Principles and practice of clinical virology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford
Wiley-Blackwell
2009
|
| Ausgabe: | 6. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 1014 S. |
| ISBN: | 9780470517994 |
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Datensatz im Suchindex
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| adam_text | Titel: Principles and practice of clinical virology
Autor: Zuckerman, Arie J.
Jahr: 2009
Contc
List of Contributors xi
Preface xiii
Past, Present and Future of Clinical Virology: An
Overview xv
1 Diagnostic Approaches 1
Katie Jeffery and Emma Aarons
Introduction 1
Electron Microscopy 2
Histology/Cytology 2
Virus Isolation 2
Serology 3
Molecular Amplification Techniques 8
Recommended Diagnostic Investigations 20
Future Trends 22
2 Viral Transmission: Infection Acquired by the
Blood-borne Route 29
Will Irving
Introduction 29
Prevention of Exposure through Infection
Control 30
Prevention of Infection through Specific Pre- and
Post-exposure Policies 30
Patient-to-patient Transmission 30
Patient-to-HCW Transmission 32
HCW-to-patient Transmission 36
3 Viral Transmission: Infection Acquired by AH
Other Routes (Respiratory, Eye-Nose-Mouth,
Inoculation and Faeco-orally) 43
Philip Rice
Introduction 43
Measles, Mumps and Rubella 44
Cytomegalovirus 47
Varicella Zoster Virus 48
Herpes Simplex Virus 53
Noroviruses 54
Rotavirus 56
?nts
Parvovirus B19 56
Respiratory Viruses 58
4 Emerging Virus Infections 69
Brian W.J. Mahy
Introduction 69
Factors Contributing to Emergence 69
Future Directions 77
5 Vaccinology 81
Francis E. Andre and Hugues H. Bogaerts
Introduction 81
Burden of Viral Diseases and their Reproductive
Rates 82
The Immune System and its Role in Natural and
Artificially-induced Immunity 83
Discovery of Protective Antigens in
Pathogens 85
Presentation of Protective Antigens through
Vaccines and Types of Vaccine 86
Research and Development on Vaccines and their
Commercial Introduction 86
Social Marketing of Introduced Vaccines 88
Planning and Implementation of Vaccination
Programmes 89
Surveillance of Disease Incidence and Adverse
Events Before and After Implementation of
Vaccination 89
Rectification of Publicized Falsehoods and
Maintenance of Vaccination Coverage 89
Viral Vaccines on the Horizon and the Roadblocks
to Future Vaccine Development 90
Closing Comments 91
6 Herpes Simplex Virus Type 1 and Type 2 95
Marianne Forsgren and Paul E. Klapper
Morphology 95
Replication 97
Epidemiology 103
Viral Diagnosis 105
Antiviral Chemotherapy 108
vi Coi
Clinical Features, Diagnosis and Management 112
Concluding Remarks 128
7 Varicella Zoster 133
Judith Breuer
Introduction 133
The Virus 133
Epidemiology 142
Clinical Features 143
Diagnosis of VZV Infection 148
Treatment 151
Prevention 153
8 Cytomegalovirus 161
Paul D. Griffiths
Introduction 161
The Vims 161
Epidemiology 166
Routes of Infection 167
Pathogenesis 168
Clinical Features 173
Diagnosis 175
Management 180
Prevention 183
Treatment 185
9 Epstein-Barr Virus 199
i Tanzina Haque and Dorothy H. Crawford
Introduction 199
The Virus 199
Epidemiology 204
EBV-associated Diseases 205
EBV Infection in the
Immunocompromized Host 215
Vaccine Development 218
10 Roseoloviruses: Human Herpesviruses 6A, 6B
and 7 223
Katherine N. Ward and Duncan A. Clark
Introduction 223
Biology of the Viruses 223
Epidemiology and Pathogenesis 228
Disease Associations 231
