Textbook of medical physiology:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia
Elsevier Saunders
2006
|
| Ausgabe: | 11. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xxxv, 1116 p. col. ill. |
| ISBN: | 9780721602400 9780808923176 080892317x 0721602401 |
Internformat
MARC
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| 100 | 1 | |a Guyton, Arthur C. |d 1919-2003 |e Verfasser |0 (DE-588)142024279 |4 aut | |
| 245 | 1 | 0 | |a Textbook of medical physiology |c Arthur C. Guyton, John E. Hall |
| 246 | 1 | 3 | |a Medical physiology |
| 250 | |a 11. ed. | ||
| 264 | 1 | |a Philadelphia |b Elsevier Saunders |c 2006 | |
| 300 | |a xxxv, 1116 p. |b col. ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Physiology |2 cabt | |
| 650 | 4 | |a Fisiología | |
| 650 | 4 | |a Fisiología patológica | |
| 650 | 7 | |a Fysiologie |2 gtt | |
| 650 | 7 | |a Menselijk lichaam |2 gtt | |
| 650 | 7 | |a Pathologische fysiologie |2 gtt | |
| 650 | 4 | |a Physiologie humaine | |
| 650 | 4 | |a Physiopathologie | |
| 650 | 4 | |a Human physiology | |
| 650 | 4 | |a Physiology, Pathological | |
| 650 | 4 | |a Physiological Processes | |
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| 700 | 1 | |a Hall, John Edward |e Verfasser |4 aut | |
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Datensatz im Suchindex
| _version_ | 1804138654726094848 |
|---|---|
| adam_text | UNIT I
Introduction to Physiology: The
Cell and General Physiology
CHAPTER 1
Functional Organization of the
Human Body and Control of the
Internal Environment 3
Cells as the Living Units of the Body 3
Extracellular Fluid—The Internal
Environment 3
Homeostatic Mechanisms of the Major
Functional Systems 4
Homeostasis 4
Extracellular Fluid Transport and Mixing
System—The Blood Circulatory System 4
Origin of Nutrients in the Extracellular Fluid 5
Removal of Metabolic End Products 5
Regulation of Body Functions 5
Reproduction 6
Control Systems of the Body 6
Examples of Control Mechanisms 6
Characteristics of Control Systems 7
Summary—Automaticity of the Body 9
CHAPTER 2
The Cell and Its Functions 11
Organization of the Cell 11
Physical Structure of the Cell 12
Membranous Structures of the Cell 12
Cytoplasm and Its Organelles 14
Nucleus 17
Nuclear Membrane 17
Nucleoli and Formation of Ribosomes 18
Comparison of the Animal Cell with
Precellular Forms of Life 18
Functional Systems of the Cell 19
Ingestion by the Cell—Endocytosis 19
Digestion of Pinocytotic and Phagocytic
Foreign Substances Inside the Ceil—
Function of the Lysosomes 20
Synthesis and Formation of Cellular
Structures by Endoplasmic Reticulum
and Golgi Apparatus 20
Extraction of Energy from Nutrients—
Function of the Mitochondria 22
Locomotion of Cells 24
Ameboid Movement 24
Cilia and Ciliary Movement 24
CHAPTER 3
Genetic Control of Protein Synthesis,
Cell Function, and Cell Reproduction 27
Genes in the Cell Nucleus 27
Genetic Code 29
The DNA Code in the Ceil Nucleus Is
Transferred to an RNA Code in the
Cell Cytoplasm—The Process
of Transcription 30
Synthesis of RNA 30
Assembly of the RNA Chain from Activated
Nucleotides Using the DNA Strand
as a Template—The Process of
Transcription 31
Messenger RNA—The Codons 31
Transfer RNA—The Anticodons 32
Ribosomal RNA 33
Formation of Proteins on the Ribosomes—
The Process of Translation 33
Synthesis of Other Substances in the
Cell 35
Control of Gene Function and
Biochemical Activity in Cells 35
Genetic Regulation 35
Control of Intracellular Function by
Enzyme Regulation 36
The DNA-Genetic System Also Controls
Cell Reproduction 37
Cell Reproduction Begins with Replication
of DNA 37
Chromosomes and Their Replication 38
Cell Mitosis 38
Control of Cell Growth and Cell
Reproduction 39
Cell Differentiation 40
Apoptosis—Programmed Cell Death 40
Cancer 40
UNIT II
Membrane Physiology, Nerve,
and Muscle
CHAPTER 4
Transport of Substances Through
the Cell Membrane 45
The Lipid Barrier of the Cell Membrane,
and Cell Membrane Transport
Proteins 45
Diffusion 46
Diffusion Through the Cell Membrane 46
Diffusion Through Protein Channels, and
Gating of These Channels 47
Facilitated Diffusion 49
Factors That Affect Net Rate of Diffusion 50
Osmosis Across Selectively Permeable
Membranes— Net Diffusion of Water 5/
Active Transport of Substances
Through Membranes 52
Primary Active Transport 53
Secondary Active Transport—Co-Transport
and Counter-Transport 54
Active Transport Through Cellular Sheets 55
Xiv Table of (
CHAPTER 5
Membrane Potentials and Action
Potentials 57
Basic Physics of Membrane
Potentials 57
Membrane Potentials Caused by
Diffusion 57
Measuring the Membrane Potential 58
Resting Membrane Potential of Nerves 59
Origin of the Normal Resting Membrane
Potential 60
Nerve Action Potential 61
Voltage-Gated Sodium and Potassium
Channels 62
Summary of the Events That Cause the
Action Potential 64
Roles of Other Ions During the Action
Potential 64
Initiation of the Action Potential 65
Propagation of the Action Potential 65
Re-establishing Sodium and Potassium
Ionic Gradients After Action Potentials
Are Completed—Importance of Energy
Metabolism 66
Plateau in Some Action Potentials 66
Rhythmicity of Some Excitable Tissues—
Repetitive Discharge 67
Special Characteristics of Signal
Transmission in Nerve Trunks 68
Excitation—The Process of Eliciting
the Action Potential 69
Refractory Period After an Action
Potential 70
Recording Membrane Potentials and
Action Potentials 70
Inhibition of Excitability— Stabilizers
and Local Anesthetics 70
CHAPTER 6
Contraction of Skeletal Muscle 72
Physiologic Anatomy of Skeletal
Muscle 72
Skeletal Muscle Fiber 72
General Mechanism of Muscle
Contraction 74
Molecular Mechanism of Muscle
Contraction 74
Molecular Characteristics of the
Contractile Filaments 75
Effect of Amount of Actin and Myosin
Filament Overlap on Tension Developed
by the Contracting Muscle 77
Relation of Velocity of Contraction to
Load 78
Energetics of Muscle Contraction 78
Work Output During Muscle Contraction 78
Sources of Energy for Muscle Contraction 79
Characteristics of Whole Muscle
Contraction 80
Mechanics of Skeletal Muscle Contraction 81
Remodeling of Muscle to Match Function 82
Rigor Mortis 83
Zontents
CHAPTER 7
Excitation of Skeletal Muscle:
Neuromuscular Transmission and
Excitation-Contraction Coupling 85
Transmission of Impulses from Nerve
Endings to Skeletal Muscle Fibers:
The Neuromuscular Junction 85
Secretion of Acetylcholine by the Nerve
Terminals 85
Molecular Biology of Acetyline
Formation and Release 88
Drugs That Enhance or Block
Transmission at the Neuromuscular
Junction 88
Myasthenia Gravis 89
Muscle Action Potential 89
Spread of the Action Potential to the
Interior of the Muscle Fiber by Way of
Transverse Tubules 89
Excitation-Contraction Coupling 89
Transverse Tubule-Sarcoplasmic Reticulum
System 89
Release of Calcium Ions by the
Sarcoplasmic Reticulum 90
CHAPTER 8
Contraction and Excitation of
Smooth Muscle 92
Contraction of Smooth Muscle 92
Types of Smooth Muscle 92
Contractile Mechanism in Smooth Muscle 93
Regulation of Contraction by Calcium Ions 95
Nervous and Hormonal Control of
Smooth Muscle Contraction 95
Neuromuscular Junctions of Smooth
Muscle 95
Membrane Potentials and Action Potentials
in Smooth Muscle 96
Effect of Local Tissue Factors and
Hormones to Cause Smooth Muscle
Contraction Without Action Potentials 98
Source of Calcium Ions That Cause
Contraction (/) Through the Cell
Membrane and (2) from the Sarcoplasmic
Reticulum 99
UNIT III
The Heart
CHAPTER 9
Heart Muscle; The Heart as a Pump
and Function of the Heart Valves 103
Physiology of Cardiac Muscle 103
Physiologic Anatomy of Cardiac Muscle 103
Action Potentials in Cardiac Muscle 104
The Cardiac Cycle 106
Diastole and Systole 106
Relationship of the Electrocardiogram to
the Cardiac Cycle 107
Function of the Atria as Primer Pumps 107
Function of the Ventricles as Pumps 108
Table oj
Function of the Valves 709
Aortic Pressure Curve 109
Relationship of the Heart Sounds to
Heart Pumping 109
Work Output of the Heart 110
Graphical Analysis of Ventricular Pumping 110
Chemical Energy Required for Cardiac
Contraction: Oxygen Utilization by
the Heart 111
Regulation of Heart Pumping 111
Intrinsic Regulation of Heart Pumping—
The Frank-Starling Mechanism ///
Effect of Potassium and Calcium Ions on
Heart Function 113
Effect of Temperature on Heart Function 114
Increasing the Arterial Pressure Load
(up to a Limit) Does Not Decrease the
Cardiac Output 114
CHAPTER 10
Rhythmical Excitation of the Heart 116
Specialized Excitatory and Conductive
System of the Heart 116
Sinus (Sinoatrial) Node 116
Internodal Pathways and Transmission of
the Cardiac Impulse Through the Atria 118
Atrioventricular Node, and Delay of Impulse
Conduction from the Atria to the Ventricles IIS
Rapid Transmission in the Ventricular
Purkinje System 119
Transmission of the Cardiac Impulse in the
Ventricular Muscle 119
Summary of the Spread of the Cardiac
Impulse Through the Heart 120
Control of Excitation and Conduction
in the Heart 120
The Sinus Node as the Pacemaker of the
Heart 120
Role of the Purkinje System in Causing
Synchronous Contraction of the
Ventricular Muscle 121
Control of Heart Rhythmicity and Impulse
Conduction by the Cardiac Nerves: The
Sympathetic and Parasympathetic Nerves 121
CHAPTER 11
The Normal Electrocardiogram 123
Characteristics of the Normal
Electrocardiogram 123
Depolarization Waves Versus
Repolarization Waves 123
Relationship of Atrial and Ventricular
Contraction to the Waves of the
Electrocardiogram 125
Voltage and Time Calibration of the
Electrocardiogram 125
Methods for Recording
Electrocardiograms 126
Pen Recorder 126
Flow of Current Around the Heart
During the Cardiac Cycle 126
Recording Electrical Potentials from a
Partially Depolarized Mass of Syncytial
Cardiac Muscle 126
f Contents XV
Flow of Electrical Currents in the Chest
Around the Heart 126
Electrocardiographic Leads 127
Three Bipolar Limb Leads 127
Chest Leads (Precordial Leads) 129
Augmented Unipolar Limb Leads 129
CHAPTER 12
Electrocardiographic Interpretation
of Cardiac Muscle and Coronary
Blood Flow Abnormalities: Yectorial
Analysis 131
Principles of Vectorial Analysis of
Electrocardiograms 131
Use of Vectors to Represent Electrical
Potentials 131
Direction of a Vector Is Denoted in Terms
of Degrees 131
Axis for Each Standard Bipolar Lead and
Each Unipolar Limb Lead 132
Vectorial Analysis of Potentials Recorded
in Different Leads 133
Vectorial Analysis of the Normal
Electrocardiogram 134
Vectors That Occur at Successive Intervals
During Depolarization of the Ventricles—
The QRS Complex 134
Electrocardiogram During Repolarization—
The T Wave 134
Depolarization of the Atria—The P Wave 136
Vectorcardiogram 136
Mean Electrical Axis of the Ventricular
QRS—And Its Significance 137
Determining the Electrical Axis from
Standard Lead Electrocardiograms 137
Abnormal Ventricular Conditions That Cause
Axis Deviation 138
Conditions That Cause Abnormal
