Cardiac remodeling:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Taylor & Francis
2006
|
| Schriftenreihe: | Fundamental and clinical cardiology
54 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 569, 16 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9780824723873 |
Internformat
MARC
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| 020 | |a 9780824723873 |9 978-0-8247-2387-3 | ||
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| 245 | 1 | 0 | |a Cardiac remodeling |c ed. by Barry Greenberg |
| 264 | 1 | |a New York [u.a.] |b Taylor & Francis |c 2006 | |
| 300 | |a XXIV, 569, 16 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Fundamental and clinical cardiology |v 54 | |
| 650 | 2 | |a Défaillance cardiaque - prévention et contrôle | |
| 650 | 2 | |a Défaillance cardiaque - étiologie | |
| 650 | 2 | |a Infarctus du myocarde - complications | |
| 650 | 2 | |a Remodelage ventriculaire | |
| 650 | 4 | |a Heart Failure |x etiology | |
| 650 | 4 | |a Heart Failure |x prevention & control | |
| 650 | 4 | |a Myocardial Infarction |x complications | |
| 650 | 4 | |a Ventricular Remodeling | |
| 650 | 4 | |a Ventricular remodeling |x Pathophysiology | |
| 650 | 4 | |a Ventricular remodeling |x Treatment | |
| 650 | 0 | 7 | |a Kardiovaskuläres System |0 (DE-588)4024665-6 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Greenberg, Barry H. |e Sonstige |4 oth | |
| 830 | 0 | |a Fundamental and clinical cardiology |v 54 |w (DE-604)BV004737761 |9 54 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-017349009 | ||
Datensatz im Suchindex
| _version_ | 1804138869020426240 |
|---|---|
| adam_text | Contents
Series Introduction .... v
Preface .... vh
Acknowledgments .... xi
Contributors .... xxi
Part I. The Process of Remodeling
1. Overview: Cardiac Remodeling and Its Relationship to the
Development of Heart Failure l
Jay N. Cohn and Inder S. Anand
Structural Changes in Remodeling .... 2
Etiologic Considerations .... 3
Cardiac Remodeling and Cardiac Function .... 4
Adaptive vs. Maladaptive Remodeling .... 5
Remodeling and Prognosis .... 5
Therapy to Reverse or Slow Remodeling .... 5
References .... 6
2. Ventricular Remodeling in Pressure vs. Volume Overload 9
Blase A. Carabello
Introduction .... 9
Hypertrophy vs. Remodeling .... 9
Hypertrophy and Demand .... 10
Mechanism of Pressure vs. Volume Overload Hypertrophy
Development .... 17
Conclusions .... 21
References .... 22
3. Changes in the Interstitial Matrix During Myocardial
Remodeling 27
Anne M. Deschamps and Francis G. Spinale
Introduction .... 27
xiii
I
xjv Contents
Basement Membrane .... 27
Collagen Network .... 28
Cardiac Disease States and Myocardial Remodeling .... 28
MI and Remodeling .... 30
Matrix MMPs .... 30
Summary: A Need for Further Clinical and
Basic Research .... 38
Abbreviations .... 39
References .... 39
4. Cardiac Myocyte Structural Remodeling 45
A. Martin Gerdes and Maurice S. Holder
Introduction .... 45
Technical Considerations in Assessment of Myocyte Shape
Alterations .... 46
Alterations in Myocyte Shape in Hypertrophy
and Failure .... 48
Molecular Mechanisms of Myocyte Lengthening and Transverse
Growth .... 52
Myocyte Slippage .... 52
Summary .... 54
References .... 54
5. Myofllament Remodeling in the Failing Human Heart 57
Peter VanBuren and Martin M. Le Winter
Introduction .... 57
The Thick Filament .... 57
The Thin Filament .... 61
Summary .... 67
References .... 67
6. Alterations in Cardiac Myocyte Cytoskeleton 73
Henk L. Granzier
Introduction .... 73
Microtubules .... 73
Intermediate Filaments .... 75
Actin Filaments .... 76
Titin .... 77
Summary .... 84
References .... 84
7. Importance of Myocyte Loss and Regeneration During the Cardiac
Remodeling Process 91
Shaila Garg and Jagat Narula
