iGenetics: a molecular approach
With its modern chapter organization and new Focus on Genomics boxes, iGenetics: A Molecular Approach reflects the increasing molecular emphasis in todays experimental study of genes while helping students develop problem-solving skills and an appreciation for classic experiments. Although molecular...
Gespeichert in:
1. Verfasser: | |
---|---|
Format: | Buch |
Sprache: | English |
Veröffentlicht: |
San Francisco, Calif. [u.a.]
Benjamin Cummings
2010
|
Ausgabe: | 3. ed., Pearson internat. ed. |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Zusammenfassung: | With its modern chapter organization and new Focus on Genomics boxes, iGenetics: A Molecular Approach reflects the increasing molecular emphasis in todays experimental study of genes while helping students develop problem-solving skills and an appreciation for classic experiments. Although molecular topics are presented first, instructors can assign the chapters in any sequence.Pedagogical features such as chapter-opening Key Questions and strategically placed Keynotes help students to efficiently master genetic concepts. The Genetics Place Companion Website contains interactive iActivities and narrated animations that help students visualize and understand processes and concepts that are illustrated in the text. |
Beschreibung: | XIX, 828 S. zahlr. Ill., graph. Darst. |
ISBN: | 9780321610225 0321610229 |
Internformat
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020 | |a 9780321610225 |9 978-0-321-61022-5 | ||
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100 | 1 | |a Russell, Peter J. |e Verfasser |4 aut | |
245 | 1 | 0 | |a iGenetics |b a molecular approach |c Peter J. Russell |
246 | 1 | 3 | |a Genetics |
250 | |a 3. ed., Pearson internat. ed. | ||
264 | 1 | |a San Francisco, Calif. [u.a.] |b Benjamin Cummings |c 2010 | |
300 | |a XIX, 828 S. |b zahlr. Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
520 | 3 | |a With its modern chapter organization and new Focus on Genomics boxes, iGenetics: A Molecular Approach reflects the increasing molecular emphasis in todays experimental study of genes while helping students develop problem-solving skills and an appreciation for classic experiments. Although molecular topics are presented first, instructors can assign the chapters in any sequence.Pedagogical features such as chapter-opening Key Questions and strategically placed Keynotes help students to efficiently master genetic concepts. The Genetics Place Companion Website contains interactive iActivities and narrated animations that help students visualize and understand processes and concepts that are illustrated in the text. | |
650 | 4 | |a Molecular genetics | |
650 | 0 | 7 | |a Genetik |0 (DE-588)4071711-2 |2 gnd |9 rswk-swf |
655 | 7 | |0 (DE-588)4123623-3 |a Lehrbuch |2 gnd-content | |
689 | 0 | 0 | |a Genetik |0 (DE-588)4071711-2 |D s |
689 | 0 | |C b |5 DE-604 | |
856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017129104&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
999 | |a oai:aleph.bib-bvb.de:BVB01-017129104 |
Datensatz im Suchindex
_version_ | 1804138634433003520 |
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adam_text | Detailed Contents
Preface
xiii
CHAPTER
CHAPTER
iffl!!SSÍÍ©S5 ŘM
ta&W
Classical and Modern Genetics
1
Geneticists and Genetic Research
2
The Subdisciplines of Genetics
2
Basic and Applied Research
2
Genetic Databases and Maps
3
Organisms for Genetics Research
5
Summary
S
CHAPTER £m
ШШі
lit
ешшшЩ
©
MsÈBiitaâ
9
The Search for the Genetic Material
9
Griffith s Transformation Experiment
10
Avery s Transformation Experiment
11
Hershey and Chase s Bacteriophage
Experiment
12
RNA
as Viral Genetic Material
14
The Composition and Structure of
DNA
and
RNA
15
The
DNÁ
Double Helix
17
Different
DNA
Structures
20
DNA in
the Cell
20
RNÄ
Structure
21
The Organization of
DNA
in Chromosoffles
21
Viral Chromosomes
21
Prokaryotic Chromosomes
21
Eukaryotic Chromosomes
23
Focus on Ceramics: Genome Size and Repetitive
DNA
Content
25
Unique-Sequence and Repetitive-
Sequence
DNÁ
28
Summary 3#
Analytical approaches to SaMtig
■
ţeneîtes
Problems
31 ■ . ■ :. ..■.-■.·
Qiiesflons sand Problems
33, . . ■ ·. .·
36
Semiconservative
DNA
Replication
36
The Meselson-Stahl Experiment
37
DNA Polymerases,
the
DNA
Replicating
Enzymes
39
DNA
Polymerase I
39
Roles of
DNA
Polymerases
40
Molecular Model of
DNA
Replication
40
Initiation of Replication
40
Semidiscontinuous
DNA
Replication
43
Rolling Circle Replication
46
DNA
Replication in Eukaryotes
48
Replicons
48
Initiation of Replication
48
Eukaryotic Replication Enzymes
50
Replicating the Ends of Chromosomes
50
Assembling Newly Replicated
DNA
into Nucleosomes
52
Focus on Genomics: Replication Origins in Yeast
54
Summary
34
Analytical Approaches to Solving
Genetics
Problems
І5
Questions and Problems SB
С И
A P T E R
le»
йюііів
60 . ■ ■
:
Gene Contro!
