Metallothioneins and related chelators:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
RSC Publ.
2009
|
| Schriftenreihe: | Metal ions in life sciences
5 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIX, 514 S. Ill., graph. Darst. |
| ISBN: | 9781847558992 |
Internformat
MARC
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| 264 | 1 | |a Cambridge |b RSC Publ. |c 2009 | |
| 300 | |a XXIX, 514 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Metal ions in life sciences |v 5 | |
| 650 | 4 | |a Chelating Agents |x metabolism | |
| 650 | 4 | |a Heavy metals |x Toxicology | |
| 650 | 4 | |a Metal ions |x Physiological effect | |
| 650 | 4 | |a Metallothionein | |
| 650 | 4 | |a Metals, Heavy |x toxicity | |
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Datensatz im Suchindex
| _version_ | 1804139212260245504 |
|---|---|
| adam_text | Titel: Metallothioneins and related chelators
Autor: Sigel, Astrid
Jahr: 2009
Contents
HISTORICAL DEVELOPMENT
AND PERSPECTIVES OF THE SERIES v
PREFACE TO VOLUME 5 vii
CONTRIBUTORS TO VOLUME 5 xvii
TITLES OF VOLUMES 1-44 IN THE
METAL IONS IN BIOLOGICAL SYSTEMS SERIES xxi
CONTENTS OF VOLUMES IN THE
METAL IONS IN LIFE SCIENCES SERIES xxiii
1 METALLOTHIONEINS: HISTORICAL DEVELOPMENT
AND OVERVIEW 1
Monica Nordberg and Gunnar F. Nordberg
Abstract 2
1. Introduction 2
2. History of Metallothioneins 3
3. Protein Chemistry and Metal Binding 7
4. Methods for Quantification of Metallothionein 8
5. Role of Metallothionein in Metal Metabolism
and Toxicology 11
6. Metallothionein and DNA, Genetic Polymorphism,
Gender Perspectives 16
7. Metallothioneins and Disease 18
Metal Ions in Life Sciences, Volume 5 Edited by Astrid Sigel, Helmut Sigel, and Roland K.. O. Sigel
£ Royal Society of Chemistry 2009
Published by the Royal Society of Chemistry, www.rsc.org DOI: 10.1039 9781847558992-FPO09
x CONTENTS
8. Future Aspects on Metallothioneins 22
9. Conclusions 23
Abbreviations 24
References 25
2 REGULATION OF METALLOTHIONEIN GENE
EXPRESSION 31
Kuppusamy Balamurugan and Walter Schaffner
Abstract 32
1. Introduction 32
2. Metallothioneins are Encoded by a Family
of Short Genes 33
3. Regulation of Metallothionein Expression is mostly
Transcriptional 35
4. Metal Response Elements in the Upstream
Promoter-Enhancer Region Confer
Metal Inducibility 36
5. Metal Response Element Binding Transcription
Factor (MTF-1) 37
6. Transcription Factors in other Species Implicated
in Heavy Metal Handling 43
7. Concluding Remarks and Open Questions 44
Acknowledgments 45
Abbreviations 45
References 45
3 BACTERIAL METALLOTHIONEINS 51
Claudia A. Blindauer
Abstract 52
1. Introduction 52
2. Structure: A Hybrid Metallothionein/Zinc Finger 57
3. Thermodynamic and Dynamic Properties 61
4. The BmtA Family 71
5. Biotechnological Uses of Metallothioneins
in Bacteria 75
6. Concluding Remarks 76
Acknowledgments 77
Abbreviations and Definitions 77
References 78
CONTENTS Xj
4 METALLOTHIONEINS IN YEAST AND FUNGI 83
Benedikt Dolderer, Hans-Jiirgen Hartmann, and Vlrich Weser
Abstract 84
1. Introduction 84
2. Family 8 Metallothioneins 86
3. Cu-Metallothionein in Saccharomyces cerevisiae 89
4. Metallothionein-like Protein Crs5 in
Saccharomyces cerevisiae 97
5. Metallothionein-1 and Metallothionen-2 in Candida glabrata 98
6. Zinc and Cadmium Buffering Systems 100
7. Concluding Remarks 100
Acknowledgments 102
Abbreviations 102
References 102
5 METALLOTHIONEINS IN PLANTS 107
Eva Freisinger
Abstract 108
1. Introduction 108
2. Classification 110
3. Function 117
4. Isolation and Purification 125
5. Spectroscopic Characterization 129
6. Incorporation of Sulfide Ions 138
7. Structure 139
8. Concluding Remarks and Future Directions 147
Acknowledgments 148
Abbreviations 148
References 149
6 METALLOTHIONEINS IN DIPTERA 155
Silvia A Irian
Abstract 156
1. Introduction 156
2. Metallothionein Genes in Drosophila melanogaster:
Genomic and Chromosomal Architecture.
