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Technical manual:

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Format:	Buch
Sprache:	English
Veröffentlicht:	Bethesda, Md. AABB 2008
Ausgabe:	16. ed.
Schlagworte:	Blood Banks > Laboratory Manuals Blood banks > Handbooks, manuals, etc Blood > Transfusion > Handbooks, manuals, etc Blutbank Bluttransfusion Standardisierung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXVII, 1039 S.
ISBN:	9783805589963 9781563952609

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Datensatz im Suchindex

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adam_text	Contents A Preface ............................................................xi QUALITY ISSUES 1. Quality Systems: Theory and Practice .............................1 Tania L. Motschman, MS, MT(ASCP)SBB, CQA(ASQ); Betsy W. Jett, MTfASCPJ, CQA, CQM/OEfASQ); and Susan L. Wilkinson, EdD, MS, MT(ASCP)SBB, CQA(ASQ) Quality Concepts ......................................................2 Practical Application of Quality Principles .................................4 References ...........................................................30 Appendix 1-1. Glossary of Commonly Used Quality Terms ..................32 Appendix 1-2. Code of Federal Regulations Quality-Related References ........34 Appendix 1-3. Statistical Tables for Binomial Distribution Used to Determine Adequate Sample Size and Level of Confidence for Validation of Pass/Fail Data ..........................................35 Appendix 1-4. Suggested Quality Control Performance Intervals for Equipment and Reagents ............................................37 2. Facilities, Work Environment, and Safety ........................41 Betsy W. Jett, MT(ASCP), CQA, CQM/OEfASQJ; Susan L. Wilkinson, EdD, MS, MT(ASCP)SBB; and Tania Motschman, MS, MT(ASCP)SBB, CQA(ASQ) Facilities .............................................................42 Safety Program .......................................................44 Fire Prevention .......................................................49 Electrical Safety .......................................................50 Biosafety ............................................................51 Chemical Safety ......................................................59 Radiation Safety ......................................................64 xiii xiv -4 AABB TECHNICAL MANUAL Shipping Hazardous Materials ..........................................67 General Waste Management ............................................68 Disaster Planning .....................................................68 Uniforms and Laboratory Coats .........................................75 Gloves ..............................................................75 Face Shields, Masks, and Safety Goggles ..................................76 Hand-Washing .......................................................77 Eyewashes ...........................................................77 References ...........................................................77 Appendix 2-1. Safety Regulations and Recommendations Applicable to Health-Care Settings ................................................73 Appendix 2-2. General Guidelines for Safe Work Practices, Personal Protective Equipment, and Engineering Controls ........................75 Appendix 2-3. Biosafety Level 2 Precautions ...............................79 Appendix 2-4. Sample Hazardous Chemical Data Sheet .....................81 Appendix 2-5. Sample List of Hazardous Chemicals in the Blood Bank ........82 Appendix 2-6. Specific Chemical Categories and How to Work Safely with Them ........................................................84 Appendix 2-7. Incidental Spill Response ..................................86 Appendix 2-8. Managing Hazardous Chemical Spills .......................89 3. Regulatory Issues in Blood Banking .............................91 Glenn Ramsey, MD Federal Laws and Regulations for Drags ..................................91 Biological Products ...................................................92 Licensure and Registration .............................................93 FDA Inspections ......................................................94 Blood-Related Devices .................................................95 Hematopoietic Progenitor Cells and Other Tissues .........................95 Testing for Infectious Diseases ..........................................96 Managing Recalls and Withdrawals ......................................97 Medical Laboratory Laws and Regulations ................................97 State and Local Regulations .............................................99 Conclusion .........................................................100 References ..........................................................100 4. Disaster Management ........................................103 Jamie Blietz, MBA, CAE; William P. FitzGerald, LTC USA (Ret); and Ruth D. Sylvester, Lt Col, USAF(Ret), MS, MT(ASCP)SBB Business Operations Planning ..........................................108 Working with Emergency Management Agencies .........................121 Regulatory Considerations in Emergencies ...............................123 Testing the Disaster Plan ..............................................125 Table of Contents Џ- xv Summary of Lessons Learned from Recent Disasters .......................127 Conclusion .........................................................127 References ..........................................................132 Appendix 4-1. Internet Resources Related to State and Local Organizations ... 