Infected biomaterials: new strategies for local anti-infective treatment
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Göttingen
Cuvillier
2009
|
| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-95998 Inhaltsverzeichnis |
| Beschreibung: | 180 S. Ill., graph. Darst. |
| ISBN: | 9783867278713 |
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| 245 | 1 | 0 | |a Infected biomaterials |b new strategies for local anti-infective treatment |c Florian Matl |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a Göttingen |b Cuvillier |c 2009 | |
| 300 | |a 180 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |a Zugl.: München, Univ., Diss., 2009 | ||
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| 650 | 0 | 7 | |a Biomaterial |0 (DE-588)4267769-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Staphylococcus aureus |0 (DE-588)4182912-8 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804138657740750848 |
|---|---|
| adam_text | TABLE OF CONTENTS CHAPTER 1 INTRODUCTION AND OBJECTIVES OF THE THESIS 1
INTRODUCTION 2 2 BIOMATERIALS 3 2.1 VASCULAR GRAFTS 3 2.2 SUTURES 6 3
INFECTIONS 7 3.1 POST-OPERATIVE INFECTIONS 8 3.2 POST-OPERATIVE
INFECTIONS IN VASCULAR SURGERY 8 3.2.1 PATHOGENESIS OF POST-OPERATIVE
INFECTIONS AFIER VASCULAR RECONSTNICTIVE INTERVENTIONS 9 3.2.2 TIME
POINT OF VASCULAR GRAFI INFECTIONS 10 3.2.3 LOCALISATION OF VASCULAR
GRAFI INFECTIONS 10 3.2.4 LNFECTION RISK OF DIFFERENT GRAFIS // 3.2.5
DIAGNOSIS OF INFECTIOUS COMPLICATIONS OEFTER VASCULAR RECONSTRUCTIVE
INTERVENTIONS 11 3.2.6 BACTERIOLOGY OFSEPTIC COMPLICATIONS IN VASCULAR
GRAFIS 12 3.2.7 SUTURES IN INFECTED AREAS 12 3.3 NEURONAL INFECTIONS 13
3.4 MEDICAL DEVICE INFECTIONS 13 3.5 BIOFILMS 14 3.5.1 BACTERIAL
ADHESION TO SURFACES 14 3.5.2 BIOFILM FORMATHN 15 3.5.3 STRATEGIES OF
BIOFILM PREVENTION 16 3.6 THERAPEUTIC METHODS 17 3.6.1 NEW TACTICS IN
SURGERY AND LOCAL WOUNDMANAGEMENT..... *.. 17 3.6.2 ANTISEPTICS IN WOUND
CARE 18 3.6.3 ANTIBIOTICS IN WOUND CARE 18 3.6.4 PROSTHESIS EXPLANTATION
19 3.7 IMPLANTS AS DRUO DELIVERY SYSTEMS 19 3.8 BIOCOMPATIBILRRY 20 3.9
HAEMOCOMPATIBIUTY 20 3.1 BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/992645182 DIGITALISIERT DURCH CHAPTER 2 NEW
ANTI-INFECTIVE COATINGS OF MEDICAL IMPLANTS BASED ON LIPID-LIKE DRUG
CARRIERS 1 INTRODUCTION 38 2 MATERIALS AND METHODS 39 2.1 MEDICAL
IMPLANT 39 2.2 THE ANTI-INFECTIVE COATING 39 2.2.1 DRUG CARRIERS 39
2.2.2 PDLLA 39 2.2.3 SOFIISART* 649 39 2.2.4 DYNASAN* 118 40 2.2.5
TOCOPHEROL ACETATE 40 2.2.6 ANTIBIOTICS 40 2.3 COATING PROCESS 40 2.4
PARTICLESIZE 41 2.5 MORPHOLOGICAL ANAL YSIS-SEM 41 2.6 ANTIBIOTIC
RELEASE 41 2.7 TEST BACTERIUM 42 2.7.1 GROWTH CURVE 42 2.7.2
ANTIBACTERIAL CHARACTERISTICS 42 2.7.3 ADHESION OFVIABLE BACTERIA AND
ANTIMICROBIAL POTENCY OEFTER 24 HOURS ELUTION 43 2.8 CELLCULTURE 43 2.9
