Uveitis and immunological disorders: progress III ; with 9 tables
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2009
|
| Schriftenreihe: | Essentials in ophthalmology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| ISBN: | 9783540694588 9783540694595 |
Internformat
MARC
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| 020 | |a 9783540694588 |9 978-3-540-69458-8 | ||
| 020 | |a 9783540694595 |9 978-3-540-69459-5 | ||
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| 245 | 1 | 0 | |a Uveitis and immunological disorders |b progress III ; with 9 tables |c ed.: Uwe Pleyer ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2009 | |
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Essentials in ophthalmology | |
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Augenentzündung |0 (DE-588)4137370-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Uveitis |0 (DE-588)4062232-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathogenese |0 (DE-588)4115512-9 |2 gnd |9 rswk-swf |
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| 689 | 1 | 1 | |a Pathogenese |0 (DE-588)4115512-9 |D s |
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| 700 | 1 | |a Pleyer, Uwe |d 1957- |e Sonstige |0 (DE-588)111452120 |4 oth | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017347008&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017347008 | ||
Datensatz im Suchindex
| _version_ | 1804138865728946176 |
|---|---|
| adam_text | Contents
Chapter
1
Histocompatibility
Matching
in
Penetrating Keratoplasty
Daniel Böhringer, Thomas Reinhard
1.1
Introduction
............................ /
1.2 Major Transplantation
Antigens
(HLA)
......................... /
1.2.1 Typing
Methods........................
2
1.2.2
Discussion of the Evidence
for
HLA
Matching in Penetrating
Keratoplasty
............................ 2
1.2.3
Differential
HLA
Matching
.............. 3
1.3
Minor (H) Transplantation
Antigens
............................... 3
1.3.1
Discussion of Selected
H
Antigens
...... 4
1.3.1.1
H-Y
..................................... 4
1.3.1.2
HA-3
................................... 4
1.3.1.3
ABO
.................................... 5
1.4
Practical Concerns:
Time on the Waiting List
................ 5
1.4.1
Waiting Time Variability as a Major
Handicap in
HLA
Matching
.............. 5
1.4.2
Predicting the Time
on the Waiting List
...................... 5
1.5
Recommended Clinical Practice
.........
б
References
.............................
б
Chapter
2
Acute Anterior Uveitis and HLA-B27:
What s New?
John H. Chang, Peter J. McCluskey,
Denis Wakefield
2.1
Introduction
............................ 9
2.2
Epidemiology of Acute Anterior
Uveitis and HLA-B27
.................... 10
2.2.1
Global Patterns of HLA-B27+
Acute Anterior Uveitis
.................. 10
2.3
HLA-B27 and Disease
................... 10
2.3.1
New Developments in the
Immunogenetics of HLA-B27
............ 11
2.3.2
Role of Microbial Triggers in
Immune-Mediated Inflammation
....... 12
2.3.3 HLA-B27-Associated
Inflammatory Disease
.................... 13
2.4
Other Genetic Risk Factors
for Acute Anterior Uveitis
................. 13
2.5
Current Understanding of
AAU Pathogenesis
........................ 13
2.5.1
Cytokines
................................ 14
2.5.2
Toll-Like Receptors (TLR)
.................. 14
2.6
Clinical Features of Acute
Anterior Uveitis
........................... 15
2.6.1
HLA-B27 and Clinical Phenotype
.......... 15
2.6.2
Ocular Complications
..................... 15
2.7
Clinical Management of AAU
.............. 16
2.8
Conclusions
.............................. 16
References
............................... 17
Chapter
3
What Can the Aqueous Humour
Tell Us About Uveitis?