135 Appendix 4-2. General Internet Resources for Disaster Management .........135 BLOOD DONATION AND COLLECTION 5. Allogeneic and Autologous Blood Donor Selection ...............137 Anne E Eder, MD, PhD Historical Perspective .................................................138 Selection of Allogeneic Donors .........................................140 Possible Measures of the Effectiveness of the Donor Interview ...............147 Blood Center-Defined Donor Eligibility Criteria ..........................148 Abbreviated Donor History Questionnaire for Frequent Donors .............153 Postdonation Instructions .............................................153 Recipient-Specific Designated Blood Donation .........................154 References ..........................................................156 Appendix 5-1. Requirements for Allogeneic and Autologous Donor Qualification .....................................................161 Appendix 5-2. The Donor History Questionnaire and Corresponding Regulations and Standards ..........................................164 Appendix 5-3. Full-Length Donor History Questionnaire ...................182 Appendix 5-4. Medication Deferral List for the Donor History Questionnaire ....................................................185 Appendix 5-5. Blood Donor Educational Materials: Making Your Blood Donation Safe ....................................................186 6. Whole Blood Collection and Component Processing ..............189 Ram Kakaiya, MD, MBBS; Colleen A. Aronson, MT(ASCP)SBB; and Janajulieis, MT(ASCP)SBB Whole Blood Collection ..............................................189 Blood Component Preparation and Processing ...........................197 Quality Control of Blood Components ..................................220 References ..........................................................225 7. Blood Component Collection by Apheresis ......................229 fames W. Smith, MD, PhD, and Edwin A, Burgstaler, MT(ASCP), HP Component Collection ...............................................229 Instruments and Systems for Donor Apheresis Collections ..................235 References .......................................................... 238 xvi «4 AABB TECHNICAL MANUAL 8. Infectious Disease Screening ..................................241 Eberhard W. Fiebig, MD, and Michael P. Busch, MD, PhD Transfusion-Transmissible Pathogens ...................................241 Strategies to Prevent Infectious Disease Transmission by Blood Transfusion ... 260 References ..........................................................278 9. Storage, Monitoring, Pretransfusion Processing, and Distribution of Blood Components ..........................283 William B. Lockwood, PhD, MD; Jill Leonard, MT(AMT); and Sandy L. Lües, MT(ASCP)SBB Blood and Blood Component Storage ...................................284 Prestorage Processing .................................................291 Poststorage Processing ................................................292 Inspection, Shipping, Receiving into Inventory, Disposition, and Issue .......295 References ..........................................................298 IMMUNOLOGIO AND GENETIC PRINCIPLES 10. Molecular Biology and Immunology in Transfusion Medicine ......301 fames C. Zimring, MD, PhD, and Steven L. Spitalnik, MD Nucleic Acid Analysis .................................................301 Protein Analysis .....................................................315 References ..........................................................322 11. Blood Group Genetics ........_...............................325 Christine Lomas-Francis, MSc, FLBMS Fundamental Principles of Genetics .....................................326 Inheritance of Genetic Traits ...........................................334 Population Genetics ..................................................347 Relationship Testing .................................................351 Blood Group Gene Mapping ...........................................353 Chimerism .........................................................353 Blood Group Terminology ............................................356 References ..........................................................359 Table of Contents ► xvii BLOOD GROUPS 12. ABO, H, and Lewis Blood Groups and Structurally Related Antigens .................................................361 Laura Cooling, MD, MS ABO System ........................................................361 The H System .......................................................372 The Lewis System ....................................................374 I and і Antigens ......................................................377 Ρ Blood Group ......................................................380 References ..........................................................383 13. The Rh System ..............................................387 Connie M. Westhoff, PhD, MT(ASCP)SBB Terminology ........................................................388 RH Genes and Rh Proteins ............................................391 Antigens ...........................................................392 i?i/Genotyping .....................................................401 Rhnull Syndrome and