Bile acid biology and therapeutic actions: proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2009
|
| Schriftenreihe: | Falk symposium
165 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 293 S. Ill., graph. Darst. cm |
Internformat
MARC
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| 245 | 1 | 0 | |a Bile acid biology and therapeutic actions |b proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 |c ed. by D. Keppler ... |
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2009 | |
| 300 | |a XVII, 293 S. |b Ill., graph. Darst. |c cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 1 | |a Falk symposium |v 165 | |
| 650 | 4 | |a Bile Acids and Salts |v Congresses | |
| 650 | 4 | |a Bile acids |x Therapeutic use |v Congresses | |
| 650 | 4 | |a Biliary Tract Diseases |v Congresses | |
| 650 | 4 | |a Liver Diseases |v Congresses | |
| 650 | 0 | 7 | |a Gallensäuren |0 (DE-588)4155851-0 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804138669707100160 |
|---|---|
| adam_text | Contents
List of principal contributors xi
List of chairpersons xv
Preface xvii
SECTION I: METABOLISM AND TRANSPORT OF BILE ACIDS
Chair: C Einarsson, J Sjovall
1 Membrane asymmetry and the regulation of bile formation
RPJ Oude Elferink, A Groen, KS Ho-Mok, C Kunne,
DR de Waart, DE Folmer, LN Bull, CC Paulusma 3
2 ATP8B1, a phosphatidylserine flippase deficient in inherited
intrahepatic cholestasis
CC Paulusma, A Groen, C Kunne, KS Ho-Mok, DE Folmer,
DR de Waart, LN Bull, RPJ Oude Elferink 9
3 Fid-deficient rat hepatocytes reveal structural and functional
defects in the bile canalicular membrane when exposed to
hydrophobic bile acids
S-Y Cai, S Gautam, T Nguyen, CJ Soroka, C Rahner, JL Boyer 18
4 Bile acids and the brain: suggested pathogenetic mechanism
in connection with formation of brain xanthomas in patients
with cerebrotendinous xanthomatosis
/ Bjorkhem, M Shafaati, U Andersson, U Panzenboeck,
M Hansson, S Shpitzen, V Meiner, W Slatter, E Leitersdorf 21
SECTION II: TRANSPORT OF BILE ACIDS
Chair: PA Dawson, D Keppler
5 Canalicular microdomains and bile formation
6 Stieger, MG Ismair, C Guyot, U Synal-Hermanns,
GA Kullak-Ublick 31
V
CONTENTS
6 Regulation of the cell surface expression and transport
capacity of bile salt export pump by small chemical molecules
H Hayashi, Y Sugiyama 36
7 The role of ABCB11 (BSEP) variation in susceptibility to
intrahepatic cholestasis of pregnancy
PH Dixon, S van Mil, S Strautnieks, R Thompson, F Lammert,
R Kubitz, V Keitel, A Glantz, L-A Mattsson, H-U Marschall,
M Molokhia, C Williamson 46
8 Intracellular transport of bile salts
KP Rembacz, A Pellicoro, J Woudenberg, FAJ van den Heuvel,
E Jonkers, F Stellaard, H Moshage, KN Faber 51
9 Conjugated bile acids regulate hepatic gluconeogenic genes
via Goci protein-coupled receptor(s) and the insulin
signalling pathway
PB Hylemon, H Zhou, E Studer, WM Pandak, P Dent 57
SECTION III: TRANSPORT AND ACTIONS OF BILE ACIDS
Chair: W Kramer, FJ Suchy
10 Role of the organic solute transporter Ostoc-Ostp
in intestinal basolateral bile acid transport and bile acid
homeostasis
A Rao, J Haywood, PA Dawson 69
11 Mechanisms of regulation of bile acid transport in the small
intestine
H Suzuki, T Takada 76
12 Expression and localization of the membrane-bound bile
acid receptor TGR5 in human gallbladder tissue
V Keitel, K Cupisti, R Kubitz, D Haussinger 82
13 Bile salts control the antimicrobial peptide cathelicidin
through nuclear receptors in the human biliary epithelium
£ d Aldebert, M-J Biyeyeme Bi Mve, M Mergey, D Wendum,
A Coilly, L Fouassier, C Corpechot, R Poupon, C Housset,
N Chignard 86
14 From Glarus to Gallenfarbstoffen: the scientific contributions
of Rudi Schmid
AF McDonagh 95
vi
CONTENTS
SECTION IV: NUCLEAR RECEPTOR REGULATION
Chair: GA Kullak-Ublick, PLM Jansen
15 Nuclear receptor regulation of bile acid transporters
GA Kullak-Ublick, JJ Eloranta 111
16 Novel roles of liver X receptor in bile acid homeostasis and
haptobiliary diseases
WXie,TWada 115
17 The nuclear hormone receptor ERoc plays a critical role
in determining estrogen-induced cholesterol gallstones
HH Wang, P Portincasa, DQ-H Wang 126
18 Role of intestinal nuclear bile acid receptor FXR in the
gut-liver axis
A Moschetta 135
SECTION V: BILE ACIDS AS METABOLIC INTEGRATORS
Chair: AF Hofmann, M Trauner
19 Linking nutrition and metabolism, a role for the membrane
bile acid receptor TGR5
C Thomas, J Auwerx, K Schoonjans 145
20 Potential role of ursodeoxycholic acid and its side-chain
modified derivatives in the treatment of non-alcoholic fatty
liver disease and associated atherosclerosis
M Trauner, P Fickert, T Moustafa, A Fuchsbichler, T Claudel,
E Halilbasic, D Kratky, H Denk 151
21 Side-chain modification as critical determinant of the
therapeutic properties of 24-/7oairsodeoxycholic acid in
Mdr2 (Abcb4) knockout mice
E Halibasic, P Fickert, R Fiorotto, HU Marschall, T Moustafa,
A Fuchsbichler, J Gumhold, D Silbert, C Langner, U Maitra,
H Denk, M Strazzabosco, M Trauner 157
22 Role of side-chain amidation for the anticholestatic action of
norursodeoxycholic acid in rat liver
