Cellular oscillatory mechanisms:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media [u.a.]
2008
|
| Schriftenreihe: | Advances in experimental medicine and biology
641 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 153 S. Ill., zahlr. graph. Darst. |
| ISBN: | 9780387097930 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804139111338999808 |
|---|---|
| adam_text | Titel: Cellular oscillatory mechanisms
Autor: Maroto, Miguel
Jahr: 2008
CONTENTS
1. CALCIUM OSCILLATIONS 1
Ruediger Thul, Tomas C. Bellamy, H. Llewelyn Roderick,
Martin D. Bootman and Stephen Coombes
Abstract 1
Introduction 1
Modelling Ca2+ Dynamics 3
Mechanistic Models 5
Homogenous Cell Models 14
Threshold Models 16
Stochastic Modelling 20
Concluding Remarks 22
2. OSCILLATIONS BY THE P53-Mdm2 FEEDBACK LOOP 28
Galit Lahav
Abstract 28
Introduction 28
The pS3-Mdm2 Negative Feedback Loop 31
Oscillations of p53 and Mdm2 32
The Mechanism of p53-Mdm2 Oscillations 32
Variability in the Response of Individual Cells 35
The Potential Function of p53 Oscillations 35
Conclusion and Key Questions in the Field 36
3. cAMP OSCILLATIONS DURING AGGREGATION
OF DICTYOSTELIUM 39
William F. Loomis
Abstract 39
Introduction 39
Proposed cAMP Oscillatory Circuit 41
Periodic Motility 43
Discussion 46
xi
xii Contents
4. MIN OSCILLATION IN BACTERIA 49
Joe Lutkenhaus
Abstract 49
Introduction 49
ZRing 50
The Min System 51
The Oscillation 52
Biochemistry of Min Proteins 55
Models 57
Conclusions 58
5. DEVELOPMENT ON TIME 62
Isabel Palmeirim, Sofia Rodrigues, J. Kim Dale and Miguel Maroto
Abstract 62
Somitogenesis Is a Strict Time-Controlled Embryonic Process 62
Time Control during Somite Formation: The Segmentation Clock 65
The Genetic Complexity Underlying the Segmentation Clock 65
The Clock and Wavefront Model 66
Temporal vs. Positional Information 68
Conclusions 68
6. OSCILLATORY EXPRESSION OF HES FAMILY
TRANSCRIPTION FACTORS: INSIGHTS
FROM MATHEMATICAL MODELLING 72
Hiroshi Momiji and Nicholas A.M. Monk
Abstract 72
Delay-Driven Oscillations in Cellular Signaling Systems 72
Hesl as a Cellular Oscillator 74
Mathematical Modelling of the Hesl Oscillator. 75
Properties of Delay-Driven Oscillations 78
Extended Models of Hesl Regulation 82
Spatio-Temporal Coordination of Oscillatory Dynamics 84
Discussion 84
7. REVERSE ENGINEERING MODELS
OF CELL CYCLE REGULATION 88
Attila Csikasz-Nagy, Bela Novak and John J. Tyson
Abstract 88
Bottom-Up Modeling and Reverse Engineering 88
Physiology of the Cell Cycle 89
Three Cell Cycle States and Three Cell Cycle Transitions 90
Contents xiii
Cell Cycle Transitions and Bifurcation Points 91
Reverse Engineering the Molecular Regulatory Network 93
The Complete Bifurcation Diagram 94
Cell Cycles and Limit Cycles 94
Conclusion 96
8. MITOCHONDRIAL OSCILLATIONS IN PHYSIOLOGY
AND PATHOPHYSIOLOGY 98
Miguel A. Aon, Sonia Cortassa and Brian O Rourke
Abstract 98
Introduction 98
The Mitochondrial Oscillator of Heart Cells: The Pathophysiological Domain 102
The Theoretical Approach 106
The Mitochondrial Oscillator in the Physiological Domain 108
Spatial Aspects: ROS and Mitochondrial Criticality Ill
From Mitochondrial Dynamics to Whole Heart Arrhythmias Ill
Conclusions 114
9. RESPIRATORY OSCILLATIONS IN YEASTS 118
David Lloyd
Abstract 118
Introduction 118
Minute-Long Oscillations in S. cerevisiae 119