Laboratory Diagnosis 236
Antiviral Therapy 240
Concluding Remarks 240
11 Kaposi s Sarcoma-associated Herpesvirus
(Human Herpesvirus 8) 245
Cornelia Henke-Gendo, Abel Viejo-Borbolla and
Thomas F. Schulz
Introduction 245
Origin and Evolution of KSHV 245
ntents
Worldwide Distribution of KSHV in the General
Population 247
Transmission 249
Clinical Manifestations 251
Pathogenesis 254
Diagnostic Assays 261
Antiviral Therapy 263
12 Hepatitis Viruses 273
Tim J. Harrison, Geoffrey M. Dusheiko and Arie
J. Zuckerman
Introduction 273
Hepatitis A 275
Hepatitis E 280
Hepatitis B 282
Hepatitis D 307
Hepatitis C 309
13 GB Virus C (GBV-C) and Torque Teno Virus
(TTV) 321
Shigeo Hino
Introduction 321
GB Virus C (GBV-C) 321
Torque Teno Virus (TTV) 325
14 Rotaviruses 337
Ulrich Desselberger and Jim Gray
Introduction 337
Rotavirus Structure, Genome and
Gene-Protein Assignment 337
Classification 337
Replication 338
Pathogenesis 342
Immune Responses and Correlates of
Protection 343
Dlness, Diagnosis and Treatment 343
Epidemiology 344
Vaccine Development 345
15 Viruses other than Rotaviruses Associated with
Acute Diarrhoeal Disease 355
Jim Gray and Ulrich Desselberger
Introduction 355
Enteric Adenoviruses 357
Noroviruses and Sapoviruses (Human
Caliciviruses) 358
Astroviruses 363
Gastrointestinal Viruses Not Regularly Associated
with Acute Diarrhoeal Disease 364
16 Influenza 373
Maria Zambon and Chris W. Potter
Contents
Introduction 373
Viral Variation 380
Virus Classification 384
Pathogenesis 385
Clinical Features 388
Diagnosis of Infection 391
Treatment and Prevention 396
17 Parainfluenza Viruses 409
Stelios Psarras, Nikolaos G. Papadopoulos and
Sebastian L. Johnston
Introduction 409
Taxonomy 409
Structure and Physical Properties 410
Receptors, Virus Entry and Host Range 411
Replication 414
Viral Transmission, Incubation and
Shedding 416
Pathogenesis 417
Antigenicity and Immunity 418
Epidemiology 420
Clinical Features 423
Diagnosis 425
Prevention 428
Treatment 429
18 Respiratory Syncytial Virus 441
Caroline Breese Hall
Introduction 441
The Virus 441
Epidemiology 442
Pathogenesis 444
Immunity 445
Clinical Features 446
Diagnosis 450
Management 452
Prevention 453
19 Adenoviruses 463
Marcela Echavarria
Introduction 463
Description and Characteristics of the
Virus 464
Pathogenesis 468
Immune Response 469
Epidemiology 470
Clinical Features 471
Respiratory Infections 471
Ocular Infections 474
Gastrointestinal Infections 475
Haemorrhagic Cystitis 475
Adenoviruses Infections in
Immunocompromized Patients 475
vii
Other Clinical Manifestations 477
Diagnosis 477
Treatment 481
Prevention 482
Future Prospects 483
20 Rhinoviruses 489
Nikolaos G. Papadopoulos, Maria Xatzipsalti and
Sebastian L. Johnston
Introduction 489
Taxonomy 489
Physical Properties 492
Incubation and Transmission 492
Host Range 493
Pathogenesis 493
Immunity 495
Epidemiology 496
Clinical Features 497
Diagnosis 498
Prevention and Treatment 500
21 Coronaviruses and Toroviruses .... 511
J.S. Malik Peiris and L.L.M. Poon
Introduction 511
The Viruses 511
Initiation of Infection and Pathogenesis 517
Epidemiology 519
Clinical Features 520
Diagnosis 523
RT-PCR 524
Prophylaxis: Active and Passive
Immunization 525
Therapy 526
Acknowledgements 526
22 Measles Virus 533
Sibylle Schneider-Schaulies and Volker ter Meulen
Introduction 533
The Virus 533
Virus Morphology 535
Genome Structure 535
MV Protein Functions 536