S Maitz, GU Denk, R Wimmer, C Rust, P Invernizzi,
S Ferdinandusse, RJ Wanders, A Fuchsbichler, P Fickert,
M Trauner, AF Hofmann, U Beuers 163
vii
CONTENTS
23 Adolf Windhaus Prize Lecture: A central role for the organic
solute and steroid transporter, Osta-Ostp, in the
enterohepatic circulation of bile acids and structurally
related molecules
N Ballatori 166
SECTION VI: BILE ACIDS: CELLULAR INJURY AND REGENERATION
Chair: D Haussinger, R Poupon
24 Pro- and antiapoptotic actions of bile acids and CD95 ligand
in hepatic stellate cells
D Haussinger, A Sommerfeld, R Reinehr 179
25 Reactivation of hepatic organic anion transporters in different
forms of acquired cholestasis by nuclear hormone receptor
activators
IV Martin, A Geier 185
26 Interactions between neuropeptides and bile acids in the
modulation of cholangiocyte biology
A Benedetti, M Marzioni 191
SECTION VII: BILE ACID-RELATED GENETIC LIVER DISEASE
Chair: GP van Berge Henegouwen, H-U Marschall
27 The many faces of ABCB4 deficiency: the relevance of
canalicular membrane-transporting proteins for human
liv©r dis0d.S6
PLM Jansen, M de Vree, H Bikker 199
28 Severe bile salt export pump (BSEP) deficiency: mutations,
immunohistochemically assessed BSEP expression, and
malignancy risk
SS Strautnieks, JA Byrne, L Pawlikowska, G Mieli-Vergani,
AS Knisely, LN Bull, RJ Thompson 206
29 Role of genetics in drug-induced liver injury
C Pauli-Magnus 217
30 Variability of cholestatic liver disease in a family with an
ABCB4 defect: ABCB4 mutation in 11 siblings
D Gotthardt, H Runz, V Keitel, AS Knisely, A Stiehl, P Sauer 223
31 ABCG5/G8 as a human risk gene for cholesterol gallstone
disease
S Weber, F Grunhage, F Lammert 229
viii
CONTENTS
32 ATP8B1 deficiency: general background, clinical
manifestations and possible therapeutic interventions
JM Stapelbroek, LM van der Velden, SFJ van de Graaf,
LWJ Klomp, RHJ Houwen 235
33 Bile acid abnormalities in peroxisomal disorders
S Ferdinandusse, RJA Wanders 243
SECTION VIM: BILE ACIDS AS THERAPEUTIC AGENTS
Chair: R Chapman, G Paumgartner
34 Ursodeoxycholic acid for the treatment of primary sclerosing
cholangitis
KD Lindor 255
35 Excellent long-term survival in patients with primary biliary
cirrhosis treated with ursodeoxycholic acid
A Pares 259
36 Intravenous use of ursodeoxycholic disulphate -
a unidirectional bile acid, for hepatoprotection in liver
transplantation and total parenteral nutrition-associated
cholestasis
KDR Setchell, N Heaton, G Mukadam, M Yii, MH Garcez
da Silva, L Zimmer-Nechemias, B. Wolfe, S Phillips, T Phillips,
S. Uddin, H Vilca-Melendez 270
37 Features, prognosis and management of primary biliary
cirrhosis in the era of ursodeoxycholic acid
R Poupon, O Chazouilleres, Y Chretien, C Corpechot 277
Index 287
ix
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| spelling | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 ed. by D. Keppler ... Dordrecht [u.a.] Springer 2009 XVII, 293 S. Ill., graph. Darst. cm txt rdacontent n rdamedia nc rdacarrier Falk symposium 165 Bile Acids and Salts Congresses Bile acids Therapeutic use Congresses Biliary Tract Diseases Congresses Liver Diseases Congresses Gallensäuren (DE-588)4155851-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2008 Amsterdam gnd-content Gallensäuren (DE-588)4155851-0 s DE-604 Keppler, Dietrich Sonstige oth Falk symposium 165 (DE-604)BV000001125 165 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017153789&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 Falk symposium Bile Acids and Salts Congresses Bile acids Therapeutic use Congresses Biliary Tract Diseases Congresses Liver Diseases Congresses Gallensäuren (DE-588)4155851-0 gnd |
| subject_GND | (DE-588)4155851-0 (DE-588)1071861417 |
| title | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 |
| title_auth | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 |
| title_exact_search | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 |
| title_full | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 ed. by D. Keppler ... |
| title_fullStr | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 ed. by D. Keppler ... |
| title_full_unstemmed | Bile acid biology and therapeutic actions proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 ed. by D. Keppler ... |
| title_short | Bile acid biology and therapeutic actions |
| title_sort | bile acid biology and therapeutic actions proceedings of the falk symposium 165 xx international bile acid meeting held in amsterdam the netherlands june 13 14 2008 |
| title_sub | proceedings of the Falk Symposium 165 ; (XX International Bile Acid Meeting) held in Amsterdam, the Netherlands, June 13 - 14, 2008 |
| topic | Bile Acids and Salts Congresses Bile acids Therapeutic use Congresses Biliary Tract Diseases Congresses Liver Diseases Congresses Gallensäuren (DE-588)4155851-0 gnd |
| topic_facet | Bile Acids and Salts Congresses Bile acids Therapeutic use Congresses Biliary Tract Diseases Congresses Liver Diseases Congresses Gallensäuren Konferenzschrift 2008 Amsterdam |
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