Heart Muscle Cell Loss in Myocardial Remodeling .... 91
Myocyte Regeneration and Remodeling .... 97
Contents xv
Conclusions .... 99
References .... 100
8. Remodeling from Compensated Hypertrophy
to Heart Failure 103
Stefan Hein and Jutta Schaper
General Morphological Considerations .... 104
Studies in Patients .... 108
General Clinical Considerations .... 115
References .... 118
9. Myocardial Remodeling: Physiological and Pathological 121
Jeffrey S. Borer and Karl H. Schuleri
Introduction .... 121
Physiological Remodeling .... 124
Pathological Remodeling .... 128
Conclusion .... 134
References .... 134
10. Experimental Animal Models of Cardiac Remodeling 139
Elaine J. Tanhehco and Hani N. Sabbah
Introduction .... 139
Chronic Rapid Pacing .... 141
Myocardial Infarction .... 143
Coronary Microembolization .... 145
Other Models of Remodeling .... 147
Conclusion .... 150
References .... 151
11. The Use of Genetically Modified Mice in the Investigation of Cardiac
Remodeling 159
Daniel J. Lips, Rutger J. Hassink, Aart Brutel de la Riviere, and
Pieter A. Doevendans
Introduction .... 159
Cardiac Remodeling and Myocardial Ischemia .... 160
Myocardial Ischemia and Apoptosis .... 166
Myocardial Hypertrophy .... 170
Hemodynamics .... 175
Conclusion .... 177
References .... 179
Part H. Causes of Remodeling
12. The Renin-Angiotensin-Aldosterone System in Cardiac Remodeling 189
Barry Greenberg
Introduction .... 189
jjyj Contents
The Classical Systemic and the Local Tissue-Based
Renin-Angiotensin-Aldosterone Systems .... 190
Cardiac Remodeling and the Effects of Angiotensin II in the
Heart .... 191
Effects of Angiotensin II on Cardiac Fibroblasts .... 192
Effects of Angiotensin II on Cardiac Myocytes .... 193
Cross-Talk Between the RAAS and Other Systems .... 195
Additional Components of the Renin-Angiotensin-Aldosterone
System .... 196
Effects of Inhibiting the RAAS on Cardiac Remodeling .... 202
Conclusions .... 203
References .... 204
13. Adrenergic Receptor Signaling and Cardiac Remodeling 215
Gerald W. Dorn II and Lynne E. Wagoner
Cardiac Remodeling as an Adrenergic Receptor-Mediated
Response .... 215
Apoptosis as a Mechanism for Cardiac Hypertrophy
Decompensation .... 218
PKC Signaling in Cardiac Hypertrophy .... 221
p-Adrenergic Signaling in Heart Failure .... 223
Modulation of Receptor Signaling in the Remodeling Heart .... 230
Conclusions .... 232
References .... 233
14. The Role of Inflammatory Mediators in Cardiac Remodeling .... 241
Gabor Szalai, Yasushi Sakata, Jana Burchfield,
Shintaro Nemoto, and Douglas L. Mann
Introduction .... 241
Overview of the Biology of Proinflammatory Cytokines .... 241
Effect of Inflammatory Mediators on Cardiac Remodeling .... 242
Interactions Between the Renin-Angiotensin System and
Proinflammatory Cytokines in Adverse Cardiac
Remodeling .... 251
Conclusion .... 254
References .... 255
15. Oxidative Stress in Heart Failure: Impact on Cardiac Function and
Ventricular Remodeling 259
Luciano C. Amado, Anastasios P. Saliaris, and Joshua M. Hare
Introduction .... 259
Biochemical Mechanisms of Oxidative Stress .... 259
Evidence for Increased Oxidative Stress in HF .... 261
Sources of Oxidative Stress in HF .... 261
Consequences of Oxidative Stress on Cardiac
Remodeling .... 268
Contents xvii
Natural Antioxidant Defense Mechanisms .... 271
Antioxidant Enzyme Systems .... 271
Antioxidant Therapies for HF .... 272
Antioxidant Therapies in Development .... 273
Conclusions .... 275
References .... 275
Part III. Clinical Aspects and Treatment of Cardiac Remodeling
16. Natural History of Cardiac Remodeling 285
Gary S. Francis and W. H. Wilson Tang
Introduction .... 285
The Index Event .... 285
Myocardial Fibrosis and Diastolic Dysfunction .... 288
Other Examples of LV Remodeling—Valvular Heart