IN VITRO CYTOTOX1CITY STUDIES 43 2.10 HAEMOCOMPATTBIUTY STUDIES 44 3
RESULTS _ - 45 3.1 MORPHOLOGICAL ANALYSIS 45 3.2 ANTIBIOTIC RELEASE 45
3.3 ANTIBACTERIAL CHARACTERISTICS 47 3.3.1 ADHESION OFVIABLE BACTERIA
AND ANTIMICROBIAL POTENCY AFTER 24 HOURS ELUTION 48 3.4 IN VITRO
CYTOTOX1CITY STUDIES 49 3.5 HAEMOCOMPATIBILITY STUDIES 50 3.5.1
MONOCLONAL ENZYME IMMUNOASSAYFORPLASMA FI-IVALUES 50 3.6 AMIDOLYTIC
SUBSTRATE ASSAY FOR FACTOR XILA-UKE ACTTVITY 50 3.6.1
THROMBOELASTOGRAPHY 50 3.6.2 COMPLEMENT C3A-DESARG ELISA 51 4 CHAPTER 3
NEW ANTI-INFECTIVE COATINGS OF SURGICAL SUTURES BASED ON A COMBINATION
OF ANTISEPTICS AND FATTY ACIDS 1 INTRODUCTION * 58 2 MATERIALS AND
METHODS _ - 58 2.1 MEDICAL IMPLANT 58 2.2 THE ANTI-INFECTIVE COATING 59
2.3 MORPHOLOGICAL ANALYSIS-SEM 59 2.4 DRUG RELEASE 59 2.5 TEST BACTERIUM
60 2.5.1 ANTIBACTERIAL CHARACTERISTICS 60 2.5.2 ADHESION OFVIABLE
BACTERIA ANDANTIMICROBIAL POTENCY AFTER 24 HOURS ELUTION 60 2.6
CELLCULTURE 61 2.7 IN VITRO CYTOTOXICITY STUDIES 61 3 RESULTS 62 3.1
MORPHOLOGICAL ANALYSIS 62 3.2 DRUG RELEASE 62 3.3 ANTIBACTERIAL
CHARACTERISTICS 64 3.4 ADHESION OF VIABLE BACTERIA AND ANTIMICROBIAL
POTENCY AFTER 24 HOURS ELUTION 65 3.5 IN VITRO CYTOTOXICITY STUDIES 66 4
DISCUSSION _ -.67 5 CONCLUSIONS - 69 6 ACKNOWLEDGEMENTS - ~ 69 7 FIGURE
CAPTIONS _ 70 8 REFERENCES * * 71 8 REFERENCES * 91 CHAPTER 4 GROWTH
INHIBITION OF STAPHYLOCOCCUS AUREUS INDUCED BY LOW-FREQUENCY ELECTRIC
AND ELECTRO-MAGNETIC FIELDS 1 INTRODUCTION * 74 2 MATERIALS AND METHODS
75 2.1 TESTBACTERIUM 75 2.2 GROWTH CURVE 75 2.3 BACTERIA ON GEL-LIKE
MEDIUM 76 2.4 BACTERIA IN FLUID MEDIUM 77 2.5 SLNUSOIDAL LOW-FREQUENCY
ELECTRO-MAGNETIC FIELD 78 2.6 ELECTROMAGNETIC FIELD COMBINED WITH AN
ADDIT1ONAL ELECTRIC ALTERNATTNG FIELD 79 2.7 SLNUSOIDAL ELECTRIC
ALTERNATING FIELD 81 2.8 DLRECT CURRENT ELECTRIC FIELD 81 2.9
CALCULATIONS AND STATISTICAL METHODS 82 3 RESULTS * 83 4 DISCUSSION 85 5
CONCLUSIONS * *.89 6 ACKNOWLEDGEMENTS 89 7 FIGURE AND TABLE CAPTIONS 90
113 CHAPTER 5 AUGMENTATION OF ANTIBIOTIC EFFICACY BY LOW-FREQUENCY
ELECTRIC AND ELECTRO- MAGNETIC FIELDS EXAMINING STAPHYLOCOCCUS AUREUS 1
INTRODUCTION _ 95 2 MATERIALS AND METHODS * 95 2.1 TEST BACTERIUM 95 2.2
GROWTH CURVE 95 2.3 ANTIBIOTIC 96 2.4 GENTAMICIN TEST CONCENTRATION 96
2.5 BACTERIA ON GEL-LIKE MEDIUM 97 2.6 BACTERIA IN FLUID MEDIUM 97 2.7
SLNUSOIDAL LOW-FREQUENCY ELECTRO-MAGNETIC FIELD 98 2.8 ELECTRO-MAGNETIC
FIELD COMBINED WITH AN ADDITIONAL ELECTRIC ALTERNATING HELD 101 2.9
SLNUSOIDAL ELECTRIC ALTERNATING FIELD 101 2.10 DLRECT CURRENT FIELD 102
2.11 CALCULATIONS AND STATISTICAL METHODS 103 3 RESULTS _ _ 103 3.1
BACTERIA ON GEL-LIKE MEDIUM 103 3.2 BACTERIA IN FLUID MEDIUM 104 3.2.1
GENTAMICIN TEST CONCENTRATION 104 3.2.2 LOW - FREQUENT ELECTROMAGNETIC
FIELD. 104 3.2.3 ELECTRO-MAGNETIC FIELD COMBINEDWITH AN ADDITIONAL
ELECTRIC FIELD. 107 3.2.4 SINUSOIDAL ALTERNATING ELECTRIC FIELD 107