RhAG ............................................402 Rh Structure and Function ............................................403 Rh Antibodies .......................................................403 Technical Considerations for Rh Typing .................................404 References ..........................................................406 Suggested Reading ...................................................409 14. Other Blood Groups .........................................411 Geoff Daniels, PhD, FRCPath The MNS System ....................................................411 The Lutheran System .................................................417 The Kell and Kx Systems ..............................................418 The Duffy System ....................................................421 The Kidd System ....................................................423 The Diego System ....................................................425 The Yt System .......................................................426 The Xg System ......................................................426 The Scianna System ..................................................427 The Dombrock System ...............................................427 The Colton System ...................................................428 The Landsteiner-Wiener System ........................................429 The Chido/Rodgers System ............................................429 xviii 4І AABB TECHNICAL MANUAL The Gerbich System ..................................................429 The Cromer System ..................................................430 The Knops System ...................................................431 The Indian System ...................................................431 The Ok System ......................................................432 The Raph System ....................................................432 The John Milton Hagen System ........................................432 The Gill System ......................................................432 Antigens That Do Not Belong to a Blood Group System ....................432 References ..........................................................434 ANTIGEN AND ANTIBODY TESTING 15. Pretransfusion Testing .......................................437 Katharine A. Downes, MD, and Ira A. Shulman, MD Requests for Transfusion ..............................................437 Identification of Recipients and Labeling of Blood Specimens ...............438 Specimen Requirements ..............................................441 Serologie Testing Principles ...........................................442 Pretransfusion Tests ..................................................447 Tubeless Methods for Pretransfusion Testing .............................450 Comparison of Current Testing Results with Previous Records ..............451 Donor RBC Unit Testing ..............................................451 Donor RBC Unit Selection ............................................451 Compatibility Testing or Crossmatch (Serologie or Computer/Electronic) .... 452 Interpretation of Antibody Screening and Crossmatch Results ..............454 Pretransfusion Orders ................................................456 Availability of Compatible Blood .......................................456 Labeling of Blood and Blood Components with the Recipient s Information. .. 458 Special Clinical Situations .............................................459 References ..........................................................460 16. Identification of Antibodies to Red Cell Antigens .................465 Phyllis S. Walker, MS, MT(ASCP)SBB Significance of Alloantibodies ..........................................465 Preanalytical Considerations ...........................................466 Analytical Phase of Antibody Identification ..............................468 Postanalytical Interpretation ...........................................493 References ..........................................................496 Suggested Readings ..................................................497 Table of Contents jfe> xix 17. The Positive Direct Antiglobulin Test and Immune-Mediated Hemolysis...............................................499 Regina M. Leger, MSQA, MT(ASCP)SBB, CMQ/OE(ASQ) The Direct Antiglobulin Test..........................................499 Autoimmune Hemolytic Anemia .......................................504 Drug-Induced Immune Hemolytic Anemia ..............................515 References.......................................................... 519 Appendix 17-1. Drugs Associated with a Positive DAT and/or Immune Hemolytic Anemia .........................................522 18. Platelet and Granulocyte Antigens and Antibodies ................525 /anice G. McFarknd, MD Platelet Antigens and Antibodies .......................................525 Granulocyte Antigens and Antibodies ...................................540 References ..........................................................542 19. The HLA System ............................................547 HowardM. Gebel, PhD; Marilyn S. Pollack, PhD; and Robert A. Bray, PhD Genetics of the Major Histocompatibility Complex ........................548 Biochemistry, Tissue Distribution, and Structure ..........................552 Detection of HLA Antigens and Alíeles ..................................556 The HLA System and Transfusion ......................................559 HLA Testing and Transplantation ......................................562 Other Clinically Significant Aspects of HLA ..............................564 Summary ........................................................... 