of Enzyme Structure
60
Garrod s Hypothesis of Inborn Errors of
Metabolism
60
The One-Gene-One-Enzyme Hypothesis
61
Genetically Based Enzyme
Deficiencies in Humans
65
Focus on Genomics: Metabolomics in the Gut
66
Phenylketonuria
66
Albinism
68
Kartagener
Syndrome
68
Тау
-Sachs Disease
68
VI
fő
α.
о
о
Gene Control
of Protein Structure
69
Sickle-Cell Anemia
70
Other Hemoglobin Mutants
71
Cystic Fibrosis
71
Genetic Counseling
72
Carnei
Detection
73
Fetal Analysis
74
Summary
Ш
Analytical Approaches to Solving Genetics Problems
Ш
Questions and Problems ?f
CHAPTER mJ
@§i@
Шришіш; Т!шшш§іїрі©ші
.81
Gene
Expression-The Central
Dogma: An Overview
81
The Transcription Process
82
Transcription in Bacteria
83
Initiation of Transcription at Promoters
83
Elongation of an
RNA
Chain
84
Termination of an
RNA
Chain
86
Transcription in Eukaryotes
87
Eukaryotic
RNA
Polymerases
87
Transcription of Protein-Coding Genes by
RNA
Polymerase II
87
Focus on Genomics: Finding Promoters
88
The Structure and Production of Eukaryotic
mRNAs
89
Self-Splicing
Introns
95
RNA
Editing
96
Summary if
Analytical Approaches to Solving Genetics Problems if
Questions and Problems
Ш
свині
U
@»ιβ
Bsp
pfisltis
Tß^isashtSii 102
Proteins
102
Chemical Structure of Proteins
102
Molecular Structure of Proteins
103
The Nature of the Genetic Code
106
The Genetic Code Is a Triplet Code
106
Deciphering the Genetic Code
107
Characteristics of the Genetic Code
108
Focus on Genomics: Other Genetic Codes
310
Translation: The Process of Protein Synthesis
110
Transfer
RNA
210
Ribosomes
123
Initiation of Translation
225
Elongation of the Polypeptide Chain
227
Termination of Translation
220
Protein Sorting in the Cell
122
Summary
123
Analytical Approaches to Solving Genetics Problems
124
Questions and Problems
125
CHAPTER
#_____________________
iiå
lipii ,
ili
130
iiå
И
îptuspiSttoS®
EiiffiMľís
DNA Mutation
231
Adaptation versus Mutation 131
Mutations
Defined
131
Spontaneous and Induced Mutations
135
Focus on Genomics: Radiation Resistance in the Archaea-
Conan the Bacterium
140
Detecting Mutations
145
Repair of
DNA
Damage
146
Direct Reversal of
DNA
Damage
146
Excision Repair of
DNA
Damage
147
Human Genetic Diseases Resulting from
DNA
Replication and Repair Mutations
149
Transposable Elements
150
General Features of Transposable Elements
150
Transposable Elements in Bacteria
151
Transposable Elements in Eukaryotes
153
Summary
їй
Analytical Approaches to Solving Genetics Problems If
1
Questions and Problems
.