Voltages of the QRS Complex 140
Increased Voltage in the Standard Bipolar
Limb Leads 140
Decreased Voltage of the Electrocardiogram 140
Prolonged and Bizarre Patterns of the
QRS Complex 141
Prolonged QRS Complex as a Result of
Cardiac Hypertrophy or Dilatation 141
Prolonged QRS Complex Resulting from
Purkinje System Blocks 141
Conditions That Cause Bizarre QRS
Complexes 141
Current of Injury 141
Effect of Current of Injury on the QRS
Complex 141
The J Point—The Zero Reference Potential
for Analyzing Current of Injury 142
Coronary Ischemia as a Cause of Injury
Potential 143
Abnormalities in the T Wave 145
Effect of Slow Conduction of the
Depolarization Wave on the
Characteristics of the T Wave 145
Shortened Depolarization in Portions of
the Ventricular Muscle as a Cause of
T Wave Abnormalities 145
XVi Table of C
CHAPTER 13
Cardiac Arrhythmias and Their
Electrocardiographic Interpretation 147
Abnormal Sinus Rhythms 147
Tachycardia 147
Bradycardia 147
Sinus Arrhythmia 148
Abnormal Rhythms That Result from
Block of Heart Signals Within the
Intracardiac Conduction Pathways 148
Sinoatrial Block 148
Atrioventricular Block 148
Incomplete Atrioventricular Heart Block 149
Incomplete Intraventricular Block—
Electrical Alternans 150
Premature Contractions 150
Premature Atrial Contractions 750
A-V Nodal or A-V Bundle Premature
Contractions 150
Premature Ventricular Contractions 151
Paroxysmal Tachycardia 151
Atrial Paroxysmal Tachycardia 152
Ventricular Paroxysmal Tachycardia 152
Ventricular Fibrillation 152
Phenomenon of Re-entry— Circus
Movements as the Basis for Ventricular
Fibrillation 153
Chain Reaction Mechanism of Fibrillation 153
Electrocardiogram in Ventricular Fibrillation 154
Electroshock Defibrillation of the Ventricle 154
Hand Pumping of the Heart
(Cardiopulmonary Resuscitation) as
an Aid to Defibrillation 155
Atrial Fibrillation 755
Atrial Flutter 756
Cardiac Arrest 756
UNIT IV
The Circulation
CHAPTER 14
Overview of the Circulation; Medical
Physics of Pressure, Flow, and
Resistance 767
Physical Characteristics of the
Circulation 767
Basic Theory of Circulatory Function 163
Interrelationships Among Pressure,
Flow, and Resistance 164
Blood Flow 164
Blood Pressure 766
Resistance to Blood Flow 167
Effects of Pressure on Vascular Resistance
and Tissue Blood Flow 170
CHAPTER 15
Vascular Distensibility and Functions
of the Arterial and Venous Systems 777
Vascular Distensibility 777
Vascular Compliance (or Vascular
Capacitance) 777
Contents
Volume-Pressure Curves of the Arterial
and Venous Circulations 172
Arterial Pressure Pulsations 173
Transmission of Pressure Pulses to the
Peripheral Arteries 174
Clinical Methods for Measuring Systolic
and Diastolic Pressures 175
Veins and Their Functions 776
Venous Pressures—Right Atrial Pressure
(Central Venous Pressure) and
Peripheral Venous Pressures 176
Blood Reservoir Function of the Veins 779
CHAPTER 16
The Microcirculation and the
Lymphatic System: Capillary Fluid
Exchange, Interstitial Fluid, and
Lymph Flow 181
Structure of the Microcirculation and
Capillary System 181
Flow of Blood in the Capillaries—
Vasomotion 182
Average Function of the Capillary System 183
Exchange of Water, Nutrients, and
Other Substances Between the Blood
and Interstitial Fluid 183
Diffusion Through the Capillary Membrane 183
The Interstitium and Interstitial Fluid 184
Fluid Filtration Across Capillaries Is
Determined by Hydrostatic and
Colloid Osmotic Pressures, and
Capillary Filtration Coefficient 185
Capillary Hydrostatic Pressure 186
Interstitial Fluid Hydrostatic Pressure 787
Plasma Colloid Osmotic Pressure 188
Interstitial Fluid Colloid Osmotic Pressure 188
Exchange of Fluid Volume Through the
Capillary Membrane 189
Starling Equilibrium for Capillary Exchange 189
Lymphatic System 190
Lymph Channels of the Body 790
Formation of Lymph 79/
Rate of Lymph Flow 192
Role of the Lymphatic System in Controlling
Interstitial Fluid Protein Concentration,
Interstitial Fluid Volume, and Interstitial
Fluid Pressure 193
CHAPTER 17
Local and Humoral Control of Blood
Flow by the Tissues 795
Local Control of Blood Flow in Response
to Tissue Needs 795
Mechanisms of Blood Flow Control 796
Acute Control of Local Blood Flow 796
Long-Term Blood Flow Regulation 200
Development of Collateral Circulation—A
Phenomenon of Long-Term Local Blood
Flow Regulation 201
Humoral Control of the Circulation 201
Vasoconstrictor Agents 207
Vasodilator Agents 202
Vascular Control by Ions and Other
Chemical Factors 202
Table o
CHAPTER 18
Nervous Regulation of the Circulation,
and Rapid Control of Arterial Pressure 204
Nervous Regulation of the Circulation 204
Autonomic Nervous System 204
Role of the Nervous System in Rapid
Control of Arterial Pressure 208
Increase in Arterial Pressure During Muscle
Exercise and Other Types of Stress 208
Reflex Mechanisms for Maintaining Normal
Arterial Pressure 209
Central Nervous System Ischemic
Response—Control of Arterial Pressure
by the Brain s Vasomotor Center in
Response to Diminished Brain Blood
Flow 212
Special Features of Nervous Control
of Arterial Pressure 213
Role of the Skeletal Nerves and Skeletal
Muscles in Increasing Cardiac Output
and Arterial Pressure 213
Respiratory Waves in the Arterial Pressure 214
Arterial Pressure Vasomotor Waves—
Oscillation of Pressure Reflex Control
Systems 214
CHAPTER 19
Dominant Role of the Kidney in Long-
Term Regulation of Arterial Pressure
and in Hypertension: The Integrated
System for Pressure Control 216
Renal-Body Fluid System for Arterial
Pressure Control 216
Quantitation of Pressure Diuresis as a Basis
for Arterial Pressure Control 217
Chronic Hypertension (High Blood Pressure)
Is Caused by Impaired Renal Fluid
Excretion 220
The Renin-Angiotensin System:
Its Role in Pressure Control and in
Hypertension 223
Components of the Renin-Angiotensin
System 223
Types of Hypertension in Which Angiotensin
Is Involved: Hypertension Caused by a
Renin-Secreting Tumor or by Infusion
of Angiotensin II 226
Other Types of Hypertension Caused by
Combinations of Volume Loading and
Vasoconstriction 227
Primary (Essential) Hypertension 228
Summary of the Integrated,
Multifaceted System for Arterial
Pressure Regulation 230
CHAPTER 20
Cardiac Output, Venous Return,
and Their Regulation 232
Normal Values for Cardiac Output at
Rest and During Activity 232
Control of Cardiac Output by Venous
Return—Role of the Frank-Starling
Mechanism of the Heart 232
f Contents XVii
Cardiac Output Regulation Is the Sum of
Blood Flow Regulation in All the Local
Tissues of the Body—Tissue Metabolism
Regulates Most Local Blood Flow 233
The Heart Has Limits for the Cardiac Output
That It Can Achieve 234
What Is the Role of the Nervous System in
Controlling Cardiac Output? 235
Pathologically High and Pathologically
Low Cardiac Outputs 236
High Cardiac Output Caused by Reduced
Total Peripheral Resistance 236
Low Cardiac Output 237
A More Quantitative Analysis of Cardiac
Output Regulation 237
Cardiac Output Curves Used in the
Quantitative Analysis 237
Venous Return Curves 238
Analysis of Cardiac Output and Right Atrial
Pressure, Using Simultaneous Cardiac
Output and Venous Return Curves 241
Methods for Measuring Cardiac
Output 243
Pulsatile Output of the Heart as Measured
by an Electromagnetic or Ultrasonic
Flowmeter 243
Measurement of Cardiac Output Using the
Oxygen Fick Principle 244
Indicator Dilution Method for Measuring
Cardiac Output 244
CHAPTER 21
Muscle Blood Flow and Cardiac
Output During Exercise; the
Coronary Circulation and Ischemic
Heart Disease 246
Blood Flow in Skeletal Muscle
and Blood Flow Regulation
During Exercise 246
Rate of Blood Flow Through the Muscles 246
Control of Blood Flow Through the Skeletal
Muscles 247
Total Body Circulatory Readjustments
During Exercise 247
Coronary Circulation 249
Physiologic Anatomy of the Coronary Blood
Supply 249
Normal Coronary Blood Flow 249
Control of Coronary Blood Flow 250
Special Features of Cardiac Muscle
Metabolism 251
Ischemic Heart Disease 252
Causes of Death After Acute Coronary
Occlusion 253
Stages of Recovery from Acute
Myocardial Infarction 254
Function of the Heart After Recovery
from Myocardial Infarction 255
Pain in Coronary Heart Disease 255
Surgical Treatment of Coronary Disease 256
CHAPTER 22
Cardiac Failure 258
Dynamics of the Circulation in
Cardiac Failure 258
XV Hi Table of
Acute Effects of Moderate Cardiac Failure 258
Chronic Stage of Failure—Fluid Retention
Helps to Compensate Cardiac Output 259
Summary of the Changes That Occur After
Acute Cardiac Failure— Compensated
Heart Failure 260
Dynamics of Severe Cardiac Failure—
Decompensated Heart Failure 260
Unilateral Left Heart Failure 262
Low-Output Cardiac Failure—
Cardiogenic Shock 262
Edema in Patients with Cardiac Failure 263
Cardiac Reserve 264
Quantitative Graphical Method for Analysis
of Cardiac Failure 265
CHAPTER 23
Heart Valves and Heart Sounds;
Dynamics of Valvular and Congenital
Heart Defects 269
Heart Sounds 269
Normal Heart Sounds 269
Valvular Lesions 271
Abnormal Circulatory Dynamics in
Valvular Heart Disease 272
Dynamics of the Circulation in Aortic
Stenosis and Aortic Regurgitation 272
Dynamics of Mitral Stenosis and Mitral
Regurgitation 273
Circulatory Dynamics During Exercise in
Patients with Valvular Lesions 273
Abnormal Circulatory Dynamics in
Congenital Heart Defects 274
Patent Ductus Arteriosus—A Left-to-Right
Shunt 274
Tetralogy of Fallot—A Right-to-Left Shunt 274
Causes of Congenital Anomalies 276
Use of Extracorporeal Circulation
During Cardiac Surgery 276
Hypertrophy of the Heart in Valvular
and Congenital Heart Disease 276
CHAPTER 24
Circulatory Shock and Physiology of
Its Treatment 278
Physiologic Causes of Shock 278
Circulatory Shock Caused by Decreased
Cardiac Output 278
Circulatory Shock That Occurs Without
Diminished Cardiac Output 278
What Happens to the Arterial Pressure in
Circulatory Shock? 279
Tissue Deterioration Is the End Result of
Circulatory Shock, Whatever the Cause 279
Stages of Shock 279
Shock Caused by Hypovolemia—
Hemorrhagic Shock 279
Relationship of Bleeding Volume to
Cardiac Output and Arterial Pressure 279
Progressive and Nonprogressive
Hemorrhagic Shock 280
Irreversible Shock 284
Hypovolemic Shock Caused by Plasma
Loss 284
Hypovolemic Shock Caused by Trauma 285
Contents
Neurogenic Shock—Increased Vascular
Capacity 285
Anaphylactic Shock and Histamine
Shock 285
Septic Shock 286
Physiology of Treatment in Shock 286
Replacement Therapy 286
Treatment of Shock with Sympathomimetic
Drugs—Sometimes Useful, Sometimes
Not 287
Other Therapy 287
Circulatory Arrest 287
Effect of Circulatory Arrest on the Brain 287
UNIT V
The Body Fluids and Kidneys
CHAPTER 25
The Body Fluid Compartments:
Extracellular and Intracellular Fluids;
Interstitial Fluid and Edema 291
Fluid Intake and Output Are Balanced
During Steady-State Conditions 291
Daily Intake of Water 291
Daily Loss of Body Water 291
Body Fluid Compartments 292
Intracellular Fluid Compartment 29.?