566 References ..........................................................566 CLINICAL CONSIDERATIONS IN TRANSFUSION PRACTICE 20. Hemotherapy Decisions and Their Outcomes ....................569 James P. AuBuchon, MD Red Cell Transfusion .................................................569 Platelet Transfusion ..................................................579 Plasma Transfusion ..................................................589 Cryoprecipitated AHF ................................................593 Granulocyte Transfusion ..............................................595 Plasma Derivatives ...................................................597 References ..........................................................603 XX 4 AABB TECHNICAL MANUAL 21. Administration of Blood Components ..........................613 Bonnie L. S. Sink, BSN, RN, HP(ASCP) Predispensing Events and Considerations ................................613 Dispensing and Transportation ........................................617 Preadministration Events and Considerations ............................618 Administration ......................................................620 Unique Transfusion Settings ...........................................621 Conclusion .........................................................622 References ..........................................................623 22. Perinatal Issues in Transfusion Practice .........................625 Melanie S. Kennedy, MD Hemolytic Disease of the Fetus and Newborn .............................625 Rh Immune Globulin .................................................630 ABO Hemolytic Disease ...............................................633 Immune Thrombocytopenia ...........................................633 References ..........................................................636 23. Neonatal and Pediatrie Transfusion Practice .....................639 Cassandra D. Josephson, MD Transfusion in Infants Less than 4 Months of Age .........................639 Transfusion of Older Infants (More than 4 Months of Age) and Children .....654 Prevention of Adverse Effects of Transfusion in Neonates and Older Children ....................................................657 References ..........................................................659 24. Blood Management .........................................665 Jonathan H. Waters, MD Behavioral Changes ..................................................665 Preoperative Anemia Management .....................................666 Perioperative Autotransfusion Program .................................667 References ..........................................................675 25. Transfusion Support for Hematopoietic Transplant Recipients .....679 Zbigniew M. Szczepiorkowski, MD, PhD, FCAP ABO and Red Cell Antigen Incompatible Transplantation ..................681 Transfusion Support for ABO-Incompatible Transplant Recipients ..........685 HSCT Recipients with HLA and/or Platelet Antibodies .....................690 Table of Contents ► xxi Neutropenic Patients with Infection Unresponsive to Antimicrobial Therapy .........................................................691 Utilization of Blood Components by HSCT Recipients .....................692 Special Processing of Blood Components for the Recipients of HSCT .........693 Other Practical Considerations .........................................694 References ..........................................................694 26. Therapeutic Apheresis .......................................697 Robertson D. Davenport, MD Modalities ..........................................................698 Indications .........................................................699 Anticoagulation .....................................................705 Replacement Fluids ..................................................705 Adverse Effects ......................................................707 Vascular Access ......................................................709 Patient Evaluation ...................................................711 References ..........................................................711 27. Noninfectious Complications of Blood Transfusion ...............715 Catherine A. Mazzei, MD;MarkA. Popovsky, MD; and Patricia M. Kopko, MD Recognition and Evaluation of a Suspected Transfusion Reaction ............715 Acute or Immediate Transfusion Reactions ..............................724 Fatality Reporting Requirements .......................................745 References ..........................................................745 28. Approaches to Blood Utilization Auditing .......................751 Alan Tinmouth, MD, FRCPC, MSc Rationale for Monitoring Blood Utilization ..............................752 Types of Transfusion Audits ...........................................752 Interventions to Change Transfusion Practice ............................757 Effectiveness of Monitoring and Interventions to Change Transfusion Practice ..........................................................758 Selecting an Audit Process to Monitor Transfusions .......................759 Conclusion .........................................................760 