CHAPTER
8
1®1®м8©ѕ;
ìli
liipptag
ami
@
70
@®ii®jis
170
The Human Genome
Project
171
Converting Genomes into Clones, and Clones into
Genomes
171
DNA
Cloning
172
Cloning Vectors and
DNA
Cloning
175
Genomic Libraries
179
Chromosome Libraries
182
DNA
Sequencing and Analysis of
DNA
Sequences
183
Dideoxy Sequencing
183
Pyrosequencing
187
Analysis of
DNA
Sequences
189
Assembling and Annotating Genome Sequences
189
Genome Sequencing Using a Whole-Genome
Shotgun Approach
189
Assembling and Finishing Genome Sequences
191
Anno tation of Variation in Genome
Sequences
292
vii
Identification and
Annotation
of
Gene
Sequences
193
Focus
on
Genomics:
The Real Old Blue Eyes
195
Insights from Genome Analysis; Genome Sizes and
Gene Densities
199
Genomes of Bacteria
199
Genomes of Archaea
199
Genomes of Eukarya
200
Selected Examples of Genomes Sequenced
202
Genomes of Bacteria
202
Genomes of Archaea
202
Genomes of Eukarya
203
Future Directions in Genomics
205
Ethical, Legal, and Social Implications of
the Human Genome
206
Summary
ЭШ
Analytical Approaches to Solving Genetics Problems 2§S
Questions and Problems
21.2
CHAPTER
il
217
Functional Genomics
218
Sequence Similarity Searches to Assign
Gene Function
218
Assigning Gene Function Experimentally
220
Organization of the Genome
229
Describing Patterns of Gene Expression
230
Comparative Genomics
234
Examples of Comparative Genomics
Studies and Uses
235
Focus on Genomics: The Neanderthal Genome
Project
236
Summary
Î4Î
Analytical Approaches to Solving Genetics Problems
Questions and Problems
24$
CHAPTER
10
@Щ
faste*®
248
Versatile
Vectors for More Than Simple Cloning
249
Shuttle Vectors
249
Expression Vectors
24-9
PCR Cloning Vectors
252
Transcribable Vectors
252
Non-Plasmid Vectors
255
Cloning a Specific Gene
255
Finding a Specific Clone Using
а
DNA
library
255
Focus on
fîënomïesî
Finding a New Gene Linked
to Type
1
Diabetes
256
I
Identifying Genes in Libraries by Complementation
of Mutations
260
Identifying Specific
DNA
Sequences in Libraries
Using Heterologous Probes
261
Identifying Genes or cDNAs in Libraries Using
Oligonucleotide Probes
261
Molecular Analysis of Cloned
DNA 261
Southern Blot Analysis of Sequences in the
Genome
261
Northern Blot Analysis of
RNA
262
The Wide Range of Uses of the Polymerase Chain
јз[
Reaction (PCR)
263
g>
Advantages of Limitations of PCR
263 5
Applications of PCR
263 3
RT-PCR and mRNA Qualification
264
Ф
Applications of Molecular Techniques
265
Site-Specific Mutagenesis of
DNA 265
Analysis of Expression of Individual Genes
266
Analysis of Protein-Protein Interactions
267
Uses of
DNA
Polymorphisms in
Genetic Analysis
269
Classes of
DNA
Polymorphisms
270
DNA
Molecular Testing for Human Genetic Disease
Mutations
273
DNA
Typing
277
Gene Therapy
280
Biotechnology: Commercial Products
281
Genetic Engineering of Plants
282
Transformation of Plant Cells
282
Applications for Plant Genetic Engineering
284
Summary 2SS
Analytical Approaches to Solving Genetics Problems 2S7
Questions and Problems
ЋШВ
CHAPTER
11
liwéiiffli e«selis
297
Genotype and Phenotype
297
Mendel s Experimental Design
298
Monohybrid
Crosses and Mendel s Principle of
Segregation
300
The Principle of Segregation
303
Representing Crosses with a Branch
Diagram
304
Confirming the Principle of Segregation: The Use
of Testcrosses
305
The Wrinkled-Pea Phenotype
306
Dihybrid Crosses and
Mendeľs
Principle of
Independent Assortment
307
The Principle of Independent Assortment
307
viii
1
CD
Q.