Extracellular Fluid Compartment 293
Blood Volume 293
Constituents of Extracellular and
Intracellular Fluids 293
Ionic Composition of Plasma and
Interstitial Fluid Is Similar 293
Important Constituents of the Intracellular
Fluid 295
Measurement of Fluid Volumes in the
Different Body Fluid Compartments—
The Indicator-Dilution Principle 295
Determination of Volumes of Specific
Body Fluid Compartments 295
Regulation of Fluid Exchange and
Osmotic Equilibrium Between
Intracellular and Extracellular Fluid 296
Basic Principles of Osmosis and
Osmotic Pressure 296
Osmotic Equilibrium Is Maintained
Between Intracellular and
Extracellular Fluids 298
Volume and Osmolality of Extracellular
and Intracellular Fluids in Abnormal
States 299
Effect of Adding Saline Solution to the
Extracellular Fluid 299
Glucose and Other Solutions
Administered for Nutritive Purposes 301
Clinical Abnormalities of Fluid Volume
Regulation: Hyponatremia and
Hypernatremia 301
Causes of Hyponatremia: Excess Water or
Loss of Sodium 301
Causes of Hypernatremia: Water Loss or
Excess Sodium 302
Edema: Excess Fluid in the Tissues 302
Intracellular Edema 302
Extracellular Edema 302
Table c
Summary of Causes of Extracellular Edema 303
Safety Factors That Normally Prevent
Edema 304
Fluids in the Potential Spaces of
the Body 305
CHAPTER 26
Urine Formation by the Kidneys:
I. Glomerular Filtration, Renal Blood
Flow, and Their Control 307
Multiple Functions of the Kidneys in
Homeostasis 307
Physiologic Anatomy of the Kidneys 308
General Organization of the Kidneys and
Urinary Tract 308
Renal Blood Supply 309
The Nephron Is the Functional Unit of the
Kidney 310
Micturition 311
Physiologic Anatomy and Nervous
Connections of the Bladder 311
Transport of Urine from the Kidney
Through the Ureters and into
the Bladder 312
Innervation of the Bladder 312
Filling of the Bladder and Bladder Wall
Tone; the Cystometrogram 312
Micturition Reflex 313
Facilitation or Inhibition of Micturition
by the Brain 313
Abnormalities of Micturition 313
Urine Formation Results from
Glomerular Filtration, Tubular
Reabsorption, and Tubular Secretion 314
Filtration, Reabsorption, and Secretion of
Different Substances 315
Glomerular Filtration—The First Step in
Urine Formation 316
Composition of the Glomerular Filtrate 316
GFR Is About 20 Per Cent of the Renal
Plasma Flow 316
Glomerular Capillary Membrane 316
Determinants of the GFR 317
Increased Glomerular Capillary Filtration
Coefficient Increases GFR 318
Increased Bowman s Capsule Hydrostatic
Pressure Decreases GFR 318
Increased Glomerular Capillary Colloid
Osmotic Pressure Decreases GFR 318
Increased Glomerular Capillary Hydrostatic
Pressure Increases GFR 319
Renal Blood Flow 320
Renal Blood Flow and Oxygen
Consumption 320
Determinants of Renal Blood Flow 320
Blood Flow in the Vasa Recta of the Renal
Medulla Is Very Low Compared with Flow
in the Renal Cortex 321
Physiologic Control of Glomerular
Filtration and Renal Blood Flow 321
Sympathetic Nervous System Activation
Decreases GFR 321
Hormonal and Autacoid Control of Renal
Circulation 322
Autoregulation of GFR and Renal
Blood Flow 323
?/ Contents xix
Importance of GFR Autoregulation in
Preventing Extreme Changes in Renal
Excretion 323
Role of Tubuloglomerular Feedback in
Autoregulation of GFR 323
Myogenic Autoregulation of Renal Blood
Flow and GFR 325
Other Factors That Increase Renal Blood
Flow and GFR: High Protein Intake and
Increased Blood Glucose 325
CHAPTER 27
Urine Formation by the Kidneys:
II. Tubular Processing of the
Glomerular Filtrate 327
Reabsorption and Secretion by the
Renal Tubules 327
Tubular Reabsorption Is Selective and
Quantitatively Large 327
Tubular Reabsorption Includes
Passive and Active Mechanisms 328
Active Transport 328
Passive Water Reabsorption by Osmosis
Is Coupled Mainly to Sodium
Reabsorption 332
Reabsorption of Chloride, Urea, and Other
Solutes by Passive Diffusion 332
Reabsorption and Secretion Along
Different Parts of the Nephron 333
Proximal Tubular Reabsorption 333
Solute and Water Transport in the Loop
of Henle 334
Distal Tubule 336
Late Distal Tubule and Cortical Collecting
Tubule 336
Medullary Collecting Duct 337
Summary of Concentrations of Different
Solutes in the Different Tubular
Segments 338
Regulation of Tubular Reabsorption 339
Glomerulotubular Balance—The Ability
of the Tubules to Increase Reabsorption
Rate in Response to Increased Tubular
Load 339
Peritubular Capillary and Renal Interstitial
Fluid Physical Forces 339
Effect of Arterial Pressure on Urine
Output—The Pressure-Natriuresis and
Pressure-Diuresis Mechanisms 341
Hormonal Control of Tubular Reabsorption 342
Sympathetic Nervous System Activation
Increases Sodium Reabsorption 343
Use of Clearance Methods to Quantify
Kidney Function 343
Inulin Clearance Can Be Used to Estimate
GFR 344
Creatine Clearance and Plasma Creatinine
Clearance Can Be Used to Estimate
GFR 344
PAH Clearance Can Be Used to Estimate
Renal Plasma Flow 345
Filtration Fraction Is Calculated from GFR
Divided by Renal Plasma Flow 346
Calculation of Tubular Reabsorption or
Secretion from Renal Clearance 346
XX Table of C
CHAPTER 28
Regulation of Extracellular Fluid
Osmolarity and Sodium
Concentration 348
The Kidneys Excrete Excess Water
by Forming a Dilute Urine 348
Antidiuretic Hormone Controls Urine
Concentration 348
Renal Mechanisms for Excreting a
Dilute Urine 349
The Kidneys Conserve Water by
Excreting a Concentrated Urine 350
Obligatory Urine Volume 350
Requirements for Excreting a Concentrated
Urine—High ADH Levels and Hyperosmotic
Renal Medulla 350
Countercurrent Mechanism Produces a
Hyperosmotic Renal Medullary Interstitium 357
Role of Distal Tubule and Collecting Ducts in
Excreting a Concentrated Urine 352
Urea Contributes to Hyperosmotic Renal
Medullary Interstitium and to a
Concentrated Urine 353
Countercurrent Exchange in the Vasa Recta
Preserves Hyperosmolarity of the
Renal Medulla 354
Summary of Urine Concentrating Mechanism
and Changes in Osmolarity in Different
Segments of the Tubules 355
Quantifying Renal Urine Concentration
and Dilution: Free Water and Osmolar
Clearances 357
Disorders of Urinary Concentrating
Ability 357
Control of Extracellular Fluid Osmolarity
and Sodium Concentration 358
Estimating Plasma Osmolarity from Plasma
Sodium Concentration 358
Osmoreceptor-ADH Feedback System 358
ADH Synthesis in Supraoptic and
Paraventricular Nuclei of the
Hypothalamus and ADH Release from
the Posterior Pituitary 359
Cardiovascular Reflex Stimulation of ADH
Release by Decreased Arterial Pressure
and/or Decreased Blood Volume 360
Quantitative Importance of Cardiovascular
Reflexes and Osmolarity in Stimulating
ADH Secretion 360
Other Stimuli for ADH Secretion 360
Role of Thirst in Controlling Extracellular
Fluid Osmolarity and Sodium
Concentration 361
Central Nervous System Centers for Thirst 361
Stimuli for Thirst 361
Threshold for Osmolar Stimulus of Drinking 362
Integrated Responses of Osmoreceptor-ADH
and Thirst Mechanisms in Controlling
Extracellular Fluid Osmolarity and Sodium
Concentration 362
Role of Angiotensin II and Aldosterone
in Controlling Extracellular Fluid
Osmolarity and Sodium Concentration 362
Salt-Appetite Mechanism for
Controlling Extracellular Fluid
Sodium Concentration and Volume 363
ontents
CHAPTER 29
Renal Regulation of Potassium,
Calcium, Phosphate, and Magnesium;
Integration of Renal Mechanisms for
Control of Blood Volume and
Extracellular Fluid Volume 365
Regulation of Potassium Excretion
and Potassium Concentration in
Extracellular Fluid 365
Regulation of Internal Potassium
Distribution 366
Overview of Renal Potassium Excretion 367
Potassium Secretion by Principal Cells of
Late Distal and Cortical Collecting
Tubules 367
Summary of Factors That Regulate
Potassium Secretion: Plasma Potassium
Concentration, Aldosterone, Tubular Flow
Rate, and Hydrogen Ion Concentration 368
Control of Renal Calcium Excretion
and Extracellular Calcium Ion
Concentration 371
Control of Calcium Excretion by the
Kidneys 372
Regulation of Renal Phosphate Excretion 372
Control of Renal Magnesium Excretion
and Extracellular Magnesium Ion
Concentration 373
Integration of Renal Mechanisms for
Control of Extracellular Fluid 373
Sodium Excretion Is Precisely Matched to
Intake Under Steady-State Conditions 373
Sodium Excretion Is Controlled by Altering
Glomerular Filtration or Tubular Sodium
Reabsorption Rates 374
Importance of Pressure Natriuresis and
Pressure Diuresis in Maintaining Body
Sodium and Fluid Balance 374
Pressure Natriuresis and Diuresis Are Key
Components of a Renal-Body Fluid
Feedback for Regulating Body Fluid
Volumes and Arterial Pressure 375
Precision of Blood Volume and Extracellular
Fluid Volume Regulation 376
Distribution of Extracellular Fluid
Between the Interstitial Spaces and
Vascular System 376
Nervous and Hormonal Factors Increase
the Effectiveness of Renal-Body Fluid
Feedback Control 377
Sympathetic Nervous System Control of
Renal Excretion: Arterial Baroreceptor and
Low-Pressure Stretch Receptor Reflexes 377
Role of Angiotensin II In Controlling Renal
Excretion 377
Role of Aldosterone in Controlling Renal
Excretion 378
Role of ADH in Controlling Renal Water
Excretion 379
Role of Atrial Natriuretic Peptide in
Controlling Renal Excretion 378
Integrated Responses to Changes in
Sodium Intake 380
Conditions That Cause Large Increases
in Blood Volume and Extracellular
Fluid Volume 380
Table o
Increased Blood Volume and Extracellular
Fluid Volume Caused by Heart Diseases 380
Increased Blood Volume Caused by
Increased Capacity of Circulation 380
Conditions That Cause Large Increases
in Extracellular Fluid Volume but with
Normal Blood Volume 381
Nephrotic Syndrome—Loss of Plasma
Proteins in Urine and Sodium Retention
by the Kidneys 381
Liver Cirrhosis—Decreased Synthesis of
Plasma Proteins by the Liver and
Sodium Retention by the Kidneys 381
CHAPTER 30
Regulation of Acid-Base Balance 383
Hydrogen Ion Concentration Is
