Rationale and design of the LURIC study: a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Ashley
2001
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| Schriftenreihe: | Pharmacogenomics
2 : Suppl. 1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | 73 S. graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Rationale and design of the LURIC study |b a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease |c Bernhard R Winkelmann ... |
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Datensatz im Suchindex
| _version_ | 1804139215873638400 |
|---|---|
| adam_text | Pharmacogenomics
February 2001
Vol. 2 No. 1 Suppl. 1
Contents
1. Introduction S9
2. Epidemiology S9
3. Genomics sio
4. Methods sio
4.1 Study design and sample size calculation SIO
4.2 Definition of atherosclerotic phenotypes sn
4.2.1 Coronary artery disease sn
4-2.2 Stable angina si2
4.23 Unstable angina si2
4.2.4 Myocardial infarction si2
4-2.5 Acute coronary syndromes S15
4.2.6 Cerebrovascular atherosclerosis S15
4-2.7 Peripheral vascular atherosclerosis S16
4-3 Definition of non-atherosclerotic phenotypes S16
4-3. l Heart failure and impaired left ventricular function S16
4-3.1.1 New York Heart Association functional classification for heart disease S16
43.2 Chronic obstructive pulmonary disease S16
4-33 Diabetes mellitus S16
434 Menopause si 7
43.5 Cardiovascular risk factors Si 7
4-4 Subject selection and informed consent S18
4-4.1 Personal and family history questionnaire Sis
4-4.2 Physical examination S19
4 5 Sample collection and storage S19
4 6 Biochemical analyses S20
4.6.1 Lipoprotein determination by a combined ultracentrifugation and precipitation method S21
4 7 Genetic studies S21
4-7.1 DNA extraction S2i
4 7.2 Lymphoblastoid cell lines
4-8 Manpower and funding S22
4 9 Database structure, documentation and storage S23
4-10 Quality control processes S24
4io.i Patients S24
4.10.2 Instruments s?4
410.3 Laboratory measurements ^24
continued...
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2001 © Ashley Publications Ltd. ISSN 1462-2416
Contents . 4. loA Data processing S25
4.11 Conversion units and detection limits S25
4.12 Data validation S25
4.13 Statistical analyses S25
41 j./ Statistical analysis plan S25
4.13.2 Statistical methods S26
4.14 Long-term follow-up S26
5. Results s26
5.1 Characteristics of the study subjects S26
5.2 Adverse events S32
6. Discussion S32
6.1 Background S32
6.2 Study aims and baseline characteristics S33
6.3 Comparison with other studies S34
6.4 Necessity of a reliable phenotype S34
6.5 Surrogate markers S35
6.6 Genetic dissection of complex diseases S35
6.7 Limitations S35
7. Conclusion S35
Bibliography S36
Websites S38
Appendix I S39
Inclusion and exclusion criteria
I. LURIC inclusion criteria. S39
n. LURIC exclusion criteria S39
Appendix II S4l
Sample size calculation for equal number of cases and controls
I. Two-sided test S41
Appendix in §43
Disease classification and risk factors (clinical phenotypes)
I. Coronary artery disease §43
I.i Angiographic CAD definition 1 (CAD10%) s43
I.ii Angiographic CAD definition 2 (CAD20%) $4}
continued...
- — - - - _ -
2001 O Ashley Publications Ltd. ISSN 1462-2416
Contents
I.iii Angiographic CAD definition 3 (CAD50%) S43
I.iv Angiographic CAD definition 4 - 0-1-2-3 vessel disease (CAD0123) S43
I.v No CAD definition 1 - angiographically normal (NoCAD10%) S43
I.vi No CAD definition 2 - no luminal narrowing (NoCAD20%) S43
I.vii No CAD definition 3 - no manifest CAD (NoCAD50%) S43
II. Myocardial infarction s43
Hi ST-elevation (formerly transmural or Q-wave) MI definition S43
Typical ECG changes S43
Typical clinical symptoms S44
1 Typical enzyme changes S44
, II.ii Non-ST-elevation (formerly non-Q, non-transmural) MI definition S44
m. Diabetes mellitus S45
IH.i Type 1 and Type 2 diabetes S46
iv. Cardiovascular risk factors S47
IV.i Lipids S47
IV.ii Total cholesterol S47
IV.iii LDL cholesterol S47
IV.iv HDL cholesterol S47
IV-v Triglycerides S47
IV.vi Non-lipid risk factors S48
i
Appendix IV S49
Personal, family history questionnaire and clinimetrlc definitions
i- Clinimetrics S54
I Definition of anginal pain S54
!• Stable angina S54
I I Unstable angina S54
I.iv New York Heart Association Functional Classification (NYHA) S54
Appendix V S57
Blood sampling and laboratory analyses
| Appendix VI s69
Conversion factors
| Appendix VII S71
| Addresses of co-operating centres
Glossary S73
| _.. I S5
¦ 20010 Ashley Publications Ltd. ISSN 1462-2416
|
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| series2 | Pharmacogenomics |
| spelling | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease Bernhard R Winkelmann ... London Ashley 2001 73 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmacogenomics 2 : Suppl. 1 Einzelaufnahme eines Zeitschr.-Bd. Pharmakogenetik (DE-588)4271255-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Pharmakogenetik (DE-588)4271255-5 s b DE-604 Winkelmann, Bernhard R. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017620745&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease Pharmakogenetik (DE-588)4271255-5 gnd |
| subject_GND | (DE-588)4271255-5 (DE-588)4143413-4 |
| title | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease |
| title_auth | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease |
| title_exact_search | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease |
| title_full | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease Bernhard R Winkelmann ... |
| title_fullStr | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease Bernhard R Winkelmann ... |
| title_full_unstemmed | Rationale and design of the LURIC study a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease Bernhard R Winkelmann ... |
| title_short | Rationale and design of the LURIC study |
| title_sort | rationale and design of the luric study a resource for functional genomics pharmacogenomics and long term prognosis of cardiovascular disease |
| title_sub | a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease |
| topic | Pharmakogenetik (DE-588)4271255-5 gnd |
| topic_facet | Pharmakogenetik Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017620745&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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