О
О
§
І
Branch Diagram of Dihybrid Crosses
309
Trihybrid Crosses
310
The Rediscovery of Mendel s Principles
312
Statistical Analysis of Genetic Data:
The Chi-Square Test
312
Mendelian Genetics in Humans
314
Pedigree Analysis
314
Focus on Genomics: Sometimes Identical Just
Isn t That Similar
315
Examples of Human Genetic Traits
316
Summary
31?
Analytical Approaches to Solving Genetics Problems
31
S
Questions and Problems
3îi
CHAPTER
12
ії
l
laste
®f
ітШтЮшзте
326
Chromosomes and Cellular Reproduction
326
Eukaryotie Chromosomes
327
Mitosis
329
Meiosis
333
Focus on Genomics: Genes Involved in Meiotic
Chromosome Segregation
337
Chromosome Theory of Inheritance
339
Sex Chromosomes
339
Sex Linkage
341
Nondisjunction of X Chromosomes
343
Sex Chromosomes and Sex Determination
346
Genotypie
Sex Determination
346
Genie Sex Determination
351
Analysis of Sex-Linked Traits in Humans
351
Х
-Linked Recessive Inheritance
351
Х
-Linked Dominant Inheritance
353
Y-Linked Inheritance
353
Summary
354
Analytical Approaches to Solving Genetics Problems 3S#
Questions and Problems 3Si
CHAPTER
13
tff
ȇ
§©?SatS@is ffift
да
і
lai
©.tiifle
ЙІшір
fes
363
Multiple Alleies 364
ABO Blood Groups
364
Drosophila
Eye Color
366
Relating Multiple
Alíeles
to
Molecular Genetics
366
Modifications of Dominance Relationships
367
Incomplete Dominance
368
Codommance
368
Molecular Explanations of Incomplete Dominance
and Codominance
369
Essential Genes and Lethal
Alíeles
369
Gene Expression and the Environment
370
Penetrance
and Expressivity
3 71
Effects of the Environment
372
Nature versus Nurture
375
Maternal Effect
376
Determining the Number of Genes Involved in a
Set of Mutations with the Same Phenotype
377
Gene interactions and Modified
Mendelian Ratios
378
Gene Interactions That Produce
New Phenotypes
379
Epistasis
380
Focus on Genomics: Redheads of the Past
382
Gene Interactions Involving Modifier Genes
384
Extranuciear Inheritance
385
Extranuclear Genomes
386
Rules of Extranuclear Inheritance
386
Examples of Extranuclear Inheritance
386
Summary 3SS
Analytical Approaches to Solving Genetics Problems
Questions and Problems 3§S
CHAMES
14
isuši®
Mapping
би Шатшуштш
401
Early Studies of Genetic Linkage: Morgan s
Experiments with
Drosophila
402
Gene Recombination and the Role of Chromosomal
Exchange
403
Constructing Genetic Maps
405
Detecting Linkage through Testcrosses
405
Gene Mapping with Two-Point
Testcrosses
407
Generating a Genetic Map
408
Gene Mapping with Three-Point
Testcrosses
410
Calculating Accurate Map Distances
415
Genetic Maps and Physical Maps Compared
416
Constructing Genetic Linkage Maps of the Human
Genome
416
The
lod
Score Method for Analyzing Linkage of
Human Genes
416
Human Genetic Maps
417
Focus
ob
Genomses:
Genome-Wide Screens for Genes
Involved in Multiple Sclerosis
418 ,
Summary.
<ШЛ
■
ches to Solving Genetics Problems
v
and
Problems
41f
· .