Precisely Regulated 383
Acids and Bases—Their Definitions
and Meanings 383
Defenses Against Changes in Hydrogen
Ion Concentration: Buffers, Lungs,
and Kidneys 384
Buffering of Hydrogen Ions in the Body
Fluids 385
Bicarbonate Buffer System 385
Quantitative Dynamics of the Bicarbonate
Buffer System 385
Phosphate Buffer System 387
Proteins: Important Intracellular
Buffers 387
Respiratory Regulation of Acid-Base
Balance 388
Pulmonary Expiration of CO2 Balances
Metabolic Formation of CO2 388
Increasing Alveolar Ventilation Decreases
Extracellular Fluid Hydrogen Ion
Concentration and Raises pH 388
Increased Hydrogen Ion Concentration
Stimulates Alveolar Ventilation 389
Renal Control of Acid-Base Balance 390
Secretion of Hydrogen Ions and
Reabsorption of Bicarbonate Ions
by the Renal Tubules 390
Hydrogen Ions Are Secreted by Secondary
Active Transport in the Early Tubular
Segments 391
Filtered Bicarbonate Ions Are Reabsorbed
by Interaction with Hydrogen Ions in the
Tubules 391
Primary Active Secretion of Hydrogen Ions in
the Intercalated Cells of Late Distal and
Collecting Tubules 392
Combination of Excess Hydrogen Ions
with Phosphate and Ammonia Buffers
in the Tubule—A Mechanism for
Generating New Bicarbonate Ions 392
Phosphate Buffer System Carries Excess
Hydrogen Ions into the Urine and
Generates New Bicarbonate 393
Excretion of Excess Hydrogen Ions and
Generation of New Bicarbonate by the
Ammonia Buffer System 393
Quantifying Renal Acid-Base Excretion 394
Regulation of Renal Tubular Hydrogen Ion
Secretion 395
f Contents XXi
Renal Correction of Acidosis—Increased
Excretion of Hydrogen Ions and
Addition of Bicarbonate Ions to the
Extracellular Fluid 396
Acidosis Decreases the Ratio of HCO3~/H+ in
Renal Tubular Fluid 396
Renal Correction of Alkalosis—Decreased
Tubular Secretion of Hydrogen Ions
and Increased Excretion of
Bicarbonate Ions 396
Alkalosis Increases the Ratio of HCO37H+
in Renal Tubular Fluid 396
Clinical Causes of Acid-Base Disorders 397
Respiratory Acidosis Is Caused by
Decreased Ventilation and Increased Pco2 397
Respiratory Alkalosis Results from Increased
Ventilation and Decreased Pco2 397
Metabolic Acidosis Results from Decreased
Extracellular Fluid Bicarbonate
Concentration 397
Treatment of Acidosis or Alkalosis 398
Clinical Measurements and Analysis of
Acid-Base Disorders 398
Complex Acid-Base Disorders and Use of
the Acid-Base Nomogram for Diagnosis 399
Use of Anion Gap to Diagnose Acid-Base
Disorders 400
CHAPTER 31
Kidney Diseases and Diuretics 402
Diuretics and Their Mechanisms of
Action 402
Osmotic Diuretics Decrease Water
Reabsorption by Increasing Osmotic
Pressure of Tubular Fluid 402
Loop Diuretics Decrease Active
Sodium-Chloride-Potassium Reabsorption
in the Thick Ascending Loop of Henle 403
Thiazide Diuretics Inhibit Sodium-Chloride
Reabsorption in the Early Distal Tubule 404
Carbonic Anhydrase Inhibitors Block
Sodium-Bicarbonate Reabsorption in the
Proximal Tubules 404
Competitive Inhibitors of Aldosterone
Decrease Sodium Reabsorption from and
Potassium Secretion into the Cortical
Collecting Tubule 404
Diuretics That Block Sodium Channels
in the Collecting Tubules Decrease
Sodium Reabsorption 404
Kidney Diseases 404
Acute Renal Failure 404
Prerenal Acute Renal Failure Caused by
Decreased Blood Flow to the Kidney 405
Intrarenal Acute Renal Failure Caused by
Abnormalities within the Kidney 405
Postrenal Acute Renal Failure Caused by
Abnormalities of the Lower Urinary
Tract 406
Physiologic Effects of Acute Renal Failure 406
Chronic Renal Failure: An Irreversible
Decrease in the Number of Functional
Nephrons 406
Vicious Circle of Chronic Renal Failure
Leading to End-Stage Renal Disease 407
Injury to the Renal Vasculature as a Cause
of Chronic Renal Failure 408
XXii Table of C
Injury to the Glomeruli as a Cause of
Chronic Renal Failure—
Glomerulonephritis 408
Injury to the Renal Interstitium as a
Cause of Chronic Renal Failure—
Pyelonephritis 409
Nephrotic Syndrome—Excretion of Protein
in the Urine Because of Increased
Glomerular Permeability 409
Nephron Function in Chronic Renal Failure 409
Effects of Renal Failure on the Body
Fluids—Uremia 411
Hypertension and Kidney Disease 412
Specific Tubular Disorders 413
Treatment of Renal Failure by Dialysis
with an Artificial Kidney 414
UNIT VI
Blood Cells, Immunity, and Blood
Clotting
CHAPTER 32
Red Blood Cells, Anemia, and
Polycythemia 419
Red Blood Cells (Erythrocytes) 419
Production of Red Blood Cells 420
Formation of Hemoglobin 424
Iron Metabolism 425
Life Span and Destruction of Red Blood
Cells 426
Anemias 426
Effects of Anemia on Function of the
Circulatory System 427
Polycythemia 427
Effect of Polycythemia on Function of the
Circulatory System 428
CHAPTER 33
Resistance of the Body to Infection: I.
Leukocytes, Granulocytes, the
Monocyte-Macrophage System, and
Inflammation 429
Leukocytes (White Blood Cells) 429
General Characteristics of Leukocytes 429
Genesis of the White Blood Cells 430
Life Span of the White Blood Cells 431
Neutrophils and Macrophages Defend
Against Infections 431
Phagocytosis 431
Monocyte-Macrophage Cell System
(Reticuloendothelial System) 432
Inflammation: Role of Neutrophils and
Macrophages 434
Inflammation 434
Macrophage and Neutrophil Responses
During Inflammation 434
Eosinophils 436
Basophils 436
Leukopenia 436
The Leukemias 437
Effects of Leukemia on the Body 437
Contents
CHAPTER 3 4
Resistance of the Body to Infection: II.
Immunity and Allergy 439
Innate Immunity 439
Acquired (Adaptive) Immunity 439
Basic Types of Acquired Immunity 440
Both Types of Acquired Immunity Are
Initiated by Antigens 440
Lymphocytes Are Responsible for
Acquired Immunity 440
Preprocessing of the T and B Lymphocytes 440
T Lymphocytes and B-Lymphocyte
Antibodies React Highly Specifically
Against Specific Antigens—Role of
Lymphocyte Clones 442
Origin of the Many Clones of Lymphocytes 442
Specific Attributes of the B-Lymphocyte
System—Humoral Immunity and the
Antibodies 443
Special Attributes of the T-Lymphocyte
System-Activated T Cells and Cell-
Mediated Immunity 446
Several Types of T Cells and Their Different
Functions 446
Tolerance of the Acquired Immunity
System to One s Own Tissues—Role
of Preprocessing in the Thymus and
Bone Marrow 448
Immunization by Injection of Antigens 448
Passive Immunity 449
Allergy and Hypersensitivity 449
Allergy Caused by Activated T Cells:
Delayed-Reaction Allergy 449
Allergies in the Allergic Person, Who Has
Excess IgE Antibodies 449
CHAPTER 35
Blood Types; Transfusion; Tissue and
Organ Transplantation 451
Antigenicity Causes Immune Reactions
of Blood 451
O-A-B Blood Types 451
A and B Antigens—Agglutinogens 451
Agglutinins 452
Agglutination Process In Transfusion
Reactions 452
Blood Typing 453
Rh Blood Types 453
Rh Immune Response 453
Transfusion Reactions Resulting from
Mismatched Blood Types 454
Transplantation of Tissues and Organs 455
Attempts to Overcome Immune Reactions
in Transplanted Tissue 455
CHAPTER 36
Hemostasis and Blood Coagulation 457
Events in Hemostasis 457
Vascular Constriction 457
Formation of the Platelet Plug 457
Blood Coagulation in the Ruptured
Vessel 458
Fibrous Organization or Dissolution of the
Blood Clot 458
Table o
Mechanism of Blood Coagulation 459
Conversion of Prothrombin to Thrombin 459
Conversion of Fibrinogen to Fibrin-
Formation of the Clot 460
Vicious Circle of Clot Formation 460
Initiation of Coagulation: Formation of
Prothrombin Activator 461
Prevention of Blood Clotting in the
Normal Vascular System—Intravascular
Anticoagulants 463
Lysis of Blood Clots—Plasmin 464
Conditions That Cause Excessive
Bleeding in Human Beings 464
Decreased Prothrombin, Factor VII,
Factor IX,and Factor X Caused by
Vitamin K Deficiency 464
Hemophilia 465
Thrombocytopenia 465
Thromboembolic Conditions in the
Human Being 465
Femoral Venous Thrombosis and Massive
Pulmonary Embolism 466
Disseminated Intravascular Coagulation 466
Anticoagulants for Clinical Use 466
Heparin as an Intravenous Anticoagulant 466
Coumarins as Anticoagulants 466
Prevention of Blood Coagulation Outside
the Body 466
Blood Coagulation Tests 467
Bleeding Time 467
Clotting Time 467
Prothrombin Time 467
UNIT VII
Respiration
CHAPTER 37
Pulmonary Ventilation 471
Mechanics of Pulmonary Ventilation 471
Muscles That Cause Lung Expansion and
Contraction 471
Movement of Air In and Out of the Lungs
and the Pressures That Cause the
Movement 472
Effect of the Thoracic Cage on Lung
Expansibility 474
Pulmonary Volumes and Capacities 475
Recording Changes in Pulmonary Volume—
Spirometry 475
Abbreviations and Symbols Used in
Pulmonary Function Tests 476
Determination of Functional Residual
Capacity, Residual Volume, and Total
Lung Capacity—Helium Dilution Method 476
Minute Respiratory Volume Equals
Respiratory Rate Times Tidal Volume 477
Alveolar Ventilation 477
Dead Space and Its Effect on Alveolar
Ventilation 477
Rate of Alveolar Ventilation 478
Functions of the Respiratory
Passageways 478
Trachea, Bronchi, and Bronchioles 478
Normal Respiratory Functions of the
Nose 480
f Contents XXUi
CHAPTER 38
Pulmonary Circulation, Pulmonary
Edema, Pleural Fluid 483
Physiologic Anatomy of the Pulmonary
Circulatory System 483
Pressures in the Pulmonary System 483
Blood Volume of the Lungs 484
Blood Flow Through the Lungs and
Its Distribution 485
Effect of Hydrostatic Pressure
Gradients in the Lungs on Regional
Pulmonary Blood Flow 485
Zones 7, 2, and 3 of Pulmonary Blood Flow 485
Effect of Increased Cardiac Output on
Pulmonary Blood Flow and Pulmonary
Arterial Pressure During Heavy Exercise 486
Function of the Pulmonary Circulation
When the Left Atrial Pressure Rises as a
Result of Left-Sided Heart Failure 487
Pulmonary Capillary Dynamics 487
Capillary Exchange of Fluid in the Lungs,
and Pulmonary Interstitial Fluid Dynamics 487
Pulmonary Edema 488
Fluid in the Pleural Cavity 489
CHAPTER 3 9
Physical Principles of Gas Exchange;
Diffusion of Oxygen and Carbon
Dioxide Through the Respiratory
