Complex enzymes in microbial natural product biosynthesis: A Overview articles and peptides
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2009
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Methods in enzymology
458 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XLIX, 636 S., [8] Bl. Ill., graph. Darst. |
| ISBN: | 9780123745880 |
Internformat
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| 245 | 1 | 0 | |a Complex enzymes in microbial natural product biosynthesis |n A |p Overview articles and peptides |c ed. by David A. Hopwood |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2009 | |
| 300 | |a XLIX, 636 S., [8] Bl. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804139240148172800 |
|---|---|
| adam_text | Contents
Contributors
xiii
Preface
xix
Volumes in Series
xxiii
Section I. Overview Articles
ι
1.
Approaches to Discovering
Novei
Antibacterial
and Antifungal Agents
3
Stefano
Donadío,
Paolo Monciardini, and
Margherita Sosio
1.
Introduction
4
2.
Strains and Samples
7
3.
Targets and Assays for Antibacterial and Antifungal Programs
13
4.
Screening
16
5.
Hit Follow-up
19
6.
Databases, Operations, and Costs
23
7.
Perspectives
25
Acknowledgment
25
References
25
2.
From Microbial Products to Novel Drugs that Target
a Multitude of Disease Indications
29
Flavia
Mannelli
1.
Microbial Diversity and Biotechnological Products
30
2.
Secondary Metabolites
30
3.
Conclusions
53
Acknowledgments
54
References
54
v¡
Contents
3.
Discovering Natural Products from Myxobacteria with
Emphasis on Rare Producer Strains in Combination with
Improved Analytical Methods
59
Ronald
0.
Garcia, Daniel
Krug,
and
Rolf Müller
1.
Introduction
60
2.
The Search for Novel Myxobacteria and Their
Metabolites—Basic Considerations
63
3.
Methods for isolation, Purification, and Preservation
of Novel Myxobacteria
71
4.
Fermentation and Screening for Known and Novel Metabolites
78
Acknowledgment
88
References
88
4.
Analyzing the Regulation of Antibiotic Production
in Streptomycetes
93
Mervyn Bibb and Andrew Hesketh
1.
Introduction
94
2.
The Regulation of Antibiotic Production in Streptomycetes
94
3.
Identifying Regulatory Genes for Antibiotic Biosynthesis
97
4.
Characterizing Regulatory Genes for Antibiotic Biosynthesis
104
Acknowledgments
113
References
113
5.
Applying the Genetics of Secondary Metabolism in Model
Actinomycetes to the Discovery of New Antibiotics
117
Gilles
P. van
Wezel,
Nancy
L
McKenzie,
and Justin R. Nodwell
1.
Introduction
118
2.
Actinomycetes as Antibiotic Factories
119
3.
Effects of Culture Conditions and Metabolism
120
4.
Molecular Genetic Factors that Regulate Antibiotic Production
125
5.
Applications for New Antibiotic Screening Technologies
129
6.
Future Prospects
133
Acknowledgments
134
References
134
6.
Regulation of Antibiotic Production by Bacterial Hormones
143
Nai-Hua Hsiao, Marco Gottelt, and
Eriko Takáno
1.
Introduction
144
2.
Rapid Small-Scale y-Butyrolactone Purification
145
3.
Antibiotic Bioassay
146
Contents
vii
4.
Kanamycin Bioassay
148
5.
Identification
of
y-Butyrolactone
Receptors
150
6.
Identification
of the
y-Butyrolactone
Receptor Targets
151
7.
Gel
Retardation Assay to Detect Target Sequences of the
y-Butyrolactone Receptors
152
8.
Conclusions
156
Acknowledgments
156
References
156
7.
Cloning and Analysis of Natural Product Pathways
159
Bertolt
Gust
1.
Introduction
160
2.
Cloning and Identification of Biosynthetic Gene Clusters
161
3.
Analysis of Natural Product Pathways by PCR-Targeted
Gene Replacement
163
4.
In Vitro Transposon Mutagenesis
170
5.
Heterologous Expression of Biosynthetic Gene Clusters
173
6.
Reassembling Entire Gene Clusters by Stitching Overlapping
Cosmid Clones
174
7.
Conclusions
177
Acknowledgments
177
References
177
8.
Methods for In Silico Prediction of Microbial Polyketide
and Nonribosomal
Peptide
Biosynthetic Pathways from
DNA
Sequence Data
181
Brian
0. Bachmann
and Jacques Ravel
1.
Introduction
182
2.
Converting Type I PKSs to Structural Elements
191
3.
Converting NRPS Domain Strings to Structural Elements
205
4.
Concluding Remarks
212
Acknowledgments
214
References
214
9.
Synthetic Probes for Polyketide and Nonribosomal
Peptide
Biosynthetic Enzymes
219
Jordan L. Meier and Michael D. Burkart
1.
Introduction
220
2.
Synthetic Probes of
PKS
and NRPS Mechanism
221
3.
Synthetic Probes of
PKS
and NRPS Structure
233
Contents
4.