Disease and Other Causes .... 289
The Role of LV Geometry .... 289
Post-Infarction Remodeling .... 290
Adaptation .... 293
Prognosis .... 294
Summary .... 295
References .... 296
17. Assessment of Ventricular Remodeling in Heart Failure 303
Inder S. Anand
Introduction .... 303
Echocardiography .... 306
Radionuclide Ventriculography .... 308
Magnetic Resonance Imaging .... 312
Conclusions .... 318
References .... 319
18. Treatment of Remodeling: Inhibition of the
Renin-Angiotensin-Aldosterone System 325
Richard D. Patten and Marvin A. Konstam
Molecular Pathways of the RAS .... 325
Experimental Models and Inhibition of the RAAS .... 327
Clinical Studies .... 333
Summary .... 342
References .... 343
19. Effects of Adrenergic Blockade on Cardiac Remodeling 349
Henry Ooi and Wilson S. Colucci
Introduction .... 349
Pharmacology of P-Blockers .... 350
P-Adrenergic Receptor Blockade in Heart Failure .... 352
xvjjj Contents
Studies of the Effects of P-Blockade on Remodeling in Heart
Failure .... 355
Time Course of Improvement .... 364
Who Benefits the Most from 0-Blockade? .... 364
Comparative Effects of P-Adrenergic Receptor Blockade and Ace
Inhibition on Remodeling .... 366
P-Adrenergic Receptor Blockade Following MI .... 367
Which P-Adrenergic Receptor Blocker to Use? .... 370
oci-Adrenergic Receptor Blockade .... 374
Central Sympathetic Nervous System Inhibition .... 374
Conclusion .... 375
References .... 376
20. The Effects of Cardiac Revascularization on the
Remodeling Process 389
Victor A. Ferrari, Craig H. Scott, and Martin St. John Sutton
Introduction .... 389
Ventricular Remodeling .... 390
Postinfarction Remodeling .... 390
Clinical Studies with Noninvasive Imaging .... 394
Revascularization and Infarct Artery Patency .... 395
Diagnosis/Prognosis .... 399
Therapy .... 402
Conclusion .... 407
References .... 407
21. Reverse Remodeling After Heart Valve
Replacement and Repair 417
Lynne Hung and Shahbudin H. Rahimtoola
Introduction .... 417
Reverse Ventricular Remodeling .... 417
Aortic Stenosis .... 422
Aortic Regurgitation .... 425
Mitral Stenosis .... 429
Mitral Regurgitation .... 431
Conclusions .... 435
Appendix .... 435
References .... 436
22. Cardiac Remodeling After LVAD Placement 441
Kenneth B. Margulies
Introduction .... 441
LVAD-Associated Regression of Pathological Structure .... 443
LVAD-Associated Improvement in Abnormal
Function .... 445
LVAD-Associated Changes in Molecular Phenotype .... 450
Contents xix
From Reverse Remodeling to Recovery with LVADs .... 452
Conclusion .... 455
References .... 455
23. Cardiac Resynchronization Therapy in Heart Failure: A Powerful
Tool for Reverse Ventricular Remodeling? 461
Chu-Pak Lau
Introduction .... 461
Electromechanical Changes .... 461
Acute Effects of CRT .... 466
LV Reverse Remodeling .... 467
Clinical Trials .... 471
Implantation .... 473
Interface of Device and HF Management .... 474
Conclusion .... 477
References .... 477
24. Other Surgical or Device-Based Approaches to Treating Cardiac
Remodeling 483
V. Dor, M. Di Donato, M. Sabatier, and F. Civaia
The Left Ventricle After Myocardial Infarction .... 483
Surgery of the Ischemic Wall .... 487
Results .... 492
Summary .... 499
Other Surgical Techniques in Process .... 499
Mechanical Assistance of the Failing Heart .... 501
Conclusion .... 501
References .... 502
25. Gene Transfer and Left Ventricular Remodeling 505
H. Kirk Hammond and David M. Roth
Introduction .... 505
Overview of Cardiac Gene Transfer .... 505
Gene Transfer and Left Ventricular Remodeling .... 510
Summary and Future Directions .... 525
References .... 525
26. Stem CeUTMyoblast Transplantation for Myocardial Regeneration 557
Donald Orlic and Marc S. Penn
Introduction .... 531
Embryonic Origin of Stem Cells .... 532