Membrane 491
Physics of Gas Diffusion and Gas
Partial Pressures 491
Molecular Basis of Gas Diffusion 491
Gas Pressures in a Mixture of Gases—
Partial Pressures of Individual Gases 491
Pressures of Gases Dissolved in Water
and Tissues 492
Vapor Pressure of Water 492
Diffusion of Gases Through Fluids—
Pressure Difference Causes Net
Diffusion 493
Diffusion of Gases Through Tissues 493
Composition of Alveolar Air—Its Relation
to Atmospheric Air 493
Rate at Which Alveolar Air Is Renewed by
Atmospheric Air 494
Oxygen Concentration and Partial Pressure
in the Alveoli 494
CO2 Concentration and Partial Pressure in
the Alveoli 495
Expired Air 495
Diffusion of Gases Through the
Respiratory Membrane 496
Factors That Affect the Rate of Gas
Diffusion Through the Respiratory
Membrane 498
Diffusing Capacity of the Respiratory
Membrane 498
Effect of the Ventilation-Perfusion
Ratio on Alveolar Gas Concentration 499
Po2-Pco2, Va/Q Diagram 500
Concept of the Physiological Shunt
(When Va/Q Is Greater Than Normal) 500
Abnormalities of Ventilation-Perfusion Ratio 501
XXIV Table of
CHAPTER 40
Transport of Oxygen and Carbon
Dioxide in Blood and Tissue Fluids 502
Transport of Oxygen from the Lungs to
the Body Tissues 502
Diffusion of Oxygen from the Alveoli to the
Pulmonary Capillary Blood 502
Transport of Oxygen in the Arterial Blood 503
Diffusion of Oxygen from the Peripheral
Capillaries into the Tissue Fluid 503
Diffusion of Oxygen from the Peripheral
Capillaries to the Tissue Cells 504
Diffusion of Carbon Dioxide from the
Peripheral Tissue Cells into the
Capillaries and from the Pulmonary
Capillaries into the Alveoli 504
Role of Hemoglobin in Oxygen Transport 505
Reversible Combination of Oxygen with
Hemoglobin 505
Effect of Hemoglobin to Buffer the
Tissue Po2 507
Factors That Shift the Oxygen-Hemoglobin
Dissociation Curve—Their Importance for
Oxygen Transport 507
Metabolic Use of Oxygen by the Cells 508
Transport of Oxygen in the Dissolved State 509
Combination of Hemoglobin with Carbon
Monoxide—Displacement of Oxygen 509
Transport of Carbon Dioxide in the Blood 510
Chemical Forms in Which Carbon Dioxide
Is Transported 510
Carbon Dioxide Dissociation Curve 577
When Oxygen Binds with Hemoglobin,
Carbon Dioxide Is Released (the Haldane
Effect) to Increase CO2 Transport 577
Change in Blood Acidity During Carbon
Dioxide Transport 572
Respiratory Exchange Ratio 572
CHAPTER 41
Regulation of Respiration 514
Respiratory Center 514
Dorsal Respiratory Group of Neurons—Its
Control of Inspiration and of Respiratory
Rhythm 514
A Pneumotaxic Center Limits the Duration
of Inspiration and Increases the
Respiratory Rate 574
Ventral Respiratory Group of Neurons—
Functions in Both Inspiration and
Expiration 515
Lung Inflation Signals Limit Inspiration—
The Hering-Breuer Inflation Reflex 515
Control of Overall Respiratory Center
Activity 576
Chemical Control of Respiration 516
Direct Chemical Control of Respiratory
Center Activity by Carbon Dioxide and
Hydrogen Ions 576
Peripheral Chemoreceptor System for
Control of Respiratory Activity—Role
of Oxygen in Respiratory Control 518
Effect of Low Arterial Po2 to Stimulate
Alveolar Ventilation When Arterial Carbon
Dioxide and Hydrogen Ion Concentrations
Remain Normal 519
Contents
Chronic Breathing of Low Oxygen Stimulates
Respiration Even More—The Phenomenon
of Acclimatization 519
Composite Effects of Pco2, pH, and Po2 on
Alveolar Ventilation 519
Regulation of Respiration During
Exercise 520
Other Factors That Affect Respiration 521
Sleep Apnea 522
CHAPTER 42
Respiratory Insufficiency—
Pathophysiology, Diagnosis, Oxygen
Therapy 524
Useful Methods for Studying Respiratory
Abnormalities 524
Study of Blood Gases and Blood pH 524
Measurement of Maximum Expiratory Flow 525
Forced Expiratory Vital Capacity and Forced
Expiratory Volume 526
Physiologic Peculiarities of Specific
Pulmonary Abnormalities 526
Chronic Pulmonary Emphysema 526
Pneumonia 527
Atelectasis 528
Asthma 529
Tuberculosis 530
Hypoxia and Oxygen Therapy 530
Oxygen Therapy in Different Types of
Hypoxia 530
Cyanosis 531
Hypercapnia 531
Dyspnea 532
Artificial Respiration 532
UNIT VIII
Aviation, Space, and Deep-Sea
Diving Physiology
CHAPTER 43
Aviation, High-Altitude, and Space
Physiology 537
Effects of Low Oxygen Pressure on the
Body 537
Alveolar Po2 at Different Elevations 537
Effect of Breathing Pure Oxygen on Alveolar
Po2 at Different Altitudes 558
Acute Effects of Hypoxia 538
Acclimatization to Low Po2 539
Natural Acclimatization of Native Human
Beings Living at High Altitudes 540
Reduced Work Capacity at High Altitudes
and Positive Effect of Acclimatization 540
Acute Mountain Sickness and High-Altitude
Pulmonary Edema 540
Chronic Mountain Sickness 547
Effects of Acceleratory Forces on the
Body in Aviation and Space Physiology 541
Centrifugal Acceleratory Forces 541
Effects of Linear Acceleratory Forces on the
Body 542
Table
Artificial Climate in the Sealed
Spacecraft 543
Weightlessness in Space 543
CHAPTER 44
Physiology of Deep-Sea Diving and
Other Hyperbaric Conditions 545
Effect of High Partial Pressures of
Individual Gases on the Body 545
Nitrogen Narcosis at High Nitrogen
Pressures 545
Oxygen Toxicity at High Pressures 546
Carbon Dioxide Toxicity at Great Depths
in the Sea 547
Decompression of the Diver After Excess
Exposure to High Pressure 547
Scuba (Self-Contained Underwater
Breathing Apparatus) Diving 549
Special Physiologic Problems in
Submarines 550
Hyperbaric Oxygen Therapy 550
UNIT IX
The Nervous System: A. General
Principles and Sensory Physiology
CHAPTER 45
Organization of the Nervous System,
Basic Functions of Synapses,
Transmitter Substances 555
General Design of the Nervous System 555
Central Nervous System Neuron: The Basic
Functional Unit 555
Sensory Part of the Nervous System—
Sensory Receptors 555
Motor Part of the Nervous System—
Effectors 556
Processing of Information— Integrative
Function of the Nervous System 556
Storage of Information—Memory 557
Major Levels of Central Nervous System
Function 557
Spinal Cord Level 557
Lower Brain or Subcortical Level 558
Higher Brain or Cortical Level 558
Comparison of the Nervous System
with a Computer 558
Central Nervous System Synapses 559
Types of Synapses—Chemical and
Electrical 559
Physiologic Anatomy of the Synapse 559
Chemical Substances That Function as
Synaptic Transmitters 562
Electrical Events During Neuronal Excitation 564
Electrical Events During Neuronal
Inhibition 566
Special Functions of Dendrites for Exciting
Neurons 568
Relation of State of Excitation of the Neuron
to Rate of Firing 569
Some Special Characteristics of
Synaptic Transmission 570
of Contents XXV
CHAPTER 46
Sensory Receptors, Neuronal Circuits
for Processing Information 572
Types of Sensory Receptors and the
Sensory Stimuli They Detect 572
Differential Sensitivity of Receptors 572
Transduction of Sensory Stimuli into
Nerve Impulses 573
Local Electrical Currents at Nerve Endings—
Receptor Potentials 573
Adaptation of Receptors 575
Nerve Fibers That Transmit Different
Types of Signals, and Their
Physiologic Classification 576
Transmission of Signals of Different
Intensity in Nerve Tracts—Spatial and
Temporal Summation 577
Transmission and Processing of Signals
in Neuronal Pools 578
Relaying of Signals Through Neuronal
Pools 579
Prolongation of a Signal by a Neuronal
Pool— Afterdischarge 5X1
Instability and Stability of Neuronal
Circuits 583
Inhibitory Circuits as a Mechanism for
Stabilizing Nervous System Function 583
Synaptic Fatigue as a Means for Stabilizing
the Nervous System 583
CHAPTER 47
Somatic Sensations: I. General
Organization, the Tactile and
Position Senses 585
CLASSIFICATION OF SOMATIC SENSES 585
Detection and Transmission of Tactile
Sensations 585
Detection of Vibration 587
TICKLE AND ITCH 587
Sensory Pathways for Transmitting
Somatic Signals into the Central
Nervous System 587
Dorsal Column-Medial Lemniscal System 588
Anterolateral System 588
Transmission in the Dorsal Column—
Medial Lemniscal System 588
Anatomy of the Dorsal Column—Medial
Lemniscal System 588
Somatosensory Cortex 589
Somatosensory Association Areas 592
Overall Characteristics of Signal
Transmission and Analysis in the Dorsal
Column-Medial Lemniscal System 592
Position Senses 594
Interpretation of Sensory Stimulus Intensity 593
Judgment of Stimulus Intensity 594
Position Senses 594
Transmission of Less Critical Sensory
Signals in the Anterolateral Pathway 595
Anatomy of the Anterolateral Pathway 595
Some Special Aspects of
Somatosensory Function 596
Function of the Thalamus in Somatic
Sensation 596
XXV i Table of C
Cortical Control of Sensory Sensitivity—
Corticofugal Signals 597
Segmental Fields of Sensation—The
Dermatomes 597
CHAPTER 48
Somatic Sensations: II. Pain,
Headache, and Thermal Sensations 598
TVpes of Pain and Their Qualities—
Fast Pain and Slow Pain 598
Pain Receptors and Their Stimulation 598
Rate of Tissue Damage as a Stimulus
for Pain 599
Dual Pathways for Transmission of Pain
Signals into the Central Nervous
System 600
Dual Pain Pathways in the Cord and Brain
Stem—The Neospinothalamic Tract and
the Paleospinothalamic Tract 600
Pain Suppression ( Analgesia ) System
in the Brain and Spinal Cord 602
Brain s Opiate System—Endorphins and
Enkephalins 602
Inhibition of Pain Transmission by
Simultaneous Tactile Sensory Signals 603
Treatment of Pain by Electrical Stimulation 603
Referred Pain 603
Visceral Pain 603
Causes of True Visceral Pain 604
Parietal Pain Caused by Visceral Disease 604
Localization of Visceral Pain— Visceral
and the Parietal Pain Transmission
Pathways 604
Some Clinical Abnormalities of Pain
and Other Somatic Sensations 605
Hyperalgesia 605
Herpes Zoster (Shingles) 605
Tic Douloureux 605
Brown-Sequard Syndrome 606
Headache 606
Headache of Intracranial Origin 606
Thermal Sensations 607
Thermal Receptors and Their Excitation 607
Transmission of Thermal Signals in the
Nervous System 609
UNIT X
The Nervous System: B.