References ..........................................................745 Appendix 28-1. Example of a Transfusion Order Form .....................762 xxii <4 AABB TECHNICAL MANUAL TRANSPLANTATION 29. Collecting and Processing Marrow Products for Transplantation -----765 Janice Davis-Sproul, MAS, MT(ASCP)SBB; N. Rebecca Haley, MD; and John D. McMannis, PhD Diseases Treated with Hematopoietic Transplantation .....................766 Autologous Hematopoietic Cell Transplantation ..........................768 Allogeneic Hematopoietic Cell Transplantation ...........................768 Unrelated Donor Transplantation ......................................768 Histocompatibility ...................................................769 Graft-vs-Host Disease ................................................769 Autologous Donors ..................................................769 Allogeneic Donors ...................................................770 Marrow Harvest .....................................................771 Collection Targets ...................................................771 Clinical Considerations ...............................................771 CD34 Antigen .......................................................771 Processing of HPC-M Products ........................................772 ABO Incompatibilities ................................................774 Short- and Long-Term Storage .........................................776 Transportation and Shipping ..........................................778 Thawing and Infusion ................................................778 Evaluation and Quality Control of Hematopoietic Products ................779 Regulations .........................................................780 Standards ...........................................................780 References ..........................................................781 30. Hematopoietic Progenitor Cells Collected by Apheresis ...........787 Thomas Lane, MD, and John D. McMannis, PhD Biology of HPC Mobilization ..........................................788 Clinical Mobilization Regimens ........................................789 Clinical Use of HPC-A ................................................795 Selection of an HPC-A Graft vs an HPC-M Graft ..........................798 Clinical Transplantation Outcomes of HPC-A vs HPC-M Grafts .............799 Selection of an HPC-A or HPC-M Graft vs an HPC-C Graft ................800 References ..........................................................801 31. Umbilical Cord Blood .......................................809 David H. McKenna, MD; Diane M. Kadidlo, MT(ASCP)SBB; and Jeffrey McCullough, MD Donor-Related Issues .................................................810 Table of Contents Џ- xxiii Collection ..........................................................814 Processing ..........................................................816 Tests after Thawing and Stability Testing ................................818 Shipment and Storage ................................................818 Receipt of UCB for Transplantation .....................................819 Thawing and Washing of UCB .........................................821 Infusion of UCB .....................................................822 Regulations and Standards ............................................823 Novel UCB-Derived Cellular Therapies ..................................825 References ..........................................................827 32. Tissue and Organ Transplantation and the Hospital Tissue Transplantation Service ..............................833 TedEastiund, MD Tissue Transplantation ...............................................833 Hospital Tissue Transplantation Services ................................838 Organ Transplantation and the Hospital Blood Transfusion Service ..........850 Diagnosis of Complications ...........................................862 Bacterial Infections ...................................................862 Viral, Prion, and Fungal Infections .....................................862 Reporting of Adverse Clinical Outcomes to Physician Peers .................863 Reporting of Suspected Adverse Outcomes to the Hospital Tissue Transplantation Service by the Physician ..............................863 Reporting of Adverse Outcomes to the FDA by the Physician ...............863 Disclosure of Adverse Outcomes to Patients ..............................863 References ..........................................................856 Appendix 32-1. Special Expertise of a Hospital Blood Transfusion Service to Serve as a Hospital Tissue Service ............................860 Appendix 32-2. One Example of Responsibilities of a Hospital Tissue Services Committee for Medical Staff Oversight ........................861 Appendix 32-3. Roles of the Recipient s Physician in the Recognition and Reporting of Suspected Adverse Events Related to Tissue Allografts ___862 METHODS Methods Introduction ..............................................865 1. General Laboratory Methods ..................................867 Introduction ........................................................867 Method 1-1. Shipping Hazardous Materials ..............................867 Method 1-2. Treating Incompletely Clotted Specimens .....................870 Method 1-3. Solution Preparation Procedure .............................871 