Gene Amplification 157
3. Metallothionein Transcripts: Tissular and
Developmental Differential Expression 161
xli CONTENTS
4. The Metallothionein Proteins in Drosophila melanogaster 166
5. Metallothioneins in Fly Physiology: Metal Homeostasis 171
6. Metallothionein Molecular Differentiation in the
Drosophila Genus 175
7. Metallothioneins in Other
(Non-Drosophilidae) Diptera and Insecta 177
8. Concluding Overview 178
Abbreviations and Definitions 179
References 179
7 EARTHWORM AND NEMATODE METALLOTHIONEINS 183
Stephen R. Stiirzenbaum
Abstract 183
1. Introduction 184
2. From Genes to Proteins 186
3. Transcriptional Regulation 190
4. Cellular and Subcellular Localization 191
5. Transgenic Worms 193
6. Concluding Remarks and Future Directions 195
Acknowledgments 195
Abbreviations 195
References 196
8 METALLOTHIONEINS IN AQUATIC ORGANISMS: FISH,
CRUSTACEANS, MOLLUSCS, AND ECHINODERMS 199
Laura Vergani
Abstract 200
1. Introduction 200
2. Non-Mammalian Metallothioneins 201
3. Aspects of Metallothionein Function in Aquatic
Organisms 202
4. Metallothioneins from Fish 204
5. Metallothioneins from Marine Crustaceans 214
6. Metallothioneins from Marine Molluscs 219
7. Metallothioneins from Echinoderms 228
8. Concluding Remarks 232
Acknowledgments 233
Abbreviations and Definitions 233
References 233
CONTENTS xiii
9 METAL DETOXIFICATION IN FRESHWATER ANIMALS.
ROLES OF METALLOTHIONEINS 239
Peter G. C. Campbell and Landis Hare
Abstract 240
1. Introduction 241
2. Basic Concepts 243
3. Review of Field Observations Linking Changes in Metal
Exposure to Changes in Subcellular Distribution and the
Onset of Deleterious Effects 253
4. Concluding Remarks and Future Directions 272
Acknowledgements 273
Abbreviations and Definitions 274
References 274
10 STRUCTURE AND FUNCTION OF VERTEBRATE
METALLOTHIONEINS 279
Juan Hidalgo, Roger Chung, Milena Penkowa, and Milan Vasdk
Abstract 280
1. Introduction 280
2. Mammalian Metallothionein Gene and Protein Structure 281
3. Non-Mammalian Vertebrate Metallothioneins 291
4. Metallothionein-1 and -2 Functional Aspects 293
5. Metallothioneins in the Central Nervous System 299
6. Concluding Remarks and Future Directions 304
Acknowledgments 305
Abbreviations 305
References 306
11 METALLOTHIONEIN-3, ZINC, AND COPPER IN THE
CENTRAL NERVOUS SYSTEM 319
Milan Vasdk and Gabriele Meloni
Abstract 320
1. Introduction 320
2. Mammalian Metallothioneins in the
Brain 321
3. Zinc and Copper in the Brain 325
4. Metallothionein-3 Structure and
Reactivity 332
xiv CONTENTS
5. Roles of Metallothionein-3 in Zinc and Copper Physiology
and Pathology 339
6. Concluding Remarks 343
Acknowledgments 343
Abbreviations 343
References 345
12 METALLOTHIONEIN TOXICOLOGY: METAL ION
TRAFFICKING AND CELLULAR PROTECTION 353
David H. Petering, Susan Krezoski, and Niloofar M. Tabatabai
Abstract 355
1. Introduction 355
2. Animal Metallothioneins 356
3. Metallothionein and Toxicology. An Overview 358
4. Metallothionein s Role in Toxicology: Results with
the MT-1- and MT-2-Null Mice and Derived Cells 361
5. Metal Ion Toxicology in Relation to
Metallothionein Chemistry 363
6. Oxidant Toxicology in Relation to
Metallothionein Chemistry 377
7. Electrophile Toxicology and Metallothionein
Chemistry 386
8. General Conclusions 388
Acknowledgments 388
Abbreviations 389
References 389
13 METALLOTHIONEIN IN INORGANIC
CARCINOGENESIS 399
Michael P. Waalkes and Jie Liu
Abstract 400
1. Introduction 400
2. Metallothionein in Metal Carcinogenesis 401