їх
CHAPTER
15
CHAPTER
17
ieiíitSes
®ff
listerei
smi
ШшШяпщ$Еш$вш
429
Genetics Analysis of Bacteria
430
Gene Mapping in Bacteria by Conjugation
431
Discovery of Conjugation in
E. coli
431
The Sex Factor
F
432
High-Frequency Recombination
Strains of
E. coli
434
F
Factors
434
Using Conjugation to Map Bacterial Genes
435
Circularity of the
E. coli
Map
435
Genetic Mapping in Bacteria by
Transformation
437
Focus on Genomics: Artificial Life-Artificial Genomes
and Genome Transfer
438
Genetic Mapping in Bacteria by Transaction
440
Bacteriophages
440
Transduction Mapping of
Bacterial Chromosomes
441
Mapping Bacteriophage Genes
445
Fine-Structure Analysis of a Bacteriophage Gene
447
Recombination Analysis of rll Mutants
447
Deletion Mapping
449
Defining Genes by Complementation (Cis-Trans)
Tests
451
Summary
4ЅШ
Analytical Approaches to Solving Genetics Problems
45
Questions and Problems 48S
С
Η Α Ρ Γ
£
fi
16
ііі
Si
Cfeí
ШтйШт
små
ШтішЬш
463
Types of Chromosomal Mutations
463
Variations in
Chromosome
Structure
464
Deletion
464
Duplication
467
Inversion
468
Focus on
Generales:
Gene Duplications and Deletions in
the
Äudrogm-Bindmg Protein
Family
469
Translocation
470
Chromosomal Mutations and Human Tumors
472
Position Effect
475
Fragile Sites and Fragile X Syndrome
475
Variations in
Chromosome
Number
476
Changes in One or a Few Chromosomes
476
Changes in Complete Sets of Chromosomes
480
Summary
4ІІ
.
:
. ■ ..
Änalföcai Äppreashes
ta
Satotag Genetics Problems 4S3S
Questions
mă
Problems
4SI ■■ ■
©î
©ею®
Ва
491
же
Focus on
Genomics:
Models of Gene Expression
492
The
/ас
Operan
of
E. coli
492
Lactose as a Carbon Source for
E. coli
492
Experimental Evidence for the Regulation of lac
Genes
494
Jacob and Monod s Operon Model for the
Regulation of lac Genes
495
Positive Control of the lac Operon
499
Molecular Details of lac Operon Regulation
502
The
trp
Operon of
£
co/i
503
Gene Organization of the Tryptophan Biosynthesis
Genes
504
Regulation of the
trp
Operon
504
The
ага
Operon of
E. coi/:
Positive and
Negative Control
507
Regulation of Gene Expression in
Phage Lambda
509
Early Transcription Events
509
The Lysogenic Pathway
510
The Lytic Pathway
511
Summary J12
Analytical Approaches to Solving Genetics Problems
5Í3
Questions and Problems
514
σ
S
92.
čo
q.
О
о
І
С
II
Α
PT
Ε
R
18
ffl
©ff fielt
Ещршіоя
li
EiiiaMľptes
518
Leveis
of Control of Gene
Expression in Eukaiyotes
519
Control of Transcription Initiation by
Regulatory Proteins
519
Regulation of Transcription
Initiation by Activators
520
Inhibiting Transcription
Initiation by Repressors
521
Case Study: Positive and Negative
Regulation of Transcription of the
Yeast
Galactose
Utilization Genes
522
Case Study: Regulation of Transcription in
Animals by Steroid Hormones
523
Combinatorial Gene Regulation: The Control of
Transcription by Combinations of Activators and
Repressors
526
The Role of Chromatis? In Regulating
Gene Transcription
529
Repression of Gene Activity by Histones
529
Facilitation of Transcription Activation by
Remodeling of Crmonratin
529
т
CL·
о
о
5f
Gene Siíencíng ani
©etioralç
imprinting
531
Gene Silencing at a Telomere
531
Gene Silencing, by
DNA Methylatiott 531
FoeasonfienoiHîes:
СЫР оа
Chip
532
Genomìc Imprinting
533
RNA
Processing
Control:
Alternatíve
Poíyadenylaíion
and Alternative Splicing
534
mRN
A Translation Control by Ribosome
Selection
536
RNA
Interference: Silencing of Gene
Expression at the Posttranscriptlonal
Level by Small Regulatory RNAs
537
The Roles of Small Regulatory
RNÁs
in
Posttranscriptìonal Gene
Silencing
537
Regulation of Gene Expression Posttranscriptionaliy
by Controlling mRNA Degradation and
Protein Degradation
540
Control of
mRNÄ
Degradation
540
Control of Protein Degradation
541
Summary
ЂМ
Analytics! Approaches to Solving Genetics Problems
ЅШ.
