Therapeutic targets of the TNF superfamily:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Springer
2009
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
647 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Ill., graph. Darst. |
| ISBN: | 9780387895192 |
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Datensatz im Suchindex
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|---|---|
| adam_text | THERAPEUTIC TARGETS OF THE TNF SUPERFAMILY EDITED BY IQBAL S. GREWAL,
PHD DEPARTMENT OF PRECLINICAL THERAPEUTICS, SEATTLE GENETICS, INC.,
BOTHELL, WASHINGTON, USA SPRINGER SCIENCE+BUSINESS MEDIA, LLC LANDES
BIOSCIENCE CONTENTS 1. OVERVIEW OF TNF SUPERFAMILY: ACHEST FUELL OF
POTENTIAL THERAPEUTIC TARGETS 1 IQBAL S. GREWAL ABSTRACT 1 INTRODUCTION
1 THERAPEUTIC POTENTIAL OF TNF SUPERFAMILY FOR ANTICANCER TREATMENT 3
THERAPEUTIC POTENTIAL OF TNF SUPERFAMILY FOR AUTOIMMUNE AND INFLAMMATORY
DISEASE 4 CHALLENGES FOR TARGETING TNF SUPERFAMILY MEMBERS 5 SUMMARY AND
CONCLUSIONS 5 2. THERAPEUTIC INTERVENTIONS TARGETING CD40L (CD154) AND
CD40: THE OPPORTUN1TIES AND CHALLENGES 8 CHE-LEUNG LAW AND IQBAL S.
GREWAL ABSTRACT 8 INTRODUCTION 8 CD40L EXPRESSION IN AUTOIMMUNE AND
INFLAINMATORY CONDITIONS 10 CD40-MEDIATED INFLAMMATORY REACTION 10
GENETIC EVIDENCE FOR THE CONTRIBUTION OF CD40-CD40LINTERACTION IN
EXPERIMENTAL AUTOIMMUNE AND INFLAMMATORY DISEASES 11 THERAPEUTIC
TARGETING OF CD40L: PROOF OF CONCEPT PRECLINICAL ANIMAL MODELS OF
AUTOIMMUNITY AND INFLAMMATION 12 CLINICAL EXPERIENCE WITH ANTI-CD40L 15
MECHANISM(S) OF ACTION OF ANTI-CD40L MABS: TOXICITY VERSUS EFFICACY 16
POTENTIAL ALTERNATIVE THERAPEUTIC APPROACHES TARGETING CD40L 17 CD40
SIGNALING IN TRANSFORMED CELLS 18 CD40 AND CANCER IMMUNE SURVEILLANCE 20
CHARACTERISTICS OF ANTI-CD40 ANTIBODIES 20 CLINICAL EXPERIENCE IN
THERAPEUTIC TARGETING OF CD40 21 CONSIDERATIONS FOR THERAPEUTICS
TARGETING CD40 25 CONCLUSIONS 25 XIV CONTENTS 3. TARGETING TNF FOR
TREATMENT OF CANCER AND AUTOIMMUNITY 37 GAUTAM SETHI, BOKYUNG SUNG,
AJAIKUMAR B. KUNNUMAKKARA AND BHARAT B. AGGARWAL ABSTRACT 37 DISCOVERY
OF TNF 37 SIGNALIN MECHANISM(S) BY TNF-A 38 ROLE OF TNF-A IN CANCER 38
ROLE OF TNF-A IN THE IMMUNE SYSTEM 41 ROLE OF TNF-A IN AUTOIMMUNE
DISEASES 41 TNF INHIBITORS 43 NATURAL PRODUCTS AS INHIBITORS OF TNF 45
CONCLUSION 45 4. TARGETING OF BAFF AND APRIL FOR AUTOIMMUNITY
ANDONCOLOGY 52 MAUREEN C. RYAN AND IQBAL S. GREWAL ABSTRACT 52
INTRODUCTION 52 THE BAFF AND APRIL RECEPTOR/LIGAND SYSTEM 52 BAFF AND
APRIL REGULATE IMMUNE FUNCTIONS 54 BAFF AND APRIL IN AUTOIMMUNITY 56
APRIL AND BAFF IN CANCER 57 PARALLELS BETWEEN AUTOIMMUNITY AND CANCER 57
NEW THERAPEUTICS FOR AUTOIMMUNITY AND CANCER 58 FUTURE APPLICATIONS, NEW
RESEARCH, ANTICIPATED DEVELOPMENTS 59 5. THE ROLE OF FASLAND FAS IN
HEALTH AND DISEASE 64 MARTIN EHRENSCHWENDER AND HARALD WAJANT ABSTRACT
64 THE FASL-FAS SYSTEM 64 THE FASL-FAS SYSTEM IN HEALTH AND DISEASE 69
THERAPEUTIC CONCEPTS TARGETING THE FASL-FAS SYSTEM 77 6. OX40 (CD134)
AND OX40L 94 MICHAEL J. GOUGH AND ANDREW D. WEINBERG ABSTRACT 94
EXPRESSION OF OX40 AND OX40L 94 BIOLOGIE FUNCTION OF OX40-OX40L
INTERACTIONS 95 EXPRESSION AND ROLE OF OX40 AND OX40LIN DISEASE 98
INTERVENTION IN OX40-OX40L INTERACTION FOR THERAPY 100 CONCLUSION 102