Synthetic Probes for Proteomic Identification of
PKS
and NRPS Enzymes
241
5.
Conclusions
250
References
250
10.
Using Phosphopantetheinyl
Transferases
for Enzyme
Posttranslational Activation, Site Specific Protein Labeling
and Identification of Natural Product Biosynthetic
Gene Clusters from Bacterial Genomes
255
Murat
Sunbul, Keya Zhang, and
Jun
Yin
1.
Introduction
256
2.
Experimental Procedures
263
3.
Conclusion
271
References
271
11.
Sugar Biosynthesis and Modification
277
Felipe
Lombo,
Carlos
Olano,
José A. Salas, and Carmen Méndez
1.
Introduction
278
2.
Deoxysugar Biosynthesis
279
3.
Deoxysugar Transfer
283
4.
Modification of the Glycosylation Pattern through Gene Inactivation
284
5.
Modification of the Glycosylation Pattern through Heterologous
Gene Expression
288
6.
Modification of the Glycosylation Pattern through
Combinatorial Biosynthesis
290
7.
Gene Cassette Plasmids for Deoxysugar Biosynthesis
292
8.
Generation of Glycosylated Compounds
299
9.
Tailoring Modifications of the Attached Deoxysugars
301
10.
Detection of Glycosylated Compounds
303
Acknowledgments
303
References
303
12.
The Power of Glycosyltransferases to Generate Bioactive
Natural Compounds
309
Johannes
Härte
and Andreas Bechthold
1.
Introduction
310
2.
Application of GTs in Producing Unnatural Bioactive Molecules
322
References
328
Contents ix
Section II. Peptides
335
13.
Nonribosomal
Peptide Synthetases:
Mechanistic and
Structural Aspects
of Essential
Domains
337
M. A. Marahiel and
L
-О.
Essen
1.
Introduction
338
2.
Mechanistic
and Structural Aspects
of Essential NRPS
Domains
339
3.
Structural
Insights into an Entire Termination
Module
347
References
349
14.
Biosynthesis of Nonribosomal
Peptide
Precursors
353
Barrie Wilkinson and Jason Micklefield
1.
Introduction
354
2.
Precursors from
Amino
Acid Metabolism
355
3.
Fatty Acid Precursor Biosynthesis
360
4.
Polyketide Precursors
364
5.
Gtycosyl Building Blocks
371
6.
Conclusion
372
References
373
15.
Plasmid-Borne Gene Cluster Assemblage and Heterologous
Biosynthesis of Nonribosomal Peptides in Escherichia
coli
379
Kenji Watanabe, Alex P. Praseuth, Mike B. Praseuth, and Kinya Hotta
1.
Introduction
380
2.
Biosynthetic Pathway of Nonribosomal Peptides
382
3.
Echinomycin Biosynthetic Pathway
383
4.
Construction of A Multigene Assembly on Expression Vectors
387
5.
Heterologous Gene Expression and NRP Biosynthesis in
£
coli
390
6.
Self-Resistance Mechanism
391
7.
Stability of
Transformants
Carrying Multiple Very Large Plasmids
392
8.
Engineering of Heterologous NRP Biosynthetic Pathways in
E. coli
393
9.
Conclusion
395
References
396
16.
Enzymology of jS-Lactam Compounds with Cephem
Structure Produced by Actinomycete
401
Paloma
Liras
and Arnold L.
Demain
1.
Introduction
402
2.
Biosynthesis of Cephamycins: Enzymes and Genes
405
3.
Early Steps Specific for Cephamycin Biosynthesis
405
Contents
4.
Common
Steps
¡η
Cephamycin-Producing
Actinomycetes and
Penicillin- or Cephalosporin-Producing Filamentous Fungi
409
5.
Specific Steps for Tailoring the Cephem Nucleus in Actinomycetes
420
6.
Regulation of Cephamycin
С
Production
422
Acknowledgments
423
References
423
17.
Siderophore Biosynthesis: A Substrate Specificity Assay for
Nonribosomal
Peptide Synthetase-lndependent
Siderophore
Synthetases Involving Trapping of Acyl-Adenylate
Intermediates with Hydroxylamine
431
Nadia
Kadi and Gregory
L Challis
1.
Introduction
432
2.
NRPS-Dependent Pathways for Siderophore Biosynthesis
434
3.
NRPS-lndependent Pathway for Siderophore Biosynthesis
442
4.
Hybrid NRPS/NIS Pathway for Petrobactin Biosynthesis
448
5.
Hydroxamate-Formation Assay for
NIS
Synthetases
450
References
455
18.
Molecular Genetic Approaches to Analyze
Glycopeptide Biosynthesis
459
Wolfgang
Wohlleben,
Evi
Stegmann,
and
Roderich
D.
Süssmuth
1.
Structural Classification of Glycopeptide Antibiotics
460
2.
Methods for Analyzing Glycopeptide Biosynthesis
462
3.
Investigation of Glycopeptide Biosynthetic Steps
466
4.
Regulation, Self-Resistance, and Excretion
477
5.
Linking Primary and Secondary Metabolism
478
6.
