Triumph of the heart: the story of statins
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVII, 201 S. Ill., graph. Darst. |
| ISBN: | 9780195323573 |
Internformat
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| 245 | 1 | 0 | |a Triumph of the heart |b the story of statins |c Jie Jack Li |
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| 500 | |a Includes bibliographical references and index | ||
| 648 | 7 | |a Geschichte 1950-2009 |2 gnd |9 rswk-swf | |
| 650 | 4 | |a Geschichte | |
| 650 | 4 | |a Statins (Cardiovascular agents) |x History | |
| 650 | 4 | |a Hydroxymethylglutaryl-CoA Reductase Inhibitors |x history | |
| 650 | 4 | |a Coronary Disease |x drug therapy | |
| 650 | 4 | |a Drug Design | |
| 650 | 4 | |a Drug Industry |x history | |
| 650 | 4 | |a History, 20th Century | |
| 650 | 4 | |a History, 21st Century | |
| 650 | 0 | 7 | |a Koronare Herzkrankheit |0 (DE-588)4073731-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lipidsenker |0 (DE-588)4167796-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Statine |0 (DE-588)4583019-8 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804138609836556288 |
|---|---|
| adam_text | Titel: Triumph of the heart
Autor: Li, Jie Jack
Jahr: 2009
CONTENTS
Foreword ix
E. J. Corey
1 Cholesterol 3
The Janus-Faced Molecule 4
One of the 10 Greatest Discoveries in Medicine 11
The Good, the Bad, and the Ugly 13
Hitler s Gift 16
The Framingham Heart Study 19
The Receptor 22
2 Genesis of Statins 27
Early Cholesterol Drugs 27
Nicotinic acid 28
Resins 30
Fibrates 32
I Refuse to Sign This Report! 33
Birth of Statins 36
Endo s discovery of the first statin 37
The fate ofmevastatin 40
Endo s fate 42
How do statins work? 43
3 Merck s Triumph 45
Merck 45
Humble beginnings 45
George W. Merck 46
Penicillin 48
Cortisone 51
Streptomycin 53
Glorious history 55
Mevacor and Zocor 56
The poor Greek immigrant kid 56
Prelude 58
Discovery 59
Halt! 61
Triumph 63
The Company, the Drugs, and the Inventors Today 67
4 Discovery of Lipitor 71
Splendid History 71
Parke, Davis Company 71
Dilantin 74
Chloromycetin 76
7fe/ ;// 78
Lo/ /W 80
Roger S. Newton 81
Bruce D. Roth 84
The Discovery of Lipitor 86
Shoulders of giants 86
The first success... and disappointment 90
The second refrain 92
CI-971 94
CI-981 96
5 Development of Lipitor 101
Checkered Life 101
Chiral or Not, You Have to Make It First 105
Clinical Trials—Divine Providence? 108
Canter and the FDA 113
What s in a Name? 120
A Marketing Partner 121
6 To Market, to Market 125
Pfizer Inc. 126
The small drug firm in Brooklyn made big 126
Penicillin 127
Drugs of its own 128
Windfall: The Era of Blockbusters 131
Viagra 132
Zoloft 134
Diflucan 135
Zithromax 137
Norvasc 138
xvi CONTENTS
The Merger 140
PROVE-IT 142
The Patent Litigation 145
7 Baycol, Crestor, and Cholesterol Drugs beyond Statins 149
The Story of Baycol 150
Crestor 152
Cholesterol Drugs beyond Statins 155
Zetia and Vytorin 155
Torcetrapib, a bitter disappointment 158
ApoA-i Milano andNewton 162
8 Reflections 167
Triumph of the Heart 167
Statins set a high standard in efficacy 168
Statins set a high standard in safety 169
Statins set a high standard in financial benefits 169
The Drug Industry and the Blockbuster Model 170
Appendix: Drug Names 173
Notes and References 175
Index 189
CONTENTS xvii
|
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| era_facet | Geschichte 1950-2009 |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T21:30:55Z |
| institution | BVB |
| isbn | 9780195323573 |
| language | English |
| lccn | 2008039597 |
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| physical | XVII, 201 S. Ill., graph. Darst. |
| publishDate | 2009 |
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| spelling | Li, Jie Jack 1964- Verfasser (DE-588)123481848 aut Triumph of the heart the story of statins Jie Jack Li Oxford [u.a.] Oxford Univ. Press 2009 XVII, 201 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Geschichte 1950-2009 gnd rswk-swf Geschichte Statins (Cardiovascular agents) History Hydroxymethylglutaryl-CoA Reductase Inhibitors history Coronary Disease drug therapy Drug Design Drug Industry history History, 20th Century History, 21st Century Koronare Herzkrankheit (DE-588)4073731-7 gnd rswk-swf Lipidsenker (DE-588)4167796-1 gnd rswk-swf Statine (DE-588)4583019-8 gnd rswk-swf Statine (DE-588)4583019-8 s Geschichte 1950-2009 z DE-604 Koronare Herzkrankheit (DE-588)4073731-7 s Lipidsenker (DE-588)4167796-1 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017111867&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Li, Jie Jack 1964- Triumph of the heart the story of statins Geschichte Statins (Cardiovascular agents) History Hydroxymethylglutaryl-CoA Reductase Inhibitors history Coronary Disease drug therapy Drug Design Drug Industry history History, 20th Century History, 21st Century Koronare Herzkrankheit (DE-588)4073731-7 gnd Lipidsenker (DE-588)4167796-1 gnd Statine (DE-588)4583019-8 gnd |
| subject_GND | (DE-588)4073731-7 (DE-588)4167796-1 (DE-588)4583019-8 |
| title | Triumph of the heart the story of statins |
| title_auth | Triumph of the heart the story of statins |
| title_exact_search | Triumph of the heart the story of statins |
| title_full | Triumph of the heart the story of statins Jie Jack Li |
| title_fullStr | Triumph of the heart the story of statins Jie Jack Li |
| title_full_unstemmed | Triumph of the heart the story of statins Jie Jack Li |
| title_short | Triumph of the heart |
| title_sort | triumph of the heart the story of statins |
| title_sub | the story of statins |
| topic | Geschichte Statins (Cardiovascular agents) History Hydroxymethylglutaryl-CoA Reductase Inhibitors history Coronary Disease drug therapy Drug Design Drug Industry history History, 20th Century History, 21st Century Koronare Herzkrankheit (DE-588)4073731-7 gnd Lipidsenker (DE-588)4167796-1 gnd Statine (DE-588)4583019-8 gnd |
| topic_facet | Geschichte Statins (Cardiovascular agents) History Hydroxymethylglutaryl-CoA Reductase Inhibitors history Coronary Disease drug therapy Drug Design Drug Industry history History, 20th Century History, 21st Century Koronare Herzkrankheit Lipidsenker Statine |
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