CONTENTS XV 7. TARGETING CD70 FOR HUMAN THERAPEUTIC USE 108 TAMAR
BOURSALIAN, JULIE MCEARCHERN, CHE-LEUNG LAW AND IQBAL S. GREWAL ABSTRACT
108 INTRODUCTION 108 CD70 EXPRESSION AND BIOLOGY 109 CD70 IN
AUTOIMMUNITY 112 CD70 IN ONCOLOGY 113 CONCLUSIONS AND FUTURE DIRECTIONS
115 8. 4-1BB AS A THERAPEUTIC TARGET FOR HUMAN DISEASE 120 SEUNG-WOO LEE
AND MICHAEL CROFT ABSTRACT 120 INTRODUCTION TO BASIC RESEARCH 120
EXPRESSION OF 4-1BB AND 4-1BBL 121 THERAPEUTIC EFFECTS OF TARGETING
4-1BB OR 4-1BBL 121 POSSIBLE MECHANISMS OF ACTION OF 4-1BB AGONISTIC
ANTIBODIES 125 CONCLUDING REMARKS 126 9. RANK(L) AS A KEY TARGET FOR
CONTROLLING BONE LOSS 130 ANDREAS LEIBBRANDT AND JOSEF M. PENNINGER
ABSTRACT 130 OVERVIEW 130 BASIC CHARACTERISTICS OF THE RANKL-RANK-OPG
AXIS 131 BONE REMODELING AND THE RANKL-RANK-OPG AXIS 131 RANK(L)
SIGNALING PATHWAYS 132 RANK(L) SIGNALING IN THE IMMUNE SYSTEM 135 RANKL
AND RHEUMATOID ARTHRITIS 138 RANK(L), T-CELLS AND MORE 139 RANKL
INHIBITION*FROM BENCH TO BEDSIDE 140 CONCLUSIONS 140 10. TARGETING THE
LIGHT-HVEM PATHWAY 146 CARL F. WARE ABSTRACT 146 INTRODUCTION 146 LIGHT
AND HVEM 147 THE LIGHT-HVEM-BTLA SWITCH 148 LIGHT-MECHANISM OF ACTION
148 IMMUNOBIOLOGY OF LIGHT 150 CLINICAL INDICATIONS FOR LIGHT 152 XVI
CONTENTS 11. GITR: A MODULATOR OF IMMUNE RESPONSE AND INFLAMMATION 156
GIUSEPPE NOCENTINI AND CARLO RICCARDI ABSTRACT 156 INTRODUCTION 156
GITR: STRUCTURE, TRANSDUCTION PATHWAY AND TISSUE DISTRIBUTION 157 GITRL:
TISSUE DISTRIBUTION AND FUNCTION 159 GITR/GITRL SYSTEM MODULATES
T-LYMPHOCYTE ACTIVATION 159 GITR/GITRL SYSTEM MODULATES INNATE IMMUNE
RESPONSE 168 CONCLUDING REMARKS 170 12. TARGETING CD30/CD30L IN ONCOLOGY
AND AUTOIMMUNE AND INFLAMMATORY DISEASES 174 EZOGELIN OFLAZOGLU, IQBAL
S. GREWAL AND HANS PETER GERBER ABSTRACT 174 GENE STRUCTURE AND
EXPRESSION OF CD30 174 GENE STRUCTURE AND EXPRESSION OF CD30L 175
SIGNALING AND BIOLOGICAL FUNCTIONS OF THE CD30/CD30L SYSTEM 176
DEVELOPMENT OF THERAPEUTIC COMPOUNDS TARGETING CD30/CD30L 177
PRECLINICAL DEVELOPMENT OF THERAPEUTIC ANTIBODIES TARGETING CD30 OR
CD30L IN HEMATOLOGICAL MALIGNANCIES 177 CLINICAL STUDIES CONDUCTED WITH
COMPOUNDS TARGETING CD30 IN HEMATOLOGICAL MALIGNANCIES 178 THERAPEUTIC
EFFECTS OF TARGETING CD30/CD30L IN PRECLINICAL MODELS OF AUTOIMMUNE AND
INFLAMMATORY DISEASES 179 DIAGNOSTIC UTILITY OF CD30 LEVEL IN SERUM OF
PATIENTS WITH INFLAMMATORY DISEASES 180 FUTURE DIRECTIONS 180 13. TUMOR
NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21: TNFR-RELATED DEATH
RECEPTOR-6, DR6.... 186 ROBERT BENSCHOP, TAO WEI AND SONGQING NA
ABSTRACT 186 INTRODUCTION 186 DR6: SEQUENCE, STRUCTURE AND EXPRESSION
187 SIGNALING OF DR6 188 BIOLOGICAL FUNCTIONS OF DR6 191 IS DR6 A DEATH
RECEPTOR? 193 ALTERNATIVE FUNCTION OF DR6 193 CONCLUSION 193 CONTENTS
XVII 14. TRAIL AND OTHERTRAIL RECEPTORAGONISTS AS NOVEL CANCER
THERAPEUTICS 195 CHRISTINA FALSCHLEHNER, TOM M. GANTEN, RONALD KOSCHNY,
UTA SCHAEFER AND HENNING WALCZAK ABSTRACT 195 THE TRAIL/TRAIL-R SYSTEM
195 APOPTOSIS SIGNALING VIA TRAIL-RL AND TRAIL-R2 196 PHYSIOLOGICAL ROLE
OF THE TRAIL/TRAIL-R SYSTEM 197 TRAIL RECEPTOR AGONISTS AS NOVEL
BIOTHERAPEUTICS IN CANCER THERAPY 199 15. THERAPEUTIC POTENTIAL OF
VEGI/TL1A IN AUTOIMMUNITY AND CANCER 207 GAUTAM SETHI, BOKYUNG SUNG AND