3. Mechanisms by which Metallothionein may Reduce Metal
Carcinogenesis 406
4. Concluding Remarks and Future Directions 408
Acknowledgments 409
Abbreviations 409
References 409
CONTENTS xv
14 THIOREDOXINS AND GLUTAREDOXINS. FUNCTIONS
AND METAL ION INTERACTIONS 413
Christopher Horst Lillig and Carsten Berndt
Abstract 414
1. Introduction 414
2. Functions of Thioredoxins and Glutaredoxins 418
3. Metal Binding Members of the Thioredoxin Family
of Proteins 421
4. Metal Ion Interactions and Physiology 425
5. Concluding Remarks and Future Directions 430
Acknowledgments 430
Abbreviations 430
References 431
15 METAL ION-BINDING PROPERTIES OF
PHYTOCHELATINS AND RELATED LIGANDS 441
Aurelie Devez, Eric Achterberg, and Martha Gledhill
Abstract 442
1. Introduction 442
2. Phytochelatins and Related Ligands 450
3. Importance of Phytochelatins and Related Ligands
in Metal Tolerance 457
4. Phytochelatin Induction in Phytoplankton in
Response to Metal Stress 460
5. Concluding Remarks and Future Directions 469
Acknowledgments 470
Abbreviations 471
References 472
SUBJECT INDEX 483
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| indexdate | 2024-07-09T21:40:29Z |
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| isbn | 9781847558992 |
| language | English |
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| publisher | RSC Publ. |
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| series | Metal ions in life sciences |
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| spelling | Metallothioneins and related chelators ed. by Astrid Sigel ... Cambridge RSC Publ. 2009 XXIX, 514 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Metal ions in life sciences 5 Chelating Agents metabolism Heavy metals Toxicology Metal ions Physiological effect Metallothionein Metals, Heavy toxicity Metallothionein (DE-588)4169618-9 gnd rswk-swf Metallion (DE-588)4169597-5 gnd rswk-swf Chelate (DE-588)4123003-6 gnd rswk-swf Metallothionein (DE-588)4169618-9 s Chelate (DE-588)4123003-6 s Metallion (DE-588)4169597-5 s DE-604 Sigel, Astrid Sonstige (DE-588)103367866X oth Metal ions in life sciences 5 (DE-604)BV022275400 5 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017618387&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metallothioneins and related chelators Metal ions in life sciences Chelating Agents metabolism Heavy metals Toxicology Metal ions Physiological effect Metallothionein Metals, Heavy toxicity Metallothionein (DE-588)4169618-9 gnd Metallion (DE-588)4169597-5 gnd Chelate (DE-588)4123003-6 gnd |
| subject_GND | (DE-588)4169618-9 (DE-588)4169597-5 (DE-588)4123003-6 |
| title | Metallothioneins and related chelators |
| title_auth | Metallothioneins and related chelators |
| title_exact_search | Metallothioneins and related chelators |
| title_full | Metallothioneins and related chelators ed. by Astrid Sigel ... |
| title_fullStr | Metallothioneins and related chelators ed. by Astrid Sigel ... |
| title_full_unstemmed | Metallothioneins and related chelators ed. by Astrid Sigel ... |
| title_short | Metallothioneins and related chelators |
| title_sort | metallothioneins and related chelators |
| topic | Chelating Agents metabolism Heavy metals Toxicology Metal ions Physiological effect Metallothionein Metals, Heavy toxicity Metallothionein (DE-588)4169618-9 gnd Metallion (DE-588)4169597-5 gnd Chelate (DE-588)4123003-6 gnd |
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