Erbe-Umwelt-Problem (DE-588)4136389-9 s Humangenetik (DE-588)4072653-8 s Ätiologie (DE-588)4000646-3 s DE-604 Prescott, Carol A. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017643535&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kendler, Kenneth S. 1950- Prescott, Carol A. Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders Mental Disorders genetics Mental Disorders epidemiology Risk Factors Twin Studies Drugsgebruik gtt Erfelijkheid gtt Maladies mentales - Aspect de l'environnement Maladies mentales - Aspect génétique Psychische stoornissen gtt Épidémiologie psychiatrique Statistik Mental illness Etiology Mental illness Genetic aspects Substance abuse Etiology Substance abuse Genetic aspects Psychische Störung (DE-588)4047686-8 gnd Humangenetik (DE-588)4072653-8 gnd Ätiologie (DE-588)4000646-3 gnd Erbe-Umwelt-Problem (DE-588)4136389-9 gnd |
| subject_GND | (DE-588)4047686-8 (DE-588)4072653-8 (DE-588)4000646-3 (DE-588)4136389-9 |
| title | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders |
| title_auth | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders |
| title_exact_search | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders |
| title_full | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders Kenneth S. Kendler ; Carol A. Prescott |
| title_fullStr | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders Kenneth S. Kendler ; Carol A. Prescott |
| title_full_unstemmed | Genes, environment, and psychopathology understanding the causes of psychiatric and substance use disorders Kenneth S. Kendler ; Carol A. Prescott |
| title_short | Genes, environment, and psychopathology |
| title_sort | genes environment and psychopathology understanding the causes of psychiatric and substance use disorders |
| title_sub | understanding the causes of psychiatric and substance use disorders |
| topic | Mental Disorders genetics Mental Disorders epidemiology Risk Factors Twin Studies Drugsgebruik gtt Erfelijkheid gtt Maladies mentales - Aspect de l'environnement Maladies mentales - Aspect génétique Psychische stoornissen gtt Épidémiologie psychiatrique Statistik Mental illness Etiology Mental illness Genetic aspects Substance abuse Etiology Substance abuse Genetic aspects Psychische Störung (DE-588)4047686-8 gnd Humangenetik (DE-588)4072653-8 gnd Ätiologie (DE-588)4000646-3 gnd Erbe-Umwelt-Problem (DE-588)4136389-9 gnd |
| topic_facet | Mental Disorders genetics Mental Disorders epidemiology Risk Factors Twin Studies Drugsgebruik Erfelijkheid Maladies mentales - Aspect de l'environnement Maladies mentales - Aspect génétique Psychische stoornissen Épidémiologie psychiatrique Statistik Mental illness Etiology Mental illness Genetic aspects Substance abuse Etiology Substance abuse Genetic aspects Psychische Störung Humangenetik Ätiologie Erbe-Umwelt-Problem Statistics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017643535&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kendlerkenneths genesenvironmentandpsychopathologyunderstandingthecausesofpsychiatricandsubstanceusedisorders AT prescottcarola genesenvironmentandpsychopathologyunderstandingthecausesofpsychiatricandsubstanceusedisorders |