BHARAT B. AGGARWAL ABSTRACT 207 INTRODUCTION 207 SIGNALING MECHANISM(S)
OF VEGI/TL1A 208 ROLE OF VEGI/TL1A IN AUTOIMMUNITY 210 ROLE OF VEGI/TL1A
AS NEGATIVE REGULATOR OF ANGIOGENESIS 212 ROLE OF VEGI/TL1A IN CANCER
213 CONCLUSION 214 INDEX 217
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| indexdate | 2024-07-09T21:40:00Z |
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| isbn | 9780387895192 |
| language | English |
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| series2 | Advances in Experimental Medicine and Biology |
| spelling | Therapeutic targets of the TNF superfamily ed. by Iqbal S. Grewal. [Participants: Bharat B. Aggarwal ...] New York Springer 2009 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in Experimental Medicine and Biology 647 Tumor necrosis factor Tumor necrosis factor / Agonists / Therapeutic use Autoimmune Diseases drug therapy Inflammation drug therapy Neoplasms drug therapy Receptors, Tumor Necrosis Factor therapeutic use Tumor Necrosis Factors therapeutic use Tumor necrosis factor Agonists Therapeutic use Grewal, Iqbal S. Sonstige (DE-588)138254826 oth Aggarwal, Bharat B. 1950- Sonstige (DE-588)138285810 oth Advances in Experimental Medicine and Biology 647 (DE-604)BV000003102 647 DE-601 pdf/application http://www.gbv.de/dms/bs/toc/584031203.pdf kostenfrei Inhaltsverzeichnis GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017597378&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Therapeutic targets of the TNF superfamily Advances in Experimental Medicine and Biology Tumor necrosis factor Tumor necrosis factor / Agonists / Therapeutic use Autoimmune Diseases drug therapy Inflammation drug therapy Neoplasms drug therapy Receptors, Tumor Necrosis Factor therapeutic use Tumor Necrosis Factors therapeutic use Tumor necrosis factor Agonists Therapeutic use |
| title | Therapeutic targets of the TNF superfamily |
| title_auth | Therapeutic targets of the TNF superfamily |
| title_exact_search | Therapeutic targets of the TNF superfamily |
| title_full | Therapeutic targets of the TNF superfamily ed. by Iqbal S. Grewal. [Participants: Bharat B. Aggarwal ...] |
| title_fullStr | Therapeutic targets of the TNF superfamily ed. by Iqbal S. Grewal. [Participants: Bharat B. Aggarwal ...] |
| title_full_unstemmed | Therapeutic targets of the TNF superfamily ed. by Iqbal S. Grewal. [Participants: Bharat B. Aggarwal ...] |
| title_short | Therapeutic targets of the TNF superfamily |
| title_sort | therapeutic targets of the tnf superfamily |
| topic | Tumor necrosis factor Tumor necrosis factor / Agonists / Therapeutic use Autoimmune Diseases drug therapy Inflammation drug therapy Neoplasms drug therapy Receptors, Tumor Necrosis Factor therapeutic use Tumor Necrosis Factors therapeutic use Tumor necrosis factor Agonists Therapeutic use |
| topic_facet | Tumor necrosis factor Tumor necrosis factor / Agonists / Therapeutic use Autoimmune Diseases drug therapy Inflammation drug therapy Neoplasms drug therapy Receptors, Tumor Necrosis Factor therapeutic use Tumor Necrosis Factors therapeutic use Tumor necrosis factor Agonists Therapeutic use |
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