Insulin and IGFs:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2009
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Vitamins and hormones
80 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. eines Zeitschr.-H. |
| Beschreibung: | XXII, 733 S. Ill. |
Internformat
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| 245 | 1 | 0 | |a Insulin and IGFs |c ed.-in-chief: Gerald Litwack |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2009 | |
| 300 | |a XXII, 733 S. |b Ill. | ||
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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| 650 | 4 | |a Somatomédine | |
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Datensatz im Suchindex
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| adam_text | Titel: Insulin and IGFs
Autor: Litwack, Gerald
Jahr: 2009
Contents
Contributors xv
Preface xxi
1. The Human Insulin Superfamily of Polypeptide Hormones 1
Fazel Shabanpoor, Frances Separovic, and John D. Wade
I. Introduction 2
II. Relaxin Peptide Hormone Subfamily 10
III. Concluding Remarks 22
Acknowledgments 22
References 22
2. The Structure and Function of Insulin: Decoding the TR Transition 33
Michael A. Weiss
I. Introduction 34
II. Structure-Activity Relationships 38
III. Implications for the Genetics of Diabetes Mellitus 44
IV. Concluding Remarks 45
Acknowledgments 46
References 46
3. Molecular Mechanisms of Differential Intracellular Signaling
From the Insulin Receptor 51
Maja Jensen and Pierre De Meyts
I. Overview 52
II. Insulin and the IR 53
III. Modulation of IR Activity 57
IV. Differential Activation of the IR 63
V. Conclusions/Final Words 67
References 68
vii
viii Contents
4. c-Abl and Insulin Receptor Signalling 77
Marco Genua, Giuseppe Pandini, Maria Francesca Cassarino,
Rosa Linda Messina, and Francesco Frasca
I. Introduction 78
II. Insulin and IGF-IRs 79
III. Metabolic Versus Mitogenic Effect of IR 83
IV. c-Abl Tyrosine Kinase 87
V. c-Abl and IR Signalling 93
VI. Concluding Remarks 98
Acknowledgments 99
References 99
5. CXCL14 and Insulin Action 107
Takahiko Hara and Yuki Nakayama
I. Introduction 108
II. Basic Properties of CXCL14 109
III. Biological Activities of CXCL14 113
IV. Novel Functions of CXCL14 Revealed by Knockout Mice 115
V. Signal Cross-Talk Between CXCL14 and Insulin 119
VI. CXCL14 as a Metabolic Regulator 119
VII. Conclusions 121
References 121
6. Crosstalk Between Growth Hormone and Insulin Signaling 125
Jie Xu and Joseph L Messina
I. Introduction 126
II. GH Signaling 127
III. Insulin Signaling 13°
IV. Regulation of GH Signaling by Insulin 131
V. Regulation of Insulin Signaling by Chronic GH 14°
VI. Conclusions 142
Acknowledgments 143
References 143
7. Intracellular Retention and Insulin-Stimulated Mobilization of
GLUT4 Glucose Transporters *55
Bradley R. Rubin and Jonathan S. Bogan
I. Introduction 156
II. GLUT4 Storage Vesicles (GSVs) 158
III. Insulin-Regulated Aminopeptidase (IRAP) 162
Contents ix
IV. Stability and Trafficking of GLUT4 and I RAP 164
V. TUG, an Essential Component of a Retention Receptor for GLUT4 166
VI. From What Membranes do GSVs Originate? 174
VII. A General Mechanism for the Regulated Targeting of
Membrane Proteins 176
VIII. Conclusions 179
Acknowledgments 179
References 179
8. Compartmentalization and Regulation of Insulin Signaling
to GLUT4 by the Cytoskeleton 193
Craig A. Eyster and Ann Louise Olson
I. Introduction 194
II. Insulin Signaling to GLUT4 Vesicles 195
III. GLUT4 Vesicle Membrane Trafficking 200
IV. GLUT4 Vesicle Fusion 205
V. Conclusions 208
Acknowledgments 208
References 208
9. Nutrient Modulation of Insulin Secretion 217
Nimbe Torres, Lilia Noriega, and Armando R. Tovar
I. Introduction 218
II. Overview of Insulin Secretion 219