The Special Senses
CHAPTER 49
The Eye: I. Optics of Vision 613
Physical Principles of Optics 613
Refraction of Light 613
Application of Refractive Principles to
Lenses 613
Focal Length of a Lens (,15
Formation of an Image by a Convex Lens 6/6
Measurement of the Refractive Power of a
Lens— Diopter 616
Optics of the Eye 617
The Eye as a Camera 617
Mechanism of Accommodation 617
Contents
Pupillary Diameter 618
Errors of Refraction 619
Visual Acuity 621
Determination of Distance of an Object
from the Eye— Depth Perception 621
Ophthalmoscope 622
Fluid System of the Eye—Intraocular
Fluid 623
Formation of Aqueous Humor by the Ciliary
Body 623
Outflow of Aqueous Humor from the Eye 623
Intraocular Pressure 624
CHAPTER 50
The Eye: II. Receptor and Neural
Function of the Retina 626
Anatomy and Function of the
Structural Elements of the Retina 626
Photochemistry of Vision 628
Rhodopsin-Retinal Visual Cycle, and
Excitation of the Rods 629
Automatic Regulation of Retinal Sensitivity-
Light and Dark Adaptation 631
Color Vision 632
Tricolor Mechanism of Color Detection 632
Color Blindness 633
Neural Function of the Retina 633
Neural Circuitry of the Retina 633
Ganglion Cells and Optic Nerve Fibers 636
Excitation of the Ganglion Cells 637
CHAPTER 51
The Eye: III. Central
Neurophysiology of Vision 640
Visual Pathways 640
Function of the Dorsal Lateral Geniculate
Nucleus of the Thalamus 640
Organization and Function of the Visual
Cortex 641
Layered Structure of the Primary Visual
Cortex 642
Two Major Pathways for Analysis of Visual
Information—(7) The Fast Position and
Motion Pathway; (2) The Accurate Color
Pathway 643
Neuronal Patterns of Stimulation During
Analysis of the Visual Image 643
Detection of Color 644
Effect of Removing the Primary Visual
Cortex 644
Fields of Vision; Perimetry 644
Eye Movements and Their Control 645
Fixation Movements of the Eyes 645
Fusion of the Visual Images from the
Two Eyes 647
Autonomic Control of Accommodation
and Pupillary Aperture 648
Control of Accommodation (Focusing the
Eyes) 649
Control of Pupillary Diameter 649
CHAPTER 52
The Sense of Hearing 651
Tympanic Membrane and the Ossicular
System 651
Table i
Conduction of Sound from the Tympanic
Membrane to the Cochlea 651
Transmission of Sound Through Bone 652
Cochlea 652
Functional Anatomy of the Cochlea 652
Transmission of Sound Waves in the
Cochlea— Traveling Wave 654
Function of the Organ of Corti 655
Determination of Sound Frequency—The
Place Principle 656
Determination of Loudness 656
Central Auditory Mechanisms 657
Auditory Nervous Pathways 657
Function of the Cerebral Cortex in Hearing 658
Determination of the Direction from Which
Sound Comes 660
Centrifugal Signals from the Central
Nervous System to Lower Auditory
Centers 660
Hearing Abnormalities 660
Types of Deafness 660
CHAPTER 53
The Chemical Senses—Taste and
Smell 663
Sense of Taste 663
Primary Sensations of Taste 663
Taste Bud and Its Function 664
Transmission of Taste Signals into the
Central Nervous System 665
Taste Preference and Control of the Diet 666
Sense of Smell 667
Olfactory Membrane 667
Stimulation of the Olfactory Cells 667
Transmission of Smell Signals into the
Central Nervous System 668
UNIT XI
The Nervous System: C. Motor and
Integrative Neurophysiology
CHAPTER 54
Motor Functions of the Spinal Cord;
the Cord Reflexes 673
Organization of the Spinal Cord for Motor
Functions 673
Muscle Sensory Receptors—Muscle
Spindles and Golgi Tendon Organs—
And Their Roles in Muscle Control 675
Receptor Function of the Muscle Spindle 675
Muscle Stretch Reflex 676
Role of the Muscle Spindle in Voluntary
Motor Activity 678
Clinical Applications of the Stretch
Reflex 678
Golgi Tendon Reflex 679
Function of the Muscle Spindles and Golgi
Tendon Organs in Conjunction with Motor
Control from Higher Levels of the Brain 680
Flexor Reflex and the Withdrawal
Reflexes 680
Crossed Extensor Reflex 681
of Contents XXVii
Reciprocal Inhibition and Reciprocal
Innervation 681
Reflexes of Posture and Locomotion 682
Postural and Locomotive Reflexes of
the Cord 682
Scratch Reflex 683
Spinal Cord Reflexes That Cause
Muscle Spasm 683
Autonomic Reflexes in the Spinal
Cord 683
Spinal Cord Transection and Spinal
Shock 684
CHAPTER 55
Cortical and Brain Stem Control of
Motor Function 685
MOTOR CORTEX AND CORTICOSPINAL
TRACT 685
Primary Motor Cortex 685
Premotor Area 686
Supplementary Motor Area 686
Some Specialized Areas of Motor Control
Found in the Human Motor Cortex 686
Transmission of Signals from the Motor
Cortex to the Muscles 687
Incoming Fiber Pathways to the Motor
Cortex 688
Red Nucleus Serves as an Alternative
Pathway for Transmitting Cortical Signals
to the Spinal Cord 688
Extrapyramidal System 689
Excitation of the Spinal Cord Motor Control
Areas by the Primary Motor Cortex and
Red Nucleus 689
Role of the Brain Stem in Controlling
Motor Function 691
Support of the Body Against Gravity—
Roles of the Reticular and Vestibular
Nuclei 691
Vestibular Sensations and Maintenance
of Equilibrium 692
Vestibular Apparatus 692
Function of the Utricle and Saccule in the
Maintenance of Static Equilibrium 694
Detection of Head Rotation by the
Semicircular Ducts 695
Vestibular Mechanisms for Stabilizing the
Eyes 696
Other Factors Concerned with Equilibrium 696
Functions of Brain Stem Nuclei in
Controlling Subconscious, Stereotyped
Movements 697
CHAPTER 56
Contributions of the Cerebellum and
Basal Ganglia to Overall Motor
Control 698
Cerebellum and Its Motor Functions 698
Anatomical Functional Areas of the
Cerebellum 699
Neuronal Circuit of the Cerebellum 700
Function of the Cerebellum in Overall
Motor Control 703
Clinical Abnormalities of the Cerebellum 706
XXViU Table of C
Basal Ganglia—Their Motor Functions 707
Function of the Basal Ganglia in Executing
Patterns of Motor Activity—The Putamen
Circuit 708
Role of the Basal Ganglia for Cognitive
Control of Sequences of Motor Patterns—
The Caudate Circuit 709
Function of the Basal Ganglia to Change
the Timing and to Scale the Intensity of
Movements 709
Functions of Specific Neurotransmitter
Substances in the Basal Ganglial
System 710
Integration of the Many Parts of the
Total Motor Control System 712
Spinal Level 712
Hindbrain Level 772
Motor Cortex Level 772
What Drives Us to Action? 713
CHAPTER 57
Cerebral Cortex, Intellectual Functions
of the Brain, Learning and Memory 714
Physiologic Anatomy of the Cerebral
Cortex 714
Functions of Specific Cortical Areas 775
Association Areas 776
Comprehensive Interpretative Function of
the Posterior Superior Temporal Lobe—
Wemicke s Area (a General
Interpretative Area) 718
Functions of the Parieto-occipitotemporal
Cortex in the Nondominant Hemisphere 779
Higher Intellectual Functions of the
Prefrontal Association Areas 779
Function of the Brain in
Communication—Language Input
and Language Output 720
Function of the Corpus Callosum and
Anterior Commissure to Transfer
Thoughts, Memories, Training, and
Other Information Between the Two
Cerebral Hemispheres 722
Thoughts, Consciousness, and Memory 723
Memory—Roles of Synaptic Facilitation and
Synaptic Inhibition 723
Short-Term Memory 724
Intermediate Long-Term Memory 724
Long-Term Memory 725
Consolidation of Memory 725
CHAPTER 58
Behavioral and Motivational
Mechanisms of the Brain—The
Limbic System and the
Hypothalamus 728
Activating-Driving Systems of the Brain 728
Control of Cerebral Activity by Continuous
Excitatory Signals from the Brain Stem 728
Neurohormonal Control of Brain Activity 730
Limbic System 731
Functional Anatomy of the Limbic
System; Key Position of the
Hypothalamus 731
ontents
Hypothalamus, a Major Control
Headquarters for the Limbic System 732
Vegetative and Endocrine Control
Functions of the Hypothalamus 733
Behavioral Functions of the Hypothalamus
and Associated Limbic Structures 734
Reward and Punishment Function of
the Limbic System 735
Importance of Reward or Punishment in
Behavior 736
Specific Functions of Other Parts of
the Limbic System 736
Functions of the Hippocampus 736
Functions of the Amygdala 737
Function of the Limbic Cortex 738
CHAPTER 59
States of Brain Activity—Sleep, Brain
Waves, Epilepsy, Psychoses 739
Sleep 739
Slow-Wave Sleep 739
REM Sleep (Paradoxical Sleep,
Desynchronized Sleep) 740
Basic Theories of Sleep 740
Physiologic Effects of Sleep 741
Brain Waves 741
Origin of Brain Waves 742
Effect of Varying Levels of Cerebral
Activity on the Frequency of the EEG 743
Changes in the EEG at Different Stages of
Wakefulness and Sleep 743
Epilepsy 743
Grand Mai Epilepsy 743
Petit Mai Epilepsy 744
Focal Epilepsy 744
Psychotic Behavior and Dementia—
Roles of Specific Neurotransmitter
Systems 745
Depression and Manic-Depressive
Psychoses—Decreased Activity of the
Norepinephrine and Serotonin
Neurotransmitter Systems 745
Schizophrenia—Possible Exaggerated
Function of Part of the Dopamine
System 745
Alzheimer s Disease—Amyloid Plaques
and Depressed Memory 746
CHAPTER 60
The Autonomic Nervous System and
the Adrenal Medulla 748
General Organization of the Autonomic
Nervous System 748
Physiologic Anatomy of the Sympathetic
Nervous System 748
Preganglionic and Postganglionic
Sympathetic Neurons 748
Physiologic Anatomy of the
Parasympathetic Nervous System 750
Basic Characteristics of Sympathetic
and Parasympathetic Function 750
Cholinergic and Adrenergic Fibers-
Secretion of Acetylcholine or
Norepinephrine 750
Receptors on the Effector Organs 752
Table o
Excitatory and Inhibitory Actions of
Sympathetic and Parasympathetic
Stimulation 753
Effects of Sympathetic and Parasympathetic
Stimulation on Specific Organs 753
Function of the Adrenal Medullae 755
Relation of Stimulus Rate to Degree of
Sympathetic and Parasympathetic Effect 756
Sympathetic and Parasympathetic Tone 756
Denervation Supersensitivity of Sympathetic
and Parasympathetic Organs after
Denervation 756
Autonomic Reflexes 757
Stimulation of Discrete Organs in Some
Instances and Mass Stimulation in
Other Instances by the Sympathetic
and Parasympathetic Systems 757
Alarm or Stress Response of the
Sympathetic Nervous System 758
Medullary, Pontine, and Mesencephalic
Control of the Autonomic Nervous
System 758
Pharmacology of the Autonomic
Nervous System 759
Drugs That Act on Adrenergic Effector
Organs—Sympathomimetic Drugs 759
Drugs That Act on Cholinergic Effector
Organs 759
Drugs That Stimulate or Block Sympathetic
and Parasympathetic Postganglionic
Neurons 759
CHAPTER 61
Cerebral Blood Flow, Cerebrospinal
Fluid, and Brain Metabolism 761
Cerebral Blood Flow 761
Normal Rate of Cerebral Blood Flow 761
Regulation of Cerebral Blood Flow 761
Cerebral Microcirculation 763
Cerebral Stroke Occurs When Cerebral
Blood Vessels are Blocked 763
Cerebrospinal Fluid System 763
Cushioning Function of the Cerebrospinal
Fluid 763
Formation, Flow, and Absorption of
Cerebrospinal Fluid 764
Cerebrospinal Fluid Pressure 765
Obstruction to Flow of Cerebrospinal Fluid
Can Cause Hydrocephalus 766
Blood-Cerebrospinal Fluid and Blood-Brain
Barriers 766
Brain Edema 766
Brain Metabolism 767
UNIT XII
Gastrointestinal Physiology
CHAPTER 6 2
General Principles of Gastrointestinal
Function—Motility, Nervous Control,
and Blood Circulation 771
General Principles of Gastrointestinal
Motility 771
f Contents XXix
Physiological Anatomy of the
Gastrointestinal Wall 771
Neural Control of Gastrointestinal
Function—Enteric Nervous System 773
Differences Between the Myenteric and
Submucosal Plexuses 774
Types of Neurotransmitters Secreted by
Enteric Neurons 775