Biology of Adult Stem Cells .... 532
Multiple Stem Cell Populations Exist in Bone Marrow .... 533
Cytokines Mobilize Stem Cells into Peripheral Blood .... 534
Bone Marrow Stem Cell Regeneration of Tissues Following Ischemic
Injury .... 535
xx Contents
Myocardial Infarction .... 536
Myocardial Regeneration .... 537
Instrumentation to Image Transplanted Cells in Myocardium .... 537
Bone Marrow Stem Cells for the Regeneration of Infarcted
Myocardium .... 538
Myocardial Infarction: Regeneration by Adult Differentiated
Cells .... 542
Autologous Transplantation of Differentiated Cells into Ischemic
Myocardium .... 543
Autologous Cell Transplantation as a Platform for Gene
Transfer .... 543
Clinical Trials in Cell Therapy .... 544
Conclusion .... 546
Glossary .... 546
References .... 547
27. Future Directions in Cardiac Remodeling 553
Barry Greenberg
Neurohormonal Blockade .... 553
Preventing Loss and Replacing Cardiac Myocytes .... 555
Targeting the Extracellular Matrix .... 555
Device Therapy .... 556
Cardiac Surgery .... 557
Concluding Thoughts .... 557
Index .... 559
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| series | Fundamental and clinical cardiology |
| series2 | Fundamental and clinical cardiology |
| spelling | Cardiac remodeling ed. by Barry Greenberg New York [u.a.] Taylor & Francis 2006 XXIV, 569, 16 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Fundamental and clinical cardiology 54 Défaillance cardiaque - prévention et contrôle Défaillance cardiaque - étiologie Infarctus du myocarde - complications Remodelage ventriculaire Heart Failure etiology Heart Failure prevention & control Myocardial Infarction complications Ventricular Remodeling Ventricular remodeling Pathophysiology Ventricular remodeling Treatment Kardiovaskuläres System (DE-588)4024665-6 gnd rswk-swf Kardiovaskuläres System (DE-588)4024665-6 s DE-604 Greenberg, Barry H. Sonstige oth Fundamental and clinical cardiology 54 (DE-604)BV004737761 54 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017349009&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cardiac remodeling Fundamental and clinical cardiology Défaillance cardiaque - prévention et contrôle Défaillance cardiaque - étiologie Infarctus du myocarde - complications Remodelage ventriculaire Heart Failure etiology Heart Failure prevention & control Myocardial Infarction complications Ventricular Remodeling Ventricular remodeling Pathophysiology Ventricular remodeling Treatment Kardiovaskuläres System (DE-588)4024665-6 gnd |
| subject_GND | (DE-588)4024665-6 |
| title | Cardiac remodeling |
| title_auth | Cardiac remodeling |
| title_exact_search | Cardiac remodeling |
| title_full | Cardiac remodeling ed. by Barry Greenberg |
| title_fullStr | Cardiac remodeling ed. by Barry Greenberg |
| title_full_unstemmed | Cardiac remodeling ed. by Barry Greenberg |
| title_short | Cardiac remodeling |
| title_sort | cardiac remodeling |
| topic | Défaillance cardiaque - prévention et contrôle Défaillance cardiaque - étiologie Infarctus du myocarde - complications Remodelage ventriculaire Heart Failure etiology Heart Failure prevention & control Myocardial Infarction complications Ventricular Remodeling Ventricular remodeling Pathophysiology Ventricular remodeling Treatment Kardiovaskuläres System (DE-588)4024665-6 gnd |
| topic_facet | Défaillance cardiaque - prévention et contrôle Défaillance cardiaque - étiologie Infarctus du myocarde - complications Remodelage ventriculaire Heart Failure etiology Heart Failure prevention & control Myocardial Infarction complications Ventricular Remodeling Ventricular remodeling Pathophysiology Ventricular remodeling Treatment Kardiovaskuläres System |
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