Method 1-4. Serum Dilution Procedure .................................873 xxiv ■* AABB TECHNICAL MANUAL Method 1-5. Dilution of % Solutions Procedure ..........................874 Method 1-6. Preparing a 3% Red Cell Suspension .........................874 Method 1-7. Preparing and Using Phosphate Buffer .......................875 Method 1-8. Reading and Grading Tube Agglutination .....................876 2. Red Cell Typing .............................................877 Method 2-1. Determining ABO Type of Red Cells — Slide test ...............877 Method 2-2. Determining ABO Group of Red Cells and Serum — Tube Test ........................................................878 Method 2-3. Determining ABO Group of Red Cells and Serum — Microplate Test ...................................................879 Method 2-4. Initial Investigation of ABO Grouping Discrepancies Procedure ........................................................880 Method 2-5. Detecting Weak A and В Antigens and Antibodies by Cold Temperature Enhancement ....................................881 Method 2-6. Confirming Weak A and В Antigens Using Enzyme- Treated Red Cells ..................................................882 Method 2-7. Confirming Weak A or В Subgroup by Adsorption and Elution .. 882 Method 2-8. Testing Saliva for А, В, Н, Lea, and Leb Antigens ...............883 Method 2-9. Confirming anti- Al in an A2 or Weak A Subgroup .............886 Method 2-10. Resolving ABO Discrepancies Caused by Unexpected Alloantibodies ....................................................886 Method 2-11. Determining Serum Group Without Centrifugation ...........887 Method 2-12. Determining Rh (D) Type—Slide Test ......................887 Method 2-13. Determining Rh (D) Type—Tube Test ......................888 Method 2-14. Determining Rh (D) Type—Microplate Test .................889 Method 2-15. Testing for Weak D ......................................889 Method 2-16. Preparing and Using Lectins ...............................890 Method 2-17. Removing Autoantibody by Warm Saline Washes .............892 Method 2-18. Using Sulfhydryl Reagents to Disperse Autoagglutination ......892 Method 2-19. Using Gentle Heat Elution to Test Red Cells with a Positive DAT .....................................................893 Method 2-20. Dissociating IgG by Chloroquine for Antigen Testing of Red Cells with a Positive DAT .......................................894 Method 2-21. Using Acid Glycine/EDTA to Remove Antibodies from Red Cells .........................................................895 Method 2-22. Separating Transfused from Autologous Red Cells by Simple Centrifugation ..............................................896 Method 2-23. Separating Transfused Red Cells from Autologous Red Cells in Patients with Hemoglobin S Disease ................................897 3. Antibody Detection, Identification, and Compatibility Testing .....899 Method 3-1. Using Immediate-Spin Compatibility Testing to Demonstrate ABO Incompatibility ...................................899 Table of Contents fe» xxv Method 3-2. Detecting Antibodies to Red Cell Antigens — Indirect Antiglobulin Tests .................................................900 Method 3-3. Prewarming Procedure ....................................902 Method 3-4. Detecting Antibodies in the Presence of Rouleaux — Saline Replacement ......................................................903 Method 3-5. Enzyme Procedures .......................................904 Method 3-6. Performing a Direct Antiglobulin Test .......................908 Method 3-8. Using Sulfhydryl Reagents to Distinguish IgM from IgG Antibodies ....................................................911 Method 3-9. Using Plasma Inhibition to Distinguish Anti-Ch and -Rg from Other Antibodies with Similar Characteristics ..........................913 Method 3-10. Treating Red Cells Using DTT Or AET ......................914 Method 3-11. Neutralizing Anti-Sda with Urine ...........................915 Method 3-12. Adsorption Procedure ....................................916 Method 3-13. Using the American Rare Donor Program ...................917 4. Investigation of a Positive DAT ................................919 Eluates .............................................................919 Method 4-1. Cold-Acid Elution Procedure ...............................919 Method 4-2. Glycine-HCl/EDTA Elution Procedure .......................920 Method 4-3. Heat Elution Procedure ....................................921 Method 4-4. Lui Freeze-Thaw Elution Procedure .........................921 Immune Hemolytic Anemia Serum/Plasma Methods ......................922 Method 4-5. Cold Autoadsorption Procedure ............................922 Method 4-6. Determining the Specificity of Cold-Reactive Autoagglutinins. ... 