Hormonal Control of Gastrointestinal
Motility 776
Functional Types of Movements in the
Gastrointestinal Tract 776
Propulsive Movements—Peristalsis 776
Mixing Movements 777
Gastrointestinal Blood Flow—
Splanchnic Circulation 777
Anatomy of the Gastrointestinal Blood
Supply 778
Effect of Gut Activity and Metabolic
Factors on Gastrointestinal Blood
Flow 778
Nervous Control of Gastrointestinal Blood
Flow 779
CHAPTER 6 3
Propulsion and Mixing of Food in the
Alimentary Tract 781
Ingestion of Food 781
Mastication (Chewing) 781
Swallowing (Deglutition) 782
Motor Functions of the Stomach 784
Storage Function of the Stomach 784
Mixing and Propulsion Of Food in the
Stomach—The Basic Electrical Rhythm
of the Stomach Wall 784
Stomach Emptying 785
Regulation of Stomach Emptying 785
Movements of the Small Intestine 786
Mixing Contractions (Segmentation
Contractions) 786
Propulsive Movements 787
Function of the lleocecal Valve 788
Movements of the Colon 788
Defecation 789
Other Autonomic Reflexes That Affect
Bowel Activity 790
CHAPTER 6 4
Secretory Functions of the Alimentary
Tract 791
General Principles of Alimentary Tract
Secretion 791
Anatomical Types of Glands 791
Basic Mechanisms of Stimulation of the
Alimentary Tract Glands 791
Basic Mechanism of Secretion by Glandular
Cells 791
Lubricating and Protective Properties of
Mucus, and Importance of Mucus in the
Gastrointestinal Tract 793
Secretion of Saliva 793
Nervous Regulation of Salivary Secretion 794
Esophageal Secretion 795
XXX Table of C
Gastric Secretion 794
Characteristics of the Gastric Secretions 794
Pyloric Glands—Secretion of Mucus and
Gastrin 797
Surface Mucous Cells 797
Stimulation of Gastric Acid Secretion 797
Regulation of Pepsinogen Secretion 798
Inhibition of Gastric Secretion by Other
Post-Stomach Intestinal Factors 798
Chemical Composition of Gastrin And Other
Gastrointestinal Hormones 799
Pancreatic Secretion 799
Pancreatic Digestive Enzymes 799
Secretion of Bicarbonate Ions 800
Regulation of Pancreatic Secretion 800
Secretion of Bile by the Liver; Functions
of the Biliary Tree 802
Physiologic Anatomy of Biliary Secretion 802
Function of Bile Salts in Fat Digestion and
Absorption 804
Liver Secretion of Cholesterol and
Gallstone Formation 804
Secretions of the Small Intestine 805
Secretion of Mucus by Brunner s Glands in
the Duodenum 805
Secretion of Intestinal Digestive Juices by
the Crypts of Lieberkiihn 805
Regulation of Small Intestine Secretion—
Local Stimuli 806
Secretions of the Large Intestine 806
CHAPTER 65
Digestion and Absorption in the
Gastrointestinal Tract 808
Digestion of the Various Foods by
Hydrolysis 808
Digestion of Carbohydrates 809
Digestion of Proteins 810
Digestion of Fats 811
Basic Principles of Gastrointestinal
Absorption 812
Anatomical Basis of Absorption 812
Absorption in the Small Intestine 813
Absorption of Water 814
Absorption of Ions 814
Absorption of Nutrients 815
Absorption in the Large Intestine:
Formation of Feces 817
CHAPTER 66
Physiology of Gastrointestinal
Disorders 819
Disorders of Swallowing and of the
Esophagus 819
Disorders of the Stomach 819
Peptic Ulcer 820
Specific Causes of Peptic Ulcer in the
Human Being 821
Disorders of the Small Intestine 821
Abnormal Digestion of Food in the Small
Intestine—Pancreatic Failure 821
Malabsorption by the Small Intestine
Mucosa—Sprue 822
Disorders of the Large Intestine 822
Constipation 822
Contents
Diarrhea 822
Paralysis of Defecation in Spinal Cord
Injuries 823
General Disorders of the
Gastrointestinal Tract 823
Vomiting 823
Nausea 824
Gastrointestinal Obstruction 824
UNIT XIII
Metabolism and Temperature
Regulation
CHAPTER 67
Metabolism of Carbohydrates,
and Formation of Adenosine
Triphosphate 829
Release of Energy from Foods, and the
Concept of Free Energy 829
Role of Adenosine Triphosphate in
Metabolism 829
Central Role of Glucose in
Carbohydrate Metabolism 830
Transport of Glucose Through the
Cell Membrane 831
Insulin Increases Facilitated Diffusion of
Glucose 831
Phosphorylation of Glucose S31
Glycogen Is Stored in Liver and
Muscle 831
Glycogenesis—The Process of Glycogen
Formation 832
Removal of Stored Glycogen—
Glycogenolysis 832
Release of Energy from the Glucose
Molecule by the Glycolytic Pathway 832
Summary of ATP Formation During the
Breakdown of Glucose 836
Control of Energy Release from Stored
Glycogen When the Body Needs Additional
Energy 836
Anaerobic Release of Energy— Anaerobic
Glycolysis 836
Release of Energy from Glucose by the
Pentose Phosphate Pathway 837
Glucose Conversion to Glycogen or Fat 838
Formation of Carbohydrates from
Proteins and Fats— Gluconeogenesis S38
Blood Glucose 839
CHAPTER 68
Lipid Metabolism 840
Transport of Lipids in the Body Fluids 840
Transport of Triglycerides and Other Lipids
from the Gastrointestinal Tract by
Lymph—The Chylomicrons 840
Removal of the Chylomicrons from the
Blood 841
Free Fatty Acids Are Transported in the
Blood in Combination with Albumin 841
Table c
Lipoproteins—Their Special Function in
Transporting Cholesterol and
Phospholipids 841
Fat Deposits 842
Adipose Tissue 842
Liver Lipids 842
Use of Triglycerides for Energy:
Formation of Adenosine Triphosphate 842
Formation of Acetoacetic Acid in the
Liver and Its Transport in the Blood 844
Synthesis of Triglycerides from
Carbohydrates 844
Synthesis of Triglycerides from Proteins 845
Regulation of Energy Release from
Triglycerides 846
Obesity 846
Phospholipids and Cholesterol 846
Phospholipids 846
Cholesterol 847
Cellular Structural Functions of
Phospholipids and Cholesterol—
Especially for Membranes 848
Atherosclerosis 848
Basic Causes of Atherosclerosis—The
Roles of Cholesterol and Lipoproteins 850
Other Major Risk Factors for
Atherosclerosis 850
Prevention of Atherosclerosis 850
CHAPTER 69
Protein Metabolism 852
Basic Properties 852
Amino Acids 852
Transport and Storage of Amino Acids 854
Blood Amino Acids 854
Storage of Amino Acids as Proteins in the
Cells 854
Functional Roles of the Plasma
Proteins 855
Essential and Nonessential Amino Acids 855
Obligatory Degradation of Proteins 857
Hormonal Regulation of Protein
Metabolism 857
CHAPTER 70
The Liver as an Organ 859
Physiologic Anatomy of the Liver 859
Hepatic Vascular and Lymph
Systems 859
Blood Flows Through the Liver from the
Portal Vein and Hepatic Artery 860
The Liver Functions as a Blood Reservoir 860
The Liver Has Very High Lymph Flow 860
Regulation of Liver Mass—Regeneration 860
Hepatic Macrophage System Serves a
Blood-Cleansing Function 861
Metabolic Functions of the Liver 861
Carbohydrate Metabolism 861
Fat Metabolism 861
Protein Metabolism 862
Other Metabolic Functions of the Liver 862
Measurement of Bilirubin in the Bile
as a Clinical Diagnostic Tool 862
Jaundice—Excess Bilirubin in the
Extracellular Fluid 863
)/ Contents XXXi
CHAPTER 71
Dietary Balances; Regulation of
Feeding; Obesity and Starvation;
Vitamins and Minerals 865
Energy Intake and Output Are Balanced
Under Steady-State Conditions 865
Dietary Balances 865
Energy Available in Foods 865
Methods for Determining Metabolic
Utilization of Proteins, Carbohydrates,
and Fats 866
Regulation of Food Intake and Energy
Storage 865
Neural Centers Regulate Food Intake 867
Factors That Regulate Quantity of Food
Intake 870
Obesity 872
Decreased Physical Activity and
Abnormal Feeding Regulation as
Causes of Obesity 872
Treatment of Obesity 873
Inanition, Anorexia, and Cachexia 874
Starvation 874
Vitamins 875
Vitamin A 875
Thiamine (Vitamin B,) 875
Niacin 876
Riboflavin (Vitamin B2) 876
Vitamin B12 876
Folic Acid (Pteroylglutamic Acid) 877
Pyridoxine (Vitamin B6) 877
Pantothenic Acid 877
Ascorbic Acid (Vitamin C) 877
Vitamin D 878
Vitamin E 878
Vitamin K 878
Mineral Metabolism 878
CHAPTER 72
Energetics and Metabolic Rate 881
Adenosine Triphosphate (ATP)
Functions as an Energy Currency
in Metabolism 881
Phosphocreatine Functions as an
Accessory Storage Depot for Energy
and as an ATP Buffer 882
Anaerobic Versus Aerobic Energy 882
Summary of Energy Utilization by the
Cells 883
Control of Energy Release in the Cell 884
Metabolic Rate 884
Measurement of the Whole-Body Metabolic
Rate 885
Energy Metabolism—Factors That
Influence Energy Output 885
Overall Energy Requirements for Daily
Activities 885
Basal Metabolic Rate (BMR)—The
Minimum Energy Expenditure for the
Body to Exist 886
Energy Used for Physical Activities 887
Energy Used for Processing Food—
Thermogenic Effect of Food 887
Energy Used for Nonshivering
Thermogenesis—Role of Sympathetic
Stimulation 887
XXXU Table of
CHAPTER 73
Body Temperature, Temperature
Regulation, and Fever 889
Normal Body Temperatures 889
Body Temperature Is Controlled by
Balancing Heat Production Against
Heat Loss 889
Heat Production 889
Heat Loss 890
Regulation of Body Temperature—Role
of the Hypothalamus 894
Neuronal Effector Mechanisms That
Decrease or Increase Body Temperature 895
Concept of a Set-Point for Temperature
Control 896
Behavioral Control of Body Temperature 897
Abnormalities of Body Temperature
Regulation 898
Fever 898
Exposure of the Body to Extreme Cold 900
UNIT XIV
Endocrinology and Reproduction
CHAPTER 74
Introduction to Endocrinology 905
Coordination of Body Functions by
Chemical Messengers 905
Chemical Structure and Synthesis of
Hormones 906
Hormone Secretion, Transport, and
Clearance from the Blood 908
Feedback Control of Hormone Secretion 909
Transport of Hormones in the Blood 909
Clearance of Hormones from the Blood 909
Mechanisms of Action of Hormones 910
Hormone Receptors and Their Activation 970
Intracellular Signaling After Hormone
Receptor Activation 910
Second Messenger Mechanisms for
Mediating Intracellular Hormonal
Functions 912
Hormones That Act Mainly on the Genetic
Machinery of the Cell 915
Measurement of Hormone
Concentrations in the Blood 915
Radioimmunoassay 915
Enzyme-Linked Immunosorbent Assay
(ELISA) 916
CHAPTER 75
Pituitary Hormones and Their Control
by the Hypothalamus 918
Pituitary Gland and Its Relation to the
Hypothalamus 918
Hypothalamus Controls Pituitary
Secretion 919
Hypothalamic-Hypophysial Portal Blood
Vessels of the Anterior Pituitary Gland 920
Physiological Functions of Growth
Hormone 921
Contents
Growth Hormone Promotes Growth of
Many Body Tissues 922
Growth Hormone Has Several Metabolic
Effects 922
Growth Hormone Stimulates Cartilage and
Bone Growth 923
Growth Hormone Exerts Much of Its Effect
Through Intermediate Substances Called
Somatomedins (Also Called Insulin-Like
Growth Factors ) 923
Regulation of Growth Hormone Secretion 924
Abnormalities of Growth Hormone Secretion 926
Posterior Pituitary Gland and Its
Relation to the Hypothalamus 927
Chemical Structures of ADH and Oxytocin 928
Physiological Functions of ADH 928
Oxytocic Hormone 929
CHAPTER 76
Thyroid Metabolic Hormones 931
Synthesis and Secretion of the Thyroid
Metabolic Hormones 931
Iodine Is Required for Formation of
Thyroxine 931
Iodide Pump (Iodide Trapping) 932
Thyroglobulin, and Chemistry of Thyroxine
and Triiodothyronine Formation 932
Release of Thyroxine and Triiodothyronine
from the Thyroid Gland 933
Transport of Thyroxine and Triiodothyronine
to Tissues 934
Physiologic Functions of the Thyroid
Hormones 934
Thyroid Hormones Increase the
Transcription of Large Numbers of Genes 934
Thyroid Hormones Increase Cellular
Metabolic Activity 934
Effect of Thyroid Hormone on Growth 936
Effects of Thyroid Hormone on Specific
Bodily Mechanisms 936
Regulation of Thyroid Hormone
Secretion 938
Anterior Pituitary Secretion of TSH Is
Regulated by Thyrotropin-Releasing