Alastair K.O. Denniston, S. John Curnow
3.1
Clinical Examination of the Aqueous Humour
in Uveitis
................................. 19
3.1.1
Introduction
............................. 19
3.1.2
Observable Changes During
Intraocular Inflammation
................. 19
3.1.3
Sampling of Aqueous Humour
............ 20
3.2
Identification of Infectious
Agents in Aqueous Humour
.............. 21
3.2.1
Intraocular Antibody and PCR
............. 21
3.2.2
Recent Technological Advances
........... 21
3.3
Leukocyte Populations
in Aqueous Humour
...................... 21
3.3.1
The Noninflamed Eye
..................... 21
3.3.2
Cytocentrifuge Analysis of
Leukocyte Populations
in Uveitis Aqueous Humour
............... 21
3.3.3
Flow Cytometric Analysis
of Uveitis Aqueous Humour
............... 22
3.3.4
Antigen Specificity of Aqueous
Humour
T
Cells
........................... 23
3.4
Changes in the Aqueous Humour
Microenvironment
During
Episodes of Uveitis
....................... 23
3.4.1
Immunological
Properties of
Aqueous Humour
..................... 23
3.4.2
Cytokine Profiles of Aqueous
Humour
............................... 23
3.4.3
IL-10 In Aqueous Humour
.............. 24
3.5
Summary and Future Directions
........ 25
References
............................ 25
Chapter
4
Is Diabetic Retinopathy an Inflammatory
Disease? Inflammation as a Stimulus
for Vascular Leakage and Proliferation
Antonia
M. Joussen
4.1
Introduction
........................... 29
4.1.1
Clinical Problems and Cellular
Interaction in Diabetic
Retinopathy
........................... 29
4.1.2
Elevated Adhesion Molecules
and Inflammatory Mediators
in Diabetic Retinopathy
................ 30
4.2
Inflammatory Processes Mediate
Diabetic Macula Edema
................ 31
4.2.1
Diabetic Vascular Leakage
is Mediated by Inflammation
........... 31
4.2.2
Diabetic Vascular Leakage
Can Be Inhibited
by Anti-inflammatory Agents
.......... 31
4.3
Inflammatory Aspects of Retinal
Vascular Remodeling and Growth
...... 32
4.3.1
Leukocytes Mediate Retinal
Vascular Remodeling During
Development and Vaso-Obliteration
in Disease
............................. 32
4.3.2
Effects of VEGF on Ocular
Neovascularisation and Vascular
Permeability
........................... 33
4.4
Clinical Application of
the Inflammatory Concept
in Diabetic Retinopathy
................ 34
4.4.1
Nonsteroidal Anti-inflammatory
Drugs
................................. 34
4.4.2
Corticosteroids
........................ 34
4.4.3
Antiangiogenic Treatment
............. 35
4.4.3.1
Phase
2
Trial: Intravitreous
Pegaptanib as a Treatment
for
DME
............................... 35
4.4.3.2
Clinical Experience with
Bevacizumab in Diabetic
Retinopathy
........................... 37
4.4.3.3
Ranibizumab in Diabetic
Macula Edema
......................... 38
References
............................ 39
Chapter
5
Steroid Sensitivity in Uveitis
Richard W.J. Lee, Lauren P. Schewitz,
Ben J.E. Raveney, Andrew D. Dick
5.1
Introduction
............................ 45
5.2
Glucocorticoids as Regulators
of the Immune Response
................ 45
5.2.1
Endogenous Glucocorticoids
and the Hypothalamic-Pituitary-
Adrenal Axis
............................. 45
5.2.2
Glucocorticoid Control
of Cell Function
.........................
485.2.3.
.The Interleukin^/Glucocorticoid
Balance
................................. 48
5.3
Glucocorticoids in the Treatment
of Noninfectious Uveitis
................. 48
5.4
Steroid Sensitivity in Other
Inflammatory Diseases
.................. 49
5.4.1
The Concept of a Common
Steroid Refractory Phenotype
............ 49
5.5
Immune Mechanisms of
Steroid Resistance
....................... 50
5.6
Future Directions: Novel Strategies
to Optimise Glucocorticoid
Treatment
............................... 52
5.6.1
Targeting Steroid Refractory
Cd4+ Cd25int Cells
........................ 52
5.6.2
Other Approaches
....................... 52
References
.............................. 52
Chapter
б
Multiple Sclerosis and Uveitis
Graeme J. Williams
6.1
Introduction
............................ 55
6.2
Association Between Multiple
Sclerosis and Uveitis
..................... 55
6.3
Clinical Findings in
MS-Associated Uveitis
................... 56
6.4
Histopathological Findings
.............. 57
6.5
Experimental Models
.................... 58
6.6
Treatment
............................... 58
References
.............................. 58
Chapter
7
Inflammation in Age-Related
Macular
Degeneration: What is the Evidence?