Questions and Problems S€S
C IJPIÍ
S
19
s
Aielpis ®ff
ШтФџшта
547
Basic Events of Development
547
Model Organisms for the Genetic
Analysis
oí
Development
548
Developmental Results from
Differential Gene Expression
550
Constancy of
DNA in
the Genome during
Development
550
Examples of Differential Gene Activity during
Development
552
Exception to the Constancy of Genomic
DNA
during Development:
DNÁ
Loss in Antibody-
Producing Cells
553
Case Study; Sex Determination and Dosage
Compensation in Mammals and
ВгторШа
557
Sex Determination in Mammals
557
Paras on Genomics: The Pbiypus-An Odd Mammal with
a ¥ery Odd Genome
558
Dosage Compensation Mechanism for X-Linked
Genes in Mammals
558
Sex Determination
ín Drosophila
559
Dosage Compensation in ProsopMa
562
■Case Study.
:.
Genetic Regulation -of the Development
of the
Шѕо^Ша
Sody
Plan
564 ■
Dr0Sť>pMd
Devebpmetital Stages
5Й
/Embryonic Development
564 :
Mtcroarmy
itaalysis
alDmsophtìa
Development
5П
The
lofes
of niiiAs In
Development
572
Seeaaiy
ЅШ
ииађвеа!
iiiroaeltes
f
β
Sehteg
tinettes
Problems SIS
ttssf
ею
»і РюЬїш$
SÎ4
β
«
І
P T f R
20
і
«I
©siiti1
578
Relationship of the Celt Cycle to Cancer
579
Molecular Control of the Cell Cycle
579
Regulation of Cell Division in Normal Cells
580
Cancers Are Genetic Diseases
581
Genes and Cancer
582
Oneogenes
582
TRimor Suppressor Genes
588
MicroRNA Genes
593
Mutator Genes
594
Telomere Shortening, Telomerase,
and Human Cancer
595
The Multistep Nature of Cancer
595
Chemicals and Radiation as Carcinogens
596
Chemical Carcinogens
596
Focus oil Genomics: The Cancer Methylome
597
Radiation
597
Summary
ЅШ
Analytical Approaches to Solving Genetics Problems
399
Questions and Problems SSi
C H
ft
P T E H
21
s
603
Genetic Structure of Populations
605
Genotype Frequencies
605
Alíele
Frequencies
605
The Hardy-Weinberg Law
608
Assumptions of the Hardy-Weinberg Law
609
Predictions of the Hardy-Weinberg Law
609
Derivation of the Hardy-Weinberg Law
609
Extensions of the Hardy-Weinberg Law to Loci
with More than Two
Alíeles
611
Extensions of the Hardy-Wemberg Law to
X-Lmked
Alíeles
612
Testing for Hardy-Weinberg Proportions
612
Using the Hardy-Weinberg Law to Estimate
Alíele
Frequencies
613
Genetic Variation in Space and Time
614
Genetic
Variation
in
Natura!
Populations
614
xi
Measuring Genetic Variation at the
Protein Level
615
Measuring Genetic Variation at the
DNA
Level
618
Focus on Genomics: The
1,000
Genome Project
621
Forces That Change Gene Frequencies
in Populations
621
Mutation 622
Random Genetic Drift
624
Migration
629
Natural Selection
630
Balance between Mutation and Selection
638
Assortative Mating
638
Inbreeding
639
Summary of the Effects of Evolutionary
Forces on the Genetic Structure of a
Population
640
Changes in
Alíele
Frequency Within a
Population
640
Increases and Decreases in Genetic Variation
Within Populations
640
The Effects of Crossing Over on
Genetic Variation
640
The Role of Genetics in Conservation
Biology
641
Speciation
641
Barriers to Gene Flow
642
Genetic Basis for Speciation
642
Summary©©
Analytical Approaches to Solving Genetics Problems
643
Questions and Problems V
С Я А РТЕ
ü
22
^
e
§щ®і©§
650
The Nature
of Continuous Traits
650
Questions Studied in Quantitative Genetics
651
The inheritance of Continuous Traits
651
Polygene Hypothesis for Quantitative
Inheritance
652
Polygene Hypothesis for Wheat
Kernel Color
652
Statistical Tools
653
Samples and Populations
654
Distributions
654
The Mean
655
The Variance and the Standard Deviation
655
Correlation
656
Regression
658
Analysis of Variance
659
Quantitative Genetic Analysis
660
Inheritance of Ear Length in Corn
660
Heritability
661
Components of the Phenotypic Variance
661
Broad-Sense and Narrow-Sense Heritability
663
Understanding Heritability
664
How Heritability is Calculated
665
Response to Selection
666
Estimating the Response to Selection
667
Genetic Correlations
668
Quantitative Trait Loci
670
Focus on Genomics: QTL Analysis of Aggression in
Drosophila melanogaster
673
Summary
§
Ш
Analytical Approaches to Solving Genetics Problems
.