III. Nutrient Regulation of Insulin Secretion 224
References 238
10. How Insulin Regulates Glucose Transport in Adipocytes 245
Joseph M. Muretta and Cynthia Corley Mastick
I. Introduction 246
II. Historical Perspective 250
III. Current Views and Controversies 265
IV. Conclusions and Future Directions 277
References 278
11. Spatio-Temporal Dynamics of Phosphatidylinositol-3,
4,5-Trisphosphate Signalling 287
Anders Tengholm and Olof Idevall-Hagren
I. Introduction 288
II. Synthesis and Degradation of PIP3 289
x Contents
III. Real-Time Measurements of PIP3 in Living Cells 292
IV. Spatio-Temporal Patterns of PIP3 Signals 295
V. PIP3 Oscillations and Autocrine Insulin Signalling in /S-Cells 297
VI. Significance of PIP3 Oscillations 300
VII. Concluding Remarks 302
Acknowledgments 303
References 303
12. Serine Kinases of Insulin Receptor Substrate Proteins 313
Sigalit Boura-Halfon and Yehiel Zick
I. Introduction 314
II. Insulin and IGF-i Signaling 314
III. Regulation of Insulin and IGF-i Signaling: Role of Ser/Thr
Phosphorylation of IRS Proteins 319
IV. The Consequences of Ser Phosphorylation of IRS Proteins 328
V. Ser Phosphorylation of IRS Proteins as an Array Phenomenon 333
VI. Summary 336
References 337
13. Phosphorylation of IRS Proteins: Yin-Yang Regulation of
Insulin Signaling 351
Xiao Jian Sun and Feng Liu
I. Introduction 352
II. Discovery of the IRS Proteins 353
III. Molecular Structure of the IRS Proteins 354
IV. Biological Function of IRS Proteins in Insulin Action 364
V. The Role of IRS Serine Phosphorylation in Mediating
the Crosstalk with Other Signaling Pathways 366
VI. Mechanisms Underlying IRS Serine Phosphorylation-lnduced
Insulin Resistance 369
VII. Conclusion 372
References 373
14. IRS-2 and Its Involvement in Diabetes and Aging 389
Jiandi Zhang and Tian-Qiang Sun
I. Introduction 39°
II. Identification of IRS-2 Protein 391
III. Basic Structure of IRS Family Proteins 392
IV. Involvement of IRS Proteins in Other Signaling Pathways 392
V. IRS-2 Protein is Well Conserved Across Species 393
VI. IRS-2, and Its Regulation in Energy Homeostasis 393
Contents xi
VII. Searching for the Regulatory Factor of IRS-2 Transcription 395
VIII. Phenotype of IRS-2 Null Mice 397
IX. The Role of IRS-2 in Female Reproduction 400
X. The Putative Role of IRS-2 in Aging Process 400
XI. Summary 402
References 403
15. Glucose-Dependent Insulinotropic Polypeptide
(Gastric Inhibitory Polypeptide; GIP) 409
Christopher H. S. Mclntosh, Scott Widenmaier, and Su-Jin Kim
I. Introduction 410
II. Glucose-Dependent Insulinotropic Polypeptide (GIP) 412
III. The GIP Gene and Precursor 415
IV. GIP Secretion and Metabolism 417
V. The GIP Receptor 421
VI. Actions of GIP 425
VII. GIP-Activated Signal-Transduction Pathways 432
VIII. Pathophysiology of GIP 439
Acknowledgments 444
References 444
16. Insulin Granule Biogenesis, Trafficking and Exocytosis 473
June Chunqiu Hou, Le Min, and Jeffrey E. Pessin
I. Introduction 474
II. Section I 476
III. Section II 480
IV. Section III 484
V. Section IV 491
References 494
17. Glucose, Regulator of Survival and Phenotype of
Pancreatic Beta Cells 507
Geert A. Martens and Daniel Pipeleers
I. Scope 508
II. Beta Cell Handling of Glucose: Metabolic Specializations to
Ensure Low-Affinity/High Capacity Glucose Sensing 509
III. Glucose as Regulator of the Differentiated Beta Cell Phenotype 512
IV. Glucose Regulation of Beta Cell Number 518
V. Beta Cell Handling of Threatening High and Low Glucose Levels 521
Acknowledgments 530
References 530
xii Contents
18. Matrix Metalloproteinases, T Cell Homing and /?-Cell Mass
in Type 1 Diabetes 541
Alexei Y. Savinov and Alex Y. Strongin
I. Matrix Metalloproteinases and Their Natural Protein Inhibitors 542
II. T Cell Membrane Type-i Matrix Metalloproteinase 547