Approaches for the Generation of New Glycopeptides
479
Acknowledgments
480
References
480
19.
In Vitro Studies of Phenol Coupling Enzymes Involved in
Vancomycin Biosynthesis
487
Dong Bo Li,
Katharina Woithe,
Nina Geib, Khaled Abou-Hadeed,
Katja Zerbe,
and John A. Robinson
1.
Introduction
483
2.
Peptide
Synthesis
491
3.
Peptide Thioesters
499
4.
In Vitro Assays with OxyB
502
5.
Production and Purification of Enzymes
503
References
507
Contents xi
20.
Biosynthesis and Genetic Engineering of Lipopeptides in
Streptomyces roseosporus
511
Richard H. Baltz
1.
Introduction
512
2.
Biosynthesis and Genetic Engineering of Daptomycin
in S. rosesoporus
514
3.
Sources of Genes for Combinatorial Biosynthesis
523
4.
Genetic Engineering of Novel Lipopeptides
524
5.
Concluding Remarks
527
Acknowledgments
528
References
528
21.
In Vitro Studies of Lantibiotic Biosynthesis
533
Bo Li, Lisa E. Cooper, and Wilfred A. van
der Donk
1.
Introduction
534
2.
Mining Microbial Genomes for Novel Lantibiotics
537
3.
Expression and Purification of Lantibiotic Precursor Peptides (LanAs)
538
4.
Expression, Purification, and Assay of LanM Enzymes
542
5.
Expression, Purification, and Assays of LanC Cyclases
547
6.
The Protease Domain of Class II Lantibiotic Transporters
552
7.
Additional Posttranslational Modifications in Lantibiotics
553
References
554
22.
Whole-Cell Generation of Lantibiotic Variants
559
Jesús Cortés,
Antony
N. Appleyard,
and Michael J. Dawson
1.
Introduction
559
2.
Variant Generation
561
3.
Conclusions
571
References
571
23.
Cyanobactin Ribosomally Synthesized Peptides—A Case of
Deep Metagenome Mining
575
Eric W. Schmidt and
Mohamed
S. Donia
1.
Introduction
576
2.
Some Remaining Questions
583
3.
Obtaining Prochloron Cells and
DNA 583
4.
Chemical Analysis
586
5.
Cyanobactin Gene Cloning and Identification
587
6.
Heterologous Expression in
£
coli
590
xii Contents
7. Deep Metagenome Mining 591
8.
Enzymatic Analysis of Cyanobactin Biosynthesis
593
9.
Applying Deep Metagenome Mining: Pathway Engineering
593
Acknowledgments
595
References
595
Author Index
597
Subject Index
627
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV035581714 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:40:56Z |
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| isbn | 9780123745880 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017637111 |
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| publishDate | 2009 |
| publishDateSearch | 2009 |
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| publisher | Elsevier, Acad. Press |
| record_format | marc |
| series | Methods in enzymology |
| series2 | Methods in enzymology |
| spelling | Complex enzymes in microbial natural product biosynthesis A Overview articles and peptides ed. by David A. Hopwood 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2009 XLIX, 636 S., [8] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in enzymology 458 Methods in enzymology ... Bakterien (DE-588)4004296-0 gnd rswk-swf Biosynthese (DE-588)4006902-3 gnd rswk-swf Antibiotikum (DE-588)4002257-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bakterien (DE-588)4004296-0 s Antibiotikum (DE-588)4002257-2 s Biosynthese (DE-588)4006902-3 s DE-604 Hopwood, David A. Sonstige oth (DE-604)BV035581679 1 Methods in enzymology 458 (DE-604)BV000000938 458 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017637111&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Complex enzymes in microbial natural product biosynthesis Methods in enzymology Bakterien (DE-588)4004296-0 gnd Biosynthese (DE-588)4006902-3 gnd Antibiotikum (DE-588)4002257-2 gnd |
| subject_GND | (DE-588)4004296-0 (DE-588)4006902-3 (DE-588)4002257-2 (DE-588)4143413-4 |
| title | Complex enzymes in microbial natural product biosynthesis |
| title_auth | Complex enzymes in microbial natural product biosynthesis |
| title_exact_search | Complex enzymes in microbial natural product biosynthesis |
| title_full | Complex enzymes in microbial natural product biosynthesis A Overview articles and peptides ed. by David A. Hopwood |
| title_fullStr | Complex enzymes in microbial natural product biosynthesis A Overview articles and peptides ed. by David A. Hopwood |
| title_full_unstemmed | Complex enzymes in microbial natural product biosynthesis A Overview articles and peptides ed. by David A. Hopwood |
| title_short | Complex enzymes in microbial natural product biosynthesis |
| title_sort | complex enzymes in microbial natural product biosynthesis overview articles and peptides |
| topic | Bakterien (DE-588)4004296-0 gnd Biosynthese (DE-588)4006902-3 gnd Antibiotikum (DE-588)4002257-2 gnd |
| topic_facet | Bakterien Biosynthese Antibiotikum Aufsatzsammlung |
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