Questions and Problems Sf
S
I
CD
a.
9
|
|
і
CHAPTER
23
iaüiteitaf
йлш!шііо>§
683
Patterns and Modes of Substitutions
684
Nucleotide Substitutions in
DNA
Sequences
684
Rates of Nucleotide Substitutions
685
Variation in Evolutionary
Rates between Genes
688
Rates of Evolution in Mitochondrial
DNA 690
Molecular Clocks
690
Molecular Phytogeny
692
Phylogenetic Trees
692
Focus on Genomics: Horizontal Gene Transfer
694
Reconstruction Methods
695
Phylogenetic Trees on a Grand Scale
698
Acquisition and Origins of New Functions
700
Multigene Families
700
Gene Duplication and Gene Conversion
701
Arabidopsis Genome
701
Summary
1Ш
Analytical Approaches to Solving Genetics Problems
Questions and Problems
Glossary
707
Suggested Readings
728
Solutions to Selected
Questions and Problems
742
Credits
802
index
805
|
any_adam_object | 1 |
author | Russell, Peter J. |
author_facet | Russell, Peter J. |
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dewey-hundreds | 500 - Natural sciences and mathematics |
dewey-ones | 572 - Biochemistry |
dewey-raw | 572.8 |
dewey-search | 572.8 |
dewey-sort | 3572.8 |
dewey-tens | 570 - Biology |
discipline | Biologie |
edition | 3. ed., Pearson internat. ed. |
format | Book |
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genre | (DE-588)4123623-3 Lehrbuch gnd-content |
genre_facet | Lehrbuch |
id | DE-604.BV035324584 |
illustrated | Illustrated |
indexdate | 2024-07-09T21:31:18Z |
institution | BVB |
isbn | 9780321610225 0321610229 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017129104 |
oclc_num | 268788630 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-20 DE-29T DE-83 DE-634 DE-19 DE-BY-UBM |
owner_facet | DE-355 DE-BY-UBR DE-20 DE-29T DE-83 DE-634 DE-19 DE-BY-UBM |
physical | XIX, 828 S. zahlr. Ill., graph. Darst. |
publishDate | 2010 |
publishDateSearch | 2010 |
publishDateSort | 2010 |
publisher | Benjamin Cummings |
record_format | marc |
spelling | Russell, Peter J. Verfasser aut iGenetics a molecular approach Peter J. Russell Genetics 3. ed., Pearson internat. ed. San Francisco, Calif. [u.a.] Benjamin Cummings 2010 XIX, 828 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier With its modern chapter organization and new Focus on Genomics boxes, iGenetics: A Molecular Approach reflects the increasing molecular emphasis in todays experimental study of genes while helping students develop problem-solving skills and an appreciation for classic experiments. Although molecular topics are presented first, instructors can assign the chapters in any sequence.Pedagogical features such as chapter-opening Key Questions and strategically placed Keynotes help students to efficiently master genetic concepts. The Genetics Place Companion Website contains interactive iActivities and narrated animations that help students visualize and understand processes and concepts that are illustrated in the text. Molecular genetics Genetik (DE-588)4071711-2 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s b DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017129104&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Russell, Peter J. iGenetics a molecular approach Molecular genetics Genetik (DE-588)4071711-2 gnd |
subject_GND | (DE-588)4071711-2 (DE-588)4123623-3 |
title | iGenetics a molecular approach |
title_alt | Genetics |
title_auth | iGenetics a molecular approach |
title_exact_search | iGenetics a molecular approach |
title_full | iGenetics a molecular approach Peter J. Russell |
title_fullStr | iGenetics a molecular approach Peter J. Russell |
title_full_unstemmed | iGenetics a molecular approach Peter J. Russell |
title_short | iGenetics |
title_sort | igenetics a molecular approach |
title_sub | a molecular approach |
topic | Molecular genetics Genetik (DE-588)4071711-2 gnd |
topic_facet | Molecular genetics Genetik Lehrbuch |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017129104&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT russellpeterj igeneticsamolecularapproach AT russellpeterj genetics |