III. Rodent Model of Human Type 1 Diabetes 550
IV. T Cell MTi-MMP and CD44 in TiD 552
Acknowledgment 556
References 556
19. Role of Wnt Signaling in the Development of Type 2 Diabetes 563
Michael Bordonaro
I. Introduction 564
II. Wnt Signaling 565
III. TCF7L2 Variants and Type 2 Diabetes Risk 570
IV. Functional Relationship Between Wnt Signaling and
Type 2 Diabetes In Vitro 574
V. Conclusions and Future Directions 575
References 578
20. Retinal Insulin Receptor Signaling In Hyperosmotic Stress 583
Raju V. S. Rajala, Ivana Ivanovic, and Ashok Kumar Dilly
I. Introduction 584
II. Experimental Procedures 586
III. Results 590
IV. Discussion 603
Acknowledgments 607
References 608
21. lnterleukin-6 and Insulin Resistance 613
Jeong-Ho Kim, Rebecca A. Bachmann, and Jie Chen
I. Introduction 614
II. Insulin Signaling and Insulin Resistance 615
III. IL-6 and Insulin Resistance 619
IV. Conclusions 625
Acknowledgment 626
References 627
Contents xiii
22. Structure, Function, and Regulation of Insulin-Degrading Enzyme 635
Raymond E. Hulse, Luis A. Ralat, and Wei-Jen Tang
I. Introduction 636
II. Structure of IDE 637
III. The Regulation of IDE Activity 642
IV. Conclusion 645
Acknowledgments 645
References 645
23. Modification of Androgen Receptor Function by Igf-i Signaling:
Implications in the Mechanism of Refractory Prostate Carcinoma 649
Toshihiko Yanase and WuQiang Fan
I. Androgen Receptor Signaling 651
II. IGF Signaling and Foxo-i 653
III. Interaction between AR and Insulin/IGF-i Signaling 654
IV. Clinical Implications of Interactions between IGF-i Signaling and AR 659
V. Conclusion 662
Acknowledgments 663
References 663
24. Insulin-Like Growth Factor-2/Mannose-6 Phosphate Receptors 667
Hesham M. El-Shewy and Louis M. Luttrell
I. Introduction 668
II. The IGF-2/M6P Receptor 671
III. Functions of the IGF-2/M6P Receptor 678
IV. Conclusions 685
References 685
25. Interactions of IGF-II with the IGF2R/Cation-lndependent
Mannose-6-Phosphate Receptor: Mechanism and
Biological Outcomes 699
). Brown, E. Y. Jones, and B. E. Forbes
I. Introduction 700
II. The Mechanism of the IGF2R:IGF-II Interaction 701
III. Conclusion 713
References 714
Index 721
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| series2 | Vitamins and hormones |
| spelling | Insulin and IGFs ed.-in-chief: Gerald Litwack 1. ed. Amsterdam [u.a.] Elsevier 2009 XXII, 733 S. Ill. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 80 Einzelaufn. eines Zeitschr.-H. Insuline Insuline ram Somatomédine Somatomédine ram Insulin-like Growth Factor (DE-588)4258771-2 gnd rswk-swf Insulin (DE-588)4027221-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Insulin (DE-588)4027221-7 s Insulin-like Growth Factor (DE-588)4258771-2 s DE-604 Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017183626&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Insulin and IGFs Insuline Insuline ram Somatomédine Somatomédine ram Insulin-like Growth Factor (DE-588)4258771-2 gnd Insulin (DE-588)4027221-7 gnd |
| subject_GND | (DE-588)4258771-2 (DE-588)4027221-7 (DE-588)4143413-4 |
| title | Insulin and IGFs |
| title_auth | Insulin and IGFs |
| title_exact_search | Insulin and IGFs |
| title_full | Insulin and IGFs ed.-in-chief: Gerald Litwack |
| title_fullStr | Insulin and IGFs ed.-in-chief: Gerald Litwack |
| title_full_unstemmed | Insulin and IGFs ed.-in-chief: Gerald Litwack |
| title_short | Insulin and IGFs |
| title_sort | insulin and igfs |
| topic | Insuline Insuline ram Somatomédine Somatomédine ram Insulin-like Growth Factor (DE-588)4258771-2 gnd Insulin (DE-588)4027221-7 gnd |
| topic_facet | Insuline Somatomédine Insulin-like Growth Factor Insulin Aufsatzsammlung |
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