923 Method 4-7. Cold Agglutinin Titer Procedure ............................925 Method 4-8. Adsorbing Warm-Reactive Autoantibodies Using Autologous Red Cells ..............................................926 Method 4-9. Adsorbing Warm-Reactive Autoantibodies Using Allogeneic Red Cells ...............................................927 Method 4-Ю. Polyethylene Glycol Adsorption Procedure ..................929 Method 4-11. Performing The Donath-Landsteiner Test ...................930 Method 4-12. Detecting Drug Antibodies by Testing Drug-Treated Red Cells .........................................................931 Method 4-13. Detecting Drug Antibodies by Testing in the Presence of Drug ..........................................................933 5. Hemolytic Disease of the Fetus and Newborn ....................935 Method 5-1. Testing for Fetomaternal Hemorrhage — The Rosette Test .......935 Method 5-2. Testing for Fetomaternal Hemorrhage — Modified Kleihauer-Betke Test. ..............................................936 Method 5-3. Using Antibody Titration Studies to Assist in Early Detection of Hemolytic Disease of the Fetus and Newborn ...............937 xxvi -4 AABB TECHNICAL MANUAL 6. Blood Collection, Component Preparation, and Storage ...........941 Method 6-1. Screening Donors for Anemia — Copper Sulfate Method ........941 Method 6-2. Preparing the Donor s Arm for Blood Collection ...............942 Method 6-3. Collecting Blood and Samples for Processing and Compatibility Tests ................................................943 Method 6-4. Preparing Red Blood Cells from Whole Blood .................946 Method 6-5. Preparing Prestorage Red Blood Cells Leukocytes Reduced from Whole Blood .................................................947 Method 6-6. Rejuvenating Red Blood Cells ...............................948 Method 6-7. Using High-Concentration Glycerol to Cryopreserve Red Cells—Meryman Method .......................................949 Method 6-8. Using High-Concentration Glycerol to Cryopreserve Red Cells— Valeri Method ..........................................952 Method 6-9. Checking the Adequacy of Deglycerolization of Red Blood Cells ...................................................954 Method 6-10. Preparing Fresh Frozen Plasma from Whole Blood ............955 Method 6-11. Preparing Cryoprecipitated AHF from Whole Blood ..........956 Method 6-12. Thawing and Pooling Cryoprecipitated AHF .................957 Method 6-13. Preparing Platelets from Whole Blood ......................958 Method 6-14. Removing Plasma from Platelets (Volume Reduction) .........960 7. Transplantation of Cells and Tissue ............................963 Method 7-1. Infusing Cryopreserved Hematopoietic Cells ..................963 Method 7-2. Processing Umbilical Cord Blood ...........................964 Method 7-3. Qualifying Tissue Suppliers .................................965 Method 7-4. Autologous Tissue Collection, Packaging, Testing, Storage, and Release Procedures .............................................966 Method 7-5. Investigating Adverse Events and Infections Following Tissue Allograft Use ...............................................968 8. Quality Control .............................................973 Method 8-1. Validating Copper Sulfate Solution ..........................973 Method 8-2. Standardizing and Calibrating Thermometers .................973 Method 8-3. Testing Blood Storage Equipment Alarms .....................975 Method 8-4. Calibrating Centrifuges for Platelet Separation .................978 Method 8-5. Calibrating a Serologie Centrifuge ...........................980 Method 8-6. Testing Automatic Cell Washers ............................982 Method 8-7. Monitoring Cell Counts of Apheresis Components .............983 Method 8-8. Counting Residual White Cells in Leukocyte-Reduced Blood and Components — Manual Method ............................ 984 Table of Contents ► xxvii APPENDICES Appendix 1. Normal Values in Adults................................... 987 Appendix 2. Selected Normal Values in Children.......................... 988 Appendix 3. Typical Normal Values in Tests of Hemostasis and Coagulation (Adults)......................................................... 990 Appendix 4. Coagulation Factor Values in Platelet Concentrates .............990 Appendix 5. Approximate Normal Values for Red Cell, Plasma, and Blood Volumes ...................................................991 Appendix 6. Blood Group Antigens Assigned to Systems ...................992 Appendix 7. Examples of Gene, Antigen, and Phenotype Symbols in Conventional and International Society of Blood Transfusion Terminology .....................................................997 Appendix 8. Examples of Correct and Incorrect Terminology ...............997 Appendix 9. Distribution of ABO/Rh Phenotypes by Race or Ethnicity .......998 Appendix 10. Directory of Organizations ................................999 Appendix 11. Resources for Safety Information ..........................1001 Index ...........................................................1003
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isbn	9783805589963 9781563952609
language	English
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subject_GND	(DE-588)4146063-7 (DE-588)4007293-9 (DE-588)4056914-7
title	Technical manual
title_auth	Technical manual
title_exact_search	Technical manual
title_full	Technical manual ed. by John D. Roback ...
title_fullStr	Technical manual ed. by John D. Roback ...
title_full_unstemmed	Technical manual ed. by John D. Roback ...
title_short	Technical manual
title_sort	technical manual
topic	Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Blutbank (DE-588)4146063-7 gnd Bluttransfusion (DE-588)4007293-9 gnd Standardisierung (DE-588)4056914-7 gnd
topic_facet	Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Blutbank Bluttransfusion Standardisierung
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017313622&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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