The Replication Cycle 538
Biological Properties of the Measles
Virus 540
Epidemiology and Relatedness of Different Virus
Isolates 541
Clinical Manifestations 542
The Pathogenesis of Measles and its
Complications 545
Diagnosis 551
Management 552
Prevention 552
viii C
23 Rubella 561
Jennifer M. Best, Joseph P. lcenogle and David
W.G. Brown
Historical Introduction 561
The Virus 562
Postnatally Acquired Infection 565
Congenitally Acquired Infection 569
Laboratory Techniques and Diagnosis 576
Prevention—Rubella Vaccination 580
24 Mumps 593
Pauli Leinikki
Introduction 593
The Virus 593
Pathogenesis 595
Clinical Picture 595
Laboratory Diagnosis 597
Epidemiology and Control 598
25 Enterovinises 601
Philip D. Minor and Peter Muir
Introduction 601
The Viruses 601
Pathobiological and Clinical Aspects of Human
Enterovinises 608
Laboratory Diagnosis of Enterovirus Infections 615
Prevention and Treatment of Enterovirus
Infections 617
Future Prospects 620
26 Poxviruses 625
Peter B. Jahrling
Introduction 625
Virus Characteristics 625
Clinical Aspects of Orthopoxvirus Infections 627
Diagnosis 632
Medical Management 634
Other Poxviruses Infecting Humans 635
Diagnosis 637
27 Alphaviruses 643
Graham Lloyd
Introduction 643
The Virus 643
Spectrum of Diseases Caused by Alphaviruses 647
Diagnosis of Alphavirus Infections 647
Management and Prevention 647
Alphaviruses Associated with Fevers and
Polyarthritis 648
Alphaviruses Associated with Encephalitis 656
Other Alphaviruses 661
Contents
28 Flaviviruses 669
Barry D. Schoub and Marietjie Venter
Introduction 669
Properties of the Virus 670
Yellow Fever 672
Other Members of the Unassigned Subgroup of
Flaviviruses 678
Dengue 679
Zika 684
Japanese Encephalitis 684
St Louis Encephalitis 687
West Nile Virus 688
Murray Valley Encephalitis 690
Tick-borne Encephalitis 691
Omsk Haemorrhagic Fever 694
Kyasanur Forest Disease 694
Powassan Virus 695
29 Bunyaviridae 699
Robert Swanepoel and Felicity J. Burt
Introduction 699
The Virus 700
Laboratory Diagnosis 703
Genus Orthobunyavirus 706
Genus Phlebovirus 711
Genus Nairovirus 717
Genus Hantavirus 721
Bunyaviruses Unassigned to Genus 726
30 Arenaviruses 733
Colin R. Howard
Introduction 733
Ultrastructure of Arenaviruses and Infected
Cells 735
Chemical Composition 737
Replication 739
Diagnosis of Human Arenavirus Infections 740
Antigenic Relationships 741
Clinical and Pathological Aspects 741
Persistent Infection 743
Pathology of Arenavirus Infections: General
Features 744
Other Arenavirus Infections 750
Summary 751
31 Filoviruses 755
Susan P. Fisher-Hoch
Introduction 755
Epidemiology 756
Ecology 761
Transmission and Risk Factors 763
Clinical Spectrum 763
Contents
Laboratory Diagnosis 764
Patient Management 765
Past Infection and Persistence 766
Virology 766
Animal Models 767
Serological Studies 768
Pathogenesis and Immunology 768
Control 769
Perspective 770
32 Rabies and Other Lyssavirus Infections . 777
Mary J. Worrell
Introduction 777
History 777
Classification 778
Virus Structure 778
Replication 780
Inactivation of Virus and Stability of Vaccine
Antigen 781
Epizootiology and Epidemiology 781
Incidence of Human Rabies 783
Pathogenesis 783
Immunology 785
Routes of Infection 786
Clinical Features of Rabies in Animals 787
Clinical Features in Humans 787
Diagnosis 794
Management of Human Rabies 796
Pathology 796
Human Rabies Prophylaxis 797
Control of Animal Rabies 800
33 Papillomaviruses 807