3.2.5 DIRECT CURRENTFIELD. 107 4 DISCUSSION ~ _.~ 107 5 CONCLUSIONS ~ »
- 110 6 ACKNOWLEDGEMENTS -.110 7 FIGURE AND TABLE CAPTIONS. _ - 111 8
REFERENCES . - . 8 REFERENCES 137 CHAPTER 6 MAGNETIC DRUG TARGETING FOR
BIOMATERIAL INFECTIONS CHARTER 6 115 1 INTRODUCTION 116 2 MATERIALS AND
METHODS 117 2.1 NANOPARTICLES 117 2.2 PARTICLESIZE AND ZETA POTENTIAL
118 2.3 DRUGLOADING 118 2.4 COATING TECHNOLOGY 119 2.5 ANTIBACTERIAL
CHARACTERISTICS 120 2.5.1 TEST BACTERIUM 120 2.5.2 CALIBRATION CURVE 120
2.5.3 ANTIMICROBIAL POTENTIAL 120 2.5.4 PATHOLOGICALLY RELEVANT
BACTERIAL CONCENTRATIONS 121 2.5.5 GENTAMICIN EFFICACY 121 2.6
GENTAMICIN RELEASE FROM NANOPARTICLES 121 2.7 IN VITRO CYTOTXIC1TY
STUDIES 122 2.7.1 CELLCULTURE 122 2.7.2 FERROFLUID TOXICITY 122 2.7.3
GENTAMICIN TOXICITY 122 2.8 CLRCULATORY EXPERIMENTS 123 2.9 IRON CONTENT
DETERMINATION 124 3 RESULTS * * 125 3.1 LOADING OF MAGNETIC
NANOPARTICLES WITH GENTAMICIN 125 3.2 ANTIBACTERIAL CHARACTERISTICS 126
3.3 PERCENT SURFACE COVERAGE 128 3.4 IN VITRO CYTOTOXICITY STUDIES 128
3.5 CLRCULATORY EXPERIMENTS 130 4 DISCUSSION * 132 5 CONCLUSIONS * 135 6
ACKNOWLEDGEMENTS 135 7 FIGURE AND TABLE CAPTIONS _ * 136 CHAPTER 7
FUNCTIONAL NEUROTOXICITY OF INDIVIDUAL ANTIBIOTICS INVESTIGATED WITH
MAMMALIAN NEURONAL NETWORKS GROWN ON MICROELECTRODE NEUROARRAY
INTRODUCTION 141 MATERIALS AND METHODS 142 2.1 COMPOUNDS 142 2.2
MICROELECTRODE ARRAYS (MEAS) 142 2.3 CELLCULTURE 143 2.4 EXPERIMENTAL
SETUP 146 2.4.1 RECORDING STATION 146 2.4.2 CHAMBER SETUP 146 2.4.3 DATA
RECORDING 148 2.4.4 DATA ANALYSIS 149 2.4.5 DOSE RESPONSE CURVES 150 2.5
EXPERIMENTAL DESIGN 150 RESULTS 3.1 SUPPRESSION OF ACTION POTENTIAL
PRODUCTION 151 3.1.1 DOSE-RESPONSE CURVES 151 3.1.2 IC JO DETERMINATION
152 3.2 BURST PARAMETER 156 3.3 DROP OUT OF INDIVIDUAL CELLS 158 3.3.1
BURSTING NEURONS 158 3.3.2 ACTIVE NEURONS 158 3.3.3 ACTIVE NEURONS
VERSUS BURSTING NEURONS 159 4 DISCUSSION 160 5 CONCLUSIONS * 161 6
ACKNOWLEDGEMENTS 162 7 APPENDIX * * * 163 7.1 ACT1VITY PATTERN OF
ANTIBIOTICS 163 7.1.1 PENICILLIN G 163 7.1.2 PENICILLIN G/STREPTOMYCIN
165 7.1.3 STREPTOMYCIN 166 7.1.4 GENTAMICIN 168 7.1.5 VANCOMYCIN 169 8
FIGURE AND TABLE CAPTIONS * * - 171 9 REFERENCES - _ 174 CHAPTE
|
| any_adam_object | 1 |
| author | Matl, Florian 1978- |
| author_GND | (DE-588)137501080 |
| author_facet | Matl, Florian 1978- |
| author_role | aut |
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| bvnumber | BV035341314 |
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| discipline | Medizin |
| edition | 1. Aufl. |
| format | Thesis Book |
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| publisher | Cuvillier |
| record_format | marc |