Ultradian (x 30-50min) Oscillations in Synchronous Cultures of Yeasts 119
Schizosaccharomyces pombe 120
Candida utilis 124
Saccharomyces cerevisiae: Self Synchronized Continuous Culture 128
Mitochondrial Respiratory Dynamics in Vivo During Growth 129
Oxidative Stress and Signalling by ROS 130
Circadian Oscillations in Yeasts 131
Other Oscillations 132
Functions of Oscillations 132
10. STOCHASTIC PHASE OSCILLATOR MODELS
FOR CIRCADIAN CLOCKS 141
Jacques Rougemont and Felix Naef
Background 141
Mathematics of Phase Models 142
Theory vs. Data 145
Conclusion 148
INDEX 151
|
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| indexdate | 2024-07-09T21:38:53Z |
| institution | BVB |
| isbn | 9780387097930 |
| language | English |
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| physical | XIII, 153 S. Ill., zahlr. graph. Darst. |
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| spelling | Cellular oscillatory mechanisms ed. by Miguel Maroto ... New York, NY Springer Science + Business Media [u.a.] 2008 XIII, 153 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 641 Horloges biologiques Modèle biologique Oscillométrie Rythme circadien Rythmes biologiques ram Rythmes circadiens ram Transduction du signal cellulaire ram Transduction du signal Biologie (DE-588)4006851-1 gnd rswk-swf Medizin (DE-588)4038243-6 gnd rswk-swf Holografie (DE-588)4025643-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1979 Münster (Westf) gnd-content Holografie (DE-588)4025643-1 s Biologie (DE-588)4006851-1 s DE-604 Medizin (DE-588)4038243-6 s Maroto, Miguel Sonstige oth Advances in experimental medicine and biology 641 (DE-604)BV000003102 641 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017551489&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cellular oscillatory mechanisms Advances in experimental medicine and biology Horloges biologiques Modèle biologique Oscillométrie Rythme circadien Rythmes biologiques ram Rythmes circadiens ram Transduction du signal cellulaire ram Transduction du signal Biologie (DE-588)4006851-1 gnd Medizin (DE-588)4038243-6 gnd Holografie (DE-588)4025643-1 gnd |
| subject_GND | (DE-588)4006851-1 (DE-588)4038243-6 (DE-588)4025643-1 (DE-588)1071861417 |
| title | Cellular oscillatory mechanisms |
| title_auth | Cellular oscillatory mechanisms |
| title_exact_search | Cellular oscillatory mechanisms |
| title_full | Cellular oscillatory mechanisms ed. by Miguel Maroto ... |
| title_fullStr | Cellular oscillatory mechanisms ed. by Miguel Maroto ... |
| title_full_unstemmed | Cellular oscillatory mechanisms ed. by Miguel Maroto ... |
| title_short | Cellular oscillatory mechanisms |
| title_sort | cellular oscillatory mechanisms |
| topic | Horloges biologiques Modèle biologique Oscillométrie Rythme circadien Rythmes biologiques ram Rythmes circadiens ram Transduction du signal cellulaire ram Transduction du signal Biologie (DE-588)4006851-1 gnd Medizin (DE-588)4038243-6 gnd Holografie (DE-588)4025643-1 gnd |
| topic_facet | Horloges biologiques Modèle biologique Oscillométrie Rythme circadien Rythmes biologiques Rythmes circadiens Transduction du signal cellulaire Transduction du signal Biologie Medizin Holografie Konferenzschrift 1979 Münster (Westf) |
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