Dennis McCance
Introduction 807
Classification 807
Physical and Chemical Properties 807
Serology 811
Viral Replication 811
Natural History of HPV Infections 812
Pathogenesis 813
Diagnosis 817
Treatment 818
Vaccination 819
34 The Human Polyomaviruses 823
Kristina Domes
Classification and Detection 823
Virion Structure and Composition 823
Virus Life Cycle 823
State of Human Polyomavirus Infection 833
Diagnostic Evaluation of Polyomavirus-associated
Disease 843
ix
Polyomavirus-specific Immune Response 845
Treatment of Polyomavirus-associated
Diseases 847
Acknowledgements 848
35 Human Parvoviruses 853
Kevin E. Brown
Introduction 853
Human Parvovirus B19 (B19V) 854
Pathogenesis 856
Epidemiology 858
Clinical Features 859
Laboratory Diagnosis 863
Treatment and Prevention 865
36 Human Retroviruses 869
Robin A. Weiss
Introduction 869
Retrovirus Replication and Genomes 869
Taxonomy 870
Human and Zoonotic Retrovirus
Infections 870
Retroviral Vectors 872
37 The Human T-lymphotropic Viruses . . 875
Graham P. Taylor
Introduction 875
History 875
The Virus 876
Diagnosis 879
Viral Variation 880
Epidemiology 881
Transmission 883
HTLV-associated Disease 884
Pathogenesis 886
Treatment 889
Prevention of Disease 891
HIV and HTLV Co-infection 891
38 Human Immunodeficiency Viruses . . . 897
Deenan Pillay, Anna Maria Geretti and Robin A.
Weiss
Introduction and Classification 897
Epidemiology 899
Replication 900
Host Genetic Determinants for HIV/AIDS 903
Viral Dynamics and Pathogenesis 903
Immune Responses 905
The Laboratory Diagnosis of HIV
Infection 906
The Natural History of HIV Infection and Its
Clinical Manifestations 909
x Ci
Antiretroviral Therapy—A Historical
Perspective 916
Monitoring of Antiretroviral Therapy and
Resistance 917
Antiretroviral Drug Classes 921
Transmission of Drug Resistance 929
Prevention 929
Vaccines 932
39 Human Prion Diseases 939
John Collinge
Introduction to Prions and Historical
Perspective 939
Structural Biology of Prions 940
Normal Cellular Function of PrP 943
Prion Strains 943
ontents
Neuronal Cell Death in Prion Disease 945
The Species Barrier 945
Pathogenesis 946
Animal Prion Diseases 947
Aetiology and Epidemiology of Human Prion
Disease 948
Clinical Features and Diagnosis 949
Molecular Diagnosis of Prion Disease 959
Pre-symptomatic and Antenatal Testing 960
Prevention and Public Health Management 960
Prognosis and Treatment 961
Concluding Remarks 962
Useful Websites 962
Index 969
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| subject_GND | (DE-588)4038243-6 (DE-588)4063597-1 (DE-588)4151278-9 |
| title | Principles and practice of clinical virology |
| title_auth | Principles and practice of clinical virology |
| title_exact_search | Principles and practice of clinical virology |
| title_full | Principles and practice of clinical virology ed. by Arie J. Zuckerman ... |
| title_fullStr | Principles and practice of clinical virology ed. by Arie J. Zuckerman ... |
| title_full_unstemmed | Principles and practice of clinical virology ed. by Arie J. Zuckerman ... |
| title_short | Principles and practice of clinical virology |
| title_sort | principles and practice of clinical virology |
| topic | Medical virology Virus diseases Medizin (DE-588)4038243-6 gnd Virologie (DE-588)4063597-1 gnd |
| topic_facet | Medical virology Virus diseases Medizin Virologie Einführung |
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