Heping Xu, John V. Forrester
7.1
Introduction
............................ 61
7.2
Evidence from Clinical Studies
........... 62
7.2.1
Genetic Link to Inflammation
............ 62
7.2.2
Epidemiological Evidence for
Inflammatory Markers in AMD
......... 62
7.2.2.1
C-Reactive Protein (CRP)
............... 62
7.2.2.2
IL-6
.................................... 62
7.2.2.3
Tumor Necrosis Factor-aCTNF-a)
....... 63
7.2.2.4
Intercellular Adhesion Molecule
(ICAMH
.............................. 63
7.2.2.5
Circulating White Blood Cell (WBC)
Count
................................. 63
7.2.2.6
Retinal Autoantibodies
................ 63
7.2.2.7
Other Markers
......................... 63
7.2.3
Inflammatory Components
in
Drusen.............................. 64
7.2.4
Evidence from Clinical
Anti-inflammatory Treatment
Studies
................................ 64
7.3
Evidence from Experimental
Studies
................................ 64
7.3.1
Myeloid Cells in the Pathogenesis
of AMD
................................ 64
7.3.1.1
Choroidal Monocytes
in the Pathogenesis of AMD
............ 64
7.3.1.2
Retinal Microglia in
the Pathogenesis of AMD
.............. 65
7.3.2
Complement Activation
in Age-Related
Macular
Degeneration
......................... 67
7.4
Conclusion
............................ 68
References
............................ 68
Chapter
8
Age-Related
Macular
Degeneration:
Immunological Factors in the Pathogenesis
and Therapeutic Consequences
Aize Kijlstra, Ellen
С
La Heij, Fleur Goezinne,
Fred Hendrikse
8.1
Introduction
........................... 73
8.2
Inflammatory Cells in the Choroid
and Retina in AMD
..................... 74
8.3
Infectious Pathogens and AMD
........ 75
8.4
Role of Autoimmunity in AMD
......... 76
8.5 Drusen
as Triggers of Complement
Activation in AMD
..................... 76
8.6
Genetic Factors Related
to Inflammation and AMD
............. 78
8.7
Anti-inflammatory Effects
of Nutritional Factors
.................. 79
8.8
Anti-inflammatory Drugs
andAMD
.............................. 80
8.8.1
Angiostatic Steroids
...................
SO
8.8.2
Antiangiogenic Therapy
in AMD
................................ 81
8.8.3
Immunotherapy for AMD
.............. 81
8.9
Retinal Transplantations
.
References
..............
82
82
Chapter
9
Patterns of Retinal Vascular
Involvement in the Diagnosis
of Retinal Vasculitis
Miles R. Stanford, Rashmi Mathew
9.1
Introduction
........................ 87
9.2
Pathology of Retinal Vasculitis
....... 88
9.2.1
General Pathology of Retinal
Vessels
.............................. 88
9.2.2
Pathology of Retinal Vessels
in Specific Diseases
.................. 88
9.2.2.1
Behçet s
Disease
..................... 88
9.2.2.2
Tuberculosis
........................ 88
9.2.2.3
Sarcoidosis
.......................... 89
9.2.2.4
Multiple Sclerosis
.................... 89
9.2.2.5
Idiopathic Isolated Retinal Vasculitis.
. 89
9.2.2.6
Acute Retinal Necrosis
............... 89
9.2.2.7
Sympathetic Ophthalmia
............ 89
9.3
Clinical Features of Retinal
Vasculitis
............................ 90
9.3.1
Primary, Idiopathic, Isolated RV
...... 90
9.3.2
Systemic Disease and RV
............ 92
9.3.2.1
Behçet s
Disease
..................... 92
9.3.2.2
Eales Disease
........................ 92
9.3.2.3
Tuberculosis
........................ 93
9.3.2.4
Sarcoidosis
.......................... 93
9.3.2.5
Multiple Sclerosis
.................... 93
9.3.3
Retinal Vasculitis Associated
with Infection
....................... 94
9.3.3.1
Viral
Retinitis........................ 94
9.3.3.2
Syphilis
............................. 95
References
.......................... 95
Chapter
10
Masquerade Syndromes
Shouvik Saha, Elizabeth M. Graham
10.1
Introduction
........................ 97
10.2
Lymphoproliferative
Malignancies
........................ 97
10.2.1
Primary Intraocular Lymphoma
...... 97
10.2.1.1
Introduction
........................ 97
10.2.1.2
Epidemiology
....................... 98
10.2.1.3
Clinical Features
..................... 98
10.2.1.4
Fluorescein Angiography
............ 99
10.2.1.5
Ultrasonography
.................... 100
10.2.2
Special Investigations
............... 100
10.2.2.1
Neuroradiology