| spelling | Matl, Florian 1978- Verfasser (DE-588)137501080 aut Infected biomaterials new strategies for local anti-infective treatment Florian Matl 1. Aufl. Göttingen Cuvillier 2009 180 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: München, Univ., Diss., 2009 Postoperative Phase (DE-588)4215423-6 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Magnetfeld (DE-588)4074450-4 gnd rswk-swf Biomaterial (DE-588)4267769-5 gnd rswk-swf Staphylococcus aureus (DE-588)4182912-8 gnd rswk-swf Gentamicin (DE-588)4156654-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Postoperative Phase (DE-588)4215423-6 s Biomaterial (DE-588)4267769-5 s Staphylococcus aureus (DE-588)4182912-8 s Magnetfeld (DE-588)4074450-4 s Gentamicin (DE-588)4156654-3 s Targeted drug delivery (DE-588)4302415-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-95998 http://edoc.ub.uni-muenchen.de/9599/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-95998 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017145608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Matl, Florian 1978- Infected biomaterials new strategies for local anti-infective treatment Postoperative Phase (DE-588)4215423-6 gnd Targeted drug delivery (DE-588)4302415-4 gnd Magnetfeld (DE-588)4074450-4 gnd Biomaterial (DE-588)4267769-5 gnd Staphylococcus aureus (DE-588)4182912-8 gnd Gentamicin (DE-588)4156654-3 gnd |
| subject_GND | (DE-588)4215423-6 (DE-588)4302415-4 (DE-588)4074450-4 (DE-588)4267769-5 (DE-588)4182912-8 (DE-588)4156654-3 (DE-588)4113937-9 |
| title | Infected biomaterials new strategies for local anti-infective treatment |
| title_auth | Infected biomaterials new strategies for local anti-infective treatment |
| title_exact_search | Infected biomaterials new strategies for local anti-infective treatment |
| title_full | Infected biomaterials new strategies for local anti-infective treatment Florian Matl |
| title_fullStr | Infected biomaterials new strategies for local anti-infective treatment Florian Matl |
| title_full_unstemmed | Infected biomaterials new strategies for local anti-infective treatment Florian Matl |
| title_short | Infected biomaterials |
| title_sort | infected biomaterials new strategies for local anti infective treatment |
| title_sub | new strategies for local anti-infective treatment |
| topic | Postoperative Phase (DE-588)4215423-6 gnd Targeted drug delivery (DE-588)4302415-4 gnd Magnetfeld (DE-588)4074450-4 gnd Biomaterial (DE-588)4267769-5 gnd Staphylococcus aureus (DE-588)4182912-8 gnd Gentamicin (DE-588)4156654-3 gnd |
| topic_facet | Postoperative Phase Targeted drug delivery Magnetfeld Biomaterial Staphylococcus aureus Gentamicin Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/9599/ https://nbn-resolving.org/urn:nbn:de:bvb:19-95998 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017145608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT matlflorian infectedbiomaterialsnewstrategiesforlocalantiinfectivetreatment |