Hormone from the Hypothalamus 938
Feedback Effect of Thyroid Hormone to
Decrease Anterior Pituitary Secretion
of TSH 939
Diseases of the Thyroid 940
Hyperthyroidism 940
Symptoms of Hyperthyroidism 940
Hypothyroidism 941
Cretinism 942
CHAPTER 77
Adrenocortical Hormones 944
Synthesis and Secretion of
Adrenocortical Hormones 944
Functions of the Mineralocorticoids-
Aldosterone 947
Renal and Circulatory Effects of
Aldosterone 948
Aldosterone Stimulates Sodium and
Potassium Transport in Sweat Glands,
Salivary Glands, and Intestinal Epithelial
Cells 949
Table
Cellular Mechanism of Aldosterone Action 95C
Possible Nongenomic Actions of
Aldosterone and Other Steroid Hormones 950
Regulation of Aldosterone Secretion 950
Functions of the Glucocorticoids 950
Effects of Cortisol on Carbohydrate
Metabolism 951
Effects of Cortisol on Protein Metabolism 952
Effects of Cortisol on Fat Metabolism 952
Cortisol Is Important in Resisting Stress
and Inflammation 952
Other Effects of Cortisol 954
Cellular Mechanism of Cortisol Action 954
Regulation of Cortisol Secretion by
Adrenocorticotropic Hormone from the
Pituitary Gland 955
Adrenal Androgens 957
Abnormalities of Adrenocortical
Secretion 957
Hypoadrenalism-Addison s Disease 957
Hyperadrenalism-Cushing s Syndrome 958
Primary Aldosteronism (Conn s Syndrome) 959
Adrenogenital Syndrome 959
CHAPTER 78
Insulin, Glucagon, and Diabetes
Mellitus 961
Insulin and Its Metabolic Effects 961
Effect of Insulin on Carbohydrate
Metabolism 963
Effect of Insulin on Fat Metabolism 965
Effect of Insulin on Protein Metabolism
and on Growth 966
Mechanisms of Insulin Secretion 967
Control of Insulin Secretion 968
Other Factors That Stimulate Insulin
Secretion 969
Role of Insulin (and Other Hormones) in
Switching Between Carbohydrate and
Lipid Metabolism 969
Glucagon and Its Functions 970
Effects on Glucose Metabolism 970
Regulation of Glucagon Secretion 971
Somatostatin Inhibits Glucagon and
Insulin Secretion 971
Summary of Blood Glucose
Regulation 971
Diabetes Mellitus 972
Type I Diabetes—Lack of Insulin Production
by Beta Cells of the Pancreas 972
Type II Diabetes—Resistance to the
Metabolic Effects of Insulin 974
Physiology of Diagnosis of Diabetes
Mellitus 975
Treatment of Diabetes 976
Insulinoma—Hyperinsulinism 976
CHAPTER 79
Parathyroid Hormone, Calcitonin,
Calcium and Phosphate
Metabolism, Vitamin D, Bone,
and Teeth 978
Overview of Calcium and Phosphate
Regulation in the Extracellular Fluid
and Plasma 978
• of Contents XXxiU
) Calcium in the Plasma and Interstitial
Fluid 978
Inorganic Phosphate in the Extracellular
i Fluids 979
1 Non-Bone Physiologic Effects of Altered
Calcium and Phosphate Concentrations
in the Body Fluids 979
Absorption and Excretion of Calcium and
Phosphate 980
Bone and Its Relation to Extracellular
Calcium and Phosphate 980
Precipitation and Absorption of Calcium
and Phosphate in Bone—Equilibrium
with the Extracellular Fluids 981
Calcium Exchange Between Bone and
Extracellular Fluid 982
Deposition and Absorption of Bone—
Remodeling of Bone 982
Vitamin D 983
Actions of Vitamin D 985
Parathyroid Hormone 985
Effect of Parathyroid Hormone on Calcium
and Phosphate Concentrations in the
Extracellular Fluid 986
Control of Parathyroid Secretion by
Calcium Ion Concentration 988
Calcitonin 988
Summary of Control of Calcium Ion
Concentration 989
Pathophysiology of Parathyroid
Hormone, Vitamin D, and Bone
Disease 990
Primary Hyperparathyroidism 990
Secondary Parathyroidism 991
Rickets—Vitamin D Deficiency 991
Osteoporosis—Decreased Bone Matrix 991
Physiology of the Teeth 992
Function of the Different Parts of the
Teeth 992
Dentition 993
Mineral Exchange in Teeth 993
Dental Abnormalities 994
CHAPTER 80
Reproductive and Hormonal
Functions of the Male (and Function
of the Pineal Gland) 996
Physiologic Anatomy of the Male
Sexual Organs 996
Spermatogenesis 996
Steps of Spermatogenesis 996
Function of the Seminal Vesicles 999
Function of the Prostate Gland 999
Semen 999
Male Sexual Act 1001
Abnormal Spermatogenesis and Male
Fertility 1001
Neuronal Stimulus for Performance of the
Male Sexual Act 1001
Stages of the Male Sexual Act 1002
Testosterone and Other Male Sex
Hormones 1003
Secretion, Metabolism, and Chemistry of
the Male Sex Hormone 1003
Functions of Testosterone 1004
Basic Intracellular Mechanism of Action of
Testosterone 1006
XXXiv Table of C
Control of Male Sexual Functions by
Hormones from the Hypothalamus and
Anterior Pituitary Gland 1006
Abnormalities of Male Sexual Function 1008
Prostate Gland and Its Abnormalities 1008
Hypogonadism in the Male 1008
Testicular Tumors and Hypergonadism in
the Male 1009
Pineal Gland—Its Function in Controlling
Seasonal Fertility in Some Animals 1009
CHAPTER 81
Female Physiology Before Pregnancy
and Female Hormones 1011
Physiologic Anatomy of the Female
Sexual Organs 1011
Female Hormonal System 1011
Monthly Ovarian Cycle; Function of the
Gonadotropic Hormones 1012
Gonadotropic Hormones and Their Effects
on the Ovaries 1012
Ovarian Follicle Growth—The Follicular
Phase of the Ovarian Cycle 1013
Corpus Luteum— Luteal Phase of the
Ovarian Cycle 1014
Summary 70/5
Functions of the Ovarian Hormones—
Estradiol and Progesterone 1016
Chemistry of the Sex Hormones 70/6
Functions of the Estrogens—Their Effects
on the Primary and Secondary Female Sex
Characteristics /077
Functions of Progesterone 1018
Monthly Endometrial Cycle and Menstruation 7078
Regulation of the Female Monthly
Rhythm—Interplay Between the
Ovarian and Hypothalamic-Pituitary
Hormones 1019
Feedback Oscillation of the Hypothalamic-
Pituitary-Ovarian System 7027
Puberty and Menarche 7027
Menopause 7022
Abnormalities of Secretion by the
Ovaries 1023
Female Sexual Act 1023
Female Fertility 1024
CHAPTER 82
Pregnancy and Lactation 7027
Maturation and Fertilization of the Ovum 7027
Transport of the Fertilized Ovum in the
Fallopian Tube 1028
Implantation of the Blastocyst in the Uterus 1029
Early Nutrition of the Embryo 7029
Function of the Placenta 7029
Developmental and Physiologic Anatomy
of the Placenta 1029
Hormonal Factors in Pregnancy 1031
Human Chorionic Gonadotropin and Its
Effect to Cause Persistence of the
Corpus Luteum and to Prevent
Menstruation ]032
Secretion of Estrogens by the Placenta 7032
Secretion of Progesterone by the Placenta 1033
Human Chorionic Somatomammotropin 1033
Other Hormonal Factors in Pregnancy 1034
Contents
Response of the Mother s Body to
Pregnancy 1034
Changes in the Maternal Circulatory System
During Pregnancy 1035
Parturition 1036
Increased Uterine Excitability Near Term 1036
Onset of Labor—A Positive Feedback
Mechanism for Its Initiation 7037
Abdominal Muscle Contractions During
Labor 1037
Mechanics of Parturition 1037
Separation and Delivery of the Placenta 1038
Labor Pains 1038
Involution of the Uterus After Parturition 1038
Lactation 1038
Development of the Breasts 1038
Initiation of Lactation—Function of
Prolactin 1039
Ejection (or Let-Down ) Process in Milk
Secretion—Function of Oxytocin 1040
Milk Composition and the Metabolic Drain
on the Mother Caused by Lactation 1041
CHAPTER 83
Fetal and Neonatal Physiology 1042
Growth and Functional Development
of the Fetus 1042
Development of the Organ Systems 1042
Adjustments of the Infant to
Extrauterine Life 1044
Onset of Breathing 1044
Circulatory Readjustments at Birth 1045
Nutrition of the Neonate 1047
Special Functional Problems in the
Neonate 1047
Respiratory System 1047
Circulation 1047
Fluid Balance, Acid-Base Balance, and
Renal Function 1048
Liver Function 7048
Digestion, Absorption, and Metabolism
of Energy Foods; and Nutrition 1048
Immunity 1049
Endocrine Problems 1049
Special Problems of Prematurity 1050
Immature Development of the Premature
Infant 7050
Instability of the Homeostatic Control
Systems in the Premature Infant 7050
Danger of Blindness Caused by Excess
Oxygen Therapy in the Premature Infant 7057
Growth and Development of the Child 7057
Behavioral Growth 7052
UNIT XV
Sports Physiology
CHAPTER 84
Sports Physiology 7055
Muscles in Exercise 7055
Strength, Power, and Endurance of Muscles 7055
Muscle Metabolic Systems in Exercise 7056
Phosphocreatine-Creatine System 7057
Table od
Nutrients Used During Muscle Activity 1059
Effect of Athletic Training on Muscles and
Muscle Performance 1060
Respiration in Exercise 1061
Cardiovascular System in Exercise 1062
Body Heat in Exercise 1065
f Contents XXXV
Body Fluids and Salt in Exercise 1065
Drugs and Athletes 1065
Body Fitness Prolongs Life 1066
Index 1067
|
| any_adam_object | 1 |
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| dewey-ones | 612 - Human physiology |
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| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 11. ed. |
| format | Book |
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| genre_facet | Einführung |
| id | DE-604.BV035339259 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:31:38Z |
| institution | BVB |
| isbn | 9780721602400 9780808923176 080892317x 0721602401 |
| language | English |
| lccn | 2004051421 |
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| physical | xxxv, 1116 p. col. ill. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
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| publisher | Elsevier Saunders |
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| spelling | Guyton, Arthur C. 1919-2003 Verfasser (DE-588)142024279 aut Textbook of medical physiology Arthur C. Guyton, John E. Hall Medical physiology 11. ed. Philadelphia Elsevier Saunders 2006 xxxv, 1116 p. col. ill. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Physiology cabt Fisiología Fisiología patológica Fysiologie gtt Menselijk lichaam gtt Pathologische fysiologie gtt Physiologie humaine Physiopathologie Human physiology Physiology, Pathological Physiological Processes Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Physiologie (DE-588)4045981-0 s DE-604 Hall, John Edward Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017143573&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Guyton, Arthur C. 1919-2003 Hall, John Edward Textbook of medical physiology Physiology cabt Fisiología Fisiología patológica Fysiologie gtt Menselijk lichaam gtt Pathologische fysiologie gtt Physiologie humaine Physiopathologie Human physiology Physiology, Pathological Physiological Processes Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4151278-9 |
| title | Textbook of medical physiology |
| title_alt | Medical physiology |
| title_auth | Textbook of medical physiology |
| title_exact_search | Textbook of medical physiology |
| title_full | Textbook of medical physiology Arthur C. Guyton, John E. Hall |
| title_fullStr | Textbook of medical physiology Arthur C. Guyton, John E. Hall |
| title_full_unstemmed | Textbook of medical physiology Arthur C. Guyton, John E. Hall |
| title_short | Textbook of medical physiology |
| title_sort | textbook of medical physiology |
| topic | Physiology cabt Fisiología Fisiología patológica Fysiologie gtt Menselijk lichaam gtt Pathologische fysiologie gtt Physiologie humaine Physiopathologie Human physiology Physiology, Pathological Physiological Processes Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Physiology Fisiología Fisiología patológica Fysiologie Menselijk lichaam Pathologische fysiologie Physiologie humaine Physiopathologie Human physiology Physiology, Pathological Physiological Processes Physiologie Einführung |
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