..................... 100
10.2.2.2
Cerebrospinal
Fluid Analysis
......... 101
10.2.3
Tissue Biopsy
........................ 101
10.2.3.1
Vitreous Sampling
................... 707
10.2.3.2
OtherTissue Sampling Techniques
___ 707
10.2.4
Tissue Analysis Techniques
.......... 707
10.2.4.1
Cytology
............................ 707
10.2.4.2
Immunohistochemistry
.............. 702
10.2.4.3
Cytokines
........................... 703
10.2.4.4
Molecular Analysis
.................. 703
10.2.5
Treatment
........................... 703
10.2.5.1
Radiation Therapy
................... 703
10.2.5.2
Chemotherapy
...................... 703
10.2.5.3
Combination Chemotherapy
and Radiotherapy
................... 704
10.2.6
Prognosis
........................... 704
10.2.7
Primary Uveal Lymphoma
........... 704
10.2.8
Secondary Intraocular
Lymphomas
......................... 705
10.2.8.1
Diffuse Large B-Cell
Lymphoma
.......................... 706
10.2.8.2
Intravascular
B-Cell
Lymphoma (Malignant
Angioendotheliomatosis)
............ 706
10.2.8.3
Τ
or T/Nk-Cell Lymphomas
........... 706
10.2.9
Leukaemias
......................... 707
10.2.10
Paraproteinaemias
.................. 107
10.3
Nonlymphoproliferative
Malignancies
........................ 108
10.3.1
Uveal Melanoma
.................... 70S
10.3.1.1
Clinical Features
..................... 708
10.3.1.2
Diagnosis
........................... 708
10.3.1.3
Management
....................... 708
10.3.2
Retinoblastoma
..................... 709
10.3.2.1
Clinical Features
..................... 709
10.3.2.2
Diagnosis
........................... 709
10.3.2.3
Management
....................... 709
10.3.3
Ocular
Métastases
................... 770
10.3.3.1
Clinical Features
..................... 7 70
10.3.3.2
Diagnosis
........................... 7 70
10.3.4
Juvenile Xanthogranuloma
.......... 777
10.3.4.1
Clinical Features
..................... 777
10.3.4.2
Diagnosis
........................... 777
10.3.4.3
Management
....................... 777
References
.......................... 7 72
Index
.......................................... 7 77
|
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| record_format | marc |
| series2 | Essentials in ophthalmology |
| spelling | Uveitis and immunological disorders progress III ; with 9 tables ed.: Uwe Pleyer ... Berlin [u.a.] Springer 2009 txt rdacontent n rdamedia nc rdacarrier Essentials in ophthalmology Literaturangaben Augenentzündung (DE-588)4137370-4 gnd rswk-swf Uveitis (DE-588)4062232-0 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Augenentzündung (DE-588)4137370-4 s Pathogenese (DE-588)4115512-9 s DE-604 Uveitis (DE-588)4062232-0 s Pleyer, Uwe 1957- Sonstige (DE-588)111452120 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017347008&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Uveitis and immunological disorders progress III ; with 9 tables Augenentzündung (DE-588)4137370-4 gnd Uveitis (DE-588)4062232-0 gnd Pathogenese (DE-588)4115512-9 gnd |
| subject_GND | (DE-588)4137370-4 (DE-588)4062232-0 (DE-588)4115512-9 (DE-588)4143413-4 |
| title | Uveitis and immunological disorders progress III ; with 9 tables |
| title_auth | Uveitis and immunological disorders progress III ; with 9 tables |
| title_exact_search | Uveitis and immunological disorders progress III ; with 9 tables |
| title_full | Uveitis and immunological disorders progress III ; with 9 tables ed.: Uwe Pleyer ... |
| title_fullStr | Uveitis and immunological disorders progress III ; with 9 tables ed.: Uwe Pleyer ... |
| title_full_unstemmed | Uveitis and immunological disorders progress III ; with 9 tables ed.: Uwe Pleyer ... |
| title_short | Uveitis and immunological disorders |
| title_sort | uveitis and immunological disorders progress iii with 9 tables |
| title_sub | progress III ; with 9 tables |
| topic | Augenentzündung (DE-588)4137370-4 gnd Uveitis (DE-588)4062232-0 gnd Pathogenese (DE-588)4115512-9 gnd |
| topic_facet | Augenentzündung Uveitis Pathogenese Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017347008&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pleyeruwe uveitisandimmunologicaldisordersprogressiiiwith9tables |